Blobel
Carl Blobel, New York, NY US
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20150241429 | IRHOM2 INHIBITION FOR THE TREATMENT OF COMPLEMENT MEDIATED DISORDERS - Disclosed are methods for treating a subject with a Complement mediated (e.g., C5a mediated) disease or an immune complex mediated disease. The method comprises the step of administering to the subject an effective amount of an agent that decreases the biological activity of iRhom2 or an agent that modulates formation of a complex between iRhom2 and TACE. Also disclosed are assays for identifying such agents. | 08-27-2015 |
20150316538 | TREATMENT OF EGF-RECEPTOR DEPENDENT PATHOLOGIES - Disclosed are methods for treating a subject with an EGFR dependent pathology. The method comprises the step of administering to the subject an effective amount of an agent (“First Agent”) that decreases the biological activity of iRhom1 and an effective amount of an agent (“Second Agent”) that decreases the biological activity of iRhom2. Alternatively, the method comprises the step of administering to the subject an effective amount of an agent (“First Agent”) that modulates formation of a complex between iRhom 1 and TACE and an effective amount of an agent (“Second Agent”) that modulates formation of a complex between TACE and iRhom2. Also disclosed are assays for identifying such agents. | 11-05-2015 |
Carl P. Blobel, New York, NY US
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20090285840 | METHODS FOR TREATING PATHOLOGICAL NEOVASCULARIZATION - Provided herein are compositions and methods that inhibit expression of Adam9 gene products, such as ADAM9 mRNA and/or ADAM9 polypeptides, as a therapeutic approach for the treatment of pathological neovascularization and conditions associated with angiogenesis. | 11-19-2009 |
Carl Peter Blobel, Eastchester, NY US
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20090068251 | METHODS AND COMPOSITIONS FOR PROMOTING WOUND HEALING - Provided herein are compositions and methods that inhibit expression of Adam12 gene products, such as ADAM12 mRNA and/or ADAM12 polypeptides, as a therapeutic approach for the treatment of, or promotion of healing of, wounds. | 03-12-2009 |
Friedhelm Blobel, Foster City, CA US
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20160106812 | TREATMENT OF CANCER WITH IMMUNE STIMULATORS - The present invention provides compositions and methods for treating cancer or a metastasis thereof in a subject. In some embodiments, the methods involve administering a composition comprising therapeutically effective amount of at least one immune stimulator to the subject. In some embodiments, a combination of at least two immune stimulators is used for the treatment. In some embodiments, the combination includes an alpha thymosin peptide and an additional immune stimulator, and/or optionally one or more additional anti-cancer agents. | 04-21-2016 |
Gerd Blobel, Bala Cynwyd, PA US
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20140199260 | COMPOSITIONS AND METHODS FOR THE TREATMENT OF HIV - Compositions and methods for the treatment of HIV are provided. | 07-17-2014 |
20150152151 | Controlled Gene Expression Methods - Methods and compositions for controlling gene expression are disclosed. | 06-04-2015 |
Gunter Blobel, New York, NY US
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20100212040 | ISOLATION OF LIVING CELLS AND PREPARATION OF CELL LINES BASED ON DETECTION AND QUANTIFICATION OF PRESELECTED CELLULAR RIBONUCLEIC ACID SEQUENCES - The invention is directed to reliable and efficient detection of mRNAs as well as other RNAs in living cells and its use to identify and, if desired, separate cells based on their desired characteristics. Such methods greatly simplify and reduce the time necessary to carry out previously-known procedures, and offers new approaches as well, such as selecting cells that generate a particular protein or antisense oligonucleotide, generating cell lines that express multiple proteins, generating cell lines with knock-out of one or more protein, and others. | 08-19-2010 |
20150143563 | ISOLATION OF LIVING CELLS AND PREPARATION OF CELL LINES BASED ON DETECTION AND QUANTIFICATION OF PRESELECTED CELLULAR RIBONUCLEIC ACID SEQUENCES - The invention is directed to reliable and efficient detection of mRNAs as well as other RNAs in living cells and its use to identify and, if desired, separate cells based on their desired characteristics. Such methods greatly simplify and reduce the time necessary to carry out previously-known procedures, and offers new approaches as well, such as selecting cells that generate a particular protein or antisense oligonucleotide, generating cell lines that express multiple proteins, generating cell lines with knock-out of one or more protein, and others. | 05-21-2015 |
Joerg Blobel, Zoetermeer NL
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20110129057 | METHOD FOR DETERMING A CORRECTION FUNCTION FOR CORRECTING COMPUTED TOMOGRAPHIC NUMBERS OF A SMALL TARGET OBJECT IN A CT IMAGE - A method of correcting target region in computed tomographic (CT) image, including the steps of obtaining a CT image of a patient; determining the size of a target object in the CT image; and correcting CT numbers of a portion of the CT image that corresponds to the target object, based on the determined size of the target object. | 06-02-2011 |
Lars Blobel, Ammerbuch-Entringen DE
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20100217073 | ELECTROSURGICAL INSTRUMENT, AND AN ENDOSCOPE WITH A CORRESPONDING INSTRUMENT - An electrosurgical instrument including a protective tube, to be inserted into a working channel of an endoscope, and an electrode disposed within the protective tube. The electrode is movable in a distal direction and a proximal direction inside the protective tube by a control element. By being moved in the distal direction, the electrode can be brought into a deployed position in which the electrode at least partially protrudes from a distal end of the protective tube. The distal end of the protective tube has a closure element with an opening for the passage of the electrode. The opening of the closure element has a maximum internal diameter smaller than the internal diameter of the protective tube and is used for guiding and/or cleaning the electrode. | 08-26-2010 |
20100262141 | SURGICAL INSTRUMENT FOR SEALING BLOOD VESSELS, AND HEAT-CURABLE ADHESIVE AS A MEDICAMENT - A surgical instrument including an injection device and a dosing device. These devices are designed such that a predetermined amount of an adhesive or an adhesive containing filler can be injected into a sealing section of the blood vessel. The blood vessel can then be cut at the filled point and is sealed on both sides. | 10-14-2010 |
20110028887 | WATER JET SURGICAL INSTRUMENT - A water jet surgical instrument including a supply line for supplying a cutting fluid and a discharge nozzle for forming and discharging a fluid jet, wherein the fluid jet has a predetermined spread angle and/or a predetermined emergence energy. A jet shaping device is arranged relative to the discharge nozzle such that the fluid jet is able to be adjusted by the jet shaping device with regard to the spread angle and/or emergence energy thereof. | 02-03-2011 |
20110071427 | CRYOSURGICAL INSTRUMENT FOR OBTAINING A TISSUE SAMPLE, METHOD FOR CHILLING A PROBE HEAD OF A CRYOSURGICAL PROBE - A cryosurgical instrument for obtaining a tissue sample with a probe, including the probe including a probe head onto which the tissue sample is frozen and a probe shank for guiding the probe head to the tissue sample, a supply means for supplying a fluid into an expansion chamber configured such that supplied fluid expands therein for cooling the probe head, and a removal means connected to the expansion chamber for removing the expanded fluid therefrom via at least one opening on a distal end of the probe to remove the expanded fluid to an outer region outside the probe. A method for cooling a probe head of a cryosurgical probe including supplying a fluid to an expansion chamber near the probe head, expanding the fluid so that heat energy is withdrawn from the probe head, and removing the expanded fluid in a distal region of the probe. | 03-24-2011 |
20120303016 | ELECTROSURGICAL ASSEMBLY AND ELECTROSURGICAL INSTRUMENT - An electrosurgical assembly is disclosed having an electrosurgical instrument, a detection device for detecting a predetermined constituent of the atmosphere in the region of a treatment site and a treatment unit, which can be connected to the instrument and a current generator for providing RF energy. The treatment unit includes a mechanism for influencing the treatment process depending on an output signal of the detection device. | 11-29-2012 |