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Brett, GB
Alan Brett, Manchester GB
| Patent application number | Description | Published |
|---|---|---|
| 20090297012 | Methods of and System for Detection and Tracking of Osteoporosis - A method and system for detection and tracking of osteoporosis is disclosed. A method of characterizing an image of a target vertebra includes building a computer model from a set of sample images of pathological and non-pathological variations of vertebrae representing variations in shape of the vertebrae. The method also includes receiving an image of a target vertebra of a subject and automatically estimating contours of lateral outlines of the superior and the inferior cortical endplates of the image. The parameters of the model are varied to determine a set that represents a model shape that approximates the estimated contours of the outlines of the cortical endplates. The method includes automatically characterizing the target vertebra based on the set of model parameters that are determined and outputting on a display device the characterization of the target vertebra. | 12-03-2009 |
Peter Brett, Birmingham GB
| Patent application number | Description | Published |
|---|---|---|
| 20110020084 | Drilling apparatus and methods - The present invention provides a method of drilling a hole in a workpiece in order to control breakthrough of the workpiece comprising the steps of: a) initiating contact between a drill bit of a drill unit and the workpiece; b) operating the drill unit to rotate the drill bit to drill the workpiece; c) during drilling of the workpiece measuring the force, F and torque, T, experienced by the drill bit; d) calculating a variable F′, based on the measured force, F, representing the rate of change of F; e) calculating a variable, T′ based on the measured torque, T, representing the rate of change of T; f) calculating a variable F″ representing the rate of change of F′; g) calculating a variable T″ representing the rate of change of T″; h) detecting the onset of breakout of the workpiece by use of the variables F′, F″, T′ and T″; i) thereby controlling the speed of rotation of the drill bit during breakthrough of the workpiece to control the degree of breakout of the drill bit from the workpiece. A drilling system is also disclosed. | 01-27-2011 |
Peter Brett, Witney GB
| Patent application number | Description | Published |
|---|---|---|
| 20100075603 | DETERMINING RELATIVE PHASE DATA OF A RECEIVED SIGNAL - A method of determining relative phase data of a signal received at multiple antennas, the signal being a phase-modulated data signal having a plurality of periods of constant frequency, the method comprising: within each period of constant frequency, sampling the signal received by a first one of the multiple antennas and sampling the signal received by at least one different one of the multiple antennas; determining from the received samples a data symbol value represented by the received signal for each of the periods of constant frequency; and using the determined data symbol value information to eliminate phase variations between the samples received by the different antennas within each constant frequency period arising from the modulation of the data signal to generate relative phase data for said different antennas. | 03-25-2010 |
Peter Nigel Brett, Sambourne GB
| Patent application number | Description | Published |
|---|---|---|
| 20120077219 | VIBRATING MICROPLATE BIOSENSING FOR CHARACTERISING PROPERTIES OR BEHAVIOUR OF BIOLOGICAL CELLS - There is described a method of characterising a property or behaviour of at least one biological cell. The method comprises the steps of: providing a microplate; submerging at least one surface of the microplate in a cell culture medium such that at least one biological cell to be characterised is in contact with the microplate; vibrating the microplate; providing a plurality of mutually spaced sensors coupled to the microplate; obtaining a respective sensory data time series from each sensor during vibration of the microplate, the microplate and the sensors being arranged such that the obtained sensory data time series are not independent from one another; and processing the sensory data time series so as to characterise a property or behaviour of the at least one biological cell. A corresponding system for characterising a property or behaviour of at least one biological cell is also described. | 03-29-2012 |
Peter Nigel Brett, Warwickshire GB
| Patent application number | Description | Published |
|---|---|---|
| 20100210974 | AUTOMATIC DISCRIMINATION OF DYNAMIC BEHAVIOUR - There is a distributive sensing technology that can discriminate between the causes of dynamic disturbances. The system applies sensing elements within a sensing medium, and the medium couples the dynamic disturbance and the sensors. By interpreting the responses of the medium, the nature of the disturbance can be discriminated in a way as to determine a description, class or category. There is a method of categorizing the dynamic body behavior, the method comprising: providing a sensing medium during at least a period of the dynamic behavior of the body; providing a plurality of sensors coupled to the sensing medium; obtaining a sensory data time series from each sensor, the sensing medium and the sensors being arranged such that the obtained sensory data time series are not independent from one another; specifying a dynamic behavior category; and processing the sensory data time series. Apparatus for performing the method is also described. | 08-19-2010 |
Peter Stuart Brett, Berkshire GB
| Patent application number | Description | Published |
|---|---|---|
| 20120012076 | METHOD OF OPERATING A HYBRID ENGINE - The invention relates to a method of operating a hybrid internal combustion engine, which method comprises: fuelling said hybrid internal combustion engine with a combustible fuel; lubricating said engine with an engine oil composition; and maintaining an oil film thickness of the engine oil composition in the big end conrod bearing shells of the engine of at least 0.4 μm; in which the temperature of the engine oil composition is maintained below 123° C. and the engine oil composition has: a high temperature, high shear viscosity of less than 2.6 cP (2.6 millipascal second) at 150° C. and at a shear rate of 10 | 01-19-2012 |
Sally Emma Brett, London GB
| Patent application number | Description | Published |
|---|---|---|
| 20110270098 | APPARATUS AND METHOD FOR MEASURING BLOOD PRESSURE - The application relates to an apparatus and a method for estimating a central systolic blood pressure (cSBP) of a subject, in which a peripheral blood pressure waveform of the subject's pulse and at least two peripheral blood pressure measurements within the cardiac cycle of the subject are determined and the peripheral blood pressure waveform is manipulated with a transfer function to provide an estimate of the central blood pressure waveform of the subject's pulse. The at least two peripheral blood pressure measurements within the cardiac cycle of the subject and the peripheral blood pressure waveform of the subject's pulse are determined at substantially the same point on a peripheral artery of the subject. The estimate of the central blood pressure waveform of the subject's pulse provides an estimate of the central systolic blood pressure of the subject. | 11-03-2011 |
Sara Brett, Stevenage GB
| Patent application number | Description | Published |
|---|---|---|
| 20090104231 | VACCINE - The present invention relates to methods and compositions useful in the treatment and prevention of Hepatitis C virus (HCV) infections and the symptoms and diseases associated therewith. In particular the present invention relates to DNA vaccines comprising polynucleotide sequences encoding HCV proteins, and methods of treatment of individuals infected with HCV comprising administration of the vaccines of the present invention. | 04-23-2009 |
| 20090232847 | Immunogenic compositions - The present invention relates to methods and compositions useful in the treatment and prevention of Hepatitis C virus (HCV) infections and the symptoms and diseases associated therewith. In particular the present invention relates to DNA vaccines that encode the HCV Core protein and a polynucleotide sequence that encodes at least one other HCV protein, wherein the vaccine causes expression of the proteins within the same cell and the sequence of the polynucleotide sequence encoding the core protein has been mutated or positioned relative to the polynucleotide sequence encoding the at least one other HCV protein such that the negative effect of expression of the Core protein upon the expression of the said at least one other HCV protein is reduced. | 09-17-2009 |
Sara Jane Brett, Hertfordshire GB
| Patent application number | Description | Published |
|---|---|---|
| 20090104153 | METHOD OF ELICITING IMMUNE RESPONSE - The present invention relates to methods of eliciting an immune response by use of a prime-boost schedule for delivering a polynucleotide encoding a heterologous non-self antigen. In particular, the invention relates to a prime-boost schedule wherein the priming polynucleotide composition is delivered by an adenoviral vector, and the boosting polynucleotide composition is coated on or incorporated in a particle and is administered by a particle acceleration device. | 04-23-2009 |
| 20090274726 | SYNTHETIC GENE - The present invention relates to synthetic genes, processes for designing said synthetic genes and their uses in gene therapy and improved DNA vaccination. The novel synthetic genes and processes are codon shuffled so that they have reduced homology relative to a naturally occurring gene encoding the same protein without altering the overall codon usage frequency of the gene. In particular the present invention relates to improved polynucleotides and methods for the treatment or prevention of disease comprising codon-shuffled GM-CSF nucleic acid sequences. Nucleic acid vaccines of the present invention may comprise a combination of a nucleotide sequence encoding codon-shuffled GM-CSF, a nucleotide encoding an antigen against which it is desired to raise an immune response and a toll-like receptor (TLR) agonist. | 11-05-2009 |
Stephen Jonathan Brett, East Malling GB
| Patent application number | Description | Published |
|---|---|---|
| 20120074998 | INTEGRATED CIRCUIT DEVICE, ELECTRONIC DEVICE AND METHOD FOR COMPENSATING FREQUENCY DRIFT OF A CONTROLLABLE OSCILLATOR - An integrated circuit device for compensating frequency drift of a controllable oscillator is described. The integrated circuit device includes at least one compensation module including: an input for receiving at least an indication of a frequency control signal (vci) from at least one frequency control module; and an output for providing at least one compensation signal (vct) to the controllable oscillator. The at least one compensation module is arranged to compare the at least indication of the frequency control signal (vci) with a reference voltage signal (vref); and generate the at least one compensation signal (vct) based at least partly on the comparison of the indication of the frequency control signal (vci) to the reference voltage signal (vref). | 03-29-2012 |