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Bohrmann
Bernd Bohrmann, Riehen CH
| Patent application number | Description | Published |
|---|---|---|
| 20100306868 | QUADRUPLE TRANSGENIC NON-HUMAN ANIMAL - The present invention relates to a transgenic non-human animal whose genome comprises a) a first transgenic DNA sequence encoding a human APP Swedish or a human APP London protein, wherein said first transgenic DNA sequence is operably linked to a first promoter; b) a second transgenic DNA sequence encoding a human Presenilin 2 protein comprising a N141I substitution, wherein said second transgenic DNA sequence is operably linked to a second promoter; c) a third transgenic DNA sequence encoding a light chain of a antibody directed against the amyloid peptide, wherein said third transgenic DNA sequence is operably linked to a third promoter and; d) a forth transgenic DNA sequence encoding a heavy chain of said antibody, wherein said forth transgenic is operably linked to the third promoter or to a forth promoter, and methods for producing said animal. | 12-02-2010 |
| 20110059093 | USE OF AN ANTI-TAU PS422 ANTIBODY FOR THE TREATMENT OF BRAIN DISEASES - An antibody binding to Tau that is phosphorylated at serine 422 (pS422), which specifically binds to phosphorylated Tau fragment of SEQ ID NO:9 and to Tau pS422, but does not bind to Tau and to phosphorylated MCAK fragment of SEQ ID NO:17. The antibody is useful in the treatment of a Tauopathy. | 03-10-2011 |
Bernd Bohrmann, Freiburg DE
| Patent application number | Description | Published |
|---|---|---|
| 20100172907 | Anti-Abeta antibodies and their use - The present invention relates to antibody molecules capable of specifically recognizing two regions of the β-A4 peptide, wherein the first region comprises the amino acid sequence AEFRHDSGY as shown in SEQ ID NO: 1 or a fragment thereof and wherein the second region comprises the amino acid sequence VHHQKLVFFAEDVG as shown in SEQ ID NO: 2 or a fragment thereof. Furthermore, nucleic acid molecules encoding the inventive antibody molecules and vectors and hosts comprising said nucleic acid molecules are disclosed. In addition, the present invention provides for compositions, preferably pharmaceutical or diagnostic compositions, comprising the compounds of the invention as well as for specific uses of the antibody molecules, nucleic acid molecules, vectors or hosts of the invention. | 07-08-2010 |
Bernd Bohrmann, Basel CH
| Patent application number | Description | Published |
|---|---|---|
| 20090252724 | Antibodies Against Amyloid Beta 4 With Glycosylated in the Variable Region - The present invention relates to a purified antibody molecule preparation being characterized in that at least one antigen binding site comprises a glycosylated asparagine (Asn) in the variable region of the heavy chain (V | 10-08-2009 |
Hans-Guenter Bohrmann, Ludwigshafen DE
| Patent application number | Description | Published |
|---|---|---|
| 20110237439 | Process for the Preparation of Random Radical Copolymers, and Active Substance Compositions Obtainable Therefrom - A process for the preparation of random radical copolymers which comprises | 09-29-2011 |
Wolfgang Bohrmann, Wiesbaden DE
| Patent application number | Description | Published |
|---|---|---|
| 20110303037 | DRIVE UNIT OF A TRANSMISSION - A drive unit of a transmission is provided that includes, but is not limited to a main shaft. The main shaft includes, but is not limited to a bore formed along its centre axis for the transport of lubricating oil. The lubricating oil can be introduced into the bore via a feed line, and a sealing element is provided in a transition region between the bore and the feed line. | 12-15-2011 |