Bonhoeffer
Philip Bonhoeffer, London GB
Patent application number | Description | Published |
---|---|---|
20090259292 | Multiple Orifice Implantable Heart Valve and Methods of Implantation - A surgically implantable multiple orifice heart valve having a valve frame with at least two orifices, each of which can accommodate a tissue valve. | 10-15-2009 |
Phillip Bonhoeffer US
Patent application number | Description | Published |
---|---|---|
20110264207 | PROSTHETIC HEART VALVE SYSTEMS - A heart valve that can be expanded following its implantation in a patient, such as to accommodate the growth of a patient and the corresponding growth of the area where the valve is implanted, and to minimize paravalvular leakage. In one aspect, the invention may maximize the orifice size of the surgical valve. The invention includes expandable implantable conduits and expandable bioprosthetic stented valves. In one aspect of the invention, the valve may be adapted to accommodate growth of a patient to address limitation on bioprosthetic valve lifespans. | 10-27-2011 |
Sebastian Bonhoeffer, Zurich CH
Patent application number | Description | Published |
---|---|---|
20140134625 | METHODS AND SYSTEMS FOR PREDICTIVE MODELING OF HIV-1 REPLICATION CAPACITY - Methods, systems, and computer readable media perform predictive modeling of gene activity. The methods may comprise obtaining the amino acid and/or nucleic acid sequence of a portion of the at least one gene from a biological sample obtained from a subject; comparing the amino acid and/or nucleic acid sequence of the portion of the at least one gene to a database of sequences for the portion of the at least one gene and for which the biological activity of the at least one gene has been evaluated; and applying a generalization of ridge regression analysis to estimate the effects of individual mutations in the at least one gene. A model is based on generalization of ridge regression (GRR) analysis to estimate the effects of individual mutations in at least one gene for the subject. At least one gene may comprise the reverse transcriptase and protease genes of an HIV vims. | 05-15-2014 |