Brasca
Alfredo Brasca, Civitanova Marche (mc) IT
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20130185956 | SOLE FOR SHOES HAVING ONE OR MORE VERTICAL ELEMENTS FOLDED OVER EACH OTHER, EXTENSIBLE AND ADAPTABLE TO THE DIFFERENT WIDTH OF THE ASSEMBLY LAST OF THE UPPER AND TO THE VARIATION OF THE CONFORMATION OF THE FOOT, EVEN PERMANENTLY - A sole is provided in a single-moulding made of non-rigid but elastic material having one or more vertical elements folded over each other in such a manner that the horizontal extension thereof mechanically adapts the width of the sole to the different width of the assembly lasts of the upper of a shoe. This also allows adapting the width of the sole to the variation of the conformation of the feet generated by the daily swellings thereof leaving the normal .flexibility and comfort of the shoe unaltered. The user may stabilize -the width of the sole to the possible -deformation of the foot by injecting, from, outside into the widened internal cavity, a foamed two-component fluid material which, upon solidification within a few minutes, blocks any widened part of the sole to the conformation or to the deformation of the feet of the user. | 07-25-2013 |
Alfredo Brasca, Civitanova Marche IT
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20100263239 | SEMI-FINISHED MONOBLOCK FOR COLD WEATHER FOOTWEAR MOULDED WITH TWO OR MORE MATERIALS AND DIRECTLY WITH INTERNAL INSOLE - The present invention concerns the footwear industry and more specifically it concerns a semi-finished monoblock for cold weather footwear. The monoblock is made with two or more materials and directly moulded to an internal insulating insole and subsequently glued or moulded to an external sole. The external sole is chosen according to the aesthetic and functional requirements of the user. The present invention produces a cold weather shoe with functional and aesthetic characteristics that are better than those currently available on the market and with the possibility for them to be moulded also with the accessories required by the relevant legislation covering the specific use designated for the particular cold weather shoe. | 10-21-2010 |
20120227290 | METHOD FOR NATURAL ADAPTING THE OUTLINE OF FOOTWEAR MADE OF A DEFORMABLE MATERIAL - A method for naturally adapting the outline of a footwear sole made of a deformable material is described. A sole with modified profile obtained according to the method and a basic kit for partially carrying out said method are also described. | 09-13-2012 |
Maria Gabriella Brasca, Milano IT
Patent application number | Description | Published |
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20100210476 | Pyrrolo[2,3-b]Pyridine Derivatives Active as Kinase Inhibitors and Pharmaceutical Compositions Comprising Them - Compounds which are pyrrolo[2,3-b]pyridine derivatives or pharmaceutically acceptable salts thereof, their preparation process and pharmaceutical compositions comprising them are disclosed; these compounds are useful in the treatment of diseases caused by and/or associated with an altered protein kinase activity such as cancer, cell proliferative disorders, Alzheimer's disease, viral infections, auto-immune diseases and neurodegenerative disorders; also disclosed is a process under SPS conditions for preparing the compounds of the invention and chemical libraries comprising a plurality of them. | 08-19-2010 |
20110136857 | PYRROLE[2,3-B]PYRIDINE DERIVATIVES ACTIVE AS KINASE INHIBITORS - Compounds which are pyrrolo[2,3-b]pyridine derivatives or pharmaceutically acceptable salts thereof, their preparation process and pharmaceutical compositions comprising them are disclosed; these compounds are useful in the treatment of diseases caused by and/or associated with an altered protein kinase activity such as cancer, cell proliferative disorders, Alzheimer's disease, viral infections, auto-immune diseases and neurodegenerative disorders; also disclosed is a process under SPS conditions for preparing the compounds of the invention and chemical libraries comprising a plurality of them. | 06-09-2011 |
Maria Gabriella Brasca, Cusago IT
Patent application number | Description | Published |
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20090082346 | Substituted Pyrrolo-Pyrazole Derivatives as Kinase Inhibitors - Compounds represented by formula (Ia) or (Ib) and wherein R and R | 03-26-2009 |
20100010008 | SUBSTITUTED PYRROLO-PYRAZOLE DERIVATIVES AS KINASE INHIBITORS - Substituted pyrrolo-pyrazole derivatives of formula (I) and pharmaceutically acceptable salts thereof, as defined in the specification, process for their preparation and pharmaceutical compositions comprising them are disclosed; the compounds of the invention may be useful in therapy in the treatment of diseases associated with dysregulated protein kinase activity, like cancer. | 01-14-2010 |
20130338148 | PYRAZOLO-QUINAZOLINE DERIVATIVES, PROCESS FOR THEIR PREPARATION AND THEIR USE AS KINASE INHIBITORS - Pyrazolo-quinazoline derivatives of formula (Ia) or (Ib) as defined in the specification, and pharmaceutically acceptable salts thereof, process for their preparation and pharmaceutical compositions comprising them are disclosed; the compounds of the invention may be useful, in therapy, in the treatment of diseases associated with a disregulated protein kinase activity, like cancer. | 12-19-2013 |
Maria Gabriella Brasca, Cusago (milan) IT
Patent application number | Description | Published |
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20090124605 | Pyrazolo-Quinazoline Derivatives, Process for Their Preparation and Their Use as Kinase Inhibitors - Pyrazolo-quinazoline derivatives of formula (Ia) or (Ib) as defined in the specification, and pharmaceutically acceptable salts thereof, process for their preparation and pharmaceutical compositions comprising them are disclosed; the compounds of the invention may be useful, in therapy, in the treatment of diseases associated with a disregulated protein kinase activity, like cancer. | 05-14-2009 |
20120041007 | CDK INHIBITOR SALTS - The present invention relates to novel crystalline form(s) of water-soluble salts and of free base of a cdk inhibitor. Such crystal salts are for example fumarate, L-malate, maleate, succinate, adipate, malonate, glycolate, phosphate, mesylate, L-lactate, hydrochloride, di-hydrochloride, tri-hydrochloride. Hydrates and polymorphs of such new salt forms, a process for their preparation, their utility in therapy and to the pharmaceutical compositions containing them are also claimed and described in the present application. | 02-16-2012 |
20130012507 | SUBSTITUTED PYRROLO-PYRAZOLE DERIVATIVES AS KINASE INHIBITORS - Compounds represented by formula (Ia) or (Ib) and wherein R and R | 01-10-2013 |
20130017170 | SUBSTITUTED PYRROLO-PYRAZOLE DERIVATIVES AS KINASE INHIBITORS - Compounds represented by formula (Ia) or (Ib) and wherein R and R | 01-17-2013 |
20130344031 | SUBSTITUTED PYRROLO-PYRAZOLE DERIVATIVES AS KINASE INHIBITORS - Compounds represented by formula (Ia) or (Ib) and wherein R and R | 12-26-2013 |
Maria Gabriella Brasca, Cusago (mi) IT
Patent application number | Description | Published |
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20110053944 | SUBSTITUTED DIHYDROPTERIDIN-6-ONE DERIVATIVES, PROCESS FOR THEIR PREPARATION AND THEIR USE AS KINASE INHIBITORS - Dihydropteridin-6-one derivatives of formula (I) as defined in the specification, and pharmaceutically acceptable salts thereof, process for their preparation and pharmaceutical compositions comprising them are disclosed; the compounds of the invention may be useful, in therapy, in the treatment of diseases associated with a disregulated protein kinase activity, like cancer. | 03-03-2011 |
20110294790 | BICYCLIC PYRAZOLE AND ISOXAZOLE DERIVATIVES AS ANTITUMOR AND ANTINEURODEGENERATIVE AGENTS - Bicyclic pyrazole and isoxazole derivatives of formula (I) and pharmaceutically acceptable salts thereof, as defined in the specification, process for their preparation and pharmaceutical compositions comprising them are disclosed; the compounds of the invention may be useful in therapy in the treatment of diseases mediated by HSP90 protein, like cancer and neurodegenerative disorders. | 12-01-2011 |
20120046266 | RESORCINOL DERIVATIVES AS HSP90 INHIBITORS - The present invention relates to substituted resorcinol derivatives which inhibit the activity of Heat Shock Protein HSP90. The compounds of the invention are therefore useful in treating proliferative diseases such as cancer and neurodegenerative diseases. The present invention also provides processes for preparing these compounds, pharmaceutical compositions comprising them, methods of treating diseases and the pharmaceutical compositions comprising these compounds. | 02-23-2012 |
20120122882 | Substituted Pyrrolo-Pyrimidine Derivatives, Process for Their Preparation and Their Use as Kinase Inhibitors - Substituted pyrrolo-pyrimidine derivatives of formula (I) and pharmaceutically acceptable salts thereof, as defined in the specification, process for their preparation and pharmaceutical compositions comprising them are disclosed; the compounds of the invention may be useful in therapy in the treatment of diseases associated with a dysregulated protein kinase activity, like cancer. | 05-17-2012 |
20120277248 | SUBSTITUTED PYRROLO-PYRAZOLE DERIVATIVES AS KINASE INHIBITORS - Substituted pyrrolo-pyrazole derivatives of formula (I) and pharmaceutically acceptable salts thereof, as defined in the specification, process for their preparation and pharmaceutical compositions comprising them are disclosed; the compounds of the invention may be useful in therapy in the treatment of diseases associated with dysregulated protein kinase activity, like cancer. | 11-01-2012 |
Maria Gabriella Brasca, Nerviano (mi) IT
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20130296305 | TRICYCLIC PYRROLO DERIVATIVES, PROCESS FOR THEIR PREPARATION AND THEIR USE AS KINASE INHIBITORS - The present invention relates to tricyclic pyrrolo derivatives of Formula (I), which modulate the activity of protein kinases and are therefore useful in treating diseases caused by dysregulated protein kinase activity. The present invention also provides methods for preparing these compounds, pharmaceutical compositions comprising these compounds, and methods of treating diseases utilizing such these compounds or the pharmaceutical compositions containing them. | 11-07-2013 |
20140051708 | PYRAZOLYL-PYRIMIDINE DERIVATIVES AS KINASE INHIBITORS - The present invention relates to pyrazolyl-pyrimidine derivatives which modulate the activity of protein kinases and are therefore useful in treating diseases caused by dysregulated protein kinase activity. The present invention also provides methods for preparing these compounds, pharmaceutical compositions comprising these compounds, and methods of treating diseases utilizing such compounds or the pharmaceutical compositions containing them. | 02-20-2014 |
20140155421 | SUBSTITUTED PYRIMIDINYL-PYRROLES ACTIVE AS KINASE INHIBITORS - The present invention relates to substituted pyrimidinyl-pyrrole compounds of formula (I) which modulate the activity of protein kinases and are therefore useful in treating diseases caused by dysregulated protein kinase activity, in particular Janus kinases. The present invention also provides methods for preparing these compounds, pharmaceutical compositions comprising these compounds, and methods of treating diseases utilizing such compounds or the pharmaceutical compositions containing them. | 06-05-2014 |
20140194406 | ALKYNYL SUBSTITUTED PYRIMIDINYL-PYRROLES ACTIVE AS KINASES INHIBITORS - The present invention relates to alkynyl substituted pyrimidinyl-pyrrole compounds which modulate the activity of protein kinases and are therefore useful in treating diseases caused by dysregulated protein kinase activity, in particular Jak and/or Src family kinases. The present invention also provides methods for preparing these compounds, pharmaceutical compositions comprising these compounds, and methods of treating diseases utilizing such compounds or the pharmaceutical compositions containing them. | 07-10-2014 |
Maria Gabriella Brasca, Milan IT
Patent application number | Description | Published |
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20100216808 | SUBSTITUTED PYRAZOLO-QUINAZOLINE DERIVATIVES, PROCESS FOR THEIR PREPARATION AND THEIR USE AS KINASE INHIBITORS - Pyrazolo-quinazoline derivatives of formula (I) as defined in the specification, and pharmaceutically acceptable salts thereof, process for their preparation and pharmaceutical compositions comprising them are disclosed; the compounds of the invention may be useful, in therapy, in the treatment of diseases associated with a disregulated protein kinase activity, like cancer. | 08-26-2010 |