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Bignell
Colin Richard Bignell, Cambridge GB
| Patent application number | Description | Published |
|---|---|---|
| 20120135029 | METHOD FOR THE PURIFICATION OF PROTEIN COMPLEXES - The present invention provides an improved method for the purification of a mixture of complexes comprising a stress protein complexed to a peptide or peptide fragment from a source mixture, typically a cell lysate. The method of the invention provides for protein complexes to be purified using ion exchange chromatography based methods, wherein a modified buffer solution is used which results in the purified stress protein complexes being more immunogenic than protein complexes obtained using conventional methodology. The purified complexes can be used to produce improved vaccine preparations which elicit enhanced immune responses in the subjects to whom the vaccine compositions are administered. | 05-31-2012 |
David Bignell, London GB
| Patent application number | Description | Published |
|---|---|---|
| 20110120288 | SYSTEMS AND METHODS FOR AUTOMATIC COLLISION AVOIDANCE, GROUPING AND ALIGNMENT OF MUSICAL SYMBOLS - Systems and methods for editing a computer-base musical score include detecting a collision between objects placed in the score and automatically moving one of the colliding objects out of the way to eliminate the collision. Selection of the object to be moved is based on a comparison of the priority levels of the colliding objects. To enhance clarity and legibility of the score, objects are organized into groups of similar type objects. Groups are treated as a single object for the purposes of avoiding collisions. Certain object types are transformed, including scaled, rotated, or sheared, to avoid collisions. | 05-26-2011 |
Helen Bignell, Waldon GB
Helen Bignell, Nr. Saffron Walden GB
| Patent application number | Description | Published |
|---|---|---|
| 20090093378 | Method for sequencing a polynucleotide template - The invention relates to methods for pairwise sequencing of a double-stranded polynucleotide template, which methods result in the sequential determination of nucleotide sequences in two distinct and separate regions of the polynucleotide template. | 04-09-2009 |
Helen Bignell, Essex GB
| Patent application number | Description | Published |
|---|---|---|
| 20120015823 | Methods for indexing samples and sequencing multiple polynucleotide templates - The invention relates to methods for indexing samples during the sequencing of polynucleotide templates, resulting in the attachment of tags specific to the source of each nucleic acid sample such that after a sequencing run, both the source and sequence of each polynucleotide can be determined. Thus, the present invention pertains to analysis of complex genomes (e.g., human genomes), as well as multiplexing less complex genomes, such as those of bacteria, viruses, mitochondria, and the like. | 01-19-2012 |
Helen Rachel Bignell, Essex GB
| Patent application number | Description | Published |
|---|---|---|
| 20090176662 | End Modification to Prevent Over-Representation of Fragments - The invention relates to a method of preparing a 5′ and 3′ modified library of template polynucleotides and also the use of the 5′ and 3′ modified library of templates in methods of solid-phase nucleic acid amplification. In particular, the invention relates to a method of preparing a 5′ and 3′ modified library of template polynucleotides which have common sequences at their 5′ ends and at their 3′ ends, wherein over-representation of “end” sequences of the primary polynucleotide molecules from whence the 5′ and 3′ modified library is generated is greatly reduced or prevented. | 07-09-2009 |
| 20100167954 | METHOD OF LIBRARY PREPARATION AVOIDING THE FORMATION OF ADAPTOR DIMERS - The invention relates to a method of preparing a library of template polynucleotides which reduces and/or prevents the formation of adaptor-dimers. The invention also relates to the use of a library of templates prepared using the method of the invention for solid-phase nucleic acid amplification. In particular, the invention relates to a method of preparing a library of template polynucleotides which have common sequences at their 5′ ends and at their 3′ ends which is substantially free of adaptor-dimers. | 07-01-2010 |