Patent application number | Description | Published |
20100233264 | TEMPERATURE AND pH-SENSITIVE BLOCK COPOLYMER HAVING EXCELLENT SAFTY IN VIVO AND HYDROGEL AND DRUG DELIVERY SYSTEM USING THEREOF - Disclosed herein are pH- and temperature-sensitive block copolymer with excellent safety and a method for preparing the same and a hydrogel and a drug carrier using the block copolymer. According to the present invention, the pH- and temperature-sensitive block copolymer comprises: obtained by copolymerization of: (a) polyethylene glycol-based compound (A); and (b) poly (β-amino ester)-based oligomer (B) or poly (amido amine)-based oligomer (C) or coupling of mixture (D) thereof. In order to control biodegradation rate, the block copolymer is mixed with poly (amido amine)-based oligomer instead of the poly (β-amino ester)-based oligomer and then coupling them. | 09-16-2010 |
20110150978 | PH-SENSITIVE BLOCK COPOLYMER FORMING POLYIONIC COMPLEX MICELLES AND DRUG OR PROTEIN CARRIER USING THE SAME - Disclosed is a pH-sensitive block copolymer that forms polyionic complex micelles. The block copolymer is prepared by copolymerization of (a) a polyethylene glycol compound, (b) a poly(amino acid) compound, and (c) a heterocyclic alkyl amine compound having the ability to induce the formation of ionic complexes. Further disclosed is a drug or protein carrier using the block copolymer. | 06-23-2011 |
20110217376 | POLY(AMIDOAMINE) OLIGOMER HYDROGEL FOR DRUG DELIVERY AND DRUG CARRIER USING THE SAME - Disclosed is a temperature- and pH-sensitive hydrogel composed of a poly(amidoamine) oligomer only. The hydrogel is prepared in a simple manner and is readily released from the body. Further disclosed are a method for preparing the hydrogel and a drug carrier using the hydrogel. | 09-08-2011 |
20130022545 | DRUG DELIVERY SYSTEM FOR TREATMENT OF LIVER CANCER BASED ON INTERVENTIONAL INJECTION OF TEMPERATURE AND pH-SENSITIVE HYDROGEL - A drug delivery system for the treatment of liver cancer that is based on interventional injection of a temperature and pH-sensitive hydrogel is provided. The drug delivery system is composed of a block copolymer applicable to hepatic arterial catheterization and a therapeutic agent is loaded inside the drug delivery system, and the drug delivery system is in the sol state outside, and undergoes a phase transition into the gel state inside the hepatic artery, thereby delaying or blocking blood supply of the hepatic artery, and slowly releasing the therapeutic agent during the phase transition into the gel state inside the hepatic artery. | 01-24-2013 |
20130225696 | pH-SENSITIVE POLYMER HYDROGEL WITH DUAL IONIC TRANSITION AND USE THEREOF - Disclosed is a dual-transition polymeric hydrogel. Also, provided is the use of the dual-transition polymeric hydrogel as a carrier for drug delivery and disease diagnosis, or in the preparation of a polymeric hydrogel-type pharmaceutical composition comprising the physiologically active agent loadable into the block copolymer. Being sensitive to pH as well as temperature, the block copolymer can form a more stable hydrogel at suitable temperatures and pH values. In addition, the block copolymer exhibits a dual transition behavior with pH values so that it can carry ionic drugs, proteins, DNA, and markers, whether positively or negatively charged, simultaneously. Therefore, it can be applied to a sustained drug delivery system for sparingly soluble, hydrophobic drugs, and hydrophilic drugs. Further, it is safe to and stable within the body, and is expected to find various applications in the medical field. | 08-29-2013 |
20140080922 | Polypeptide Based Block Copolymer and the Process for the Preparation Thereof, and the Polymer Micelles Using the Same - A polypeptide based block copolymer having biodegradability due to peptidase, a process for the preparation thereof, and polymer micelles using the same are provided. The block copolymer is a block copolymer of a polyethylene glycol-based compound having properties such that the solubility for water is different depending on the pH, but cannot form micelles due to a self-assembly phenomenon; and a polyglutamic acid-based compound formed using an aminolysis reaction of glutamic acid and tertiary amine in which the end of one alkyl group is substituted with NH | 03-20-2014 |
Patent application number | Description | Published |
20080274190 | TEMPERATURE AND pH - SENSITIVE BLOCK COPOLYMER HAVING EXCELLENT GEL STRENGTH, METHOD OF PREPARING THE SAME, AND DRUG DELIVERY SYSTEM USING THE SAME - Disclosed herein is a temperature- and pH-sensitive block copolymer having excellent gel strength, including: (a) a poly(ethylene glycol)-based compound (A) or a copolymer (B) of the poly(ethylene glycol)-based compound (A) and a biodegradable polymer; and (b) a polyurethane-based oligomer (C). Further, a method of preparing a temperature and pH-sensitive block copolymer having excellent gel strength, including: (a) synthesizing a poly(ethylene glycol)-based compound (A) or a copolymer (B) of the poly(ethylene glycol)-based compound (A) and a biodegradable polymer; and (b) coupling a polyurethane-based oligomer (C) with the copolymer (B), is disclosed. Also disclosed is a polymer hydrogel type drug delivery system, including: (a) the block copolymer; and (b) a physiologically active substance which can be included in the block copolymer. | 11-06-2008 |
20080293827 | Temperature and Ph Sensitive Block Copolymer and Polymeric Hydrogels Using the Same - Disclosed is a block copolymer formed by coupling the following components with each other: (a) a copolymer (A) of a polyethylene glycol (PEG) type compound with a biodegradable polymer; and (b) at least one oligomer (B) selected from the group consisting of poly(β-amino ester) and poly(amido amine). A method for preparing the same block copolymer, and a polymeric hydrogel type drug composition comprising the temperature and pH-sensitive block copolymer and a physiologically active substance that can be encapsulated with the block copolymer are also disclosed. The multiblock copolymer is obtained by copolymerization of a pH-sensitive poly(β-amino ester) and/or poly(amido amine) type oligomer, a hydrophilic and temperature-sensitive polyethylene glycol type compound and a hydrophobic and biodegradable polymer. Therefore, the block copolymer can form a polymeric hydrogel structure due to its amphiphilicity resulting from the combination of a hydrophilic group and a hydrophobic group in the copolymer and ionization characteristics depending on pH variations, and thus can be used as a drug carrier for target-directed drug delivery depending on pH variations in the body. | 11-27-2008 |
20120027690 | PH-SENSITIVE GRAFT COPOLYMER, MANUFACTURING METHOD FOR SAME, AND POLYMER MICELLES USING METHOD - The present document relates to a manufacturing method for pH-sensitive graft polymer micelles and a polymer micelle-type pharmaceutical composition containing the graft copolymer. The pH-sensitive graft copolymer micelles are usable as various markers and contrast agents for various molecular images for the diagnosis and treatment of diseases and a carrier for delivery of various medicines according to disease. The pH-sensitive graft copolymer forms micelles that can be used in target-oriented diagnosis and medicine release according to changes in the pH of a body. The polymer micelles are provided by inducing a graft copolymer of poly(β-amino ester) compounds which has a solubility in water depending on pH but is incapable of forming the micelles due to a self-assembly phenomenon, and hydrophilic poly(ethylene glycol) compounds. | 02-02-2012 |
Patent application number | Description | Published |
20110086216 | FOAMED RESIN PRODUCT AND FOAMED RESIN MOLDING MACHINE TO MANUFACTURE THE SAME - Disclosed is a foamed resin molding machine including a first mold having a first molding surface, a second mold having a second molding surface, and a third mold. A cavity is formed between the first molding surface and the second molding surface, and the third mold is movably mounted with respect to the first molding surface, such that the third mold can protrude into the cavity. The cavity is fillable with resin particles. | 04-14-2011 |
20110220543 | PACKAGE MEMBER FOR FLAT PANEL DISPLAY APPARATUS - A package member includes a first cushioning member coupled to one end of a flat panel display apparatus, and a second cushioning member coupled to the other end of the flat panel display apparatus. The package member further includes a reinforcing pad formed of a plate-shaped member and having both ends supported by the first cushioning member and the second cushioning member. The reinforcing member increases the strength of the first and second cushioning members, enabling more safe protection of the flat panel display apparatus packaged in the package member | 09-15-2011 |
20120079796 | AUTOMATIC PACKING APPARATUS AND AUTOMATIC PACKING METHOD USING THE SAME - According to example embodiments, an automatic packing apparatus includes at least one box supply unit configured to move a box stack upwards such that a product is inserted into a packing box of the box stack, the packing box being the uppermost box of the box stack, an inlet formation unit configured to lift the upper surface of the packing box to form an inlet on at least one unbonded side surface of the packing box, a product supply unit configured to transfer the product to the inlet; and a side surface bonding unit configured to bond the at least one unbonded side surface of the packing box. The at least one unbonded side surface includes the inlet and the packing box includes the product inserted therein. | 04-05-2012 |
20150015357 | MULTILAYER INDUCTOR - Disclosed herein is a multilayer inductor including: a multilayered body formed by alternately multilayering magnetic sheets and internal electrodes and a pair of external terminals provided at both end portions of the multilayered body, the internal electrodes being interlayer-connected through a via to form a coil, wherein a ratio (Ts/Te) between a space Ts between internal electrodes of upper and lower layers and a thickness Te of a single internal electrode and a ratio (Fw/W) between an inner width Fw of the internal electrode and a width W of the multilayered body are determined according to parasitic capacitance C generated between the internal electrodes of upper and lower layers, parasitic capacitance C generated between the internal electrodes and the external terminals, inductance L proportional to the number of layers of the internal electrodes, and inductance L proportional to an internal sectional area of the coil. | 01-15-2015 |
20150187486 | MULTILAYER ELECTRONIC COMPONENT AND MANUFACTURING METHOD THEREOF - A multilayer electronic component in which when an internal coil is formed in a direction perpendicular with respect to a substrate mounting surface and external electrodes are only formed on one surface (a lower surface) of the chip element facing a substrate at the time of mounting the chip element, the one surface to which the internal coil is exposed and on which the external electrodes need to be formed may be easily distinguished, and a manufacturing method thereof. | 07-02-2015 |