Bowman, MA
Harry Frederick Bowman, Needham, MA US
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20100145168 | Method for assessing endothelial function - The system assesses the endothelial function of a subject. Particularly, peripheral tissue perfusion measurements taken in a subject are compared to reference perfusion data and the comparison yields the assessment of endothelial function. The reference may be data indicative of peripheral tissue perfusion in a healthy person. Also, peripheral tissue perfusion measurements taken in a subject when perfusion is in an unperturbed state (the reference) can be compared to perfusion measurements taken promptly after a challenge to normal or unperturbed tissue perfusion of the subject. | 06-10-2010 |
H. Frederick Bowman, Needham, MA US
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20090216136 | Blood flow monitor with arterial and venous sensors - A technique is disclosed for determining blood flow in a living body by changing the thermal energy level in the venous blood flow path and determining temperatures in both the venous and arterial blood flow paths. Blood flow is calculated as a function of the change in energy level and the temperature differences in the venous and arterial blood flow paths. | 08-27-2009 |
20100241016 | System for quantifying blood flow in tissue and updating tissue baseline conditions - Methods and apparatus for determining blood flow in tissue are disclosed. The methods and apparatus are used to establish a baseline for both thermal properties of the tissue and non-physiologic conditions. Periodic changes in either or both constituents of the baseline are determined and, when the changes correspond to a need for a new baseline, a new baseline is established. | 09-23-2010 |
20130218034 | System for quantifying blood flow in tissue and updating tissue baseline conditions - Methods and apparatus for determining blood flow in tissue are disclosed. The methods and apparatus are used to establish a baseline for both thermal properties of the tissue and non-physiologic conditions. Periodic changes in either or both constituents of the baseline are determined and, when the changes correspond to a need for a new baseline, a new baseline is established. | 08-22-2013 |
20130218046 | System for assessing endothelial function - The system assesses the endothelial function of a subject. Particularly, peripheral tissue perfusion measurements taken in a subject are compared to reference perfusion data and the comparison yields the assessment of endothelial function. The reference may be data indicative of peripheral tissue perfusion in a healthy person. Also, peripheral tissue perfusion measurements taken in a subject when perfusion is in an unperturbed state (the reference) can be compared to perfusion measurements taken promptly after a challenge to normal or unperturbed tissue perfusion of the subject. | 08-22-2013 |
20140303513 | Edema Monitor - An edema monitor uses patient-specific measurements of tissue conductivity and tissue perfusion and an empirically developed perfusion coefficient of thermal conductivity to obtain tissue intravascular water and tissue extravascular water components of tissue total water. Edema is an excess of tissue extravascular water. A value for edema is obtained by deducting from the obtained value for tissue extravascular water a normal value for tissue extravascular water. | 10-09-2014 |
20140378775 | Unitary multilumen cranial bolt - A unitary multilumen cranial bolt for use in multimodal monitoring of a plurality of physiological parameters in brain tissue incorporates a plurality of lumens, each lumen directing a catheter borne sensor through a bore hole in the cranium and into brain tissue of a patient. The lumens are configured to cause the catheters to splay outward as they enter the cranial cavity and reach their intended depth of penetration. Each lumen is associated with a guide. The guides are adapted for use with introducers that enable fragile and/or flexible sensors to be introduced into brain tissue. Each catheter borne sensor can be positioned and repositioned within brain tissue independently of all other sensors. | 12-25-2014 |
James Bowman, Boston, MA US
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20160140522 | METHODS AND SYSTEMS FOR IMPLEMENTING DYNAMIC BILLING - Described herein are methods and systems for administering a life insurance policy that provide an alternative to the traditional approach by querying a client for a set of coverage objectives and using a set of algorithms to automatically adjust billed premiums on an ongoing basis to maintain the client-specified coverage objectives—a methodology referred to herein as “dynamic billing.” Dynamic billing enables clients to take corrective action sooner than it would otherwise be taken and/or provides an automated mechanism or prompt for clients to take such action on an ongoing basis. For example, in certain embodiments, the disclosed technology computes adjusted premiums and allows the policy owner to be billed the amount required to keep his/her policy on track with his/her current insurance policy objectives. | 05-19-2016 |
Jeremy Bowman, Arlington, MA US
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20100041974 | Physiological monitoring garment - A physiological monitoring garment includes a fabric portion. At least one elongate stretchable textile data/power bus is disposed the fabric portion. The elongate stretchable textile data/power bus includes a plurality of integral conductors, woven, knitted, or braided along the length thereof. One or more sensors are connected to the elongate stretchable textile data/power bus. | 02-18-2010 |
John Kevin Bowman, Brighton, MA US
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20110290894 | METHOD FOR CONTROLLING COOLING IN A DATA STORAGE SYSTEM - A system having: a midplane having air flow channels therein; a disk drive mounted to a first side of the midplane; and a temperature sensors mounted to the midplane. The system includes a pair of electrical chassis connected to a second side of the midplane. A first one of the chassis has therein: a fan; and a fan controller for controlling speed of the fan in response to a temperature control signal. A second one of the chassis has therein: a microprocessor for: detecting temperature signals produced by the temperature sensors; comparing differences between the detected temperature signals; and selecting one of the detected temperature control signal from the compared differences as the temperature control signal. A faulty one of the temperature sensors is detected by: selecting one of the detected temperature control signal as the faulty one of the plurality of temperature sensors from the compared differences. | 12-01-2011 |
Keith Bowman, Cambridge, MA US
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20110200582 | LIPIDS, LIPID COMPOSITIONS, AND METHODS OF USING THEM - Disclosed are formulation and optimization protocols for delivery of therapeutically effective amounts of biologically active agents to liver, tumors, and/or other cells or tissues. Also provided are compositions and uses for cationic lipid compounds of formula (I). | 08-18-2011 |
20140309277 | LIPIDS, LIPID COMPOSITIONS, AND METHODS OF USING THEM - Disclosed are formulation and optimization protocols for delivery of therapeutically effective amounts of biologically active agents to liver, tumors, and/or other cells or tissues. Also provided are compositions and uses for cationic lipid compounds of formula (I). | 10-16-2014 |
20160106842 | LIPIDS AND LIPID COMPOSITIONS FOR THE DELIVERY OF ACTIVE AGENTS - This invention provides for a compound of formula (I): or a pharmaceutically acceptable salt thereof, wherein R | 04-21-2016 |
Michael Bowman, Westwood, MA US
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20090214520 | Soluble CLCA-1 and antagonists to CLCA-1 - The invention relates to methods of treating a disease or condition, wherein expression or activity of soluble CLCA1 is up-regulated, by administering inhibitors of soluble CLCA1. The invention also relates to methods of isolating soluble CLCA1 from a bodily fluid. | 08-27-2009 |
Michael R. Bowman, Westwood, MA US
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20090156537 | COMPOSITIONS AND METHODS FOR DIAGNOSING AND TREATING ASTHMA OR OTHER ALLERGIC OR INFLAMMATORY DISEASES - The present invention provides compositions and methods useful for detecting or treating asthma or other allergic or inflammatory diseases. In one aspect, the methods of the present invention include inhibiting the activity or expression of a component of an arginine metabolic pathway in tissues affected by asthma or other allergic or inflammatory diseases. In many embodiments, the component being inhibited is a cationic amino acid transporter, an arginase, or a component downstream of the arginase. In many other embodiments, the activity or expression of the component is inhibited by an agent that binds to the component. In still many other embodiments, the activity or expression of the component is inhibited by an agent that binds a polynucleotide encoding the component. | 06-18-2009 |
20090274696 | METHODS FOR TREATING INFLAMMATION - Provided are methods and compositions for reducing airway hyperresponsiveness and other inflammatory diseases, disorders and conditions in a mammal by decreasing FIZZ1 (Found in Inflammatory Zone 1) activity. Also provided are methods and compositions for identifying modulators of airway inflammation and/or inhibitors of FIZZ1. The present invention encompasses modulators of airway inflammation and/or inhibitors of FIZZ1 and uses thereof. In addition, the present invention provides methods and compositions for enhancing an immune response based on FIZZ1 protein. | 11-05-2009 |
Michael Ronald Bowman, Westwood, MA US
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20080226645 | Methods and compositions for assessment and treatment of asthma - The present invention provides methods and compositions for the assessment and treatment of asthma and other inflammatory diseases, particularly those mediated by interleukin-13 (IL-13). The present invention also provides arrays comprising markers for asthma as well as IL-13 responsiveness. The markers of the present invention can be used in methods to diagnose a patient as having asthma or an IL-13-mediated condition, to evaluate the effectiveness of potential therapeutic agents, to identify or evaluate agents capable of modulating marker expression levels, and to select a treatment for a patient suffering from asthma or an IL-13-mediated condition. | 09-18-2008 |
Steve Mark Bowman, Sherborn, MA US
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20140081339 | ANCHOR HAVING A CONTROLLED DRIVER ORIENTATION - The present disclosure relates to an interference screw having a body with a proximal end, distal end, and longitudinal axis extending between thereinbetween. The screw further includes threads for fixing the screw into bone. The screw further includes a through bore defined by the body. The through bore extends between the proximal and distal ends along the longitudinal axis, and has a surface. The screw further includes a controlling member formed by the through bore surface. To install the screw into bone, a surgeon turns the screw with a driver that engages with the controlling member. The driver only engages the controlling member when it is in a driving orientation with respect to the controlling member. Advantageously, with this “one-way” engagement the surgeon can control and confirm the orientation of the driver without seeing the driver and/or screw. | 03-20-2014 |
Steven Mark Bowman, Sherborn, MA US
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20130072942 | FLEXIBLE DEPTH PROBE - An instrument includes a flexible shaft portion and a hook portion. The flexible shaft portion has a proximal end and a distal end and includes markings along an outer surface of the shaft portion. The hook portion is located at the distal end of the shaft portion. The shaft portion and the hook portion define a lumen that terminates in an opening at the hook portion. | 03-21-2013 |
20130204367 | IMPLANTABLE BIOLOGIC HOLDER - A tissue graft suspension device includes a platform member, a graft connecting element coupled to the platform member such that a portion of the graft connecting element forms a loop for attachment to a tissue graft, and an enclosure member coupled to the loop of the graft connecting element and configured to enclose a biologic material. The enclosure member defines an opening configured to receive the biologic material. The graft connecting element and the enclosure member are configured such that, during use, the tissue graft is coupled to the loop and in contact with the enclosure member. | 08-08-2013 |
20140155899 | SURGICAL INSTRUMENT - A cannulated retrograde reamer that is adjustable to create tunnels of multiple different diameters. The cannulated retrograde reamer substantially reduces the risk of tunnel malposition and/or misalignment, and can be adjusted to create a range of tunnel diameters, thereby allowing inventory levels to be reduced for a surgical case. | 06-05-2014 |
20140222010 | Flexible Depth Probe - An instrument includes a flexible shaft portion and a hook portion. The flexible shaft portion has a proximal end and a distal end and includes markings along an outer surface of the shaft portion. The hook portion is located at the distal end of the shaft portion. The shaft portion and the hook portion define a lumen that terminates in an opening at the hook portion. | 08-07-2014 |
20160058550 | IMPLANTABLE BIOLOGIC HOLDER - A tissue graft suspension device includes a platform member, a graft connecting element coupled to the platform member such that a portion of the graft connecting element forms a loop for attachment to a tissue graft, and an enclosure member coupled to the loop of the graft connecting element and configured to enclose a biologic material. The enclosure member defines an opening configured to receive the biologic material. The graft connecting element and the enclosure member are configured such that, during use, the tissue graft is coupled to the loop and in contact with the enclosure member. | 03-03-2016 |
Tim Bowman, Amherst, MA US
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20110230682 | MICROORGANISMS WITH INACTIVATED LACTATE DEHYDROGENASE GENE (LDH) FOR CHEMICAL PRODUCTION - This invention provides systems and methods for the increased production of ethanol and other chemical compounds by recombinant | 09-22-2011 |
Ward Bowman, Foxboro, MA US
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20140358968 | METHOD AND SYSTEM FOR SEAMLESS QUERYING ACROSS SMALL AND BIG DATA REPOSITORIES TO SPEED AND SIMPLIFY TIME SERIES DATA ACCESS - Included herein is a method for providing seamless access to time series data located in multiple time series data storage units. A user makes a data query without knowing where the data is stored or in what format. The data request is received and parsed by a query interface and the data interface formulates one or more data requests for the specific time series data storage device where the queried data are stored. The time series data received from the data storage device is assembled by the query interface and displayed to the user. | 12-04-2014 |
20160054951 | APPARATUS AND METHOD FOR OPTIMIZING TIME SERIES DATA STORAGE - Characterization information related to time series data is obtained. A data storage rule is automatically determined based upon the characterization information. The rule defines at least one of a location for the storage of the time series data and a format for storage of the time series data. The rule is applied to the time series data and the time series data is stored according to the rule. | 02-25-2016 |
Ward Bowman, Mendon, MA US
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20160070737 | APPARATUS AND METHOD FOR OPTIMIZING TIME SERIES DATA STORE USAGE - A first attribute is associated with a first data storage device and a second attribute is associated with a second data storage device. The first data storage device stores first time series data and the second data storage device stores second time series data. In parallel, the first attribute is applied to the first time series data and the second attribute is applied to the second time series data. The application is effective to cause an alteration of one or more of the first time series data or the second time series data. The alteration may be a thinning or reduction of the time series data. | 03-10-2016 |
Ward Linnscott Bowman, Mendon, MA US
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20160055204 | APPARATUS AND METHOD FOR EXECUTING PARALLEL TIME SERIES DATA ANALYTICS - Time series data is identified that is related to a predetermined characteristic and the predetermined characteristic being at least one of an identity of a sensor or a time range. Based upon the identified time series data, the time series data is moved to selected ones of the plurality of separate data storage devices, and the movement is temporary for processing purposes. In parallel, queries are performed on the time series data on each of the selected ones of the plurality of separate data storage devices to obtain a plurality of results. The plurality of results are aggregated. | 02-25-2016 |
20160055211 | APPARATUS AND METHOD FOR MEMORY STORAGE AND ANALYTIC EXECUTION OF TIME SERIES DATA - A user query or analytic user is received. The user query or analytic requires one or more portions of time series data from a plurality of transient memories. The time series data is linked together across the transient memories devices. A location of one or more portions of the time series data is identified at the plurality of transient memories. One or more portions of the time series data is automatically retrieved from the transient memories. | 02-25-2016 |
Ward Linscott Bowman, Mendon, MA US
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20160055186 | APPARATUS AND METHOD FOR OPTIMIZING TIME SERIES DATA STORAGE BASED UPON PRIORITIZATION - A data storage policy is determined. Time series data is received and a score for the time series data is determined. The score prioritizes the time series data according to a likelihood the time series data will be needed for future use. Based upon the data storage policy and the score, the time series data is stored at one or more data storage devices. The score is updated over time to reflect changing priorities regarding the use of the data. | 02-25-2016 |
William Bowman, Arlington, MA US
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20140222553 | Dynamic Website Campaign Builder for Merchandising - Dynamic website Campaign builder software for enabling merchandising via the Internet. The Campaign builder software has an application programming interface for display on programming computing devices with display screens to permit building a Campaign. Plural Campaign templates are retained in electronic memory, and an insertion mechanism, such as a Destination Script or an iFrame, permits insertion of assets into the Campaign template to create Campaigns. A saving mechanism permits selective saving of Campaigns, and a publishing mechanism permits selective publication of Campaigns, including with fixed width and responsive design templates. A recipient user interface is operative on recipient computing devices with display screens to permit viewing and usage of published Campaigns. Campaigns are saved to content delivery network (CDN) Media Cloud Server storage for rapid CDN publishing. A linking mechanism permits a linking of Campaigns to an Analytic program for harvesting and analysis of user interaction and Ecommerce data. | 08-07-2014 |