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Birnbaum, US
Aaron R. Birnbaum, Brier, WA US
| Patent application number | Description | Published |
|---|---|---|
| 20080256229 | Detecting Machine Utilization Activity - Detecting machine utilization activity may be provided. Client machine activity within a computer network may be monitored to determine if the client machine is available for use, or if the computer is already engaged in one or more activities. During a predetermined receive period, machine activity information for a given client machine. The machine activity information for the client machine is compared to previously stored machine activity information to determine if an activity state for the client machine has changed. If the activity state of the client machine has changed, the activity state for the machine is updated. Machine activity information for all computers in the computer network may be used to track and optimize resources with the computer network. | 10-16-2008 |
Angela Birnbaum, Minneapolis, MN US
| Patent application number | Description | Published |
|---|---|---|
| 20100204178 | NOVEL PARENTERAL CARBAMAZEPINE FORMULATION - The present invention is directed to a carbamazepine-cyclodextrin inclusion complex useful for the parenteral administration of carbamazepine. The carbamazepine-cyclodextrin inclusion complex is prepared by the admixture of a modified cyclodextrin and carbamazepine in a physiologically acceptable fluid. Modified cyclodextrins include 2-hydroxypropyl-beta-cyclodextrin and sulfoalkyl cyclodextrins. More particularly, the sulfoalkyl cyclodextrins are those described and disclosed in U.S. Pat. Nos. 5,134,127 and 5,376,645. A physiologically acceptable fluid includes sterile isotonic water, Ringer's lactate, D5W (5% dextrose in water), physiological saline, and similar fluids suitable for parenteral administration. | 08-12-2010 |
Bernardo Birnbaum, Miami, FL US
| Patent application number | Description | Published |
|---|---|---|
| 20090235966 | ERGONOMIC CRUTCHES - A forearm crutch with a telescopic leg that includes a shoe assembly at the distal end with convex surfaces for the forward and rear portions to maximize contact area upon making contact with a supporting horizontal surface and as the load transmission ends. The other end of the leg is rigidly mounted to a housing that receives a pivotally mounted handle assembly with a locking mechanism for settling the former at a predetermined angular disposition over a given angular range. An adjustable forearm support assembly is mounted to the housing, opposite to where the leg is mounted. The crutch includes battery operated light and horn circuits that can be readily actuated by a user. | 09-24-2009 |
David Birnbaum, New York, NY US
| Patent application number | Description | Published |
|---|---|---|
| 20090070239 | OPEN PLATFORM FOR UNREGISTERED SECURITIES (OPUS) - A computer-implemented, web-interfaced method of trading and settlement of unregistered securities issued under an exception outlined in Rule 144A includes providing access to a website in communication with a network. A data structure is established and stored in a memory and includes information relating to one or more unregistered securities and entities involved with the trade. A trade request is received via the network from an interested investor, and a QIB eligibility status is determined for each of the interested investors. Eligible QIBs are allocated an investment slot if a number of allocated investment slots is less than a regulated value. Otherwise, an investment slot is denied to any remaining QIBs. A related system and computer-readable medium are also disclosed. | 03-12-2009 |
Eva R. Birnbaum, Los Alamos, AZ US
| Patent application number | Description | Published |
|---|---|---|
| 20080220441 | Advanced drug development and manufacturing - X-ray fluorescence (XRF) spectrometry has been used for detecting binding events and measuring binding selectivities between chemicals and receptors. XRF may also be used for estimating the therapeutic index of a chemical, for estimating the binding selectivity of a chemical versus chemical analogs, for measuring post-translational modifications of proteins, and for drug manufacturing. | 09-11-2008 |
| 20090046832 | Well Plate - The present invention includes an apparatus for preparing samples for measurement by x-ray fluorescence spectrometry. The apparatus comprises a plate having one or more holes passing through the plate. The holes are covered by a film on one side of the plate. The holes are less than 500 micrometers across in one dimension where the film covers the holes. The film is translucent to x-rays. The present invention also includes an apparatus for preparing samples for measurement by x-ray fluorescence spectrometry. The apparatus comprises a plate having one or more holes passing through the plate. The holes are covered on one side of the plate by a detachable cover forming a water-tight seal against the plate. The cover is substantially free of the elements osmium, yttrium, iridium, phosphorus, zirconium, platinum, gold, niobium, mercury, thallium, molybdenum, sulfur, lead, bismuth, technetium, ruthenium, chlorine, rhodium, palladium, argon, silver, and thorium. The holes are less than about 500 micrometers across in one dimension where the cover covers the holes. The present invention also includes a method for preparing samples for measurement by x-ray fluorescence spectrometry. The method comprises providing a solution of with less than 10 micromolar solute and a volume of between about 2 microliters and about 2 milliliters. The solution is concentrated and analyzed using x-ray fluorescence spectrometry. | 02-19-2009 |
| 20090087919 | Method and Apparatus for Measuring Protein Post-Translational Modification - The present invention includes a method for analyzing reactions. The method includes the steps of providing a solution of at least one acceptor chemical and at least one donor chemical. The donor chemical is capable of donating a chemical moiety to the acceptor chemical. The solution further includes at least one controller chemical that affects the reaction between the donor chemical and the acceptor chemical. The solution is then incubated so that a portion of the acceptor chemical reacts with the donor chemical to form an acceptor product. Unreacted donor chemical is separated from the acceptor product. The acceptor product or the donor chemical is then measured using X-ray fluorescence. Another aspect of the present invention includes a method for analyzing protein function. The method includes the steps of providing a solution of at least one acceptor chemical and at least one donor chemical. The donor chemical is capable of donating a chemical moiety to the acceptor chemical. The donor chemical includes a functional group selected from ester, anhydride, imide, acyl halide, and amide. The solution is then incubated so that a portion of the acceptor chemical reacts with the donor chemical to form an acceptor product. Unreacted donor chemical is separated from the acceptor product. The acceptor product or the donor chemical is then measured using X-ray fluorescence. Yet another aspect of the present invention includes a method for analyzing protein function. The method includes the steps of providing a solution of at least one acceptor chemical and at least one donor chemical. The solution is then incubated so that a portion of the acceptor chemical reacts with the donor chemical to form an acceptor product. Unreacted donor chemical is separated from the acceptor product. The acceptor product or the donor chemical is then measured using X-ray fluorescence. An additional analytical method is also used to measure either the acceptor product or the donor chemical. | 04-02-2009 |
| 20100003697 | Method and Apparatus for Measuring Analyte Transport Across Barriers - The present invention includes a method and apparatus for measuring the transport of analytes through a cell barrier. | 01-07-2010 |
Jack M. Birnbaum, Southampton, PA US
| Patent application number | Description | Published |
|---|---|---|
| 20080301749 | SELECTION OF ELECTRONIC CONTENT AND SERVICES - A system and method to facilitating selecting or otherwise providing access to electronic content and services. Access to the content and services may be provided in such as a manner as to facilitate access to higher quality forms of the content. The higher quality forms of the content may be relate to any number of characteristics associated with displaying, transmitting, compressing, securing, and/or otherwise manipulating the content to more suitable forms relative to another form. | 12-04-2008 |
Jay Birnbaum, Montville, NJ US
| Patent application number | Description | Published |
|---|---|---|
| 20080220103 | METHOD FOR TREATING/CONTROLLING/KILLING FUNGI AND BACTERIA ON LIVING ANIMALS - Provided is a method of treating a fungal infection on an animal epidermis, nail or hair, or in an orifice of an animal. The method comprises contacting the fungus infection with a composition comprising an antifungal botanical. | 09-11-2008 |
Jay E. Birnbaum, Montville, NJ US
| Patent application number | Description | Published |
|---|---|---|
| 20100048724 | Subunguicide, and Method for Treating Onychomycosis - Onychomycosis is a fungal infection of the nail bed and is difficult to treat topically because penetration of the nail plate is difficult, and systemic antifungal treatments are prone to side effects and drug interactions. The present invention treats onychomycosis by applying an antifungal composition to the nail bed directly using a solid, semi-solid, or flowable carrier. The carrier can be in the form of a semi-solid into which the user digs and scrapes the nail, a solid carrier can be inserted directly under the nail in contact with the nail bed, or a flowable composition can be injected in contact with the nail bed. | 02-25-2010 |
Kenneth D. Birnbaum, Brooklyn, NY US
| Patent application number | Description | Published |
|---|---|---|
| 20090094711 | Methods of affecting plant growth with microRNA - Provided herein are compositions and methods for producing transgenic plants. In specific embodiments, transgenic plants comprise a construct comprising a polynucleotide encoding microRNA167 (miR167), or precursor thereof, operably linked to a plant pericycle-specific promote, wherein the miR167 is ectopically overexpressed in the transgenic plants, and wherein the promoter is optionally a constitutive or inducible promoter. In some embodiments, the transgenic plant has an improved agronomic or nutritional characteristic when cultivated in nitrogen-rich conditions as compared to a wild type plant cultivated in the same conditions. Also provided herein are commercial products (e.g., pulp, paper, paper products, or lumber) derived from the transgenic plants (e.g., transgenic trees) produced using the methods provided herein. | 04-09-2009 |
Lawrence Birnbaum, Evanston, IL US
| Patent application number | Description | Published |
|---|---|---|
| 20110209150 | AUTOMATIC METHOD AND SYSTEM FOR FORMULATING AND TRANSFORMING REPRESENTATIONS OF CONTEXT USED BY INFORMATION SERVICES - An information retrieval system for automatically retrieving information related to the context of an active task being manipulated by a user. The system observes the operation of the active task and user interactions, and utilizes predetermined criteria to generate a context representation of the active task that are relevant to the context of the active task. The information retrieval system then processes the context representation to generate queries or search terms for conducting an information search. The information retrieval system reorders the terms in a query so that they occur in a meaningful order as they naturally occur in a document or active task being manipulated by the user. Furthermore, the information retrieval system may access a user profile to retrieve information related to the user, and the select information sources or transform search terms based on attributes related to the user, such as the user's occupation, position in a company, major in school, etc. | 08-25-2011 |
Lawrence A. Birnbaum, Evanston, IL US
| Patent application number | Description | Published |
|---|---|---|
| 20090019013 | Processing a content item with regard to an event - Aggregating a content item with an event is disclosed. An event is created based on a user-provided or a feed sourced content item. The user-provided or feed sourced content item is aggregated with the event. The user-provided or feed sourced content item is identified using a query to one or more repositories. | 01-15-2009 |
| 20090030899 | Processing a content item with regard to an event and a location - Associating a content item with an event is disclosed. A location associated with a received content item is determined. The received content item is associated with an event, at least in part based on an indicia of relatedness, other than the determined location, between the received content item and the event. A criterion that the indicia of relatedness is required to satisfy for the content item to be determined to be associated with the event has a lower value if the determined location associated with the received content item has a first degree of correspondence to a location associated with the event than if the determined location associated with the received content item has a second, lower degree of correspondence to the location associated with the event. | 01-29-2009 |
| 20090049041 | Ranking content items related to an event - Ranking content items is disclosed. A user input is received from each of one or more users indicating an opinion of the user with respect to a content item included in a plurality of content items. Based at least in part on a number of users from whom user input has been received, a degree is determined to which a ranking of the content item relative to one or more other content items in the plurality of content items is determined by user input. | 02-19-2009 |
Seth N. Birnbaum, Boston, MA US
| Patent application number | Description | Published |
|---|---|---|
| 20090198765 | Digital asset usage accountability via event journaling - A technique for establishing a perimeter of accountability for usage of digital assets such as data files. The accountability model not only tracks authorized users' access to files, but monitors passage of such files to uncontrollable removable storage media or through network connections and the like which may indicate possible abuse of access. In accordance with a preferred embodiment, an autonomous independent agent process running at a point of use, such as in the background of a client operating system kernel, interrupts requests for access to resources. The agent process senses low level system events, filters, aggregates them, and makes reports to a journaling server. The journaling server analyzes sequences of low level events to detect when aggregate events of interest occur, such as “FileEdit”, network file transfers and the like. Reports can be generated to provide an understanding of how digital assets have been accessed, used or communicated by individuals in an enterprise. | 08-06-2009 |
Shari G. Birnbaum, Dallas, TX US
| Patent application number | Description | Published |
|---|---|---|
| 20100222376 | CHELERYTHRINE, ANALOGS THEREOF AND THEIR USE IN THE TREATMENT OF BIPOLAR DISORDER AND OTHER COGNITIVE DISORDERS - The present invention relates to the use of chelerythrine and chelerythrine analogs in pharmaceutical compositions for the treatment of prefrontal cortical cognitive disorders, including bipolar disorder, among others. | 09-02-2010 |
Yochai Birnbaum, Houston, TX US
| Patent application number | Description | Published |
|---|---|---|
| 20090042849 | Phosphorylation of 5-lipoxygenase at ser523 and uses thereof - The present invention provides novel mechanisms that regulate the production of anti-inflammatory and pro-inflammatory mediators generated by 5-lipoxygenase. In this regard, the present invention establishes that phosphorylation of 5-Lipoxygenase by protein kinase A, has a crucial role in determining the end products of 5-Lipoxygenase. With translocation to the nucleus, potent proinflammatory leukotrienes are produced, whereas following phosphorylation by protein kinase A, anti-inflammatory mediators are produced. The present invention also discloses compounds that regulate these pro- and anti-inflammatory mediators. | 02-12-2009 |
| 20100063423 | ULTRASONIC BATH TO INCREASE TISSUE PERFUSION - The present invention describes a method of using an ultrasonic bath to enhance tissue perfusion, enhance the development of collateral blood vessels and/or enhance collateral circulation in an extremity in need thereof. Also described is an ultrasonic bath adapted to hold media and to permit the immersion of an extremity and comprising one or more ultrasonic transducers to generate and transmit ultrasonic energy to the extremity or the inventive method | 03-11-2010 |
| 20100292278 | Methods of treating vascular disease and injury - The present invention provides a method of treating a vascular disease or injury in an individual in need of such treatment, comprising the step of administering a compound or composition that down-regulates or decreases the activity of microRNA-29 in the individual. Also provided is a method of down-regulating or decreasing the activity of microRNA-29 in an individual in need of such treatment, comprising the step of administering a PPAR-γ agonist compound or PPAR-γ agonist containing composition that down-regulates or decreases the activity of microRNA-29 in the individual. Further provided is a method of treating a vascular disease or injury in an individual in need of such treatment, comprising the step of administering a microRNA-29 antagonist that down-regulates or decreases the activity of microRNA-29 in said individual. | 11-18-2010 |
| 20110092456 | Methods of increasing cAMP levels and uses thereof - The present invention shows that cilostazol, a phosphodiesterase 3 inhibitor has additional beneficial effects to atorvastatin on myocardial remodeling by inducing and preserving eNOS phosphorylation. The present invention demonstrates a cardioprotective effect of Cilostazol indicating the therapeutic potency of this drug. In addition, the present invention demonstrates that the additional effect of Cilostazol and atorvastatin therapy against ischemia injury is due to the augmentation of phosphatodylicositol 3-kinase/AKT (PI3-/AKT), PKA and p-eNOS signaling. | 04-21-2011 |
| 20110130334 | Methods and Compositions for Treatment of Reperfusion Injury and other Cardiac Conditions - The present invention discloses methods to prevent and treat cardiovascular disorders, hi certain aspects the methods are drawn to releasing endogenous calcitonin-gene related peptide from intrinsic cardiac adrenergic cells within the heart. In further aspects, a combination of a β | 06-02-2011 |