Bieschke
Eric Kenson Bieschke, San Francisco, CA US
Patent application number | Description | Published |
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20140074861 | System and Method for Combining Inputs to Generate and Modify Playlists - Systems, methods, and computer readable storage mediums are provided for selecting a media content object for a user using a combination of inputs. A media input seed associated with a user is obtained. A plurality of channels of media content objects is obtained. At least one of the plurality of channels is associated with the media input seed. Also, in some embodiments, each media content object of each of those channels has a score specific to that channel. A combination score for a respective media content object is calculated based at least in part on that respective media content object's channel specific score for each of at least two of the plurality of channels. Then at least some of the media content objects are ranked based at least in part on their respective combination scores. Finally, at least one ranked media content object is then selected for transmission. | 03-13-2014 |
Jan Bieschke, San Diego, CA US
Patent application number | Description | Published |
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20100029773 | Systematic identification of new anti-prion drugs by high-throughput screening based on scanning for intensely fluorescent targets (sift) - The present invention relates to a method of identifying a compound for inhibiting aggregation of proteins involved in diseases linked to protein aggregation and/or neurodegenerative diseases, comprising the steps of: (a) bringing into contact a labeled monomeric protein and a differently labeled aggregate of said protein in the (1) presence and (2) absence of a candidate inhibitor of aggregation, (b) determining the amount of co-localized labels, representing the extent of binding of the monomeric proteins to the aggregates of said protein; and (c) comparing the result obtained in the presence and absence of said compound, wherein a decrease of co-localized labels in the presence of said compound is indicative of the compound's ability to inhibit aggregation of said protein. Moreover, the present invention relates to a pharmaceutical composition containing said inhibitor of aggregation as well as to a kit. | 02-04-2010 |
Jan Gerd Maximilian Bieschke, Berlin DE
Patent application number | Description | Published |
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20090208960 | METHODS FOR IDENTIFYNG CELLULAR MODULATORS OF DISAGGREGATION ACTIVITY OR AGGREGATION ACTIVITY IN AN ANIMAL - Methods for identifying a cellular modulator of a biological disaggregation activity or a biological aggregation activity of an animal are provided. Methods for identifying a compound which modulates biological disaggregation activity or a biological aggregation activity in a biological sample are provided. | 08-20-2009 |