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| 20110311209 | TRANSPARENT FLUID RECIRCULATION RESERVOIR SYSTEM - A method for channeling hot/warm working fluid includes coupling a first fluid supply path in flow communication with an inlet of a first transparent fluid reservoir to a fluid inlet valve, coupling an outlet of the first transparent fluid reservoir in flow communication to a fluid outlet supply path, coupling a second fluid reservoir in flow communication with the first transparent fluid reservoir, and coupling a second fluid supply path in flow communication with an outlet of the second fluid reservoir to a fluid outlet valve. The method also includes directing working fluid of a temperature that is above a minimum threshold temperature from the fluid inlet valve to the fluid outlet supply path through the first transparent fluid reservoir, and directing working fluid of a temperature that is below the minimum threshold temperature from the first transparent fluid reservoir to the fluid outlet valve through the second fluid reservoir. | 12-22-2011 |
| 20120026614 | ACTUATOR MOTION CONTROL MECHANISM FOR A CONCAVE MIRROR - A method for varying a radius of curvature of a concave mirror includes coupling a concave mirror to a mirror frame, coupling the mirror frame to a vertical slide, coupling the vertical slide to a horizontal slide, coupling the horizontal slide to a fixed support, coupling an end of the mirror frame to an actuator, coupling a first proximity sensor to the mirror frame, coupling a second proximity sensor to the horizontal slide, and coupling a third proximity sensor to the vertical slide. The method also includes translating the mirror frame along the vertical slide and translating the vertical slide along the horizontal slide to facilitate aligning a pole of the concave mirror with a center of an object, and varying the radius of curvature of the concave mirror to magnify an image of an object in the concave mirror for optimum clarity. | 02-02-2012 |
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| 20100106695 | SCALABLE BLOB STORAGE INTEGRATED WITH SCALABLE STRUCTURED STORAGE - Embodiments of the present invention relate to systems, methods and computer storage media for facilitating the structured storage of binary large objects (Blobs) to be accessed by an application program being executed by a computing device. Generally, the structured storage of Blobs includes a primary structured storage index for indexing Blobs, a secondary hash index that is integrated into the structured storage system, a Blob log stream, and a Blob data stream for storing blocks that include the Blob data. In an embodiment, a block is created and written to a Blob store along with a block list. The block list facilitates the locating of one or more blocks that store the Blob data. In this embodiment, a primary structured storage index and a secondary hash index are updated to facilitate efficient access of the Blob in a structured storage system. | 04-29-2010 |
| 20100106734 | BLOB MANIPULATION IN AN INTEGRATED STRUCTURED STORAGE SYSTEM - Embodiments of the present invention relate to systems, methods and computer storage media for facilitating the structured storage of binary large objects (Blobs) to be accessed by an application program being executed by a computing device. Generally, the manipulation of Blobs in a structured storage system includes receiving a request for a Blob, which may be located by way of a Blob pointer. The Blob pointer allows for the data, such as properties, of the Blob to be identified and located. Expired properties are garbage collected as a manipulation of the Blob data within a structured storage system. In an embodiment, the Blob is identified by a key that is utilized within a primary structured index to located the requested Blob. In another embodiment, the requested Blob is located utilizing a secondary hash index. In an additional embodiment, the Blob is locate utilizing a file table. | 04-29-2010 |
| 20100106934 | PARTITION MANAGEMENT IN A PARTITIONED, SCALABLE, AND AVAILABLE STRUCTURED STORAGE - Partition management for a scalable, structured storage system is provided. The storage system provides storage represented by one or more tables, each of which includes rows that represent data entities. A table is partitioned into a number of partitions, each partition including a contiguous range of rows. The partitions are served by table servers and managed by a table master. Load distribution information for the table servers and partitions is tracked, and the table master determines to split and/or merge partitions based on the load distribution information. | 04-29-2010 |
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| 20090175890 | USE OF IMMATURE DENDRITIC CELLS TO SILENCE ANTIGEN SPECIFIC CD8+ T CELL FUNCTION - This invention provides methods for silencing a pre-existing immune response in a mammal, as for example, in the setting of autoimmune diseases. The method comprises administering to a mammal immature dendritic cells which have been contacted in vitro with an antigen, or to target the antigen to immature dendritic cells in vivo, in order to silence and/or suppress a pre-existing CD8+ T cell immune response and induce IL-10 producing CD8+ T cells in said mammal. This invention further relates to methods for propagating immature dendritic cells, for maintaining immaturity by modification ex vivo, and uses thereof, including generation of regulatory T cells for passive immunotherapy. The present invention also relates to compositions and kits comprising immature dendritic cells and antigens. | 07-09-2009 |
| 20110195045 | Methods, agents and peptides for inducing an immune response to matrix metalloproteinase-2 expressing tumors - The present invention relates to enhancing, modulating or stimulating the immune response to MMP-2 expressing tumors, including melanoma, and to the modulation and application of immune modulators and MMP-2 peptides for melanoma or other MMP-2 expressing tumor vaccines. The invention provides methods and means to activate an effective response to MMP-2 expressing tumors and modulate the ability of MMP-2 to skew CD4+ T cell responses toward that of T | 08-11-2011 |
| 20110275089 | Methods for predicting survival in metastatic melanoma patients - Cellular and genetic signatures and methods of using same for subcategorizing stage III melanoma tumors are described herein. The signatures and methods are particularly useful with regard to establishing more distinct criteria on which basis to differentiate stage IIIB and IIIC melanoma patients. Assessment of the cellular and genetic signatures of a melanoma sample using methods described herein yields information on which basis differential survival duration and sensitivity to various cancer therapies can be predicted for a Stage IIIB or Stage IIIC melanoma patients. As described herein, gene expression profiling, determination of mitotic index (MI), and quantification of tumor infiltrating leukocytes (TILs) and CD3+ cells in metastatic lesions may be utilized to predict or assess drug response, drug sensitivity, and clinical outcome in metastatic melanoma patients. | 11-10-2011 |
