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Bernhard Gleich, Hamburg DE

Bernhard Gleich, Hamburg DE

Patent application numberDescriptionPublished
20080204009Method of Determining a Spatial Distribution of Magnetic Particles - The invention relates to a method of determining a spatial distribution of magnetic particles in an examination zone, in which method a first magnetic field is generated, which forms in the examination zone a first sub-zone having a relatively low magnetic field strength and a second sub-zone having a relatively high magnetic field strength. The position in space of the two sub-zones is then changed by a second magnetic field, whereby the magnetization in the examination zone is changed. Signals dependent on the change in magnetization are acquired and evaluated to extract information concerning the spatial distribution of the magnetic particles. The second magnetic field is generated so that the time derivative of the second magnetic field is substantially identical for each spatial component.08-28-2008
20080230715Optical Imaging - An optical imaging apparatus (09-25-2008
20080231264System and Method for Magnetic Tracking of a Sensor for Interventional Device Localization - A system and method for determining the location of a remote object using a magnetic tracking sensor. The system and method include locating a magnetic core (09-25-2008
20080278168Transmission Line for Use in Rf Fields - An electrically conductive link (connection lead) or transmission line (11-13-2008
20080308746Optical Fluorescence Tomography - The invention relates to an optical fluorescence tomography system of biological targets. For increasing the resolution an the penetration depth of the impact radiation, in order to result a better depth signal, the biological target is supplied with a fluorescence dye (Material), bleachable by impact radiation, wherein a controllable dynamic tissue-wise bleaching-effect of the fluorescence dye is generated, so that by time dependant measuring of the maximum fluorescence response signal can be correlated to the actual selective bleaching front in depth.12-18-2008
20090240135METHOD OF DETERMINING A SPATIAL DISTRIBUTION OF MAGNETIC PARTICLES - The invention relates to a method of determining a spatial distribution of magnetic particles in an examination zone, in which a magnetic field is generated that has a first sub-zone of lower magnetic field strength and a second sub-zone of higher magnetic field strength. The positions of the two sub-zones are changed, as a result of which the magnetization in the examination zone changes. Measured values that depend on the change in magnetization are acquired. A reference response function by means of which measured values can be determined mathematically from a spatial distribution of magnetic particles is then determined by means of at least extensive magnetic specimen distribution. Finally, the spatial distribution of magnetic particles is reconstructed from the measured values by means of the reference response function.09-24-2009
20090251236TRANSMISSION PATH FOR USE IN RF FIELDS - A transmission path (10-08-2009
20090281416ARRANGEMENT AND METHOD FOR DETERMINING THE SPATIAL DISTRIBUTION OF MAGNETIC PARTICLES - The invention relates to an arrangement and a method for determining the spatial distribution of magnetic particles in an examination area. Magnetic field means are used to generate a spatially inhomogeneous gradient magnetic field with at least one region with a low field strength, in which the magnetization of the particles is in a state of non- saturation, whereas they are in a state of saturation in the remaining region. By using change means to shift the area with a low field strength within the examination area, a change in the magnetization of the magnetic particles is brought about which can be detected from outside by detection means and contains information about the spatial distribution of the magnetic particles in the examination area. The magnetic field means or the change means or the detection means or a combination of these means are arranged at least partially on a medical instrument.11-12-2009
20090299176MARKER FOR POSITION DETERMINATION WITH A MAGNETIC METHOD - The invention relates to an arrangement and a method for determining the spatial distribution of magnetic particles in an examination area. Magnetic field means are used to generate a spatially inhomogeneous gradient magnetic field with at least one region with a low field strength, in which the magnetization of the particles is in a state of non-saturation, whereas they are in a state of saturation in the remaining region. By using change means to shift the area with a low field strength within the examination area, a change in the magnetization of the magnetic particles is brought about which can be detected from outside by detection means and contains information about the spatial distribution of the magnetic particles in the examination area The magnetic field means or the change means or the detection means or a combination of these means are arranged at least partially on a medical instrument.12-03-2009
20100004528INTERVENTIONAL DEVICE FOR RF ABLATION FOR USE IN RF FIELDS - A interventional device for RF ablation for use in a RF electrical and/or magnetic field especially of a MR imaging system is disclosed, comprising an ablation catheter which is preferably trackable or can be guided or visualized in the image generated by the MR imaging system by means of a MR micro-coil (01-07-2010
20100033171ARRANGEMENT AND METHOD FOR INFLUENCING AND/OR DETECTING MAGNETIC PARTICLES IN A REGION OF ACTION - An arrangement and a method for influencing and/or detecting magnetic particles in a region of action is disclosed, which arrangement comprises:—selection means for generating a magnetic selection field having a pattern in space of its magnetic field strength such that a first sub-zone having a low magnetic field strength and a second sub-zone having a higher magnetic field strength are formed in the region of action,—drive means for changing the position in space of the two sub-zones in the region of action by means of a magnetic drive field so that the magnetization of the magnetic particles changes locally, wherein the selection means comprises at least one permanent magnet wherein the permanent magnet is at least partially shielded by an electrically high conductive shielding means.02-11-2010
20100033172ARRANGEMENT AND METHOD FOR INFLUENCING AND/OR DETECTING AND/OR LOCATING MAGNETIC PARTICLES IN A REGION OF ACTION - An arrangement and a method for influencing and/or detecting and/or locating magnetic particles in a region of action is disclosed, which arrangement comprises: —drive means for generating a magnetic drive field so that the magnetization of the magnetic particles changes, wherein the magnetic particles comprise at least a first and a second magnetic particle, —the receiving means comprising at least a first receiving probe providing a first signal (02-11-2010
20100033174ARRANGEMENT AND METHOD FOR INFLUENCING AND/OR DETECTING MAGNETIC PARTICLES IN A REGION OF ACTION - An arrangement for influencing and/or detecting magnetic particles, a method for calibrating such an arrangement and a method for influencing and/or detecting magnetic particles in a region of action is disclosed, which arrangement comprises selection means for generating a magnetic selection field having a pattern in space of its magnetic field strength such that a first sub-zone having a low magnetic field strength and a second sub-zone having a higher magnetic field strength are formed in the region of action, drive means for changing the position in space of the two sub-zones in the region of action by means of a magnetic drive field so that the magnetization of the magnetic particles changes locally, the arrangement comprising a drive signal chain, receiving means for acquiring detection signals, which detection signals depend on the magnetization in the region of action, which magnetization is influenced by the change in the position in space of the first and second sub-zone, the arrangement comprising a detection signal chain, wherein the arrangement comprises a compensation controller providing a compensation signal to the drive signal chain and/or to the detection signal chain by means of a coupling means.02-11-2010
20100041977CATHETER AND MEDICAL ASSEMBLY - The present invention relates to a catheter (02-18-2010
20100045280ARRANGEMENT AND METHOD FOR INFLUENCING AND/OR DETECTING MAGNETIC PARTICLES IN A REGION OF ACTION, COIL ARRANGEMENT - An arrangement and a method for influencing and/or detecting magnetic particles in a region of action is disclosed, which arrangement comprises: selection means for generating a magnetic selection field having a pattern in space of its magnetic field strength such that a first sub-zone having a low magnetic field strength and a second sub-zone having a higher magnetic field strength are formed in the region of action, drive means for changing the position in space of the two sub-zones in the region of action by means of a magnetic drive field so that the magnetization of the magnetic particles changes locally, receiving means for acquiring signals, which signals depend on the magnetization in the region of action, which magnetization is influenced by the change in the position in space of the first and second sub-zone, wherein the arrangement comprises a coil arrangement comprising a surrounding coil and a magnetic field generator such that the surrounding coil almost completely surrounds the magnetic field generator.02-25-2010
20100072984INFLUENCING AND/OR DETECTING MAGNETIC PARTICLES IN A REGION OF ACTION OF AN EXAMINATION OBJECT - A method and an arrangement for influencing and/or detecting magnetic particles in a region of action of an examination object is disclosed, which method comprises the steps of: generating a magnetic selection field by means of selection means, the magnetic selection field having a pattern in space of its magnetic field strength such that a first sub-zone having a low magnetic field strength and a second sub-zone having a higher magnetic field strength are formed in the region of action, changing the position in space of the two sub-zones in the region of action by means of a magnetic drive field generated by drive means so that the magnetization of the magnetic particles change locally, acquiring signals by means of receiving means, which signals depend on the magnetization in the region of action, which magnetization is influenced by the change in the position in space of the first and second sub-zone, wherein the selection means and/or the drive means and/or the receiving means are provided at least partly movable relative to the examination object during the acquisition and/or the change in the position in space of the two sub-zones in the region of action.03-25-2010
20100072991METHOD AND ARRANGEMENT FOR LOCATING MAGNETIC MARKERS IN A REGION OF ACTION - A method and an arrangement for influencing and/or detecting and/or locating magnetic markers in a region of action is disclosed, which method comprises the steps of: generating a magnetic drive field so that the magnetization of the magnetic marker changes, generating a magnetic selection field having a pattern in space of its magnetic field strength providing a magnetic field gradient in the region of action, acquiring a first signal by means of a first receiving probe and acquiring a second signal by means of a second receiving probe, the first receiving probe and the second receiving probe being located at different locations relative to the region of action, the first signal and the second signal depending on the magnetization of the magnetic marker in the drive field and in the selection field and further depending on the location of the magnetic marker, the magnetic selection field having a first magnetic field strength configuration, repeating at least once the acquisition of the first signal and of the second signal in the presence of the selection field having a second magnetic field strength configuration, computing an estimation of the location of the magnetic marker by means of the acquired signals.03-25-2010
20100243574SEPARATOR COLUMN, SEPARATOR SYSTEM, METHOD OF FRACTIONATING MAGNETIC PARTICLES, METHOD OF MANUFACTURING A SEPARATOR COLUMN AND USE OF A SEPARATOR COLUMN - A separator system with a separator column and a method of fractionating magnetic particles, preferably using field-flow fractionation is proposed, which allows for more effective fractionation of magnetic particles with respect to their dynamic magnetic response in a wide frequency and amplitude range of an applied magnetic field, in particular relevant for magnetic particle imaging (MPI).09-30-2010
20100249578ARRANGEMENT AND METHOD FOR DETERMINING THE SPATIAL DISTRIBUTION OF MAGNETIC PARTICLES - The invention relates to an arrangement and a method for determining the spatial distribution of magnetic particles in an examination area. Magnetic field means are used to generate a spatially inhomogeneous gradient magnetic field with at least one region with a low field strength, in which the magnetization of the particles is in a state of non-saturation, whereas they are in a state of saturation in the remaining region. By using change means to shift the area with a low field strength within the examination area, a change in the magnetization of the magnetic particles is brought about which can be detected from outside by detection means and contains information about the spatial distribution of the magnetic particles in the examination area. The magnetic field means or the change means or the detection means or a combination of these means are arranged at least partially on a medical instrument.09-30-2010

Patent applications by Bernhard Gleich, Hamburg DE