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Boynton, US
Alton L. Boynton, Andover, KS US
| Patent application number | Description | Published |
|---|---|---|
| 20120045501 | CONNEXIN ENHANCES CHEMOTHERAPY-INCLUDED APOPTOSIS IN HUMAN CANCER CELLS INHIBITING TUMOR CELL PROLIFERATION - The present invention provides methods and compositions for the inhibition of proliferation rate of target cells, for example tumor cells. In particular, a nucleic acid encoding a connexin protein, fragment, derivative or analog thereof can be incorporated into a target cell. Expression of the nucleic acid sequence encoding the connexin protein, fragment, derivative or analog thereof, particularly connexin 43 and non-phosphorylated connexin 43, reduces the level of bc1-2 expression in the cells thereby inducing the cells to enter apoptosis. Connexin protein, fragments, derivatives, or analogs thereof can also be administered to the cell population to reduce bc1-2 expression inducing apoptosis in the cell population. It has further been found that the addition of an antagonist of MCP-1 activity can enhance the effects of connexin on tumor cell proliferation. Also, the prognosis of a subject undergoing standard chemotherapy can be assessed by correlating the expression levels of connexin and bc1-2. | 02-23-2012 |
Alton L. Boynton, Redmond, WA US
| Patent application number | Description | Published |
|---|---|---|
| 20110189150 | TANGENTIAL FLOW FILTRATION DEVICES AND METHODS FOR LEUKOCYTE ENRICHMENT - The present invention provides tangential flow filtration devices and methods for enriching a heterogenous mixture of blood constituents for leukocytes by removal of non-leukocyte blood constituents. In one particular embodiment the device can provide a composition enriched in monocytes. | 08-04-2011 |
Alton L. Boynton, Kingston, WA US
| Patent application number | Description | Published |
|---|---|---|
| 20080254537 | Compositions and Methods for Inducing the Activation of Immature Monocytic Dendritic Cells - The present invention provides methods for inducing the maturation of immature dendritic cells (DC) and for activating those cells without the use of a dendritic cell maturation agent. The activated DC can be used for inducing an antigen specific T cell response. Methods of the invention can also comprise the addition of a directional maturation agent, such as interferon gamma, to induce a Th-I and/or Th-2 bias in the response obtained. The present invention also provides dendritic cell populations useful for activating and for inducing antigen specific T cells. Similarly, activated antigen specific T cell populations, and methods of making the same are provided. | 10-16-2008 |
| 20100062003 | THERAPEUTIC AND DIAGNOSTIC APPLICATIONS BASED ON THE ROLE OF THE CXCR-4 GENE IN TUMORIGENESIS - The present invention relates to the identification of a novel role of CXCR-4 in cell transformation and aberrant cellular proliferation. In particular, the present invention relates to the altered gene expression of CXCR-4 in a number of primary tumors and cell lines derived from tumors, in addition to, the altered gene expression of ligands for CXCR-4. Further, the present invention relates, in part, to the Applicant's surprising discovery that the inhibition of CXCR-4 gene expression or the inhibition of CXCR-4 activity in transformed cells reverses the transformed phenotype. | 03-11-2010 |
Geoffrey M. Boynton, Seattle, WA US
| Patent application number | Description | Published |
|---|---|---|
| 20110184490 | Multi-Electrode Integration in a Visual Prosthesis - The present invention is a method of stimulating visual neurons to create the perception of light. A visual prosthesis electrically stimulating the retina with implanted electrodes exhibits interaction between electrodes stimulated closely together in both space and time. The method of the present invention includes determining a minimum distance at which spatiotemporal interactions occur, determining a minimum time at which spatiotemporal interactions occur, and avoiding stimulation of electrodes within the minimum distance during the minimum time. The minimum are ideally established for each individual patient. Alternatively, approximate minimums have been established by the applicants at 2 mm and 1.8 μsec. | 07-28-2011 |
| 20120059697 | ADVERTISING DURING ACCELERATED MEDIA PLAYBACK - A system and a method are disclosed for displaying an image during an operation of an accelerated media playback (e.g., fast-forward or reverse) such that the image appears concurrently with a cue signaling a resume point. First, a video frame within an advertisement is identified from a plurality of advertisements. The video frame contains the cue and indicates a resume point for media content. Additionally, an image is embedded on the video frame such that the video frame, the cue and the image are displayed for less than a second during accelerated media playback, such as a fast-forward operation. The presence of the action cue or resume cue presented concurrently with the advertisement assists viewers in preferentially recalling the product related to the image. | 03-08-2012 |
Jayne L. Boynton, Jeannette, PA US
| Patent application number | Description | Published |
|---|---|---|
| 20120065927 | METHOD FOR AUTOMATED POSITION VERIFICATION - An improved method for verifying a position of a sensor with respect to an object under test includes detecting a signal from the sensor that is positioned at a given location on an object under test and comparing the signal from the sensor with a historical signal that is associated with a Uniquely Identified Location (UIL) on the object under test. If the two signals are consistent, and if the position of the sensor at the given location on the object under test is the same as the UIL, it is concluded that the position of the sensor is correct. | 03-15-2012 |
Jayne L. Boynton, New Stanton, PA US
| Patent application number | Description | Published |
|---|---|---|
| 20110125462 | TETHERLESS TUBE INSPECTION SYSTEM - Apparatus and a method to inspect tubing by means of a free flying, autonomous inspection head that is not attached by wires to external control and data acquisition equipment. The inspection head travels through the tube with an attached module that integrates all the necessary support for the electronic and mechanical control of a nondestructive sensor within the inspection head. | 05-26-2011 |
Joanna Boynton, Wellington, FL US
| Patent application number | Description | Published |
|---|---|---|
| 20110315566 | CUSTOMIZABLE STORAGE CONTAINER SYSTEM - A series of interlocking or non-interlocking stackable containers have an identical size and shape. The containers may include transparent sides and a transparent cover. The cover may include a raised area. The bottom of container may include an inward recess sized to accept the raised area of the cover of a lower container. Each container may include an interchangeable faceplate that affixes to the transparent cover. The interchangeable faceplate may be used to accessorize the containers for visual recognition and cover an outer area of the cover, leaving an inner area of the cover exposed for viewing contents. The containers may similarly display contents at both a merchant and a customer location. A customer may purchase a container for home-use such as for interlocking or stacking with previously purchased containers of the same size. The containers may contain contents of the same type, such as jewelry, shoes, or other articles. | 12-29-2011 |
| 20110315567 | Customizable Storage Container System - A series of interlocking or non-interlocking stackable containers have an identical size and shape. The containers may include transparent sides and a transparent cover. The cover may include a raised area. The bottom of container may include an inward recess sized to accept the raised area of the cover of a lower container. Each container may include an interchangeable faceplate that affixes to the transparent cover. The interchangeable faceplate may be used to accessorize the containers for visual recognition and cover an outer area of the cover, leaving an inner area of the cover exposed for viewing contents. The transparent cover may have an downwardly extending lip that snaps onto a protrusion on a container base. The faceplate may cover both horizontal and vertical surfaces of the cover. The cover may have a depressed perimeter configured to accept the faceplate. An insert may be provided that holds contents in place. | 12-29-2011 |
John Boynton, Pasadena, CA US
| Patent application number | Description | Published |
|---|---|---|
| 20090135495 | CAMERA, HANDLENS, AND MICROSCOPE OPTICAL SYSTEM FOR IMAGING AND COUPLED OPTICAL SPECTROSCOPY - An optical system comprising two lens cells, each lens cell comprising multiple lens elements, to provide imaging over a very wide image distance and within a wide range of magnification by changing the distance between the two lens cells. An embodiment also provides scannable laser spectroscopic measurements within the field-of-view of the instrument. | 05-28-2009 |
| 20110141582 | CAMERA, HANDLENS, AND MICROSCOPE OPTICAL SYSTEM FOR IMAGING AND COUPLED OPTICAL SPECTROSCOPY - An optical system comprising two lens cells, each lens cell comprising multiple lens elements, to provide imaging over a very wide image distance and within a wide range of magnification by changing the distance between the two lens cells. An embodiment also provides scannable laser spectroscopic measurements within the field-of-view of the instrument. | 06-16-2011 |
Lee R. Boynton, Lake Oswego, OR US
| Patent application number | Description | Published |
|---|---|---|
| 20110099363 | SECURE END-TO-END TRANSPORT THROUGH INTERMEDIARY NODES - A communication network encrypts a first portion of a transaction associated with point-to-point communications using a point-to-point encryption key. A second portion of the transaction associated with end-to-end communications is encrypted using an end-to-end encryption key. | 04-28-2011 |
| 20110213898 | MOBILE DEVICE POWER MANAGEMENT IN DATA SYNCHRONIZATION OVER A MOBILE NETWORK WITH OR WITHOUT A TRIGGER NOTIFICATION - A real-time communication architecture establishes a continuous connection between an enterprise network and a communication management system. The connection is continuously held open allowing mobile devices real-time access to enterprise email systems. The real-time communication architecture can support an entire enterprise email system or individual email users. The foregoing and other objects, features and advantages of the invention will become more readily apparent from the following detailed description of a preferred embodiment of the invention which proceeds with reference to the accompanying drawings. | 09-01-2011 |
Scott Boynton, East Windsor, CT US
| Patent application number | Description | Published |
|---|---|---|
| 20110284511 | METHOD AND APPARATUS FOR LASER STRIP SPLICING - A splicing apparatus for joining a trailing end of a downstream metal strip to the leading end of an upstream metal strip includes a base having a working surface, a cover assembly operatively connected to the base and movable between an open position and a closed position, a fixed platen fixedly secured to the working surface, a moving platen slidably connected to the working surface, and a laser device for both cutting said downstream and upstream metal strips and for welding said metal strips together, the laser device including a laser source and a laser head in communication with the laser source, the laser head being connected to said cover assembly. | 11-24-2011 |
Scott Anthony Boynton, San Jose, CA US
| Patent application number | Description | Published |
|---|---|---|
| 20090135810 | Device to terminate a modem relay channel directly to an IP network - A modem data aggregating gateway that supports modem relay functionality for permitting reliable switching of modem traffic between a VoIP network and a data packet switch Internet Protocol (IP) network, s.a. the Internet. The modem relay aggregator may receive modem data encapsulated as Voice over IP (VoIP) data packets in accordance with a Simple Packet Relay Transport (SPRT) mechanism. The packet data may be error corrected and/or decompressed before being repackaged for forwarding to the ultimate destination. In the event that the destination is itself an IP device, the modem relay aggregator may forward the packets directly over the IP network. As a result, if the destination of a modem call is an IP device (such as a Web site or other Internet-enabled device) the technique eliminates two points from a processing path in which digital signal processing (DSPs) would otherwise have to perform modem protocol processing. Otherwise, minimal modem reformatting can be performed at the aggregation point. | 05-28-2009 |
Stephen E. Boynton, Spanish Fork, UT US
| Patent application number | Description | Published |
|---|---|---|
| 20100282540 | LADDERS, LADDER COMPONENTS, LADDER ACCESSORIES, LADDER SYSTEMS AND RELATED METHODS - Various embodiments of ladders, ladder components, accessories for ladders, ladder systems and related methods are provided. In one embodiment a ladder and platform system is provided having at least two ladders and a platform or plank. The platform or plank has coupling mechanisms that provide adjustable but secure coupling of the platform to the ladders, either with the top cap or with the rungs. Other embodiments include storage devices and paint trays for use with ladders and ladder systems incorporating such devices. | 11-11-2010 |
| 20100300805 | ADJUSTABLE LADDERS AND RELATED METHODS - The present invention relates to ladders and, more particularly, various configurations of ladders including straight and extension ladders, as well as to methods relating to the use and manufacture of such ladders. In accordance with one embodiment of the present invention, a ladder is provided that includes a first pair of spaced apart rails and a plurality of rungs extending between and coupled to the first pair of spaced apart rails. The ladder also includes a pair of lateral support members, wherein each support member is selectively displaceable in a lateral direction relative to an associated rail. Additionally, the ladder includes a pair of adjustable legs, each leg having a first end slidably coupled to an associated rail of the first pair of spaced apart rails and being slidably coupled to an associated lateral support member. | 12-02-2010 |
Thomas A. Boynton, Floresville, TX US
| Patent application number | Description | Published |
|---|---|---|
| 20080275408 | LOCALIZED LIQUID THERAPY AND THERMOTHERAPY DEVICE - A device for directly applying thermotherapeutic liquid to an area upon the surface of an afflicted patient, and methods of use thereof, are described. In particular, a device for apply water-based liquid at a therapeutic temperature directly to an afflicted area in order to create a localized hyperthermia, is presented. The afflicted area may be either on the skin of the patient, or subcutaneous. The device is also effective for disinfection, irrigation, lavage, and the like, when employing a suitable solution. The liquid may also have a mild oxidizing effect, which, if greater upon afflicted than upon non-afflicted cells, would enhance the therapeutic effect in conjunction with the therapy herein described. | 11-06-2008 |
| 20110022013 | NEGATIVE PRESSURE ASSISTED TISSUE TREATMENT SYSTEM - A system for stimulating the healing of tissue comprises a porous pad positioned within a wound cavity, and an airtight dressing secured over the pad, so as to provide an airtight seal to the wound cavity. A proximal end of a conduit is connectable to the dressing. A distal end of the conduit is connectable to a negative pressure source, which may be an electric pump housed within a portable housing, or wall suction. A canister is positioned along the conduit to retain exudates suctioned from the wound site during the application of negative pressure. A first hydrophobic filter is positioned at an opening of the canister to detect a canister full condition. A second hydrophobic filter is positioned between the first filter and the negative pressure source to prevent contamination of the non-disposable portion of the system by exudates being drawn from the wound. An odor filter is positioned between the first and second hydrophobic filters to aid in the reduction of malodorous vapors. A securing means is supplied to allow the portable housing to be secured to a stationary object, such as a bed rail or intravenous fluid support pole. A means for automated oscillation of pressure over time is provided to further enhance and stimulate the healing of an open wound. A means for varying pump drive frequency and a means for managing a portable power supply are provided to increase battery life and improve patient mobility. | 01-27-2011 |
Vicki Boynton, Wilkeson, WA US
| Patent application number | Description | Published |
|---|---|---|
| 20100040708 | HERBAL COMPOSITION - An herbal composition for treating menopausal symptoms in a woman includes yarrow, damiana, skullcap, chaste tree berry, wild yam, corn silk, cramp bark, bloodroot, fenugreek, feverfew, cardamom, and | 02-18-2010 |