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Bramlett
Helen M. Bramlett, Miami, FL US
| Patent application number | Description | Published |
|---|---|---|
| 20090104200 | MODULATING INFLAMMASOME ACTIVITY AND INFLAMMATION IN THE CENTRAL NERVOUS SYSTEM - Compositions and methods for reducing inflammation in the central nervous system (CNS) of a mammal that has been subjected to a stroke, traumatic injury to the CNS such as traumatic brain injury (TBI), spinal cord injury (SCI), or having an autoimmune or CNS disease have been developed. The compositions and methods described herein include antibodies that specifically bind to at least one component (e.g., ASC, NALP1) in a mammalian inflammasome (e.g., the NALP1 inflammasome) and have use as treatments for SCI, TBI, stroke, and autoimmune and CNS diseases in a mammal. In a rodent model of SCI, therapeutic neutralization of ASC using a polyclonal antibody that specifically binds to ASC inhibited the inflammasome, reduced caspase-1 activation, XIAP cleavage, and interleukin processing, resulting in significant tissue sparing and functional improvement. Additionally, in a rodent model of TBI, neutralization of ASC after TBI reduced caspase-1 activation and XIAP cleavage. Further, in a rodent thromboembolic stroke model, neutralization of NLRP1 resulted in reduced histopathological damage in mice and reduced cytokine activation, suggesting that the inflammasome complex forms in the brain after stroke and is a therapeutic target for reducing the detrimental consequences of post-stroke inflammation. | 04-23-2009 |
Kevin D. Bramlett, Mars Hill, NC US
| Patent application number | Description | Published |
|---|---|---|
| 20100077775 | FROST REDUCTION BY ACTIVE CIRCULATION - An ultra low temperature refrigeration system and technique, includes a cabinet with a storage chamber maintained at a certain temperature range, a door providing a seal with the cabinet when engaged with the cabinet, and a dehumidifying unit connected to the cabinet for dehumidifying the storage chamber within the cabinet. | 04-01-2010 |
Larry Bramlett, Marana, AZ US
| Patent application number | Description | Published |
|---|---|---|
| 20110104650 | Heart Compression Simulation Device - A heart compression simulation device featuring a base with a compression spring; an actuator atop the compression spring that can move between an extended and fully compressed position; two pedestals atop the base opposite each other; actuator prongs on the actuator facing each pedestal; a hub attached to each pedestal that can pivot between a disengaged position and engaged position; leaf springs disposed on each hub adapted to engage the actuator prongs when the hubs are in the disengaged position and the actuator is moved to the fully compressed position, which causes a cracking sound to be produced; and a lock-out mechanism for securing the hubs in the engaged position keeping the leaf springs out of range of the actuator prongs, the lock-out mechanism is activated when the actuator is moved to the fully compressed position. | 05-05-2011 |
| 20110165546 | Heart Compression Simulation Device - A heart compression simulation device featuring a base; a resistance means disposed on the base; and an actuator operatively connected to the resistance means. The actuator can move between at least a starting position wherein the actuator is positioned at a starting position above the base and an end position wherein the actuator is pushed down near or contacting the base. The actuator is biased in the starting position caused by the resistance means. A tear effect providing mechanism provides resistance when moving the actuator from the starting position to the end position a first time. A lock-out mechanism is adapted to disengage the tear effect providing mechanism after the actuator has been moved from the starting position to the end position such that subsequent movements of the actuator between the starting position and the end position are not hindered by the tear effect providing mechanism. | 07-07-2011 |