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Berberich, US
Carl J. Berberich, Rochester, MN US
| Patent application number | Description | Published |
|---|---|---|
| 20100057507 | Real-Time Manufacturing Routing Optimization Using Content and Quality Level - Dynamically generating manufacturing routings in a manufacturing environment, using content and quality level information. The content and quality level information may pertain to multiple, disparate commodities (e.g., parts and/or assemblies) which are to be processed as a group, and some of those commodities may have already undergone various processes (such as testing of various types and durations). The generated routings may reflect parameterizations pertaining to the commodities. | 03-04-2010 |
David W. Berberich, St.peters, MO US
| Patent application number | Description | Published |
|---|---|---|
| 20090156819 | Processes for the preparation of normorphinan salts - The invention provides a process for the conversion of opioid derivatives into normorphinan compounds useful for making “nal” compound analgesics and antagonists. In particular, the process may be used for the production of pure normorphinan salts from crude opioid substrates. | 06-18-2009 |
David W. Berberich, Saint Peters, MO US
| Patent application number | Description | Published |
|---|---|---|
| 20100068242 | Medical Devices for Localized Drug Delivery - In certain embodiments, the invention relates to an implantable medical device that includes a body having an internal cavity. Receptor sites in the internal cavity may be adapted to repeatedly bind to, temporarily hold, and release an active agent. An opening may extend through the body and into the internal cavity to allow the active agent into and out of the internal cavity. This opening may be sized and shaped to prevent blood cells from entering the internal cavity through the opening while allowing the active agent to enter and/or exit the cavity via the opening. A polymeric structure may be located in the internal cavity. This polymeric structure may include artificial receptor site mimics for the active agent. | 03-18-2010 |
David Wayne Berberich, St. Peters, MO US
| Patent application number | Description | Published |
|---|---|---|
| 20100048905 | Novel Opiate Reduction Utilizing Catalytic Hydrogen Transfer Reaction - An improved opiate synthesis scheme is provided. An improvement to the oxidation of oripavine and oripavine derivatives comprises the in-situ formation of the peroxacids required to oxidize the oripavine and oripavine derivatives to form an intermediate. An improvement to the reduction of the intermediate to form oxycodone and oxycodone derivatives comprises reduction utilizing a hydrogen transfer reagent. These improvements allow the production of oxycodone and oxycodone derivatives without isolation of the intermediate, providing a one-pot synthesis method. | 02-25-2010 |
| 20100113787 | Preparation of Oxymorphone from Oripavine - An improved method for the preparation of oxymorphone from oripavine is provided. Oripavine is oxidized to form 14-hydroxymorphinone after which the oxidation reaction is quenched to prevent the formation of 1-1′-dimer side products. The 14-hydroxymorphinone is then reduced, typically by catalytic hydrogenation to form oxymorphone. The inventive method disclosed is further applicable to the production of morphinan derivatives. | 05-06-2010 |
Jason Berberich, Pittsburg, PA US
| Patent application number | Description | Published |
|---|---|---|
| 20090045056 | Stable three enzyme creatinine biosensor - The invention provides methods for preparing a stable, multiple-use three enzyme biosensor for the amperometric determination of creatinine in biological liquids that has a useful lifetime that extends significantly beyond that of presently available amperometric biosensors. The biosensor prepared by the methods of the invention encompasses a plurality of immobilized enzymes that are applied to the biosensor as an enzyme-polymer composition. The enzymes, which can include creatinine amidohydrolase, creatine amidinohydrolase and sarcosine oxidase, are immobilized into the enzyme-polymer composition simultaneously as well as applied to the biosensor simultaneously. Prior to being immobilized, the enzymes can be chemically modified by attaching one or more polyethylene glycol (PEG) chains per enzyme monomer. The polymer component can be provided by a polyurethane membrane. The invention also provides a method of preparing a biosensor that limits the diffusion of silver ions emanating the reference electrode, thereby preventing, contact between the silver ions and the enzymes. Related methods of preparing an enzyme-polymer composition for incorporation into a multiple use three enzyme biosensor for the amperometric determination of creatinine in biological liquids also are provided. The invention also provides multiple-use biosensors and enzyme-polymer compositions prepared by the methods disclosed. | 02-19-2009 |
Jason A. Berberich, Pittsburgh, PA US
| Patent application number | Description | Published |
|---|---|---|
| 20100028927 | SEAFOOD SPOILAGE INDICATOR - An enzyme based nondestructive sensor for the qualitative detection of spoilage in seafood is provided wherein the sensor does not alter the physical composition of the seafood specimen. The sensor comprises a sampling matrix, at least three or more enzymes in contact with the sampling matrix, and at least one indicator compound in contact with the sampling matrix. The enzymes are capable of interacting with four target chemicals comprising putrescine, cadaverine, histamine and tyramine, which are located on the surface of the seafood specimen. The indicator compound is capable of changing the color of the sampling matrix thereby indicating a qualitative visually detectable color change. A method for the nondestructive detection of the quality of a seafood specimen at any given time and for determining the remaining usable shelf life of the seafood specimen is disclosed. | 02-04-2010 |
Jason A. Berberich, Lexington, KY US
| Patent application number | Description | Published |
|---|---|---|
| 20100227345 | Enzyme containing liquid and delivery system for detection of analytes on surfaces - An aqueous enzyme based sensor comprising one or more enzymes and at least one indicator compound capable of indicating a reaction of at least one of the enzymes with at least one target analyte, wherein the enzyme and the indicator are capable of being delivered, preferably by being sprayed, to a surface having the target analyte without sampling the surface. An aqueous enzyme based sensor is provided that is capable of detecting an enzyme specific substrate as the analyte. This aqueous enzyme based sensor further comprises of one or more enzyme specific substrates in which the sensor detects enzyme inhibition. The aqueous enzyme based sensor optionally comprises one or more of a light scattering additive(s), an adhesive polymer(s), a protein stabilizer(s), a protein stabilizing sugar(s), a surfactant(s), and a solvent(s), and combinations thereof. A dispensing system and a method of detecting a target chemical on a surface without sampling the surface is provided. | 09-09-2010 |
Nathan Robert Berberich, Rotterdam, NY US
| Patent application number | Description | Published |
|---|---|---|
| 20090050410 | METHODS AND SYSTEMS FOR SEALING ROTATING MACHINES - Methods and systems for reducing a flow of ambient air into a bearing lubricating oil system are provided. The system includes a lubricating oil bearing cover that is stationary with respect to the bearing wherein the bearing is configured to support a portion of a rotatable machine shaft. The cover includes a first end cap extending radially inwardly towards the shaft such that a cavity surrounding the bearing is formed by the cover and the first end cap and a set of seal rings positioned substantially concentric with the shaft and forming a seal against lubricating oil flow. The seal rings include a plurality of wire bristles extending radially inwardly from the end cap wherein the wire bristles are configured to extend to a surface of the shaft when assembled and the bristles are configured to present a tortuous flow path to gas infiltrating the cavity. | 02-26-2009 |