Brenan
Colin Brenan, Marblehead, MA US
Patent application number | Description | Published |
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20090062134 | ASSAY IMAGING APPARATUS AND METHODS - A method of conducting an assay on a plurality of samples is provided. The method includes the steps of performing an assay at each sample site in a sample array having greater than 100 sample sites simultaneously illuminating each sample site using one or more LEDs, and simultaneously imaging each of the sample sites to produce imaging data pertinent to the optical effect of each site. Each assay provides an optical effect. | 03-05-2009 |
20090062152 | THERMAL CYCLING APPARATUS AND METHOD - A thermal cycling device and a method of thermal cycling are provided. A thermal cycling device includes a fluid device system, a case, and a cycling head. The fluid delivery system develops a flow of controlled-temperature fluid. The case has a fluid-tight cavity for holding a microfluidic array. The array includes a sheet of material having a pair of opposed surfaces, a thickness, and a plurality of through-holes running through the thickness between the surfaces. The cycling head holds the case and delivers the flow of fluid over the case. | 03-05-2009 |
20100261159 | Apparatus for assay, synthesis and storage, and methods of manufacture, use, and manipulation thereof - The invention features methods of making devices, or “platens”, having a high-density array of through-holes, as well as methods of cleaning and refurbishing the surfaces of the platens. The invention further features methods of making high-density arrays of chemical, biochemical, and biological compounds, having many advantages over conventional, lower-density arrays. The invention includes methods by which many physical, chemical or biological transformations can be implemented in serial or in parallel within each addressable through-hole of the devices. Additionally, the invention includes methods of analyzing the contents of the array, including assaying of physical properties of the samples. | 10-14-2010 |
20110003699 | Thermal Cycler for Microfluidic Array Assays - A system for thermal cycling a plurality of samples. The system includes a case having a fluid-tight cavity defining an interior volume. A microfluidic array is disposed in the interior volume, the array including a sheet of material having a pair of opposed surfaces, a thickness, and a plurality of through-holes running through the thickness between the surfaces. A thermal cycler having at least one thermally controlled surface is adapted to thermally contact the case. | 01-06-2011 |
20110251084 | System for the Detection of a Biological Pathogen and Use Thereof - The invention features compositions and methods that are useful for the detection of a target analyte, such as a pathogen, in a sample. | 10-13-2011 |
20120021951 | Apparatus for Assay, Synthesis and Storage, and Methods of Manufacture, Use, and Manipulation Thereof - The invention features methods of making devices, or “platens”, having a high-density array of through-holes, as well as methods of cleaning and refurbishing the surfaces of the platens. The invention further features methods of making high-density arrays of chemical, biochemical, and biological compounds, having many advantages over conventional, lower-density arrays. The invention includes methods by which many physical, chemical or biological transformations can be implemented in serial or in parallel within each addressable through-hole of the devices. Additionally, the invention includes methods of analyzing the contents of the array, including assaying of physical properties of the samples. | 01-26-2012 |
20120245038 | THERMAL CYCLING APPARATUS AND METHOD - A system for holding at least one of sample and reagent for analysis. The system includes a pair of parallel covers, at least one of which is light transmissive, of which pair a light transmissive cover forms a top, and of which pair the other forms a bottom. A frame is disposed between the covers to define, in relation to the covers, an interior volume. The frame and the covers are associated with one another to form a case, the case being substantially tight to liquids. A microfluidic array is disposed in the interior volume. The array includes a sheet of material having a pair of opposed surfaces, a thickness, and a plurality of through-holes running through the thickness between the surfaces, the through-holes containing at least one of sample and reagent. | 09-27-2012 |
20140179566 | Thermal Cycling Apparatus and Method - A system for holding at least one of sample and reagent for analysis. The system includes a pair of parallel covers, at least one of which is light transmissive, of which pair a light transmissive cover forms a top, and of which pair the other forms a bottom. A frame is disposed between the covers to define, in relation to the covers, an interior volume. The frame and the covers are associated with one another to form a case, the case being substantially tight to liquids. A microfluidic array is disposed in the interior volume. The array includes a sheet of material having a pair of opposed surfaces, a thickness, and a plurality of through-holes running through the thickness between the surfaces, the through-holes containing at least one of sample and reagent. | 06-26-2014 |
Colin J.h. Brenan, Marblehead, MA US
Patent application number | Description | Published |
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20090258797 | SYSTEMS FOR FILLING A SAMPLE ARRAY BY DROPLET DRAGGING - Systems for filling sample array by droplet dragging are provided. One aspect of the invention provides an array filling system for filling a platen having a platen surface and an array of receptacles, the receptacles having an internal surface and the receptacles separated by the platen surface, the system comprising: a liquid transfer device capable of holding liquid; and a controller configured to position the liquid transfer device in proximity to the platen surface and to move the liquid transfer device across the surface and over the receptacles to be filled so as to cause sequential communication of liquid in the liquid transfer device with the interior surface of each receptacle. | 10-15-2009 |
20110152108 | Devices and Methods for Thermally-Mediated Chemical Reactions - One aspect of the invention provides container for thermal cycling a plurality of samples in a microfluidic array. The container includes a plurality of walls defining an interior volume and a conductive member for heating the interior volume. Another aspect of the invention provides container for thermal cycling a plurality of samples in a microfluidic array. The container includes a plurality of walls defining an interior volume and a plurality of conductive members for heating an interior volume. Another aspect of the invention provides a container for thermal cycling a plurality of samples in a microfluidic array. The container includes a plurality of walls defining an interior volume and a first conductive member located in the interior volume and adapted to contact a first end of the microfluidic array. | 06-23-2011 |
20110319300 | Systems for Filling a Sample Array by Droplet Dragging - A method and an array filling system for loading a plurality of disparate sample containers, the sample containers comprising an integral structure. Each receptacle is characterized by a hydrophilic surface, and the receptacles are separated by a hydrophobic surface. The system has a liquid transfer device capable of holding liquid and adapted for motion to cause sequential communication of liquid held in the liquid transfer device with successive receptacles of the array by dragging the liquid across the hydrophobic surface. | 12-29-2011 |
Colin J. H. Brenan, Woburn, MA US
Patent application number | Description | Published |
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20110319877 | APPARATUS AND METHOD FOR LASER TREATMENT WITH SPECTROSCOPIC FEEDBACK - A platform Smart Scalpel system using rapid real-time feedback for effecting laser treatment. The platform system includes an imaging system for rapid real-time detection of tissue characteristics, a processing system for processing the detected characteristics, and a treatment system for effecting treatment in accordance with results of the processing. The platform system provides for preprogramming and real-time inputting conditions and parameters for diagnosis using the imaging system and/or treatment using the treatment system. | 12-29-2011 |
Colin J. H. Brenan, Marblehead, MA US
Patent application number | Description | Published |
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20090054266 | Microfluidic transfer pin - A liquid dispenser for a microfluidic assay system is described. The dispenser includes at least one transfer pin for transferring a microfluidic sample of liquid to a target receptacle. A pin tip at one end of the transfer pin is structured to cooperate with an opening in the target receptacle. The tip uses capillary action to transfer the sample from the pin to the receptacle. | 02-26-2009 |
Colin John Herbert Brenan, Marblehead, MA US
Patent application number | Description | Published |
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20140332112 | Microfluidic Transfer Pins - A liquid dispenser for a microfluidic assay system is described. The dispenser includes at least one transfer pin for transferring a microfluidic sample of liquid to a target receptacle. A pin tip at one end of the transfer pin is structured to cooperate with an opening in the target receptacle. The tip uses a high voltage potential to transfer the sample from the pin to the receptacle. | 11-13-2014 |
20150038377 | Microfluidic Transfer Pins - A liquid dispenser for a microfluidic assay system is described. The dispenser includes at least one transfer pin for transferring a microfluidic sample of liquid to a target receptacle. A pin tip at one end of the transfer pin is structured to cooperate with an opening in the target receptacle. The tip uses a high voltage potential to transfer the sample from the pin to the receptacle. | 02-05-2015 |
Heather Brenan, West Lafayette, IN US
Patent application number | Description | Published |
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20120285873 | ORGANIC WASTE MANAGEMENT SYSTEM - A portable, integrated organic waste management system comprises a receiver for receiving waste organic material, a particle size reducer for grinding waste organic material, a first pump for pumping ground waste organic material, a storage vessel for receiving pumped ground waste organic material in the form of a slurry, and a second pump for recirculating ground waste organic material in the form of a slurry. The system is contained in a portable module that can be transported to a desired site. | 11-15-2012 |
John Brenan, West Lafayette, IN US
Patent application number | Description | Published |
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20120285873 | ORGANIC WASTE MANAGEMENT SYSTEM - A portable, integrated organic waste management system comprises a receiver for receiving waste organic material, a particle size reducer for grinding waste organic material, a first pump for pumping ground waste organic material, a storage vessel for receiving pumped ground waste organic material in the form of a slurry, and a second pump for recirculating ground waste organic material in the form of a slurry. The system is contained in a portable module that can be transported to a desired site. | 11-15-2012 |