| Patent application number | Description | Published |
|---|
| 20080274556 | DETECTING ISOMERS USING DIFFERENTIAL DERIVATIZATION MASS SPECTROMETRY - Methods of evaluating molecular isomers of branched-chain amino acids are featured. The methods can include: derivatizing one or more molecular isomers of branched-chain amino acids in a sample comprising a branched-chain amino acid labeled with one or more heavy atoms as a first standard; adding, to the sample, after derivatization, a nonderivatized or derivatized branched chain amino acid that is labeled with one or more heavy atoms, as a second standard; evaluating the sample using tandem mass spectrometry; and detecting peaks indicative of derivatized and nonderivatized forms of one or more branched-chain amino acids in the sample. | 11-06-2008 |
| 20080274563 | DETECTING SUCCINYLACETONE - This invention relates, inter alia, to detecting and/or measuring succinylacetone and one or more additional biological analytes using mass spectrometry. | 11-06-2008 |
| 20090068634 | SUBSTRATES AND INTERNAL STANDARDS FOR MASS SPECTROMETRY DETECTION - An inventive substrate is provided which includes a substrate compound of formula A-B | 03-12-2009 |
| 20090111137 | SIMULTANEOUS DETECTION OF METABOLIC ENZYME ACTIVITY AND METABOLITE LEVELS - Provided are methods for detecting a metabolic disorder in an individual using mass spectrometry. One method involves (a) contacting a sample containing (i) one or more metabolically indicative enzymes and (ii) one or more metabolic analytes, with one or more substrates for said one or more enzymes to produce a reaction admixture, under conditions wherein at least one of said enzymes is capable of acting on a corresponding substrate to generate at least one product, and wherein one or more protease inhibitors are present; (b) contacting said reaction admixture with a reagent that inhibits the ability of said one or more enzymes to act on a corresponding substrate, wherein said one or more metabolic analytes and said at least one product are soluble in said reagent; to produce a test sample and (c) determining the presence or amount of said one or more metabolic analytes and said at least one product contained in said test sample using mass spectrometry, wherein a determined presence or amount of said one or more metabolic analytes and said at least one product correlates with presence or absence of said metabolic disorder product correlates with presence or absence of said metabolic disorder. | 04-30-2009 |
| 20090253117 | ENZYMATIC SUBSTRATES FOR MULTIPLE DETECTION SYSTEMS - An inventive substrate is provided which includes a substrate compound of formula A-B | 10-08-2009 |
| 20100227412 | Simultaneous Detection of Estrogen and Non Estrogen Steroids - Methods for determining the amounts of estrogen and non-estrogen steroids in a sample are provided. The methods employ the selective derivatization of estrogen steroids present in a sample and detection of the molecular ions and fragments of the derivatized estrogens and non-estrogen steroids in the sample. The methods provided herein enable the simultaneous quantification of estrogen and non-estrogen steroids in a sample. | 09-09-2010 |
| 20110020942 | MEASURING LEVELS OF A METABOLITE - Described herein are methods for determining an amount of an analyte in a test sample. The methods involve preparing a calibration curve using standard samples containing an isotopically-labeled standard in a biological matrix. | 01-27-2011 |
| 20110189780 | DETECTING ISOMERS USING DIFFERENTIAL DERIVATIZATION MASS SPECTROMETRY - Methods of evaluating molecular isomers of branched-chain amino acids are featured. The methods can include: derivatizing one or more molecular isomers of branched-chain amino acids in a sample comprising a branched-chain amino acid labeled with one or more heavy atoms as a first standard; adding, to the sample, after derivatization, a nonderivatized or derivatized branched chain amino acid that is labeled with one or more heavy atoms, as a second standard; evaluating the sample using tandem mass spectrometry; and detecting peaks indicative of derivatized and nonderivatized forms of one or more branched-chain amino acids in the sample. | 08-04-2011 |
