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Bookbinder, US
Dana C. Bookbinder, Corning, NY US
| Patent application number | Description | Published |
|---|---|---|
| 20080273839 | Connectorized nano-engineered optical fibers and methods of forming same - Connectorized nano-engineered optical fibers and method for forming them are disclosed. The methods include heating a mid-span bare fiber portion of the nano-engineered fiber to collapse the airlines therein so as to form an airline-free portion. The fiber is then inserted into a ferrule channel so that the fiber end protrudes beyond the ferrule end face, but with the airline-free portion positioned at the ferrule end face. The fiber is then cleaved at or near the ferrule end face in the airline-free portion, and the new fiber end face polished to create a solid fiber end face that coincides with the ferrule end face. The methods result in at most only minimal changes to the mode field diameter (MFD) and/or to the outer cladding diameter, which is essential in forming a connectorized nano-engineered fiber that can connect to like-size nano-engineered or non-nano-engineered fibers. | 11-06-2008 |
| 20080304796 | Connectorized nano-engineered optical fibers and methods of forming same - Connectorized nano-engineered optical fibers and method for forming them are disclosed. The methods include heating a mid-span bare fiber portion of the nano-engineered fiber to substantially collapse the airlines therein so as to form a substantially airline-free portion. The fiber is then inserted into a ferrule channel so that the fiber end protrudes beyond the ferrule end face, but with the substantially airline-free portion positioned at the ferrule end face. The fiber is then cleaved at or near the ferrule end face in the substantially airline-free portion, and the new fiber end face polished to create a solid fiber end face that coincides with the ferrule end face. The methods result in relatively small changes to the mode field diameter (MFD) and/or to the outer cladding diameter. | 12-11-2008 |
Dana Craig Bookbinder, Corining, NY US
| Patent application number | Description | Published |
|---|---|---|
| 20120106909 | LARGE EFFECTIVE AREA OPTICAL FIBER WITH LOW BEND LOSS - An optical fiber includes a central glass core region comprising maximum refractive index delta percent Δ | 05-03-2012 |
Lonnie Bookbinder, Corvallis, MT US
| Patent application number | Description | Published |
|---|---|---|
| 20110293698 | Reagents and Methods for Treating Cancer - This invention describes a genetic system for targeting the EVI1 gene in mammalian cells. The EVI1 gene is an oncogenic transcription factor that, when expressed, accelerates cell division and inhibits death of cells. Nucleotide sequences that block the expression of EVI1 and drug delivery systems for them are described. These nucleotide sequences cause a block in cell growth and division and trigger death of mammalian cells, including lung and ovarian cancer cells. | 12-01-2011 |
Louis Bookbinder, San Diego, CA US
| Patent application number | Description | Published |
|---|---|---|
| 20100143457 | Extended soluble PH20 polypeptides and uses thereof - Soluble PH20 polypeptides are provided, including extended soluble PH20 polypeptides, and uses thereof. Also provided are other C-terminally truncated PH20 polypeptides and partially deglycosylated PH20 polypeptides and uses thereof. | 06-10-2010 |
| 20100284995 | Temperature sensitive mutants of matrix metalloproteases and uses thereof - Provided are modified matrix metalloprotease (MMP) enzymes that exhibit temperature-dependent activity and uses thereof. The MMPs can be used, for example, to treat ECM-mediated diseases or disorders characterized by increased deposition or accumulation of one or more ECM components. | 11-11-2010 |
| 20110229451 | TEMPERATURE SENSITIVE MUTANTS OF MATRIX METALLOPROTEASES AND USES THEREOF - Provided are modified matrix metalloprotease (MMP) enzymes that exhibit temperature-dependent activity and uses thereof. The MMPs can be used, for example, to treat ECM-mediated diseases or disorders characterized by increased deposition or accumulation of one or more ECM components. | 09-22-2011 |
Louis H. Bookbinder, San Deigo, CA US
| Patent application number | Description | Published |
|---|---|---|
| 20110008309 | Soluble glycosaminoglycanases and methods of preparing and using soluble glycosaminoglycanases - The invention relates to the discovery of novel soluble neutral active Hyaluronidase Glycoproteins (sHASEGPs), methods of manufacture, and their use to facilitate administration of other molecules or to alleviate glycosaminoglycan associated pathologies. Minimally active polypeptide domains of the soluble, neutral active sHASEGP domains are described that include asparagine-linked sugar moieties required for a functional neutral active hyaluronidase domain. Included are modified amino-terminal leader peptides that enhance secretion of sHASEGP. The invention further comprises sialated and pegylated form of a recombinant sHASEGP to enhance stability and serum pharmacokinetics over naturally occurring slaughterhouse enzymes. Further described are suitable formulations of a substantially purified recombinant sHASEGP glycoprotein derived from a eukaryotic cell that generate the proper glycosylation required for its optimal activity. | 01-13-2011 |
Mark J. Bookbinder, Blue Ash, OH US
| Patent application number | Description | Published |
|---|---|---|
| 20090270685 | ABSORBING FLUIDS IN A SURGICAL ACCESS DEVICE - The present invention generally provides methods and devices for removing fluid from a surgical instrument. Surgical access devices and seal systems are generally provided having one or more valves or seal assemblies to create a closed system between the outside environment and the environment in which the surgical access device is being inserted. In one embodiment, a seal assembly is provided and can include a seal having an opening configured to receive a surgical instrument therethrough and a fluid remover in the form of an absorbent element, a scraper element, a wicking element, or any combination thereof can be associated with the seal and configured to remove fluid from the opening and/or a surgical instrument. | 10-29-2009 |
| 20090270686 | METHODS AND DEVICES FOR MAINTAINING VISIBILITY DURING SURGICAL PROCEDURES - Methods and devices are provided for maintaining visibility during surgical procedures. In general, the methods and devices can allow for a surgical instrument to maintain visibility during a surgical procedure using a protective element coupled to the surgical instrument. The protective element can protect a viewing element on the surgical instrument while the surgical instrument is being passed through an introducer device into or out of a body cavity (e.g., during insertion and/or withdrawal). The protective element can also optionally protect the surgical instrument's viewing element while at least a portion of the surgical instrument is disposed in a body cavity. | 10-29-2009 |
| 20110184311 | Tissue Retrieval Device with Resilient Member - A specimen retrieval instrument comprises a tubular member, a resilient member, and a retrieval bag. The resilient member is associated with a distal end of the tubular member. The bag is secured to the resilient member. The resilient member is compressible such that the resilient member and bag fit within a hollow interior portion of the tubular member. A rod may advance the resilient member and bag out of the tubular member. Alternatively, the tubular member may comprise a sheath that is retractable to reveal the resilient member and bag. The resilient member may have a hoop, spiral, or rolled strip configuration. The resilient member may alternatively comprise telescoping arms. The resilient member opens the bag when the resilient member and bag are deployed relative to the tubular member. The resilient member may also unfurl the bag when the resilient member and bag are deployed. | 07-28-2011 |
| 20110184431 | Tissue Retrieval Device with Buckling Arms - A specimen retrieval instrument comprises a handle assembly, an actuating rod, an introducer tube, and a retrieval bag. In some versions the instrument includes a fixed arm and a buckling arm that attach to the retrieval bag and that are in communication with the actuating rod. Upon translation of the rod through the tube, the bag may be distally deployed from a proximal position within the introducer tube, and the buckling arm may open the bag for receiving a specimen. In some versions the instrument includes a support arm and a spring loop, with the spring loop attaching to the retrieval bag and the support arm attaching to the spring loop. The support arm and spring loop are in communication with the actuating rod such that movement of the rod deploys the bag from an initial position within the tube and opens the retrieval bag for receiving a specimen. | 07-28-2011 |