Patent application number | Description | Published |
20080262326 | Signal Processing Method and Apparatus for Processing a Physiologic Signal such as a Photoplethysmography Signal - A signal processing method of processing a physiologic signal, such as a Photoplethysmography Signal having at least some cardiac components and/or respirator components in the physiologic signal, the processing including the steps of: Identifying a potential cardiac and or respiratory components of a physiologic signal wherein the potential cardiac and or respiratory components have a series of peaks and valleys; Calculating a comparison of the durations of a peak to valley sub-component and a valley to peak sub component of the potential cardiac and or respiratory components; and Utilizing the calculated comparison to evaluate the potential cardiac and or respiratory components. | 10-23-2008 |
20080295842 | Method and Apparatus for Simplified Precise Mechanical Gas Mixing and Delivery for Animal Research - An apparatus for supplying a precise oxygen-nitrogen gas mixture to an animal comprises (i) A source of pressurized oxygen gas, (ii) A source of pressurized nitrogen gas, (iii) A mechanical two-gas blending valve having a first and second gas inlet couplings, and an outlet coupling, the gas blending valve having a manual selector that can incrementally adjust the oxygen-nitrogen gas mixture within a range of mixtures, and a face plate on the blending valve including markings adjacent to the manual selector that are indicative of specific oxygen-nitrogen mixtures, wherein the gas inlets are coupled to the sources of oxygen and nitrogen, respectively, (iv) A gas dispenser coupled to the outlet of the mechanical two gas blending valve; and (v) An animal interface coupling to deliver the gas mixture to the subject animal. The apparatus may be provided for mixtures of air and any gas of interest. | 12-04-2008 |
20090099425 | INTEGRATED TAIL MOUNTED BLOOD PRESSURE MONITOR AND PULSE OXIMETER SYSTEM FOR ANIMAL RESEARCH - An integrated tail mounted blood pressure monitor and pulse oximeter system includes a tail blood flow occlusion member configured to selectively occlude blood flow through the tail; a sensor coupled to the tail blood flow occlusion member detecting a degree of operation thereof; Light sources coupled to the tail closer to the distal end of the tail than the tail blood flow occlusion member, and selectively directing light of two different wavelengths into the tail; a light receiver coupled to the tail and selectively receiving a signal associated with light directed into the tail from the light sources; and a controller configured to selectively determine blood pressure parameters from the data and pulse oximeter parameters from the data. | 04-16-2009 |
20100113902 | Small Bore Magnetic Resonance Imaging Photoplethysmographic Sensor - An efficient, effective, MRI compatible small bore MRI noninvasive photoplethysmographic sensor for animals such as small rodents, namely rats and mice. The photoplethysmographic sensor for animals comprising: a non-magnetic sensor coupling attachable to an animal; fiber optic cable coupled to the sensor coupling and configured to deliver a signal to and receive a signal from the animal tissue adjacent the sensor coupling; an opto-electical converter coupled to the fiber optic cable, the converter including a receiver coupled the fiber optic cable portion configured to receive a signal from the animal tissue and including an emitter coupled to the fiber optic portion configured to deliver a signal to the animal tissue; an electronic coupling extending from the opto-electric converter and configured to be coupled to the emitter and the receiver, wherein the electronic coupling is configured to extend outside of the MRI chamber; and a processor coupled to the electronic coupling. | 05-06-2010 |
20100145170 | Small Animal Pulse Oximeter User Interface - A user interface for a pulse oximetry device that calculates physiologic parameters of a subject including at least a subject's heart rate and S | 06-10-2010 |
20100160751 | PHOTOPLETHYSMOGRAPHIC SENSOR BASED BLOOD GAS MONITOR DEVICE FOR ANALYSIS, RESEARCH AND CALIBRATION IN AN EXTRACORPOREAL CIRCUIT OR EXTRACORPOREAL PULSE SIMULATION SYSTEM - A blood oxygenation monitoring device may comprise an extracorporeal pulse simulation system including one at least partially transparent blood holding element with a photoplethysmographic sensor coupled to the element and adapted to measure particular gas content of the blood. The system includes a pulse simulation mechanism configured to simulate pulsatile behavior of the blood within the element relative to the photoplethysmographic sensors. The blood holding element may be a reservoir, wherein the pulse simulation mechanism includes a magnetic stirrer and stir bar within the reservoir. The blood holding member may be flexible tubing having blood flow there through, wherein the pulse simulation mechanism is a peristaltic pump coupled to the tubing. The monitoring device can rapidly and accurately form oxygen dissociation curves. The monitoring device can be utilized in conjunction with a heart lung bypass machine or other extra corporeal circuit devices or can be a calibration tool for sensors. | 06-24-2010 |
20110137185 | Saddle Faced Small Animal Sensor Clip - A noninvasive photoplethysmographic sensor platform for small animals provides a spring biased sensor clip, wherein at least one side of the sensor clip is provided with a saddle faced clip face member. The saddle shape of the clip face member may have a hinge end, toward the hinge of the clip, which is longer in the longitudinal direction of the clip and shorter in depth than the distal end. The shorter distal end side (measured longitudinally) of this saddle shape facilitates the ability to align the transmitted and received light with the bone, while the overall saddle shape of the facing provides a physical grip to capture enough tissue to prevent the clip from relocating over time while it is attached to the limb. The shorter hinge end side (depth-wise) also allows the clip to close when it is fully assembled. The edges of the saddle shaped clip are preferably rounded off to prevent the contusions of the tissue that may result from long-term contact. This saddle faced feature works well on only one side of the clip. | 06-09-2011 |
20110313264 | FULL BODY PLETHYSMOGRAPHIC CHAMBER INCORPORATING PHOTOPLETHYSMOGRAPHIC SENSOR FOR USE WITH SMALL NON-ANESTHETIZED ANIMALS - A full body plethysmographic chamber includes a noninvasive photoplethysmographic sensor within the chamber. The noninvasive photoplethysmographic sensor is for mobile animals such as small rodents, namely rats and mice in the full body plethysmographic chamber and is useful in a laboratory research environment. The noninvasive photoplethysmographic sensor may be a neck clip or collar which provides an easily affixed attachment mechanism. The neck location will provide significant blood flow under all conditions and also offers inherent bite resistance to the sensor platform. The system of the present invention provides a commutator for the sensor wires for allowing untwisting of the system wires. | 12-22-2011 |
20120004517 | BLOOD PRESSURE MONITOR AND PULSE OXIMETER SYSTEM FOR ANIMAL RESEARCH - An integrated blood pressure monitor and pulse oximeter system includes a blood flow occlusion member configured to selectively occlude blood flow through an appendage of the animal (e.g., the neck or tail); a sensor coupled to the blood flow occlusion member detecting a degree of operation thereof; Light sources coupled to the tail closer to the distal end of the tail than the tail blood flow occlusion member, and selectively directing light of two different wavelengths into the appendage; a light receiver coupled to the appendage and selectively receiving a signal associated with light directed into the appendage from the light sources; and a controller configured to selectively determine blood pressure parameters from the data and pulse oximeter parameters from the data. | 01-05-2012 |
20120143071 | ALGORITHMS FOR CALCULATION OF PHYSIOLOGIC PARAMETERS FROM NONINVASIVE PHOTOPLETHYSMOGRAPHIC SENSOR MEASUREMENTS OF AWAKE ANIMALS - A noninvasive photoplethysmographic sensor system for mobile animals such as small rodents, namely rats and mice is useful such as in a laboratory research environment. The noninvasive photoplethysmographic sensor for mobile animals such as small rodents utilizes multiple FFT's in the processing of the phtotoplethysmograophic signal, where each FFT has a different time record of the signals such as a number of points, or a zero padded FFTs. The noninvasive photoplethysmographic sensor for mobile animals provides actigraphy measurements for the animal. | 06-07-2012 |
20130085354 | TECHNIQUES FOR ACCURATELY DERIVING PHYSIOLOGIC PARAMETERS OF A SUBJECT FROM PHOTOPLETHYSMOGRAPHIC MEASUREMENTS - Several techniques are disclosed for isolating either heart or breath rate data from a photoplethysmograph, which is a time domain signal such as from a pulse oximeter. The techniques involve the use of filtering in the frequency domain, after a Fast Fourier Transform (FFT) has been conducted on a given photoplethysmograph also references as a given set of discrete time-domain data. The filtering may be applied to an identified fundamental frequency and one or more harmonics for heart related parameters. The filter may be truncated to the frequency data set and further applied multiple times to improve roll off. After filtering, an Inverse FFT (IFFT) is used to reconstruct the time-domain signal, except with undesirable frequency content eliminated or reduced. Calculation or measurement of parameters is then conducted on this reconstructed time-domain signal. | 04-04-2013 |