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Birch-Machin
Ian Birch-Machin, Oxfordshire GB
| Patent application number | Description | Published |
|---|---|---|
| 20110177056 | NON-CYTOTOXIC FUSION PROTEINS COMPRISING EGF MUTEINS - The present invention relates to fusion proteins comprising a non-cytotoxic protease and a EGF mutein ligand. The EGF mutein provides improved EGF receptor activation for the claimed fusion proteins. Also provided is the use of said polypeptides as therapeutics for suppressing mucus hypersecretion, inflammation, endocrine neoplasia and/or neuroendocrine disorders, neuroendocrine tumours, for suppressing cancers such as colorectal cancer, prostate cancer, breast cancer, and lung cancer. | 07-21-2011 |
Mark Birch-Machin, Tyne And Wear GB
| Patent application number | Description | Published |
|---|---|---|
| 20110045471 | Methods for Assaying MC1R Variants and Mitochondrial Markers in Skin Samples - The present invention relates to methods for predicting, diagnosing and monitoring skin states and skin diseases. The methods combine the use of non-invasive skin collecting techniques with one or more assays for determining mitochondrial DNA (mtDNA) aberrations and Melanocortin 1 Receptor (MC1R) variants, thereby providing a comprehensive tool for identifying, predicting and/or monitoring photoageing, ultraviolet radiation (UVR) damage or skin disease. The methods of the invention may also be effective in screening for new therapeutic agents, skin care products and treatment regimes, and may also be useful for monitoring the response of a subject to a preventative or therapeutic treatment. | 02-24-2011 |
Mark Birch-Machin, Gosforth GB
| Patent application number | Description | Published |
|---|---|---|
| 20090192047 | Mitochondrial mutations and rearrangements as a diagnostic tool for the detection of sun exposure, prostate cancer and other cancers - Mitochondrial DNA deletions useful for the detection of cancers and sun exposure are provided. In particular, methods and kits for detecting mitochondrial DNA deletions for the early detection, diagnosis and progression of prostate cancer, sun exposure and non-melonoma skin cancer are provided. | 07-30-2009 |
Mark Birch-Machin, Newcastle Upon Tyne UK
| Patent application number | Description | Published |
|---|---|---|
| 20110201011 | METHODS FOR ASSAYING MC1R VARIANTS AND MITOCHONDRIAL MARKERS IN SKIN SAMPLES - The present invention relates to methods for predicting, diagnosing and monitoring skin states and skin diseases. The methods combine the use of non-invasive skin collecting techniques with one or more assays for determining mitochondrial DNA (mtDNA) aberrations and Melanocortin 1 Receptor (MC1R) variants, thereby providing a comprehensive tool for identifying, predicting and/or monitoring photoageing, ultraviolet radiation (UVR) damage or skin disease. The methods of the invention may also be effective in screening for new therapeutic agents, skin care products and treatment regimes, and may also be useful for monitoring the response of a subject to a preventative or therapeutic treatment. | 08-18-2011 |
Mark Birch-Machin, Newcastle Upon Tyne GB
| Patent application number | Description | Published |
|---|---|---|
| 20120058483 | MITOCHONDRIAL MUTATIONS AND REARRANGEMENTS AS A DIAGNOSTIC TOOL FOR THE DETECTION OF SUN EXPOSURE, PROSTATE CANCER AND OTHER CANCERS - Mitochondrial DNA deletions useful for the detection of cancers and sun exposure are provided. In particular, methods and kits for detecting mitochondrial DNA deletions for the early detection, diagnosis and progression of prostate cancer, sun exposure and non-melonoma skin cancer are provided. | 03-08-2012 |