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Benakli, US
Kamel Benakli, Blue Bell, PA US
| Patent application number | Description | Published |
|---|---|---|
| 20100093720 | MACROCYCLIC ANTAGONISTS OF THE MOTILIN RECEPTOR FOR TREATMENT OF GASTROINTESTINAL DYSMOTILITY DISORDERS - The present invention provides conformationally-defined macrocyclic compounds that bind to and/or are functional modulators of the motilin receptor including subtypes, isoforms and/or variants thereof. These macrocyclic compounds, at a minimum, possess adequate pharmacological properties to be useful as therapeutics for a range of disease indications. In particular, these compounds are useful for treatment and prevention of disorders characterized by hypermotilinemia and/or gastrointestinal hypermotility, including, but not limited to, diarrhea, cancer treatment-related diarrhea, cancer-induced diarrhea, chemotherapy-induced diarrhea, radiation enteritis, radiation-induced diarrhea, stress-induced diarrhea, chronic diarrhea, AIDS-related diarrhea, | 04-15-2010 |
Kamel Benakli, Skippack, PA US
| Patent application number | Description | Published |
|---|---|---|
| 20090137817 | SPATIALLY-DEFINED MACROCYCLIC COMPOUNDS USEFUL FOR DRUG DISCOVERY - Novel spatially-defined macrocyclic compounds containing specific conformational control elements are disclosed. Libraries of these macrocycles are then used to select one or more macrocycle species that exhibit a specific interaction with a particular biological target. In particular, compounds according to the invention are disclosed as agonists or antagonists of a mammalian motilin receptor and a mammalian ghrelin receptor. | 05-28-2009 |
| 20090198050 | Macrocyclic Modulators of the Ghrelin Receptor - The present invention provides novel conformationally-defined macrocyclic compounds that have been demonstrated to be selective modulators of the ghrelin receptor (growth hormone secretagogue receptor, GHS-R1a and subtypes, isoforms and variants thereof). Methods of synthesizing the novel compounds are also described herein. These compounds are useful as agonists of the ghrelin receptor and as medicaments for treatment and prevention of a range of medical conditions including, but not limited to, metabolic and/or endocrine disorders, gastrointestinal disorders, cardiovascular disorders, obesity and obesity-associated disorders, central nervous system disorders, genetic disorders, hyperproliferative disorders and inflammatory disorders. | 08-06-2009 |
| 20090240027 | INTERMEDIATES FOR MACROCYCLIC COMPOUNDS - The present invention is directed to novel macrocyclic compounds of formula (I) and their pharmaceutically acceptable salts, hydrates or solvates: | 09-24-2009 |
Mourad Benakli, Shrewbury, MA US
| Patent application number | Description | Published |
|---|---|---|
| 20110085267 | Media Design for High TPI for Write Fringing Reduction - A recording media design having discrete track recording structure where the trenches between tracks are filled with a soft magnetic material is provided. The soft magnetic material provides a low magnetic impedance path to the soft underlayer such that fringe fields from the write head are conducted to the soft underlayer without having a negative effect such as adjacent track erasure. A method of manufacturing the media includes a nano-imprint step and ion milling out the data layer to create the trenches. A B | 04-14-2011 |
Mourad Benakli, Bloomington, MN US
| Patent application number | Description | Published |
|---|---|---|
| 20100061019 | MAGNETIC STORAGE SYSTEM WITH READ DURING WRITE - A magnetic storage system includes a magnetic storage medium and a transducer positioned adjacent the magnetic storage medium. The transducer has a reader positioned adjacent writer and a reader bias coil located on the transducer. Transducer circuitry is configured to apply a bias signal to the reader bias coil during a read-write operation. The reader bias coil generates a reader bias field proximate the reader. | 03-11-2010 |
| 20110007428 | WRITE POLE WITH A SYNTHESIZED LOW MAGNETIZATION SHIELD - A magnetic writer comprises a surface, a write pole, a trailing shield and a gap. The write pole has a write pole tip proximate the surface. The trailing shield is proximate the surface and space away from the write pole. The gap is proximate the surface and located between the write pole tip and the trailing shield. The gap has an effective thickness. The gap comprises a first write gap and a synthesized low magnetization shield. The synthesized low magnetization shield is configured such that a magnetization of the synthesized magnetization shield adjacent the surface has a perpendicular component in an opposite direction to the magnetization of the write pole tip during a write operation. | 01-13-2011 |
| 20110109999 | MAGNETIC SHIELD STRUCTURE - An apparatus and associated method for a magnetic shield structure for data transduction from a recordable media in a data storage device. Various embodiments of the present invention are generally directed to a data transducer and a magnetic shield structure comprising a write shield magnetic material constructed of exchange decoupled material. | 05-12-2011 |
Mourad Benakli, Pittsburgh, PA US
| Patent application number | Description | Published |
|---|---|---|
| 20090004509 | PATTERNED MAGNETIC MEDIA FOR MAGNETIC RECORDING - A patterned magnetic media is disclosed. The patterned media includes etched recording portions including etched portions of a soft magnetic underlayer. In illustrated embodiments, the soft magnetic layer is etched to form recording bits or etched soft magnetic segments to enhance magnetic field strength in the magnetic recording portions. In other embodiments, soft magnetic layers are deposited in etched regions or areas of the media. | 01-01-2009 |