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Bradbury, US
Andrew M. Bradbury, Santa Fe, NM US
| Patent application number | Description | Published |
|---|---|---|
| 20090142820 | Directed evolution methods for improving polypeptide folding, solubility and stability - The invention provides directed evolution methods for improving the folding, solubility and stability (including thermostability) characteristics of polypeptides. In one aspect, the invention provides a method for generating folding and stability-enhanced variants of proteins, including but not limited to fluorescent proteins, chromophoric proteins and enzymes. In another aspect, the invention provides methods for generating thermostable variants of a target protein or polypeptide via an internal destabilization baiting strategy. Internally destabilization a protein of interest is achieved by inserting a heterologous, folding-destabilizing sequence (folding interference domain) within DNA encoding the protein of interest, evolving the protein sequences adjacent to the heterologous insertion to overcome the destabilization (using any number of mutagenesis methods), thereby creating a library of variants. The variants in the library are expressed, and those with enhanced folding characteristics selected. | 06-04-2009 |
| 20100009441 | POLYNUCLEOTIDES ENCODING ANTI-SULFOTYROSINE ANTIBODIES - The invention provides anti-sulfotyrosine specific antibodies capable of detecting and isolating polypeptides that are tyrosine-sulfated. The sulfotyrosine antibodies and antibody fragments of the invention may be used to discriminate between the non-sulfated and sulfated forms of such proteins, using any number of immunological assays, such ELISAs, immunoblots, Western Blots, immunoprecipitations, and the like. Using a phage-display system, single chain antibodies (scFvs) were generated and screened against tyrosine-sulfated synthetic peptide antigens, resulting in the isolation of scFvs that specifically recognize sulfotyrosine-containing peptides and/or demonstrate sulfotyrosine-specific binding in tyrosine sulfated proteins. The VH and VL genes from one such sulfotyrosine-specific scFv were employed to generate a full length, sulfotyrosine-specific immunoglobulin. | 01-14-2010 |
| 20100215662 | Anti-influenza M2e antibody - Humanized recombinant and monoclonal antibodies specific for the ectodomain of the influenza virus M2 ion channel protein are disclosed. The antibodies of the invention have anti-viral activity and may be useful as anti-viral therapeutics and/or prophylactic/vaccine agents for inhibiting influenza virus replication and for treating individuals infected with influenza. | 08-26-2010 |
| 20100222551 | Highly thermostable fluorescent proteins - Thermostable fluorescent proteins (TSFPs), methods for generating these and other stability-enhanced proteins, polynucleotides encoding such proteins, and assays and method for using the TSFPs and TSFP-encoding nucleic acid molecules are provided. The TSFPs of the invention show extremely enhanced levels of stability and thermotolerance. In one case, for example, a TSFP of the invention is so stable it can be heated to 99° C. for short periods of time without denaturing, and retains 85% of its fluorescence when heated to 80° C. for several minutes. The invention also provides a method for generating stability-enhanced variants of a protein, including but not limited to fluorescent proteins. | 09-02-2010 |
| 20110245464 | HIGHLY THERMOSTABLE FLUORESCENT PROTEINS - Thermostable fluorescent proteins (TSFPs), methods for generating these and other stability-enhanced proteins, polynucleotides encoding such proteins, and assays and method for using the TSFPs and TSFP-encoding nucleic acid molecules are provided. The TSFPs of the invention show extremely enhanced levels of stability and thermotolerance. In one case, for example, a TSFP of the invention is so stable it can be heated to 99° C. for short periods of time without denaturing, and retains 85% of its fluorescence when heated to 80° C. for several minutes. The invention also provides a method for generating stability-enhanced variants of a protein, including but not limited to fluorescent proteins. | 10-06-2011 |
| 20120064085 | ANTI-INFLUENZA M2e ANTIBODY - Humanized recombinant and monoclonal antibodies specific for the ectodomain of the influenza virus M2 ion channel protein are disclosed. The antibodies of the invention have anti-viral activity and may be useful as anti-viral therapeutics and/or prophylactic/vaccine agents for inhibiting influenza virus replication and for treating individuals infected with influenza. | 03-15-2012 |
| 20120077266 | HIGHLY THERMOSTABLE FLUORESCENT PROTEINS - Thermostable fluorescent proteins (TSFPs), methods for generating these and other stability-enhanced proteins, polynucleotides encoding such proteins, and assays and method for using the TSFPs and TSFP-encoding nucleic acid molecules are provided. The TSFPs of the invention show extremely enhanced levels of stability and thermotolerance. In one case, for example, a TSFP of the invention is so stable it can be heated to 99° C. for short periods of time without denaturing, and retains 85% of its fluorescence when heated to 80° C. for several minutes. The invention also provides a method for generating stability-enhanced variants of a protein, including but not limited to fluorescent proteins. | 03-29-2012 |
Andrew M. Bradbury, Sante Fe, NM US
| Patent application number | Description | Published |
|---|---|---|
| 20120077960 | FLUOROBODIES: INTRINSICALLY FLUORESCENT BINDING LIGANDS - Binding ligands with intrinsic fluorescence (“fluorobodies”), fluorobody libraries, and methods of preparing fluorobodies are provided. In one aspect, the invention provides fluorobodies generated from a highly stable, artificial fluorescent protein, eCGP123 and derivatives thereof. | 03-29-2012 |
Barton James Bradbury, Wallingford, CT US
| Patent application number | Description | Published |
|---|---|---|
| 20090012071 | 4-SUBSTITUTED-1H-ISOTHIAZOLO[5,4-B][1,4]OXAZINO[2,3,4-IJ]QUINOLINE-7,8(2H,9H)-DIONES AND RELATED COMPOUNDS AS ANTI-INFECTIVE AGENTS - The present invention provides compounds of the formula that possess antimicrobial activity. Certain compounds provided herein possess potent antibacterial, antiprotozoal, or antifungal activity. Particular compounds provided herein are also potent and/or selective inhibitors of microbial DNA synthesis and reproduction. The invention provides anti-microbial compositions, including pharmaceutical compositions, containing a compound of the invention and one or more or more carriers. The invention provides pharmaceutical compositions containing a 4-substituted- | 01-08-2009 |
| 20110213152 | METHOD FOR SYNTHESIS OF 8-ALKOXY-9H-ISOTHIAZOLO[5,4-B]QUINOLINE-3,4-DIONES - The present invention provides process for synthesis of 8-methoxy-9H-isothiazolo[5,4-b]quinoline-3,4-diones and 8A,9-dihydro-4aH-isothiazolo[5,4-b]quinoline-3,4-diones of the Formula A. | 09-01-2011 |
| 20110223132 | ISOTHIAZOLOQUINOLONES AND RELATED COMPOUNDS AS ANTI-INFECTIVE AGENTS - The invention provides compounds and salts of Formula I and Formula | 09-15-2011 |
| 20120040959 | 8-METHOXY-9H-ISOTHIAZOLO[5,4-B]QUINOLINE-3,4-DIONES AND RELATED COMPOUNDS AS ANTI-INFECTIVE AGENTS - The invention provides compound and salts of Formula I and II, disclosed herein, which includes compounds of Formula A and Formula B: | 02-16-2012 |
| 20120114601 | NEW ISOTHIAZOLOQUINOLONES AND RELATED COMPOUNDS AS ANTI-INFECTIVE AGENTS - The invention provides certain compounds and salts of Formula I and Formula II: | 05-10-2012 |
Carly Bradbury, Philadelphia, PA US
| Patent application number | Description | Published |
|---|---|---|
| 20120005053 | BEHAVIORAL-BASED CUSTOMER SEGMENTATION APPLICATION - Embodiments of the invention relate to systems, methods, and computer program products for comprehensive and holistic behavior-based customer segmentation and customer profiling based on the segmentation. In specific embodiments of the invention, the segmentation includes internal credit behavior segmentation and external credit segmentation. In other embodiments, the segmentation includes internal credit behavior segmentation and external credit segmentation, and spend preference segmentation. In still further embodiments any combination of behavior algorithms may be implemented to segment the customer base and determine a related customer profile. The application additionally provides for new behavior algorithms to be added as needed in the future and the ability to interface with existing/legacy segmentation applications. | 01-05-2012 |
Christopher Matthew Bradbury, Essex Junction, VT US
| Patent application number | Description | Published |
|---|---|---|
| 20100305043 | CCL18 AND CCL3 METHODS AND COMPOSITIONS FOR DETECTING AND TREATING CANCER - The invention relates to methods of treating cancer by administering one or more chemokines that are downregulated in cancerous cells. More specifically, the invention provides methods for treating or preventing cancers such as malignant melanoma by administering a chemokine such as CCL18 and/or CCL3. The invention further provides methods for diagnosing cancer such as melanoma. | 12-02-2010 |
Colin Bradbury, San Diego, CA US
| Patent application number | Description | Published |
|---|---|---|
| 20090262138 | ENHANCED POWER DISTRIBUTION UNIT WITH SELF-ORIENTING DISPLAY - An enhanced power distribution unit (PDU) with self-orienting display uses an orientation sensor in conjunction with a microprocessor to properly orient visual display of information by one or more displays of the enhanced PDU. Information displayed can relate to electrical current furnished to one or more power outlets of the enhanced PDU and/or information related to temperature, humidity or other conditions of the enhanced PDU. | 10-22-2009 |
Daniel P. Bradbury, Cumming, GA US
| Patent application number | Description | Published |
|---|---|---|
| 20120236509 | Lightweight Unitary Display - A lightweight display includes a plurality of display modules having a plurality of pixels carried by a display mounting frame. A support frame integral with the display mounting frame provides support. An electronic support member carries electrical components electrically communicating with the plurality of display modules for controlling the display of an image. Wherein the depth of the plurality of display modules, display mounting frame, support frame and electronic support member is less than four inches when defining a display assembly. Also wherein the display assembly has a screen size measured diagonally in a range of 114 inches to 224 inches and a weight in the range of 90 pounds to 120 pounds and wherein the display assembly has an aspect ratio ranging from 1.67 to 1.82. | 09-20-2012 |
Dave Bradbury, Center Bamstead, NH US
| Patent application number | Description | Published |
|---|---|---|
| 20120000493 | CONTINUAL FLOW PIN WASHER - A multi-chambered deposition pin wash station is provided. The wash station includes a lower chamber and an upper drain basin connected by a plurality of wash tubes. Cleaning fluid is provided to the lower chamber and passes through the cleaning tubes into the upper drain basin. The cleaning tubes are adapted to clean a single deposition pin with a single tube per wash cycle. | 01-05-2012 |
Dave Bradbury, Center Barnstead, NH US
| Patent application number | Description | Published |
|---|---|---|
| 20090101175 | CONTINUAL FLOW PIN WASHER - A multi-chambered deposition pin wash station is provided. The wash station includes a lower chamber and an upper drain basin connected by a plurality of wash tubes. Cleaning fluid is provided to the lower chamber and passes through the cleaning tubes into the upper drain basin. The cleaning tubes are adapted to clean a single deposition pin with a single tube per wash cycle. | 04-23-2009 |
David Bradbury, Ipswich, MA US
| Patent application number | Description | Published |
|---|---|---|
| 20100142850 | System, method, and product for scanning of biological materials - An embodiment of a scanning system is described including optical elements that direct an excitation beam at a probe array, detectors that receive reflected intensity data responsive to the excitation beam, where the reflected intensity data is responsive to a focusing distance between an optical element and the probe array, a transport frame that adjusts the focusing distance in a direction with respect to the probe array, an auto-focuser that determines a best plane of focus based upon characteristics of the reflected intensity data of at least two focusing distances where the detectors further receive pixel intensity values based upon detected emissions from a plurality of probe features disposed on the probe array at the best plane of focus, and an image generator that associates each of the pixel intensity values with at least one image pixel position of a probe array based upon one or more position correction values. | 06-10-2010 |
| 20110243411 | System, method, and product for scanning of biological materials - An embodiment of a scanning system is described including optical elements that direct an excitation beam at a probe array, detectors that receive reflected intensity data responsive to the excitation beam, where the reflected intensity data is responsive to a focusing distance between an optical element and the probe array, a transport frame that adjusts the focusing distance in a direction with respect to the probe array, an auto-focuser that determines a best plane of focus based upon characteristics of the reflected intensity data of at least two focusing distances where the detectors further receive pixel intensity values based upon detected emissions from a plurality of probe features disposed on the probe array at the best plane of focus, and an image generator that associates each of the pixel intensity values with at least one image pixel position of a probe array based upon one or more position correction values. | 10-06-2011 |
| 20120235016 | System, Method, and Product for Scanning of Biological Materials - An embodiment of a scanning system is described including optical elements that direct an excitation beam at a probe array, detectors that receive reflected intensity data responsive to the excitation beam, where the reflected intensity data is responsive to a focusing distance between an optical element and the probe array, a transport frame that adjusts the focusing distance in a direction with respect to the probe array, an auto-focuser that determines a best plane of focus based upon characteristics of the reflected intensity data of at least two focusing distances where the detectors further receive pixel intensity values based upon detected emissions from a plurality of probe features disposed on the probe array at the best plane of focus, and an image generator that associates each of the pixel intensity values with at least one image pixel position of a probe array based upon one or more position correction values. | 09-20-2012 |
Frank K. Bradbury, Saugus, MA US
| Patent application number | Description | Published |
|---|---|---|
| 20100067373 | REDUNDANCY IN VOICE AND DATA COMMUNICATIONS SYSTEM - Apparatus is used in communicating in a data and voice communication system. The apparatus includes a line card and a crosspoint switch in communication with the line card. The apparatus also includes an accelerator card in communication with the line card and the crosspoint switch. The crosspoint switch is configured to provide a redundant communications path between the line card and the accelerator card. | 03-18-2010 |
| 20110096661 | REDUNDANCY IN VOICE AND DATA COMMUNICATIONS SYSTEMS - A method includes receiving information at an interface circuit and providing the information from the interface circuit to a processing circuit through a direct communications path between the interface circuit and a processing circuit, which processes the information received from the interface circuit. The method further includes providing the information from the interface circuit to the processing circuit via a crosspoint switch in response to a failure of the direct communications path, wherein the direct communication does not pass through the crosspoint switch. | 04-28-2011 |
Glenn Allen Bradbury, Mason, OH US
| Patent application number | Description | Published |
|---|---|---|
| 20100043167 | Plural nozzle cleaning implement - A plural nozzle cleaning implement. The nozzles are oriented inwardly, to provide a converging spray pattern. The converging spray pattern provides more coverage of the target surface, which increases residence time of fluid sprayed onto debris. | 02-25-2010 |
| 20110146011 | APPARATUS FOR COLLECTING DEBRIS FROM A TARGET SURFACE - An apparatus for removing debris from a target surface. The apparatus comprises a hollow roller with a supply roll and take-up roll axially rotatably disposed within the volume of the hollow roller. A sheet material, such as adhesive tape, extends from the supply roll through a slot, around the periphery of the roller at least 180°, back into the slot and onto be take-up roll. A partition separates the supply roll and take-up roll, reducing contamination of tape on the supply roll. An index mechanism may be provided to advance the tape one path length from the supply roll to take-up roll, the user does not overuse or underuse fresh tape. | 06-23-2011 |
| 20120084933 | CLEANING HEAD FOR A TARGET SURFACE - A unit dose for cleaning an unsanitary surface, such as a toilet bowl. The unit dose comprises a water dispersible shell containing granules defining a core. The granules obviate the need for sheet material in the unit dose and provide cleaning efficacy when submerged. | 04-12-2012 |
| 20120096662 | CLEANING DEVICE HAVING PLURAL AND CUSTOMIZABLE CLEANING SURFACES - A device for cleaning debris from a target surface. The device has a sole plate with permanent bristles and a removable/replaceable pad. The device also has a replaceable, on-board supply of cleanser. The pad/cleanser may be replaced when depleted and replaced with a new pad/cleanser or may simply be replaced with a new pad/cleanser when that pad/cleanser is more suitable for a particular cleaning task. | 04-26-2012 |
| 20120246853 | Starch Head Having a Stiffening Member - A head for cleaning a target surface, such as a toilet bowl. The head has a longitudinal axis and comprises a starch based material. The material may be provided as a sheet, and formed to make a generally round head or a head of laminae. The head may optionally contain granules, which optionally define a core and improve the stiffness of the head. The starch based material may be extruded to have a machine direction oriented in the longitudinal direction of the cleaning device. | 10-04-2012 |
| 20120246854 | Water Disposable Head Comprising Plural Water Disposable Materials - A head for cleaning a target surface, such as a toilet bowl. The head has a longitudinal axis and comprises a starch based material. The material may be provided as a sheet, and formed to make a generally round head or a head of laminae. The head may optionally contain granules, which optionally define a core and improve the stiffness of the head. The starch based material may be extruded to have a machine direction oriented in the longitudinal direction of the cleaning device. | 10-04-2012 |
James R. Bradbury, Littleton, CO US
| Patent application number | Description | Published |
|---|---|---|
| 20090212184 | Articulated Mounting Systems And Bearings For Joints Thereof - An articulated mounting system ( | 08-27-2009 |
James S. Bradbury, Bothell, WA US
| Patent application number | Description | Published |
|---|---|---|
| 20110307780 | CLOUD-BASED APPLICATION HELP - A cloud help system is described herein that is a confederation of both internet and product help content that gives the user of a software application a rich web-based user interface for searching the internet in conjunction with and in the context of the software application. An application developer associates identifiers with various features and areas within an application. Upon detecting a user request for product help, the system receives the identifier and identifies instructional material related to the received identifier. The instructional material combines traditional local and online help information with dynamic content from an online data source. The online data source includes an association between each identifier and one or more searches for online content. An administrator can update the online searches over time so that new material can be incorporated. | 12-15-2011 |
Jonathan Bradbury, Inglewood, CA US
| Patent application number | Description | Published |
|---|---|---|
| 20090203446 | Methods of Playing Video Games - Video game systems for executing instructions according to a video game contained on an item of first media including: an item of second media containing data defining an aspect of the video game; and a video game console including a housing, a first media device supported by the housing, a second media device supported by the housing, and a control unit supported by the housing and configured to control the first media device to read the item of first media and to control the second media device to read the item of second media. | 08-13-2009 |
| 20110092286 | Video Game System and Methods of Operating a Video Game - Video game systems for executing instructions according to a video game contained on an item of first media including: an item of second media containing data defining an aspect of the video game; and a video game console including a housing, a first media device supported by the housing, a second media device supported by the housing, and a control unit supported by the housing and configured to control the first media device to read the item of first media and to control the second media device to read the item of second media. | 04-21-2011 |
Keith J. Bradbury, Blauvelt, NY US
| Patent application number | Description | Published |
|---|---|---|
| 20100228570 | COMPUTER SYSTEM AND METHOD FOR GENERATING HEALTHCARE RISK INDICES USING MEDICATION COMPLIANCE INFORMATION - A healthcare risk index is generated using a patient or individual's pharmacy claims. The index may be used to explain and predict variation in pharmacy-related costs and variation in total healthcare costs or utilization. In particular, the index is generated by first examining the individual's pharmacy claims to identify any chronic conditions possessed by the individual. Similarly, the individual's pharmacy claims are examined to identify any compliance medications prescribed to the individual. The chronic condition information is used to generate a chronic condition score by summing regression coefficients for each chronic condition possessed by the individual. Likewise, the compliance medication information is used to generate a compliance medication score by summing products of regression coefficients for each compliance medication prescribed to the individual with associated medication supply weights. From there, a modified chronic condition score is generated by multiplying the chronic condition score by an overall chronic condition regression coefficient. The modified chronic condition score may then be further modified by subtracting a no-claims weight from the chronic condition score in cases where the individual has no pharmacy claims. Finally, the risk index may be determined by summing the modified chronic condition score and the compliance medication score. | 09-09-2010 |
| 20100235193 | COMPUTER SYSTEM AND METHOD FOR GENERATING HEALTHCARE RISK INDICES USING MEDICATION COMPLIANCE INFORMATION - A healthcare risk index is generated using a patient or individual's pharmacy claims. The index may be used to explain and predict variation in pharmacy-related costs and variation in total healthcare costs or utilization. In particular, the index is generated by first examining the individual's pharmacy claims to identify any chronic conditions possessed by the individual. Similarly, the individual's pharmacy claims are examined to identify any compliance medications prescribed to the individual. The chronic condition information is used to generate a chronic condition score by summing regression coefficients for each chronic condition possessed by the individual. Likewise, the compliance medication information is used to generate a compliance medication score by summing products of regression coefficients for each compliance medication prescribed to the individual with associated medication supply weights. From there, a modified chronic condition score is generated by multiplying the chronic condition score by an overall chronic condition regression coefficient. The modified chronic condition score may then be further modified by subtracting a no-claims weight from the chronic condition score in cases where the individual has no pharmacy claims. Finally, the risk index may be determined by summing the modified chronic condition score and the compliance medication score. | 09-16-2010 |
Laura Bradbury, Newton, MA US
| Patent application number | Description | Published |
|---|---|---|
| 20090209737 | USE OF DENATURING AGENTS DURING AFFINITY CAPTURE - A method for affinity capturing target molecules is disclosed, comprising obtaining a sample comprising a target molecule; and, in the presence of a denaturing agent; affinity capturing the target molecule with a single chain affinity molecule or antigen binding portion thereof that specifically binds the target molecule, wherein the affinity molecule or antigen binding portion thereof is immobilized on a support. | 08-20-2009 |
Michelle Bradbury, New York, NY US
| Patent application number | Description | Published |
|---|---|---|
| 20130039848 | FLUORESCENT SILICA-BASED NANOPARTICLES - The present invention provides a fluorescent silica-based nanoparticle that allows for precise detection, characterization, monitoring and treatment of a disease such as cancer The nanoparticle has a fluorescent compound positioned within the nanoparticle, and has greater brightness and fluorescent quantum yield than the free fluorescent compound To facilitate efficient urinary excretion of the nanoparticle, it may be coated with an organic polymer, such as polyethylene glycol) (PEG) The small size of the nanoparticle, the silica base and the organic polymer coating minimizes the toxicity of the nanoparticle when administered in vivo The nanoparticle may further be conjugated to a ligand capable of binding to a cellular component associated with the specific cell type, such as a tumor marker A therapeutic agent may be attached to the nanoparticle Radionuclides/radiometals or paramagnetic ions may be conjugated to the nanoparticle to permit the nanoparticle to be detectable by various imaging techniques. | 02-14-2013 |
Robert Bradbury, Saugus, MA US
| Patent application number | Description | Published |
|---|---|---|
| 20090305905 | COMPOSITIONS AND METHODS RELATING TO CHARACTERIZATION AND THERAPEUTIC APPLICATION OF PRISTINE STEM CELLS - “Pristine” stem cells are provided by a process of precise selection wherein stem cells exhibiting ideal behavior, good morphology and proper gene expression are selected. Stem cells are divided into pools and observed for optimum speed of growth, proper gene expression levels, and other tests indicative of healthy cell function due to lack of mutation or misrepair of genes. Autologous pools of such “pristine” stem cells provide a source of stem cells having the genome least affected by mutation, and therefore in a more pristine state. | 12-10-2009 |
Stanley Jay Bradbury, San Francisco, CA US
| Patent application number | Description | Published |
|---|---|---|
| 20090203390 | METHOD AND SYSTEMS FOR DYNAMIC ASSIGNMENT OF COMMON SHORT CODES FOR SHARED USE TEXT MESSAGE ROUTING - A computer-readable medium encoded with executable instructions for a text messaging service for dynamically associating a first user to a first business via a shared common short code is provided. The instructions are for receiving a first text message from a first user via a first shared common short code, determining a user history associated with the first user based on an identification of the first user, and determining an association of the first shared common short code with a first business based on the user history associated with the first user. The instructions are further for storing the association of the first shared common short code with the first business for the first user in the user history associated with the first user and routing the first text message to the first business. | 08-13-2009 |
Thomas Albert Bradbury, Peoria, AZ US
| Patent application number | Description | Published |
|---|---|---|
| 20090057497 | Innovative Duct Bank Spacer - An Innovative Duct Bank Spacer allows the manipulation of the duct bank spacer to accommodate multiple conduit sizes in a single ready-made duct bank spacer. The inventive device includes PVC Pipe that is fitted thru drilled High Density Polyethylene (HDPE) slats. PVC pipe spacers are placed in between the HDPE slats to accommodate the conduit size and spacing needed and/or required. The PVC Pipe is glued into PVC couplings at each end of the Innovative Duct Bank Spacer to secure the placement of the PVC pipes. Two or more Innovative Duct Bank Spacers may be easily joined together with a piece of PVC pipe at either end to create an even larger duct bank spacer. | 03-05-2009 |