Patent application number | Description | Published |
20130131006 | METHOD FOR INHIBITING THE INDUCTION OF CELL DEATH BY INHIBITING THE SYNTHESIS OR SECRETION OF AGE-ALBUMIN IN CELLS OF THE MONONUCLEAR PHAGOCYTE SYSTEM - The present invention relates to a method for inhibiting the induction of cell death by inhibiting the synthesis or secretion of AGE-albumin in cells of the mononuclear phagocyte system, to an AGE-albumin synthesis inhibitor, and to a pharmaceutical composition comprising the AGE-albumin synthesis inhibitor for preventing or treating degenerative disease and autoimmune disease. The AGE-albumin of the present invention is synthesized and secreted in human microglia or human macrophages in an Alzheimer's model, stroke model, Parkinson's disease model and rheumatoid arthritis model. The AGE-albumin synthesis and secretion are caused by oxidative stress. The expression of RAGE increases in first-order human neurons or cartilage cells to which AGE-albumin is administered, whereupon a MAPK signaling pathway is activated and the expression of Bax increases to induce an increase in calcium in mitochondria, thus finally inducing cell death. Therefore, the AGE-albumin synthesis inhibitor of the present invention can be valuably used in the diagnosis or treatment of degenerative diseases or autoimmune diseases such as Alzheimer's disease, strokes, Parkinson's disease, amyotrophic lateral sclerosis, rheumatoid arthritis, diabetic retinopathy, AIDS, aging, pulmonary fibrosis, spinal cord injuries, etc. | 05-23-2013 |
20140234343 | COMPOSITION FOR PREVENTION OR TREATMENT OF ISCHEMIC CARDIAC DISEASE, COMPRISING INHIBITOR AGAINST AGE-ALBUMIN SYNTHESIS OR RELEASE OF MONONUCLEAR PHAGOCYTE SYSTEM CELLS AS ACTIVE INGREDIENT - Disclosed is a pharmaceutical composition for the prevention or treatment of ischemic heart diseases, comprising as an active ingredient an inhibitor which acts to restrain mononuclear phagocyte system cells from synthesizing or releasing AGE-albumin, which induces the apoptosis of cardiomyocytes upon the onset of the ischemic heart disease. Also, a method is provided for screening an inhibitor against the AGE-albumin synthesis or release of mononuclear phagocyte system cells. Inhibitory or suppressive of AGE-albumin-induced cell death, the pharmaceutical composition comprising as an active ingredient an inhibitor against the AGE-albumin synthesis or release of mononuclear phagocyte system cells can be applied to the prevention or treatment of a wide spectrum of ischemic heart diseases including myocardial infarction. | 08-21-2014 |
Patent application number | Description | Published |
20080286018 | IMAGE FORMING APPARATUS AND FUSING UNIT THEREOF - An image forming apparatus and a fusing unit thereof. The image forming apparatus includes a photosensitive body on which to form an electrostatic latent image, an exposure device to irradiate light to the photosensitive body to form the electrostatic latent image, a developer adhering device to adhere a developer to the photosensitive body on which the electrostatic latent image has been formed to form a visible image, a transfer device to transfer the visible image formed on the photosensitive body onto a printing medium, and a fusing unit to fuse the visible image transferred onto the printing medium to the printing medium. The fusing unit includes a press roller, a heating belt to closely contact the press roller to form a fusing nip to apply heat and pressure to the printing medium onto which the visible image has been transferred, first and second support rollers disposed apart from each other to circulatingly support the heating belt, and an elastic support device to elastically bias the first support roller and/or the second support roller in a direction away from each other to maintain a constant tension of the heating belt. | 11-20-2008 |
20100098442 | WASTE DEVELOPER COLLECTING UNIT AND IMAGE FORMING APPARATUS HAVING THE SAME - Disclosed is a waste developer collecting unit of an image forming apparatus that can include a casing configured to store waste developer, an auger rotatably disposed inside the casing and configured to move the waste developer around inside the casing, a detection unit configured to detect a load applied to the auger, the applied load being in corresponding relationship with an amount of waste developer stored in the casing, and a control unit configured to determine whether the amount of waste developer in the casing has reached a reference amount based on the detection result produced by the detection unit. | 04-22-2010 |
20120063798 | Image forming apparatus and method for controlling fuser thereof - An image forming apparatus includes a heat roller heated to a preset temperature; a pressure roller for having conductivity and forming a nip by pressure-contacting with the heat roller; a power supply unit to apply a bias voltage to the pressure roller; and a controller to, when a printing paper enters the nip, control the power supply unit to apply the bias voltage to the pressure roller. When a time interval is longer than a preset time, the controller can control the power supply unit not to apply the bias voltage when the printing paper is not placed in the nip, and when the time interval is shorter than the preset time, the controller can control the power supply unit to apply the bias voltage when the printing paper is not placed in the nip. | 03-15-2012 |
20120207524 | Fusing apparatus and electrophotographic image forming apparatus using the same - A fusing apparatus to fuse a toner image transferred to a printing medium by applying heat and pressure. The fusing apparatus includes a separation member that is rotatably mounted on a rotation axis to separate the printing medium from one of a heating roller and a pressing roller. The separation member includes a hollow portion into which the rotation axis is inserted, and a separation portion that contacts an outer circumference of the heating roller. The separation member is installed so as to be pitched around the rotation axis and a pitching axis having an inclination angle within a range of ±10° with respect to a line that connects a contact point between the separation portion and the outer circumference of the roller from which the printing medium is to be separated and a center of the roller from which the printing medium is to be separated. | 08-16-2012 |
20150198919 | FIXING DEVICE AND IMAGE FORMING APPARATUS HAVING THE SAME - A fixing device including a lubricant supply unit is provided. The lubricant supply unit supplies a lubricant between a fixing belt and a nip forming member and includes a lubricant storage member and an impregnation member. The lubricant storage member stores the lubricant, and the impregnation member impregnates the lubricant discharged from the lubricant storage member and supplies the lubricant to an inner surface of the fixing belt. The lubricant stored in the lubricant storage member includes base oil and a thickener, and a weight of the thickener is equal to or less than 20% with respect to a weight of the lubricant. | 07-16-2015 |