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Benner, US
Alan Benner, Poughkeepsie, NY US
| Patent application number | Description | Published |
|---|---|---|
| 20100220749 | METHOD AND ARRANGEMENT FOR LOCAL SYCHRONIZATION IN MASTER-SLAVE DISTRIBUTED COMMUNICATION SYSTEMS - A communication system which consists of several modules—operating in parallel on segments of a packet—to increase speed and handling capacity. One module acts as master, the others are slave modules controlled by control signals derived by the master module. It is important that in each module the data segment and the respective control signal of each packet are correctly synchronized, because in large systems the data paths carrying packet segments and the control signal paths may have substantially different delays. The invention provides for measurement of the propagation delay differences and for introducing a controlled delay in each slave module, so that data segments and control signals can be correctly correlated by delaying either the one or the other. Synchronization packets are transmitted besides normal data packets, for obtaining time stamps which are used to determine the delay difference. | 09-02-2010 |
| 20110019962 | Removable Sleeve for Fiber Optic Connectors for High Density Applications - A sleeve has a handle and extensions to engage a fiber optic connector for insertion into and removal from high density adapters. The sleeve may have multiple connectors installed in a single sleeve and it may be removable. The sleeve has first and second extensions to engage the inner and outer housings, respectively, to insert and remove the fiber optic connector from an adapter. | 01-27-2011 |
| 20110149729 | SWITCHING ARRANGEMENT AND METHOD WITH SEPARATED OUTPUT BUFFERS - A switching device is able to route the arriving data packets according to data packet destination information to dedicated output ports. The switching arrangement has, for each set of input ports in the switching device, a set of output buffers with an output buffer for storing the payload of each data packet at an address in the output buffer which pertains to the same set of output buffers and belongs to the dedicated output ports. At least one of the output buffers has a set of output queues with an output queue for each output port for storing the address of each payload stored in the corresponding output buffer. An arbiter controls a readout order of the stored addresses. For the output buffers which pertain to the same set of output ports a multiplexer multiplexes according to the readout order the payloads from the output buffers to the output ports. | 06-23-2011 |
Alan F. Benner, Poughkeepsie, NY US
| Patent application number | Description | Published |
|---|---|---|
| 20090106771 | System and Method for Providing a Memory Region or Memory Window Access Notification on a System Area Network - A system and method for providing a memory region/memory window (MR/MW) access notification on a system area network are provided. Whenever a previously allocated MR/MW is accessed, such as via a remote direct memory access (RDMA) read/write operation, a notification of the access is generated and written to a queue data structure associated with the MR/MW. In one illustrative embodiment, this queue data structure may be a MR/MW event queue (EQ) data structure that is created and used for all consumer processes and all MR/MWs. In other illustrative embodiments, the EQ is associated with a protection domain. In yet another illustrative embodiment, an event record may be posted to an asynchronous event handler in response to the accessing of the MR/MW. In another illustrative embodiment, a previously posted queue element may be used to generate a completion queue element in response to the accessing of the MR/MW. | 04-23-2009 |
| 20090213861 | Reliable Link Layer Packet Retry - Communication over a computer network with a node having a first port with a point-to-point link connection to a second node having a second port. The first port transmits to the second port a reliable link layer (RLL) packet over the link. The RLL packet comprises a first RLL header and a first data packet, the first RLL header preceding the first data packet, the first RLL header comprising an RLL start-of-frame (SOF) character and an RLL packet sequence number (PSN). If the first port receives an RLL acknowledgment control packet from the link, it acknowledges receipt of the first data packet, and the first port does not retain the first data packet in the buffer. If the first port does not receive the RLL acknowledgment packet from the link, acknowledging receipt of the first data packet, the first port re-transmits from the buffer the first data packet. | 08-27-2009 |
| 20100206627 | ELECTROMAGNETIC INTERFERENCE SHIELDING APPARATUS AND METHOD - A shielding apparatus has first and second electrically conductive sheets attached to an interior of a housing. A gap between the first and second electrically conductive sheets has a size based on a predefined desired cutoff frequency, and the widths of the first and second electrically conductive sheets are no more than twice the size of the gap. The lengths of the first and second electrically conductive sheets are at least four times the size of the gap. | 08-19-2010 |
Alan Frederic Benner, Poughkeepsie, NY US
| Patent application number | Description | Published |
|---|---|---|
| 20090276571 | Enhanced Direct Memory Access - A method for facilitating direct memory access in a computing system in response to a request to transfer data is provided. The method comprises selecting a thread for transferring the data, wherein the thread executes on a processing core within the computing system; providing the thread with the request, wherein the request comprises information for carrying out a data transfer; and transferring the data according to the request. The method may further comprise: coordinating the request with a memory management unit, such that virtual addresses may be used to transfer data; invalidating a cache line associated with the source address or flushing a cache line associated with the destination address, if requested. Multiple threads can be selected to transfer data based on their proximity to the destination address. | 11-05-2009 |
Blair R. Benner, Grand Rapids, MN US
| Patent application number | Description | Published |
|---|---|---|
| 20080307960 | Air Pollutant Removal Using Magnetic Sorbent Particles - Absorbent magnetic particles are used to remove air pollutants. The adsorbent magnetic particles can adsorb various air pollutants, including nitrogen oxides, sulfur oxides, and mercury, and may be regenerated for reuse. | 12-18-2008 |
Carl L. Benner, Bryan, TX US
| Patent application number | Description | Published |
|---|---|---|
| 20090088988 | ARCING EVENT DETECTION - Methods for detecting electrical arcing on an electrical power system are provided, as well as systems and computer program products for carrying out the method. The method includes the steps of: a) obtaining data indicative of the temporal behavior of a signal which is indicative of a first periodic property of the electrical power system; and b) determining whether an arcing event is present on the electrical power system based on the shape observed in the first data. | 04-02-2009 |
| 20090116600 | PHASE DRIFT COMPENSATION FOR SAMPLED SIGNALS - Methods for processing a signal of interest in an electrical power system are provided, as well as systems and computer program products for carrying out the methods. The methods include obtaining a representative window of data points from the signal of interest; obtaining a window of interest containing data points from the signal of interest; and comparing a phase drift compensated window to the representative window, wherein the compensated window is calculated in accordance with the window of interest and a phase drift that is present in the window of interest relative to the representative window. | 05-07-2009 |
| 20090150686 | ELECTRICAL POWER SYSTEM EVENT DETECTION AND ANTICIPATION - A method for analyzing an electrical power system includes analyzing data representing a signal of interest of the power system, the data containing at least one power system event; and based on the analysis, associating the power system event with a root cause. A computer program product is also provided for carrying out the method. | 06-11-2009 |
| 20090210100 | PRIORITIZATION OF POWER SYSTEM RELATED DATA - A method for prioritizing events on an electrical power system, including: (a) acquiring at least one data portion representative of the behavior of the electrical power system, the at least one data portion containing at least one power system event; (b) assigning at least one rank value to the at least one data portion based on the type of power system event, the rank value indicative of a priority of the event; and (c) conducting subsequent operations on the at least one data portion in accordance with the at least one rank value. | 08-20-2009 |
| 20090327201 | IDENTIFICATION OF POWER SYSTEM EVENTS USING FUZZY LOGIC - A method for analyzing an electrical power system using fuzzy logic includes: (a) acquiring data representing a signal of interest of the power system; (b) analyzing the signal using at least one fuzzy logic rule; and (c) based on the analysis, detecting and classifying at least one power system event within the power system. | 12-31-2009 |
| 20100169029 | DIAGNOSIS AND POSITION IDENTIFICATION FOR REMOTE CAPACITOR BANKS - A method of evaluating one or more capacitor banks in an electrical power system includes: (a) acquiring data representing a signal of interest of the power system, where the data describes a plurality of power system events; and (b) based on one or more patterns contained in the data, identifying at least one of the power system events as being associated with capacitor operation. | 07-01-2010 |
| 20110137590 | ARCING EVENT DETECTION - A system for detecting electrical arcing on an electrical power system includes: a) a data acquisition unit that is electrically connected to an electrical power system, wherein the data acquisition unit is configured to monitor signals indicative of a first periodic property of the electrical power system, wherein the signal includes a normal load component; and b) a computing device operably connected to the data acquisition unit. The computing device is programmed to: i) obtain first data from the data acquisition unit indicative of the temporal behavior of the first signal; ii) remove the normal load component from the first data; and iii) determine that an arcing event is present on the electrical power system when the at least one burst within the first data presents a generally sinusoidal shape which includes generally flat regions which are present where the generally sinusoidal shape crosses over a zero-magnitude line. | 06-09-2011 |
David Benner, Honesdale, PA US
| Patent application number | Description | Published |
|---|---|---|
| 20110272658 | PIVOTING FENCING APPARATUS AND FENCING SYSTEM - A fencing apparatus for preventing animals from climbing over a fence, which includes a plurality of first and corresponding second elongated members, is provided. Each of the first and second elongated members pivot relative to each other from a first stationary position to a second variable position. A flexible plastic netting is connected to and extends across the plurality of first and second elongated members. When connected to a vertically extending fence, the fencing apparatus extends from the vertically extending fence such that the second elongated member pivots downwardly upon being subject to a load e.g., by the weight of a climbing animal. | 11-10-2011 |
David Alan Benner, Honesdale, PA US
| Patent application number | Description | Published |
|---|---|---|
| 20080277638 | CAT CONFINEMENT FENCE - A cat confinement fence for limiting a cat from escaping from a confinement area includes a plurality of posts spaced apart and mounted in the ground to define the confinement area. Each of the posts includes a main section and a pivoting section. A first end of each main section is mounted in a ground surface and a second end of each main section is secured to the pivoting section. The pivoting section is pivotable between an upright position and an extended position. Upper fencing is mounted to and between the plurality of posts and extends across at least a portion of the main section and at least a portion of the pivoting section of each of the plurality of posts. A resilient member is mounted proximate to the second end of the main section of each post and biases the pivoting section of the respective post toward the upright position. | 11-13-2008 |
| 20090293411 | Confinement Fence Structure For Climbing Animals and its Associated Methods of Construction and Installation - A fencing system for confining climbing animals. The fencing system uses a plurality of vertical posts that are set in place along a fence line. Arch support brackets are provided that attach to the vertical posts. Each arch support bracket has an ascending section that climbs to an apex point and a descending section that descends from that apex point. Flexible plastic netting is suspended between the rigid supports that are created by the vertical posts and the arch support brackets. Flexible plastic netting is supported vertically by the vertical posts. Above the vertical posts, the flexible plastic netting is supported in an ascending” angle to an apex point by each ascending section of “the arch support brackets. From the apex point, the flexible plastic netting is supported in a descending angle to the free end of the arch support bracket. | 12-03-2009 |
Devin Benner, Pleasant Ridge, MI US
| Patent application number | Description | Published |
|---|---|---|
| 20090255026 | EYE SHADE HAVING CONFORMABLE NOSE PIECE - An eye shade is provided having a first side, a second side, a first eye portion and a second eye portion form from the first side and the second side, a nose portion formed from the first side and the second side, and a conformable nose piece associated with the nose portion wherein the conformable nose piece is adapted to allow the nose portion of the eye shade to be conformed to the user's nose to substantially prevent light from passing between a user's face and the eye shade. | 10-15-2009 |
| 20110094822 | FLAT EARPLUG AND PACKAGE - A flat earplug and flat earplug package assembly is provided and a method of forming a flat earplug. The flat earplug includes a flat, rectangular foam sheet having a first surface and second surface, and adapted to be rolled up upon itself to form a coiled earplug for insertion into a user's ear. An inner coil is compressed to form a rigid coil when rolled up upon itself and an outer coil expands after the coiled earplug is inserted into the user's ear. The flat earplug package assembly includes a tray container for retaining the foam sheet therein and a wrapping for enclosing the flat earplug and tray container therein. | 04-28-2011 |
| 20110308533 | APPARATUS AND METHOD OF ANCHORING AN EAR PIECE - An apparatus and method of anchoring an earpiece is provided. The apparatus includes a flexible member of moldable expandable, semi-adhesive material. The flexible member has a predetermined shape. The method of anchoring an earpiece includes the steps of placing an earpiece in the ear. The method also includes the steps of shaping the flexible member into a ball and placed the shaped flexible member into the concha portion of the ear, such that the shaped flexible member is disposed the earpiece and the antihelix and the earpiece anchor expands to retain the earpiece in the ear. | 12-22-2011 |
James Jay Benner, Morrow, OH US
| Patent application number | Description | Published |
|---|---|---|
| 20110041325 | Modular Converting Line for Fabricating Absorbent Articles - The present disclosure relates to converting lines for manufacturing absorbent articles. The converting lines include a plurality of process equipment converting modules connected with each other along a machine direction (MD). Adjacent converting modules may be releasably connectable to each other with converting module couplers. The converting modules may also have substantially identical dimensions, wherein each converting module defines the same or substantially the same MD length, CD width, and height. The converting modules may also be sized to be received within a standard shipping container. The converting lines may includes a plurality of accessory service modules supported by respective converting modules and connected with each other along the machine directions. The accessory service modules may also be adapted to be received within standard shipping containers. Adjacent accessory service modules may be releasably connected to each other with accessory module couplers, which may include quick-disconnect couplers. | 02-24-2011 |
| 20110041417 | Reconfigurable Converting Line for Fabricating Absorbent Articles - The present disclosure relates to converting lines for manufacturing absorbent articles, and more particularly, to converting lines having modular process equipment modules and converting mechanisms reconfigurable for making different absorbent articles. | 02-24-2011 |
| 20110041997 | Speed Change Kit For An Absorent Article Converting Line - The present disclosure relates to speed change kits adapted to allow converting lines to be reconfigured to operate at different speeds. In one form, a system for fabricating disposable absorbent articles includes a plurality of converting modules; a plurality of absorbent article converting mechanisms; and a speed kit. The plurality of absorbent article converting mechanisms can be configured from a first configuration to a second configuration by modifying the plurality of absorbent article converting mechanisms to include the speed kit. In the first configuration, the plurality of absorbent article converting mechanisms operate to produce absorbent articles at a first speed range; and when in the second configuration, the plurality of absorbent article converting mechanisms operate to produce absorbent articles at a second speed range different from the first speed range. | 02-24-2011 |
| 20110042012 | Systems and Methods for Continuous Delivery of Web Materials - Apparatuses and methods for producing an absorbent article are provided. Generally, the apparatuses and methods allow for continuous delivering of a plurality of web material to downstream equipment during a manufacturing process. In some embodiments, the apparatuses and methods allow for simultaneously unwinding, splicing, and lamination of multiple rolls of web material rotatably mounted to a frame and delivering the web material to various downstream manufacturing processes. | 02-24-2011 |
| 20110046772 | Flexible Manufacturing Systems and Methods - A converting line comprises a first unit at a first region of the converting line and a second unit at a second region of the converting line. The first unit is positioned in series with the second unit. The converting line further comprises a third unit at a third region of the converting line and a fourth unit at a fourth region of the converting line. The first, second, third, and fourth units are configured to each perform at least one function. The third unit is positioned in parallel with the first unit, the second unit, or the fourth unit. The converting line further comprises a controller configured to activate at least one of the units based a received product order. The converting line is configured to produce a first product different from a second product during a single run of the converting line. | 02-24-2011 |
Seico Benner, Santa Cruz, CA US
| Patent application number | Description | Published |
|---|---|---|
| 20090264621 | Lipid-assisted synthesis of polymer compounds and methods for their use - The invention herein disclosed provides for methods for the synthesis of polymers from monomers. In particular the method provides for the synthesis of polynucleotides from mononucleotides in the absence of catalytic enzymes. The invention is of particular use in the fields of molecular biology, structural biology, cell biology, molecular switches, molecular circuits, and molecular computational devices, and the manufacture thereof. | 10-22-2009 |
| 20100035260 | Compositions, devices, systems, for using a Nanopore - The invention herein disclosed provides for devices and methods that can detect and control an individual polymer in a mixture is acted upon by another compound, for example, an enzyme, in a nanopore in the absence of requiring a terminating nucleotide. The devices and methods are also used to determine rapidly (˜>50 Hz) the nucleotide base sequence of a polynucleotide under feedback control or using signals generated by the interactions between the polynucleotide and the nanopore. The invention is of particular use in the fields of drug discovery, molecular biology, structural biology, cell biology, molecular switches, molecular circuits, and molecular computational devices, and the manufacture thereof. | 02-11-2010 |
| 20110005918 | Compositions, devices, systems, and methods for using a nanopore - The invention herein disclosed provides for devices and methods that can detect and control an individual polymer in a mixture is acted upon by another compound, for example, an enzyme, in a nanopore. The devices and methods are also used to determine rapidly (˜>50 Hz) the nucleotide base sequence of a polynucleotide under feedback control or using signals generated by the interactions between the polynucleotide and the nanopore. The invention is of particular use in the fields of molecular biology, structural biology, cell biology, molecular switches, molecular circuits, and molecular computational devices, and the manufacture thereof. | 01-13-2011 |
| 20110174625 | COMPOSITIONS, DEVICES, SYSTEMS, AND METHODS FOR USING A NANOPORE - The invention herein disclosed provides for devices and methods that can detect and control an individual polymer in a mixture is acted upon by another compound, for example, an enzyme, in a nanopore. The devices and methods are also used to determine rapidly (˜>50 Hz) the nucleotide base sequence of a polynucleotide under feedback control or using signals generated by the interactions between the polynucleotide and the nanopore. The invention is of particular use in the fields of molecular biology, structural biology, cell biology, molecular switches, molecular circuits, and molecular computational devices, and the manufacture thereof. | 07-21-2011 |
Stephen J. Benner, Lansdale, PA US
| Patent application number | Description | Published |
|---|---|---|
| 20080202568 | Cleaning cup system for chemical mechanical planarization apparatus - The present invention is related to an improved cleaning cup arrangement for CMP systems that efficiently and effectively removes most, if not all, of any slurry material present on the abrasive conditioning disk and conditioner head as they are resting in the cup between conditioning cycles. The cleaning cup of the present invention includes an underside water knife for directing a high velocity stream of cleaning fluid against the rotating abrasive disk (or conditioning brush, which may be used instead of a disk) surface, and at least a pair of spray stems for directing columns of cleaning fluid with sufficient cleaning force against all exposed portions of the conditioner head. | 08-28-2008 |
| 20090287340 | In-line effluent analysis method and apparatus for CMP process control - An apparatus and method for collecting and analyzing the effluent stream created by a chemical mechanical planarization (CMP) process performs a continuous measurement of at least one effluent characteristic and integrates the results over time to create a volumetric analysis of the planarization process. The volumetric analysis can be used as feedback/feedforward signals to control the planarization process itself (e.g., endpoint detection based upon an known initial thickness of film material), create alarm signals for out-of-range measurements, and/or waste stream indicators useful in treating the effluent prior to discharge (e.g., determining a pH correction). | 11-19-2009 |
| 20110039485 | Apertured Abrasive Disk Assembly With Improved Flow Dynamics - The evacuation properties of an abrasive disk are improved by forming its apertures to exhibit a configuration that will direct process fluids onto or away from a workpiece (or contact) interface through capillary action, surface tension/affinity, and/or boundary layer pump actions. The capillary action is accomplished by modifying the geometries of the apertures to form capillary tubes, where the orientation and lift angle of the capillary tubes is controlled to improve the flow of relatively thin layers of liquids. The surface tension/affinity between a liquid material and the abrasive disk is controlled by modifying the through-hole apertures to exhibit a serrated inner surface, which will decrease the attraction between the material of the abrasive disk and the process liquid. A plurality of apertured disks may be stacked, and their respective apertures properly arranged on each surface, to create a Tesla pump such that the kinetic energy associated with rotation of the disk assembly will preferentially bias both the vertical and tangential flow of liquids between the working surface and the disk assembly. | 02-17-2011 |
| 20110177623 | Active Tribology Management of CMP Polishing Material - An arrangement and method for managing the tribology associated with a chemical mechanical planarization (CMP) process continuously monitors and modifies the properties of a polishing slurry in order to assist in controlling the removal rate associated with the CMP process. The viscosity of slurry as it leaves the CMP system (“spent slurry”) and the material removal rate associated with the semiconductor wafer are measured, and then the viscosity of the incoming slurry is adjusted if the measured material removal rate differs from a desired removal rate. If the removal rate is considered to be too fast, the viscosity of the fresh slurry being dispensed onto polishing pad is decreased; alternatively, if the removal rate is too slow, the viscosity is increased. As an alternative to modifying the viscosity of the slurry (or, perhaps in addition to modifying the viscosity), a lubricant may be added to the slurry to slow down the removal rate. | 07-21-2011 |
Steven A. Benner, Gsinesville, FL US
| Patent application number | Description | Published |
|---|---|---|
| 20110319298 | Differential detection of single nucleotide polymorphisms - This patent application claims processes and compositions of matter that enable the discovery of single nucleotide polymorphisms (SNPs) that distinguish the genomes of two individual organisms in the same species, as well as that distinguish the paternal and maternal genetic inheritance of a single individual, as well as distinguish the genomes of cells in special tissues (e.g. cancer tissues) within an individual from the genomes of the standard cells in the same individuals, as well as the SNPs that are discovered using these processes and compositions. Two steps are essential to the invention disclosed in this application. The first step provides four sets of primers, which are designated “T-extendable”, “A-extendable”, “C-extendable”, and “G-extendable”. These primers, when targeted against a reference genome as a template, add (respectively) T, A, C, and G to their 3′-ends in a template-directed primer extension reaction. The second step presents these four primer sets, separately, to a sample of the target genome DNA under conditions where they bind to their complementary segments within the target DNA. Once bound, members of each primer set serve as primers for a template-directed primer extension reaction using the target genome as the template. If the template from the target genome presents the same templating nucleotide for the first nucleotide added in the extension reaction as the reference genome, then the T-extendable, A-extendable, C-extendable, and G-extendable primers will be extended (respectively) by T, A, C, and G. If, however, the template from the target genome presents a nucleotide different from the reference genome, then the T-extendable, A-extendable, C-extendable, and G-extendable primers will be extended (respectively) by not T, not A, not C, and not G (referred to here as “3N” or “3”, to indicate the other three nucleotides, where which of the other three is understood by context). In these cases, the primers have discovered a SNP, a difference between the target and reference genomes. Then, the T-extendable, A-extendable, C-extendable, and G-extendable primers that add (respectively) not-T, not-A, not-C, and not-G are separated or made otherwise physically distinct (through, for example, the use of irreversible terminators, such as 2′,3′-dideoxynucleosides) from those that added T, A, C, and G (respectively). Those that added T, A, C, and G (respectively) did not discover a SNP, and are discarded. The primers that added “not-T”, “not-A”, “not-C”, and “not-G” discovered a SNP, and presented in a mixture enriched (relative to those primers that did not discover a SNP) in a useful deliverable. Following these steps, the SNPs discoveries are realized by sequencing the extracted species. The information obtained from this sequencing allows the identification of the locus of the SNP in the in silico genome. | 12-29-2011 |
Steven A. Benner, Gainesville, FL US
| Patent application number | Description | Published |
|---|---|---|
| 20110275124 | Reagents for reversibly terminating primer extension - This invention relates to the field of nucleic acid chemistry, more specifically to the field of compositions of matter that comprise triphosphates of modified 2′-deoxynucleosides and oligonucleotides that are formed when these are appended to the 3′-end of a primer, wherein said modifications comprise NH | 11-10-2011 |
Steven Albert Benner, Gainesville, FL US
| Patent application number | Description | Published |
|---|---|---|
| 20090270601 | Differential detection of single nucleotide polymorphisms - This application claims processes and compositions that enable discovery of single nucleotide polymorphisms (SNPs) and other sequence variation that follows two essentially identical sequences, one a reference, the other a target, as well as SNPs discovered using these processes and compositions. The inventive process comprises preparation of four sets of primers, “T-extendable”, “A-extendable”, “C-extendable”, and “G-extendable”. These primers, when templated on a reference genome, add (respectively) T, A, C, and G to their 3′-ends. The invention also comprises a step where these primer sets are separately bound to complementary sequences on target DNA and, once bound, prime extension reactions using target DNA as the template. If the target DNA directs incorporation of the same nucleotide as the reference DNA, then the T-, A-, C-, and G-extendable primers are extended (respectively) by T, A, C, and G. The architecture of the process distinguishes products from these extensions from products derived if not T, not A, not C and not G (“3N” or “3”, to indicate the other three nucleotides) are not added. Thus, this process discovers differences between the target and reference DNA in the site queried by the primer extension reaction. The distinction makes the two kinds of products either separable or differentially extendable. This distinction is used to disregard products that added T, A, C, and G and to identify the sequence(s) of primers that added not-T, not-A, not-C, and not-G. Further and optionally, information from these sequences identifies loci of the SNPs in an in silico genome. | 10-29-2009 |
| 20110117554 | Formamide-containing mixtures for detecting nucleic acids - Specific sequences of DNA are often detected by a process that comprises a step where the sequence to be detected (the “analyte”) binds to give a duplex with a DNA molecule or analog that is complementary in the Watson-Crick sense to some portion of the analyte in an aqueous “assay environment” that may contain buffer, salt, and/or detergent. Such purely aqueous systems cannot be exposed indefinitely to the environment, however, as the water in the system will evaporate. Further, such systems often support the growth of bacteria and other organisms, destroying their effectiveness. This invention provides for compositions of matter and processes that use them that comprise assay mixtures containing more than 40% formamide. This mixture remains a liquid at equilibrium with water in environments normally inhabited by humans. This invention also provides for mixtures containing formamides that include detergents. Formamide is usually regarded as a denaturant for duplex formation, destabilizing the binding that is key to detection. This invention therefore also provides for materials that form duplexes in formamide-water mixtures. | 05-19-2011 |
| 20110124053 | POLYMERASE INCORPORATION OF NON-STANDARD NUCLEOTIDES - The disclosed invention teaches processes to amplify oligonucleotides by contacting templates and primers with DNA polymerases and triphosphates of non-standard nucleotides, which form nucleobase pairs fitting the standard Watson-Crick geometry, but joined by hydrogen bonding patterns different from those that join standard A:T and G:C pairs. Thus, this invention relates to nucleotide analogs and their derivatives that, when incorporated into DNA and RNA, expand the number of replicatable nucleotides beyond the four found in standard DNA and RNA. The invention further relates to polymerases that incorporate those non-standard nucleotide analogs into oligonucleotide products using the corresponding triphosphate derivatives, and more specifically, polymerases and non-standard nucleoside triphosphates that support the polymerase chain reaction (PCR), including PCR where the products contain more than one non-standard nucleotide unit. Examples are provides that show this process using 6-amino-5-nitro-3-(1′-beta-D-2′-deoxyribofuranosyl)-2(1H)-pyridone to implement the non-standard “small” donor-donor-acceptor (pyDDA) hydrogen bonding pattern, and 2-amino-8-(r-beta-D-2′-deoxyribofuranosyl)-imidazo[1,2-α]-1,3,5-triazin-4(8H)-one to implement the “large” acceptor-acceptor-donor (puADD) pattern. | 05-26-2011 |
W. Henry Benner, Danville, CA US
| Patent application number | Description | Published |
|---|---|---|
| 20080302666 | APPARATUS FOR DIFFERENTIAL CHARGED-PARTICLE MOBILITY - The invention provides methods of preparation of lipoproteins from a biological sample, including HDL, LDL, Lp (a), IDL, and VLDL, for diagnostic purposes utilizing differential charged particle mobility analysis methods. Further provided are methods for analyzing the size distribution of lipoproteins by differential charged particle mobility, which lipoproteins are prepared by methods of the invention. Further provided are methods for assessing lipid-related health risk, cardiovascular condition, risk of cardiovascular disease, and responsiveness to a therapeutic intervention, which methods utilize lipoprotein size distributions determined by methods of the invention. | 12-11-2008 |
| 20080305549 | LIPOPROTEIN ANALYSIS BY DIFFERENTIAL CHARGED-PARTICLE MOBILITY - The invention provides methods of preparation of lipoproteins from a biological sample, including HDL, LDL, Lp(a), IDL, and VLDL, for diagnostic purposes utilizing differential charged particle mobility analysis methods. Further provided are methods for analyzing the size distribution of lipoproteins by differential charged particle mobility, which lipoproteins are prepared by methods of the invention. Further provided are methods for assessing lipid-related health risk, cardiovascular condition, risk of cardiovascular disease, and responsiveness to a therapeutic intervention, which methods utilize lipoprotein size distributions determined by methods of the invention. | 12-11-2008 |
| 20100213061 | ION MOBILITY ANALYSIS OF LIPOPROTEINS - A medical diagnostic method and instrumentation system for analyzing noncovalently bonded agglomerated biological particles is described. The method and system comprises: a method of preparation for the biological particles; an electrospray generator; an alpha particle radiation source; a differential mobility analyzer; a particle counter; and data acquisition and analysis means. The medical device is useful for the assessment of human diseases, such as cardiac disease risk and hyperlipidemia, by rapid quantitative analysis of lipoprotein fraction densities. Initially, purification procedures are described to reduce an initial blood sample to an analytical input to the instrument. The measured sizes from the analytical sample are correlated with densities, resulting in a spectrum of lipoprotein densities. The lipoprotein density distribution can then be used to characterize cardiac and other lipid-related health risks. | 08-26-2010 |
| 20110089037 | BIOLOGICAL PARTICLES - A medical diagnostic method and instrumentation system for analyzing noncovalently bonded agglomerated biological particles is described. The method and system comprises: a method of preparation for the biological particles; an electrospray generator; an alpha particle radiation source; a differential mobility analyzer; a particle counter; and data acquisition and analysis means. The medical device is useful for the assessment of human diseases, such as cardiac disease risk and hyperlipidemia, by rapid quantitative analysis of lipoprotein fraction densities. Initially, purification procedures are described to reduce an initial blood sample to an analytical input to the instrument. The measured sizes from the analytical sample are correlated with densities, resulting in a spectrum of lipoprotein densities. The lipoprotein density distribution can then be used to characterize cardiac and other lipid-related health risks. | 04-21-2011 |
William Benner, Flower Mound, TX US
| Patent application number | Description | Published |
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| 20110049048 | WATER PURIFICATION SYSTEM - The present invention concerns a water purification system comprising an ultrafiltration unit, a reverse osmosis unit, and a tank. The ultrafiltration unit is upstream of the tank on an operation conduit and the tank is upstream of the reverse osmosis unit on a reverse osmosis conduit. A backwash conduit is situation between said tank and said ultrafiltration unit. | 03-03-2011 |
| 20110049049 | WATER PURIFICATION SYSTEM SKID - The present invention concerns a water purification system comprising a tank section and a membranes section, wherein the tank section can be positioned with respect to the membranes section to accommodate the specific requirements of the location housing the water purification system. | 03-03-2011 |