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Bottino

Aldo Bottino, Genova IT

Patent application numberDescriptionPublished
20110091369METHOD FOR THE RECOVERY OF AMMONIA FROM A GASEOUS STREAM IN A SYNTHESIS PROCESS OF UREA - The present invention relates to a process for the recovery of ammonia contained in a gaseous purging stream produced in a synthesis process of urea, comprising the following phases: a) subjecting the gaseous purging stream to a washing with an aqueous acidic solution, at a pH ranging from 1 to 6, with the formation of a first purified gaseous stream and an aqueous solution containing an ammonium salt; b) subjecting the aqueous solution containing the ammonium salt coming from phase a) to stripping, after treatment with a strong base, at a temperature ranging from 50 to 250° C. and a pressure ranging from 1 to 40 absolute bar, with the formation of a second gaseous stream comprising NH04-21-2011

Christina Bottino, Genova IT

Patent application numberDescriptionPublished
20100285531Therapeutic and Diagnostic Methods and Compositions Targeting 4Ig-B7-H3 and its Counterpart NK Cell Receptor - The present invention relates to the identification of 4Ig-B7-H3 protein as a tumor associated molecule that imparts protection from NK cell-mediated lysis via a 4Ig-B7-H3 receptor on NK cells. The invention provides compounds that interfere with interactions between the 4Ig-B7-H3 protein and its receptor that can be used to potentiate NK cell cytotoxicity. Also provided are compounds that bind 4Ig-B7-H3-expressing cells so as to inhibit or eliminate them. The compounds are particularly useful in the treatment of tumors, inflammatory conditions, infections and transplantation. Also provided are methods for diagnosing disease by detecting a 4Ig-B7-H3 protein.11-11-2010

Cristina Bottino, Genova IT

Patent application numberDescriptionPublished
20080248045POLYPEPTIDES HAVING A TRIGGERING NK ACTIVITY AND BIOLOGICAL APPLICATIONS - The invention relates to polypeptides having a triggering NK activity and an amino acid sequence that is at least 80% identical over its entire length to the polypeptide having SEQ ID NO: 1, and any immunogenic fragments thereof, as well as to the polyclonal and monoclonal antibodies directed against said polypeptides, and immuno-reactive fragments thereof. Application for detecting NK cells in a sample, for their removal from a sample or for enrichment of NK cells, and for NK cell natural cytotoxicity regulation.10-09-2008
20100015153Novel Triggering Receptor Involved in Natural Cytotoxicity Mediated by Human Natural Killer Cells and Antibodies That Identify the Same - The invention relates to a novel compound termed NKp30 that is selectively expressed by all mature NK cells and that is involved in human natural cytoxicity as an activatory receptor, to new antibodies that bind to the NKp30 structure, and to the pharmaceutical and medicinal uses thereof.01-21-2010

Patent applications by Cristina Bottino, Genova IT

Gennaro Paolo Bottino, Milano IT

Patent application numberDescriptionPublished
20110179783DEVICE TO ACTIVELY CONTROL THE VIBRATIONS OF AN ARTICULATED ARM TO PUMP CONCRETE - The device to actively control the vibrations of an articulated arm consisting of a plurality of segments each comprising at least its own actuator associated with a hydraulic drive circuit including a block valve. At least one of said actuators is associated with an auxiliary control circuit of the vibrations, comprising at least a sensor able to detect the vibrations and/or the position of one or more segments, a processing unit to process the signals of the sensor/sensors and a pump commanded by the processing unit and cooperating with said block valve. The auxiliary control circuit is associated with the hydraulic drive circuit.07-28-2011