Bessac
Bret Fajans Bessac, Kingsville, TX US
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20110144137 | METHOD FOR PREVENTING OR ALLEVIATING THE NOXIOUS EFFECTS RESULTING FROM TOXICANT EXPOSURE - The present invention provides a method of using agents which can modulate TRPA1 function as counteragents to inhibit the physical effects of chemical irritants/toxicants when given prior to exposure or to lessen the physical effects when administered post exposure, and more specifically, to a method for counteracting the acute physical noxious effects of toxicants, including but not limited to, tear gases, chlorine, hydrogen peroxide, ammonia, phosgene, chloropicrin, isocyanates and mustard gas. Administering the counteragents counteracts pain, inflammation, lachrymation, blepharospasm, respiratory irritation and depression, airway mucus secretion, airway obstruction and injury, cough and incapacitation and cutaneous chemical injuries. Another embodiment provides a method of preventing or treating a disease or condition in a mammal, which disease or condition includes hypersensitivity to chemical stimuli, particularly in regards to inflammatory airway conditions, such as asthma, rhinitis, etc., by administering to the mammal a therapeutically effective amount of a compound that inhibits TRPA1 function, wherein the compound reduces the hypersensitivity and mediates the response to such chemical stimuli in the mammal. The invention also includes a kit containing the compound that inhibits the TRPA1 function as a counteracting agent for administration prior to or post exposure to prevent or limit the effects of the exposure. | 06-16-2011 |
Christophe Bessac, Cebazat FR
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20090200706 | Method and Device for Moulding Elastomeric Objects - A process and a device for moulding elastomeric articles. The device comprises: a mould ( | 08-13-2009 |
Christophe Bessac, Clermont-Ferrand Cedex 9 FR
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20130236665 | Method for Producing a Vehicle Tire Tread - In the process for producing a tread ( | 09-12-2013 |
Christophe Bessac, Clermont-Ferrand FR
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20140290814 | TREAD INCLUDING AT LEAST ONE WAVY GROOVE, AND METHOD FOR PRODUCING SAME - Tire for a heavy goods vehicle comprising a tread of total thickness E and total volume V, having a tread surface intended to come into contact with a roadway, at least one cavity or groove that is continuous in a main direction, and delimited by side walls connected by a bottom, a cross section, the points furthest towards the inside of the bottom of each cavity defining a bottom line, wherein each cavity or groove comprises a plurality of open sections open onto the tread surface in the new state and a plurality of closed sections, connected to the open sections being arranged in alternation, each closed section being spaced away from the tread surface by a bridge of rubber, wherein the points on the bottom line of said cavity or groove lie at distances between a minimum distance Dm and a maximum distance DM with respect to the tread surface, the bottom lineof each cavity or groove following a wavy geometry of positive amplitude equal to the difference (DM−Dm). | 10-02-2014 |
20140348692 | METHOD AND APPARATUS FOR PRODUCING THREE-DIMENSIONAL OBJECTS - An apparatus and a process for manufacturing a three-dimensional object by successive layer-by-layer consolidation of selected zones of a powder stratum, the consolidated zones corresponding to successive sections of the three-dimensional object, each layer being divided into a central internal portion and an external border , said process comprising the following steps in order: | 11-27-2014 |
20150064048 | METHOD AND APPARATUS FOR PRODUCING THREE-DIMENSIONAL OBJECTS WITH IMPROVED PROPERTIES - Method for fabricating a three-dimensional object by successive consolidation, layer by layer, of selected regions of a layer of powder, consolidated regions corresponding to successive sections of the three-dimensional object, comprising in order: | 03-05-2015 |
Laurence Bessac, Paris FR
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20140154262 | HUMAN ANTIBODIES TO PCSK9 FOR USE IN METHODS OF TREATING PARTICULAR GROUPS OF SUBJECTS - The present invention relates to methods for treating diseases or conditions in which proprotein convertase subtilisin/kexin type 9 (PCSK9) expression or activity causes an impact by administration of PCSK9-specific antibodies or antigen-binding fragments thereof and preferably by additional administration of an inhibitor of 3-hydroxy-3-methyl-glutaryl-CoA reductase (HMG-CoA reductase). The present invention further relates to PCSK9-specific antibodies or antigen-binding fragments thereof for use in the treatment of diseases or conditions in which PCSK9 expression or activity causes an impact. | 06-05-2014 |
20140178402 | PHARMACEUTICAL COMPOSITIONS COMPRISING HUMAN ANTIBODIES TO PCSK9 - The present invention relates to Pharmaceutical compositions comprising an antibody specifically binding to human proprotein convertase subtilisin/kexin type 9 (PCSK9), to methods for treating diseases or conditions in which proprotein convertase subtilisin/kexin type 9 (PCSK9) expression or activity causes an impact by administration of PCSK9-specific antibodies or antigen-binding fragments thereof and preferably by additional administration of an inhibitor of 3-hydroxy-3-methyl-glutaryl-CoA reductase (HMG-CoA reductase). The present invention further relates to PCSK9-specific antibodies or antigen-binding fragments thereof for use in the treatment of diseases or conditions in which PCSK9 expression or activity causes an impact. | 06-26-2014 |