Patent application number | Description | Published |
20100059321 | POSITION SENSITIVE DAMPER - The damper generally has a cylinder with a damping fluid, and a piston having a connecting rod slidably carrying a first damping piston head and an obstructing portion in the cylinder. Further, a second damping piston head is slidably mounted in the cylinder, independently from the piston, and biased to a neutral position. The second damping piston head has a damping flow path and a bypass flow path which is normally kept in an open state. When an abnormally strong shock occurs, the displacement of the first damping piston head exceeds its normal displacement span and the obstructing portion is placed into obstruction with the bypass flow path, thereby forcing the damping fluid through the damping flow path of the second damping piston head. | 03-11-2010 |
20110254363 | TRACK ASSEMBLY FOR A MOTORIZED VEHICLE - A track assembly for a motorized vehicle having wheels comprises a longitudinal endless track belt; a mounting structure to mount the longitudinal endless track belt to the vehicle; and inner wheels in contact with an inner surface of the track belt. The mounting structure includes driving gears disposed externally to the track belt and configured to frictionally engaged an outer surface of one of the motorized vehicle wheels. The driving gears are drivingly connected with the track belt for transmitting power thereto. Each one of the driving gears has a rotation axis, a plurality of elongated traction bars extending substantially parallel and circumferentially to the rotation axis, and apertured ends. The elongated traction bars are spaced-apart from one another and define therebetween channels allowing granular and liquid materials to flow inwardly towards the rotation axis, and outwardly of the driving gears through the apertured ends. | 10-20-2011 |
20130221738 | TRACK SYSTEM FOR AN ALL-WHEEL DRIVE VEHICLE - The track system includes a plurality of track assemblies, each having track; a frame structure to mount the track to the vehicle; and inner wheels in contact with an inner surface of the track. The track assembly also includes two drive gears disposed externally to the track and configured to frictionally engaged an outer surface of a corresponding one of the tires. The drive gears are drivingly connected with the track for transmitting power thereto. Each one of the drive gears has a rotation axis, a plurality of elongated traction bars extending substantially parallel and circumferentially to the rotation axis, and open ends. The elongated traction bars are spaced-apart from one another and define channels therebetween allowing granular and liquid materials to flow inwardly towards the rotation axis, and outwardly of the drive gears through the apertured ends. | 08-29-2013 |
20160023694 | TRACK SYSTEM FOR AN ALL-WHEEL DRIVE VEHICLE - The track system includes a plurality of track assemblies, each having track; a frame structure to mount the track to the vehicle; and inner wheels in contact with an inner surface of the track. The track assembly also includes two drive gears disposed externally to the track and configured to frictionally engaged an outer surface of a corresponding one of the tires. The drive gears are drivingly connected with the track for transmitting power thereto. Each one of the drive gears has a rotation axis, a plurality of elongated traction bars extending substantially parallel and circumferentially to the rotation axis, and open ends. The elongated traction bars are spaced-apart from one another and define channels therebetween allowing granular and liquid materials to flow inwardly towards the rotation axis, and outwardly of the drive gears through the apertured ends. | 01-28-2016 |
Patent application number | Description | Published |
20140335163 | TARGETED IDURONATE-2-SULFATASE COMPOUNDS - The present invention is related to a compound that includes a lysosomal enzyme and a targeting moiety, for example, where compound is a fusion protein including iduronate-2-sulfatase and Angiopep-2. In certain embodiments, these compounds, owning to the presence of the targeting moiety can crossing the blood-brain barrier or accumulate in the lysosome more effectively than the enzyme alone. The invention also features methods for treating lysosomal storage disorders (e.g., mucopolysaccharidosis Type II) using such compounds. | 11-13-2014 |
20150037311 | TARGETED LYSOSOMAL ENZYME COMPOUNDS - The present invention is related to a compound that includes a lysosomal enzyme and a targeting moiety, for example, where compound is a fusion protein including iduronate-2-sulfatase and Angiopep-2. In certain embodiments, these compounds, owning to the presence of the targeting moiety can crossing the blood-brain barrier or accumulate in the lysosome more effectively than the enzyme alone. The invention also features methods for treating lysosomal storage disorders (e.g., mucopolysaccharidosis Type II) using such compounds. | 02-05-2015 |
20150147310 | TARGETED ENZYME COMPOUNDS AND USES THEREOF - The present invention is related to a compound that includes (a) α-L-iduronidase (IDUA), fragment, or analog thereof and (b) a targeting moiety, for example, where compound is a fusion protein including IDUA and Angiopep-2. In certain embodiments, these compounds, owning to the presence of the targeting moiety can crossing the blood-brain barrier or accumulate in the lysosome more effectively than the enzyme alone. The invention also features methods for treating mucopolysaccharidosis type I (MPS-I) using such compounds. | 05-28-2015 |
20150290341 | TARGETED IDURONATE-2-SULFATASE COMPOUNDS - The present invention is related to a compound that includes a lysosomal enzyme and a targeting moiety, for example, a compound that includes iduronate-2-sulfatase conjugated to Angiopep-2 through a linker formed by specific click chemistry reactions. In certain embodiments, these compounds, owing to the presence of the targeting moiety, can cross the blood-brain barrier or accumulate in the lysosome more effectively than the enzyme alone. The invention also features pharmaceutical compositions containing such compounds and methods for treating lysosomal storage disorders (e.g., mucopolysaccharidosis Type II) using such compounds. | 10-15-2015 |
Patent application number | Description | Published |
20110288009 | LEPTIN AND LEPTIN ANALOG CONJUGATES AND USES THEREOF - The present invention features a compound having the formula A-X-B, where A is peptide vector capable of enhancing transport of the compound across the blood-brain barrier or into particular cell types, X is a linker, and B is a leptin, a leptin analog, or OB receptor agonist. The compounds of the invention can be used to treat any disease in which increased amounts of leptin are desired, such as metabolic diseases including obesity and diabetes. | 11-24-2011 |
20120196803 | FUSION PROTEINS FOR DELIVERY OF GDNF AND BDNF TO THE CENTRAL NERVOUS SYSTEM - The present invention relates to a compound that includes a peptide vector, such as angiopep-2 which acts as a carrier across the blood-brain barrier, linked to glial-derived neurotrophic factor (GDNF), brain-derived neurotrophic factor (BDNF), or a related molecule, such as an analog or a fragment thereof. The compounds of the invention may be used to treat any disease where increased neuronal survival or growth is desired, e.g., neurodegenerative diseases, such as Parkinson's disease or amyotrophic lateral sclerosis. Other diseases can be treated using the compounds include schizophrenia and depression. | 08-02-2012 |
Patent application number | Description | Published |
20110046001 | Multiplex Assay for Respiratory Viruses - A method of detecting the presence of a plurality of respiratory viruses using a multiplexed diagnostic assay is disclosed. The method provides a plurality of oligonucleotides that each is specific for a specific respiratory virus. A multiplex PCR is run using the oligonucleotides, which produces double-stranded products. The method also provides a plurality of extension oligonucleotides that each is specific for a specific double-stranded product. Each extension oligonucleotide also has a distinct second portion having a unique sequence. A primer extension reaction is run using the extension oligonucleotides, which produces single-stranded products. The single-stranded products are hybridized to a solid carrier. | 02-24-2011 |
20120157538 | Compounds for the Inhibition of Herpes Viruses - 3D protein modeling and virtual screening of commercially-available compounds were performed to identify new inhibitors of the herpesvirus DNA polymerase, a key enzyme in the viral replication cycle. Two compounds (Nos 2 and 9) were particularly active against HSV-1 and HSV-2 strains and one compound (No 3) inhibited specifically cytomegalovirus (CMV) strains (overall hit rate of 25%). Some of the tested compounds inhibited wild-type viruses and strains resistant to current antiviral agents. New chemical entity derivatives of compound 2 with binding potential to the DNA polymerase retained an excellent activity against HSV-1, HSV-2 and VZV like the parental compound, as well against strains resistant to current antiviral agents. These non-nucleosidic herpesvirus DNA polymerase inhibitors with in vitro activity against drug-resistant clinical isolates warrant further pre-clinical studies. | 06-21-2012 |
20140378502 | Par1 Inhibitors for Use in the Treatment or Prevention of Paramyxoviridae Infections - The present invention is concerned with the use of Protease-Activated Receptor-1 (PAR1) inhibitors for preventing or treating a Paramyxoviridae infection in a subject. Described herein are methods, compounds and pharmaceutical compositions useful in addressing such infections, and more particularly infections from human respiratory syncytial virus (hRSV) and human metapneumovirus (hMPV). | 12-25-2014 |
Patent application number | Description | Published |
20160096555 | AERODYNAMIC TRACTOR-TRAILER GAP REDUCER AND ASSEMBLY THEREOF - This invention relates to a gap-reducer for reducing a gap between a road tractor and a trailer attached thereto, the gap-reducer comprising a top portion and a bottom portion, the bottom portion being located further forward than the top portion when the gap-reducer is secured on the trailer in an operating position. The gap-reducer extending over the width of the trailer to reduce the drag of the trailer. | 04-07-2016 |
20160096556 | AERODYNAMIC TRACTOR-TRAILER GAP REDUCER AND ASSEMBLY THEREOF - This invention relates to a gap-reducer for reducing a gap between a road tractor and a trailer attached thereto, the gap-reducer comprising a top portion and a bottom portion, the bottom portion including a flange sized and designed to match and secure an uneven front trailer surface. The gap-reducer can also be equipped of matching corners adapted to match corresponding corners of the trailer. | 04-07-2016 |
20160096557 | MODULAR AERODYNAMIC SKIRT ASSEMBLY - This invention relates to aerodynamic trailer skirts adapted to be mounted on trailers to improve the aerodynamic efficiency of the trailer. The present invention more precisely relates to a modular self-repositioning aerodynamic skirt assembly with reduced size skirt panel portions and improved shock transmission properties. | 04-07-2016 |
20160096558 | MODULAR AERODYNAMIC SKIRT ASSEMBLY - This invention relates to packaging of a modular aerodynamic trailer skirts that is adapted to minimize the size of a shipment thereof. The packaging further protects the skirt portions by stacking skirt portions and using interconnecting edges thereof to secure a skirt portion therebetween. | 04-07-2016 |
Patent application number | Description | Published |
20090044508 | Brush cutting head with internally housed drive and bearing assembly - The present invention relates generally to brush cutters and to brush cutting heads therefor, and more specifically, to brush cutting heads having internally housed drive and bearing assemblies. The brush cutting head includes a hollow support body having a first end, an opposed second end, an outer surface and an inner surface. The inner surface of the support body defines a hollow which extends between the first and second ends of the support body. Also provided is a drive and bearing assembly housed at least partially within the hollow of the support body. The drive and bearing assembly includes a drive block mounted to extend within the hollow of the support body at the first end thereof. The drive block includes a motor provided with a torque transmitting driveshaft. A first coupling assembly is connected to the driveshaft of the motor and the support body. The first coupling assembly is operable to transmit the torque produced by the motor to the support body to thereby urge rotation of the brush cutting head. The drive and bearing assembly further includes a second coupling assembly mounted to extend within the hollow of the support body at the second end thereof. The second coupling assembly has a first end and a second end. The second end of the coupling assembly is fixedly attached to the support body. The second coupling assembly includes a bearing support member, a bearing assembly housed within the bearing support member and a coupling member. The bearing assembly is mounted in surrounding relation with a portion of the coupling member to thereby allow free rotation of the coupling member relative to the bearing support member. | 02-19-2009 |
20100044487 | Protective guard members for cutting tooth assemblies mounted on a brush cutting head - The present invention relates generally to brush cutting heads, and more specifically, to protective guard members for cutting tooth assemblies mounted on brush cutting heads. A brush cutting head includes a support body having a first end, an opposed second end and an intermediate portion extending therebetween. The intermediate portion has an outer surface. A plurality of collars is mounted to the support body at spaced intervals along the intermediate portion with each collar extending outwardly from the outer surface. The brush cutting head further also has a plurality of cutting teeth assemblies carried on the outer surface of the support body. Each cutting tooth assembly is associated with at least one collar. Also provided is at least one guard member for protecting at least one cutting tooth of the plurality from impacts with hard objects. The at least one guard member is carried on one of the collars with at least a portion thereof projecting beyond the outermost edge of the one collar. The at least one guard member has an outermost margin which defines a protective envelope that at least partially encompasses the at least one cutting tooth. | 02-25-2010 |
20110266382 | PROTECTIVE GUARD MEMBERS FOR CUTTING TOOTH ASSEMBLIES MOUNTED ON A BRUSH CUTTING HEAD - The present invention relates generally to brush cutting heads, and more specifically, to protective guard members for cutting tooth assemblies mounted on brush cutting heads. A brush cutting head includes a support body having a first end, an opposed second end and an intermediate portion extending therebetween. The intermediate portion has an outer surface. A plurality of collars is mounted to the support body at spaced intervals along the intermediate portion with each collar extending outwardly from the outer surface. The brush cutting head further also has a plurality of cutting teeth assemblies carried on the outer surface of the support body. Each cutting tooth assembly is associated with at least one collar. Also provided is at least one guard member for protecting at least one cutting tooth of the plurality from impacts with hard objects. The at least one guard member is carried on one of the collars with at least a portion thereof projecting beyond the outermost edge of the one collar. The at least one guard member has an outermost margin which defines a protective envelope that at least partially encompasses the at least one cutting tooth. | 11-03-2011 |
Patent application number | Description | Published |
20100317038 | GRANZYME A AND GRANZYME B DIAGNOSTICS - A method for identifying a subject being at risk for or having a chronic inflammatory disease, fibrillinopathy, atherosclerosis, or coronary artery disease is provided. The method may include determining the concentration of GrA and/or GrB in a blood or serum sample from said subject; and comparing the concentrations to the corresponding concentration in a control sample, wherein an elevated concentration of GrA and/or GrB may be indicative of a chronic inflammatory disease, fibrillinopathy, atherosclerosis, or coronary artery disease. The method may further include identifying concentrations of fibrinogen, elastin and/or fibrillin. | 12-16-2010 |
20110229546 | TREATMENT OF DISSECTION, ANEURYSM, AND ATHEROSCLEROSIS USING GRANZYME B INHIBITORS - A method of medical treatment or prevention of a vasculopathy, comprising administering a therapeutically effective amount of a granzyme B inhibitor to a subject in need thereof is provided. In other aspects uses of Granzyme B inhibitors for treatment or for preparation of medicaments for treatment of a vasculopathy are provided. | 09-22-2011 |
20130323749 | GRANZYME A AND GRANZYME B DIAGNOSTICS - A method for identifying a subject being at risk for or having a chronic Inflammatory disease, fibrillinopathy, atherosclerosis, or coronary artery disease is provided. The method may include determining the concentration of GrA and/or GrB in a blood or serum sample from said subject; and comparing the concentrations to the corresponding concentration in a control sample, wherein an elevated concentration of GrA and/or GrB may be indicative of a chronic inflammatory disease, fibrillinopathy, atherosclerosis, or coronary artery disease. The method may further include identifying concentrations of fibrinogen, elastin and/or fibrillin. | 12-05-2013 |
20140255953 | GRANZYME A AND GRANZYME B DIAGNOSTICS - A method for identifying a subject being at risk for or having a chronic inflammatory disease, fibrillinopathy, atherosclerosis, or coronary artery disease is provided. The method may include determining the concentration of GrA and/or GrB in a blood or serum sample from said subject; and comparing the concentrations to the corresponding concentration in a control sample, wherein an elevated concentration of GrA and/or GrB may be indicative of a chronic inflammatory disease, fibrillinopathy, atherosclerosis, or coronary artery disease. The method may further include identifying concentrations of fibrinogen, elastin and/or fibrillin. | 09-11-2014 |