Patent application number | Description | Published |
20130202500 | APPARATUS AND METHOD FOR SEPARATING COMPONENTS OF A SAMPLE LIQUID - Sample liquid is collected in a chamber downstream of a separating device. Adjoining the chamber are a plurality of channels which guide the sample liquid to one or more investigating regions. | 08-08-2013 |
20130206253 | MICROFLUIDIC DEVICE AND METHOD FOR PRODUCING SAME - A microfluidic device and a method of producing it are proposed, in which a film covers a chamber in a carrier. The film is locally re-tightened in the region of the chamber after the film has been secured to the carrier. In this way it is possible to prevent undesirable bulging of the film into the chamber. | 08-15-2013 |
20130209331 | APPARATUS AND METHOD FOR SEPARATING CONSTITUENT PARTS OF A SAMPLE LIQUID - A device and a process are proposed for separating constituents of a sample fluid, wherein the sample fluid is supplied by capillary force to a receiving region ( | 08-15-2013 |
20130236985 | METHOD AND DEVICE FOR OPTICAL EXAMINATION - A method and a device for the optical examination of a surface region are proposed. Fluorescence measurement is used to determine the amount of a substance bound to the surface region. Light interference is shut out thanks to the surface region being covered with an optically active liquid which filters, reflects, scatters and/or absorbs light with a wavelength at least substantially corresponding to the light radiated in and/or out. | 09-12-2013 |
20140166108 | Microfluidic Platform - The invention relates to a microfluidic platform ( | 06-19-2014 |
Patent application number | Description | Published |
20080201791 | T Cell Line-Based Packaging Cell Line for the Production of Retroviruses by Enriching of Cd3 Expressing Cells - The present invention relates to retroviral vector systems, in particular the development of packaging or helper cell lines that are based on T cells and that are suitable for producing T cell receptor retroviruses. Thereby, the present invention relates to T cell line specific retroviral expression vectors, and mammalian T cell line-based helper cell lines. The invention further relates to methods for expressing transgenes and to T cell line specific retroviral vector systems, including biochemical kits, that utilize and/or comprise the T cell line specific retroviral expression vectors and/or mammalian T cell line-based helper cell lines. | 08-21-2008 |
20100104556 | EPITOPE-TAG FOR SURFACE-EXPRESSED PROTEINS AND USES THEREOF - The present invention relates to a method for selecting a host cell population expressing a functional fusion protein comprising at least one epitope-providing amino acid sequence (epitope-tag) and the amino acid sequence of a protein that is expressed on the surface of said host cell. Preferably, the amino acid sequence comprises an alpha or beta chain of a T-cell receptor. The present invention further relates to uses of said functional T-cell receptor (TCR) alpha or beta chain fusion protein in medicine, in particular in adoptive transfer. | 04-29-2010 |
20100160416 | USE OF POL III PROMOTERS FOR CONTROLLED EXPRESSION OF THERAPEUTIC PROTEINS - The present invention relates generally to the field of molecular biology. More specifically, the present invention relates to expression systems for use in modulating the expression of protein coding target genes in vivo or in vitro. More specific, this invention relates to RNA polymerase III-based methods and systems for expression of therapeutic proteins in cells in vivo or in vitro. | 06-24-2010 |
20100189728 | Generation of Antigen Specific T Cells - The present invention is directed to a method of generating antigen specific T cells. Furthermore, the invention is directed to antigen specific T cells, isolated transgenic TCR's, pharmaceutical compositions containing same and their use in adoptive cell therapy. This invention in particular pertains to the use of cells co-expressing allogeneic MHC molecules and antigens to induce peptide-specific T cells from non-selected allogeneic T cell repertoires. | 07-29-2010 |
20110189141 | MULTIPLE TARGET T CELL RECEPTOR - The present invention is directed to a functional T cell receptor (TCR) fusion protein (TFP) recognizing and binding to at least one MHC-presented epitope, and containing at least one amino acid sequence recognizing and binding an antigen. The present invention is further directed to an isolated nucleic acid molecule encoding the same, a T cell expressing said TFP, and a pharmaceutical composition for use in the treatment of diseases involving malignant cells expressing said tumor-associated antigen. | 08-04-2011 |
20140141026 | GENERATION OF ANTIGEN SPECIFIC T CELLS - The present invention is directed to a method of generating antigen specific T cells. Furthermore, the invention is directed to antigen specific T cells, isolated transgenic TCR's, pharmaceutical compositions containing same and their use in adoptive cell therapy. This invention in particular pertains to the use of cells co-expressing allogeneic MHC molecules and antigens to induce peptide-specific T cells from non-selected allogeneic T cell repertoires. | 05-22-2014 |