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Brinker, US

Achim Brinker, San Diego, CA US

Patent application numberDescriptionPublished
20100086943METHOD FOR THE DETECTION OF POST-TRANSLATIONAL MODIFICATIONS - Method for the detection in homogeneous medium of a post-translational modification of a protein substrate catalyzed by a cell enzyme, characterized in that the post-translational modification reaction takes place in intact living cells, in that these cells comprise a heterologous expression vector coding for a fusion protein comprising the protein substrate and a first coupling domain and in that it comprises the following stages: (v) Incubation of the cells in the presence or in the absence of a compound to be tested capable of modulating the activity of said enzyme, (vi) Addition to the reaction medium of a first fluorescent compound member of a first pair of FRET partners covalently bonded to a coupling agent capable of binding specifically to the first coupling domain present on the protein substrate, (vii) Addition to the reaction medium of a second fluorescent compound member of this first pair of FRET partners, and covalently bonded to a binding domain specific to the site of the protein substrate having undergone the post-translational modification and not binding to the non-modified protein substrate, (i) Measurement of the FRET signal emitted by the sample, this signal being representative of the quantity of protein substrate having undergone said post-translational modification; and cells for the implementation of said method.04-08-2010

Benjamin Brinker, Plainville, MA US

Patent application numberDescriptionPublished
20100078347Foldable Package - The present disclosure relates to medical packaging for the accommodation of medical supplies. The medical packaging discussed herein has a plurality of panels, including a first panel, a second panel, and a third panel, that are releasably secured together to establish a first sterile environment between the first panel and the second panel for the retention of a first medical supply, and a second sterile environment between the second panel and the third panel for the retention of a second medical supply. The panels are configured for relative movement such that movement of the first panel relative to the second panel reveals the first medical supply without compromising the second sterile environment, and movement of the second panel relative to the third panel reveals the second medical supply. The panels are arranged for sequential separation in accordance with the steps of the procedure in which the medical supplies are employed.04-01-2010
20110253573Foldable Package - The present disclosure relates to medical packaging for the accommodation of medical supplies. The medical packaging discussed herein has a plurality of panels, including a first panel, a second panel, and a third panel, that are releasably secured together to establish a first sterile environment between the first panel and the second panel for the retention of a first medical supply, and a second sterile environment between the second panel and the third panel for the retention of a second medical supply. The panels are configured for relative movement such that movement of the first panel relative to the second panel reveals the first medical supply without compromising the second sterile environment, and movement of the second panel relative to the third panel reveals the second medical supply. The panels are arranged for sequential separation in accordance with the steps of the procedure in which the medical supplies are employed.10-20-2011

Charles Jeffrey Brinker, Albuquerque, NM US

Patent application numberDescriptionPublished
20080210053HOLLOW SPHERE METAL OXIDES - In accordance with invention, there are methods for fabricating hollow spheres and nanofoams. The method for making hollow spheres can include providing a homogeneous precursor solution including a first solvent and one or more anhydrous precursor species and forming aerosol droplets having a first size distribution using the homogeneous precursor solution in an anhydrous carrier gas. The method can also include transporting the aerosol droplets through an aerosol reactor including a reactant to form a plurality of hollow spheres, wherein each of the plurality of hollow spheres can be formed by one or more chemical reactions occurring at a surface of the aerosol droplet. The method can further include controlling size and thickness of the hollow spheres by one or more of the precursor solution concentration, aerosol droplet size, temperature, residence time of the aerosol droplets in the aerosol reactor, and the reactant distribution in the aerosol reactor.09-04-2008
20110206925DURABLE POLYMER-AEROGEL BASED SUPERHYDROPHOBIC COATINGS, A COMPOSITE MATERIAL - Provided are polymer-aerogel composite coatings, devices and articles including polymer-aerogel composite coatings, and methods for preparing the polymer-aerogel composite. The exemplary article can include a surface, wherein the surface includes at least one region and a polymer-aerogel composite coating disposed over the at least one region, wherein the polymer-aerogel composite coating has a water contact angle of at least about 140° and a contact angle hysteresis of less than about 1°. The polymer-aerogel composite coating can include a polymer and an ultra high water content catalyzed polysilicate aerogel, the polysilicate aerogel including a three dimensional network of silica particles having surface functional groups derivatized with a silylating agent and a plurality of pores.08-25-2011
20120040577SUPERHYDROPHOBIC AEROGEL THAT DOES NOT REQUIRE PER-FLUORO COMPOUNDS OR CONTAIN ANY FLUORINE - Provided are superhydrophobic coatings, devices and articles including superhydrophobic coatings, and methods for preparing the superhydrophobic coatings. The exemplary superhydrophobic device can include a substrate component and one or more superhydrophobic coatings disposed over the substrate component, wherein at least one of the one or more superhydrophobic coatings has a water contact angle of at least about 150° and a contact angle hysteresis of less than about 1°. The one or more superhydrophobic coatings can include an ultra high water content acid catalyzed polysilicate gel, the polysilicate gel including a three dimensional network of silica particles having surface functional groups derivatized with a silylating agent and a plurality of pores.02-16-2012

Patent applications by Charles Jeffrey Brinker, Albuquerque, NM US

C. Jeffrey Brinker, Albuquerque, NM US

Patent application numberDescriptionPublished
20090175948AEROSOL METHOD FOR NANO SILVER-SILICA COMPOSITE ANTI-MICROBIAL AGENT - A method of forming and resulting nano-structured composite includes atomizing a mixture of an amount of each of aminopropyltriethoxysilane, AgNO07-09-2009
20100178468ULTRA-THIN MICROPOROUS/HYBRID MATERIALS - Ultra-thin hybrid and/or microporous materials and methods for their fabrication are provided. In one embodiment, the exemplary hybrid membranes can be formed including successive surface activation and reaction steps on a porous support that is patterned or non-patterned. The surface activation can be performed using remote plasma exposure to locally activate the exterior surfaces of porous support. Organic/inorganic hybrid precursors such as organometallic silane precursors can be condensed on the locally activated exterior surfaces, whereby ALD reactions can then take place between the condensed hybrid precursors and a reactant. Various embodiments can also include an intermittent replacement of ALD precursors during the membrane formation so as to enhance the hybrid molecular network of the membranes.07-15-2010
20110186971METHOD OF MAKING DENSE, CONFORMAL, ULTRA-THIN CAP LAYERS FOR NANOPOROUS LOW-K ILD BY PLASMA ASSISTED ATOMIC LAYER DEPOSITION - Barrier layers and methods for forming barrier layers on a porous layer are provided. The methods can include chemically adsorbing a plurality of first molecules on a surface of the porous layer in a chamber and forming a first layer of the first molecules on the surface of the porous layer. A plasma can then be used to react a plurality of second molecules with the first layer of first molecules to form a first layer of a barrier layer. The barrier layers can seal the pores of the porous material, function as a diffusion barrier, be conformal, and/or have a negligible impact on the overall ILD k value of the porous material.08-04-2011

Patent applications by C. Jeffrey Brinker, Albuquerque, NM US

Daniel Brinker, Troy, MI US

Patent application numberDescriptionPublished
20100236069KNUCKLE HUB ASSEMBLY AND METHOD FOR MAKING SAME - A knuckle hub assembly (09-23-2010

Patent applications by Daniel Brinker, Troy, MI US

Jeffrey Brinker, North Brunswick, NJ US

Patent application numberDescriptionPublished
20100089428WASHING SYSTEM FOR DISSOLUTION VESSELS AND THE LIKE - In one embodiment, a washing system including a nozzle assembly having a nozzle and having formed therein a rinse passageway and a waste passageway. Each passageway has first and second ends. The first end of the waste passageway is adapted to be coupled to a waste pump adapted to remove waste fluid via a waste aperture defining the second end of the waste passageway. The first end of the rinse passageway is adapted to be coupled to a rinse pump adapted to provide rinse fluid via a rinse aperture defining the second end of the rinse passageway. The nozzle is coupled to the rinse aperture and is adapted to rotate and direct flow of the rinse fluid outwardly while rotating.04-15-2010

Jeffrey Brinker, Westfield, NJ US

Patent application numberDescriptionPublished
20110247435DISSOLUTION-TESTING VESSEL COVER - In one embodiment, a contiguous, elastic cover, for a dissolution-testing vessel, has a slit from a central opening to its outer edge. The cover may be placed around a stirring shaft by deforming the elastic cover to temporarily enlarge the slit. After returning to its original shape, the cover is placed over the vessel with the shaft free to rotate unimpeded within the central opening. The cover has a first raised annular disk on one side and a second raised annular disk on the other side, where the disks have different outer diameters to enable the cover to be used with differently sized vessels. The cover has a first opening having a first diameter and a second opening having a different, second diameter such that a conventional probe fits either at one depth within the first opening or at a different, second depth within the second opening.10-13-2011

Jeffrey Brinker, Baltimore, MD US

Patent application numberDescriptionPublished
20120083767IMPLANTABLE BIOREACTOR FOR DELIVERY OF PARACRINE FACTORS - An implantable bioreactor containing a barrier which is designed to allow the release of cell-derived biomolecules, but restricts the entry of immunologic and other cells, or the egress of the cells contained within the bioreactor. Two broad classes of implantable bioreactors are envisioned, encompassing devices for both systemic delivery of the bio-products and local delivery at the target tissue. Bioreactors of both classes can be implanted via surgery, through percutaneous techniques, or other techniques which effect implantation.04-05-2012

Jeffrey C. Brinker, Albuquerque, NM US

Patent application numberDescriptionPublished
20110268791POROUS NANOPARTICLE SUPPORTED LIPID BILAYER NANOSTRUCTURES - Various exemplary embodiments provide protocell nanostructures and methods for constructing and using the protocell nanostructures. In one embodiment, the protocell nanostructures can include a core-shell structure including a porous particle core surrounded by a shell of lipid bilayer(s). The protocell can be internalized in a bioactive cell. Various cargo components, for example, drugs, can be loaded in and released from the porous particle core of the protocell(s) and then delivered within the bioactive cell.11-03-2011

Jeffrey T. Brinker, Seattle, WA US

Patent application numberDescriptionPublished
20100205018SYSTEM AND METHOD FOR MANAGING INVENTORY - A system and method for managing inventory data are provided. A travel server obtains inventory data from one or more inventory suppliers and stores the inventory data as SKU group, SKU and SKU inventory records. The travel server utilizes the SKU group, SKU and SKU inventory records. The travel server utilizes the SKU group, SKU and SKU inventory records to process user requests for available inventory and supplier inventory action requests.08-12-2010

Joseph Ralph Brinker, Lafayette, IN US

Patent application numberDescriptionPublished
20090000592Engine pre-lubrication system - A system for pre-lubricating an engine is disclosed. The system has an engine, a first pump driven by the engine to lubricate the engine, and a second pump configured to lubricate the engine. The system also has at least one component driven by the engine and fluidly connected downstream of the second pump and upstream of the engine. The system further has a sensor located at the engine to generate a signal indicative of an engine lubrication status. Starting of the engine is inhibited based on the engine lubrication status.01-01-2009

Joseph S. Brinker, Highland, IL US

Patent application numberDescriptionPublished
20090143925ROBUST CONTROL EFFECTOR ALLOCATION - Method and apparatus is disclosed which allocates the execution of a commanded vehicle maneuver among the vehicle's control effectors capable of affecting such maneuver, with consideration given to the possible nonlinear and/or non-monotonic effects each control effector's displacement may have on the vehicle and on each other's performance.06-04-2009

Kevin John Brinker, Clarkston, MI US

Patent application numberDescriptionPublished
20090113784Fishing line release system - A fishing line release system is disclosed. The fishing line release system includes a fishing line quick release mechanism that may be used in conjunction with a planar device for trolling or may alternatively be used with a down rigger cable and weight when used in down rigger fishing. When used in conjunction with the planar device, the system may be used for directional trolling. The planar device comprises a planar body, the fishing line quick release mechanism attached to the planar body, and a line locking assembly for securing a portion of a fishing line to the planar body. When used in conjunction with a down rigger cable and weight, the quick release mechanism may be used either on the down rigger cable or may be attached to the down rigger weight.05-07-2009

Klaus Brinker, Princeton, NJ US

Patent application numberDescriptionPublished
20080205774Document clustering using a locality sensitive hashing function - Documents from a data stream are clustered by first generating a feature vector for each document. A set of cluster centroids (e.g., feature vectors of their corresponding clusters) are retrieved from a memory based on the feature vector of the document using a locality sensitive hashing function. The centroids may be retrieved by retrieving a set of cluster identifiers from a cluster table, the cluster identifiers each indicative of a respective cluster centroid, and retrieving the cluster centroids corresponding to the retrieved cluster identifiers from a memory. Documents may then be clustered into one or more of the candidate clusters using distance measures from the feature vector of the document to the cluster centroids.08-28-2008
20080205775Online document clustering - Documents from a data stream are clustered by first generating a feature vector for each document. A set of cluster centroids (e.g., feature vectors of their corresponding clusters) are retrieved from a memory based on the feature vector of the document and a relative age of each of the cluster centroids. The centroids may be retrieved by retrieving a set of cluster identifiers from a cluster table, the cluster identifiers each indicative of a respective cluster centroid, and retrieving the cluster centroids corresponding to the retrieved cluster identifiers from a memory. A list of cluster identifiers in the cluster table may be maintained based on the relative age of cluster centroids corresponding to the cluster identifiers. Cluster identifiers that correspond to cluster centroids with a relative age exceeding a predetermined threshold are periodically removed from the list of cluster identifiers.08-28-2008
20080208847Relevance ranking for document retrieval - Documents and/or document clusters are ranked with respect to their geographical locations and/or user specific (e.g., user input) relevance. Highly relevant documents and/or document clusters are assigned higher ranks than less relevant documents and/or clusters. In this way, ranked lists of documents and/or clusters, top clusters (e.g., top stories), top documents (e.g., most important articles), etc. may be served (e.g., presented, delivered, etc.) to users.08-28-2008

Mark Brinker, Houston, TX US

Patent application numberDescriptionPublished
20110081682PRODUCTION OF BONE MORPHOGENIC PROTEINS (BMPS) USING A NOVEL TISSUE CULTURE PLATFORM - The present disclosure provides methods for producing Bone Morphogenetic Proteins (BMPs). The BMPs are produced using ex vivo-derived mineralized three-dimensional bone constructs of varying degrees of maturity and mineralization. The bone constructs are obtained by culturing osteoblasts and osteoclast precursors under randomized gravity vector conditions whereupon the bone constructs secrete BMPs into the culture medium. Culture medium is periodically removed from the bone construct culture, and the BMPs are purified from the removed culture medium.04-07-2011
20110086080EX-VIVO PRODUCTION OF HUMAN DEMINERALIZED BONE MATRIX - The present disclosure provides ex vivo-derived human demineralized bone matrix. The bone matrix is produced using mineralized three-dimensional bone constructs. The bone constructs are obtained by culturing osteoblasts and osteoclast precursors under randomized gravity vector conditions. Preferably, the randomized gravity vector conditions are obtained using a low shear stress rotating bioreactor, such as a High Aspect Ratio Vessel (HARV) culture system. The ex vivo-derived human demineralized bone matrix of the disclosure can be used in, for example, orthopedic and periodontal procedures.04-14-2011
20110091862GENERATION OF AN HLA-NEGATIVE OSTEOGENIC PRECURSOR CELL LINE - The present disclosure provides methods for producing human osteogenic cell lines in which HLA Class I expression is absent or reduced. The resulting osteogenic cells can then be used, for example, to form mineralized three-dimensional bone constructs which can be used, for example, in bone grafting procedures. The lack of HLA Class I expression in the cells of the mineralized three-dimensional bone constructs reduces or eliminates the potential for host-graft rejection.04-21-2011
20110129866NOVEL TISSUE CULTURE PLATFORM FOR SCREENING OF POTENTIAL BONE REMODELING AGENTS - The present disclosure provides methods for identifying candidate compounds having bone anti-resorption activity or bone pro-formation activity. The methods involve the use of ex vivo-derived mineralized three-dimensional bone constructs. The bone constructs are obtained by culturing osteoblasts and osteoclast precursors under randomized gravity vector conditions in the presence of the candidate compound. Preferably, the randomized gravity vector conditions are obtained using a low shear stress rotating bioreactor, such as a High Aspect Ratio Vessel (HARV) culture system.06-02-2011
20110217352DEVELOPMENT OF A HUMAN COLLOIDAL BONE GRAFT MATERIAL - The present disclosure provides colloidal bone graft compositions comprising a plurality of mineralized three-dimensional bone constructs, a polymerizable biocompatible matrix, an osteoblast differentiation agent, and at least one osteoblast mineralization agent. The colloidal bone graft compositions of the disclosure are used to perform bone grafts in human or animal patients.09-08-2011

Mark R. Brinker, Houston, TX US

Patent application numberDescriptionPublished
20110082549MINERALIZED THREE-DIMENSIONAL BONE CONSTRUCTS FORMED FROM OSTEOBLASTS - The present disclosure provides ex vivo-derived mineralized three-dimensional bone constructs. The bone constructs are obtained by culturing osteoblasts under randomized gravity vector conditions. Preferably, the randomized gravity vector conditions are obtained using a low shear stress rotating bioreactor, such as a High Aspect Ratio Vessel (HARV) culture system. The bone constructs of the disclosure have utility in physiological studies of bone formation and bone function, in drug discovery, and in orthopedics.04-07-2011

Patent applications by Mark R. Brinker, Houston, TX US

Michael Brinker, Rochester, MN US

Patent application numberDescriptionPublished
20080271140Verification for Computer Programs that Include External Call References - A program verification mechanism includes an external call reference verification mechanism that verifies external call references in a computer program. The external call reference verification mechanism checks the computer program after the computer program has been loaded by a loader/linker. The loader/linker stores a list of trusted entry points that specifies a trusted entry point for each external call reference, along with a list of allowable caller code for each trusted entry point. The external call reference verification mechanism determines the entry point for each instruction that is an external call reference, determines whether the entry point is listed as the trusted entry point for the external call reference, and whether the external call reference instruction is in the list of allowable caller code for the trusted entry point. If so, the computer program is verified. If not, verification of the computer program fails.10-30-2008

Michael J. Brinker, Rochester, MN US

Patent application numberDescriptionPublished
20090049309Method and Apparatus for Verifying Integrity of Computer System Vital Data Components - Vital data components of a computer system are protected by a mechanism for detecting unauthorized alteration, preferably in the form of digital signatures to detect unauthorized alteration. A vital data validation mechanism is provided to verify that vital data modules have not been tampered with. The vital data validation mechanism verifies the current state of each vital data module, preferably by decrypting the digital signature. The validation mechanism also checks an alteration log to verify that no alterations have been made to the corresponding memory locations. The second verification is intended to detect whether a vital data module has been altered temporarily, and then restored to its initial state.02-19-2009

Ronald J. Brinker, Ellisville, MO US

Patent application numberDescriptionPublished
20080242548Method of microencapsulating an agricultural active having a high melting point and uses for such materials - A method of producing a controlled release form of an agricultural active material includes the provision of an organic liquid composition in which the active is present, but where the liquid composition is free from aromatic solvents and is maintained below the normal melting point of the active. The liquid composition is formed into small droplets and the droplets are enclosed by a non-water soluble shell to provide microcapsules, the shell of which is designed to release the agricultural active at a pre-selected controlled rate when the microcapsule is exposed to natural environmental conditions. Controlled release forms of agricultural actives are also provided.10-02-2008
20080305952CROPPING SYSTEMS FOR MANAGING WEEDS - The invention provides cropping systems for managing weeds in crop environments. The cropping systems comprise, in one embodiment, transgenic plants that display tolerance to an auxin-like herbicide such as dicamba. Method for minimizing the development of herbicide resistant weeds are also provided.12-11-2008
20090105077METHODS AND COMPOSITIONS FOR IMPROVING PLANT HEALTH - The present invention provides methods and compositions for improving plant health. In particular, application of dicamba or another substrate of DMO, or metabolites thereof including DCSA, to a plant confers tolerance to, or defense against, abiotic or biotic stresses such as oxidative stress including herbicide application, and plant disease, and enhances crop yield. Such application may be in combination with the application of another herbicide such as glyphosate.04-23-2009
20100234228NOVEL SURFACTANTS AND FORMULATIONS - A herbicidal composition is provided comprising an aqueous solution of N-phosphonomethylglycine, predominantly in the form of the potassium salt thereof, at a concentration of at least 300 g a.e./l of the composition; and a surfactant component in solution or stable suspension, emulsion, or dispersion in the water, comprising one or more surfactants in a total amount of about 20 to about 300 g/l of the composition, wherein the composition has a viscosity of less than about 250 centipoise at 0° C. or a Gardner color value less than 10.09-16-2010
20110034332Herbicidal compositions containing N-phosphonomethyl glycine and an auxin herbicide - Herbicidal compositions are provided which cause rapid symptomology while delivering long term control of regrowth of plants. The herbicidal concentrate compositions comprise N-phosphonomethylglycine or a herbicidal derivative thereof, an auxin herbicide or a herbicidal derivative thereof, and at least one surfactant. Also provided is a method for killing or controlling the growth of certain plants by contacting the foliage of the plants with the diluted concentrate composition.02-10-2011
20110067134SOYBEAN TRANSGENIC EVENT MON 87708 AND METHODS OF USE THEREOF - The invention provides a transgenic soybean event MON 87708 plant and plants, plant cells, seeds, plant parts, and commodity products derived from event MON 87708. The invention also provides polynucleotides specific for event MON 87708 and plants, plant cells, seeds, plant parts, and commodity products comprising polynucleotides specific for event MON 87708. The invention also provides methods related to event MON 87708.03-17-2011
20110152096METHODS FOR WEED CONTROL - The invention provides methods for weed control with dicamba and related herbicides. It was found that pre-emergent applications of dicamba at or near planting could be made without significant crop damage or yield loss. The techniques can be combined with the herbicide glyphosate to improve the degree of weed control and permit control of herbicide tolerant weeds.06-23-2011
20110245080CROPPING SYSTEMS FOR MANAGING WEEDS - The invention provides cropping systems for managing weeds in crop environments. The cropping systems comprise, in one embodiment, transgenic plants that display tolerance to an auxin-like herbicide such as dicamba. Method for minimizing the development of herbicide resistant weeds are also provided.10-06-2011

Patent applications by Ronald J. Brinker, Ellisville, MO US