| Patent application number | Description | Published |
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| 20100068701 | CHROMOSOME LABELING METHOD - A method of sample analysis is provided. In certain embodiments, the method may involve a) contacting a genomic sample comprising a test chromosome with a plurality of sets of labeled oligonucleotide probes under in situ hybridization conditions to produce a contacted sample having an oligonucleotide binding pattern; b) imaging the contacted sample to provide an image showing the oligonucleotide binding pattern; and c) analyzing the oligonucleotide binding pattern to identify a chromosomal rearrangement in the test chromosome relative to a reference chromosome. | 03-18-2010 |
| 20100221708 | METHOD FOR CHROMOSOME ENUMERATION - A method of sample analysis is provided. The method comprises: a) contacting a genomic sample comprising a plurality of intact chromosomes, i.e., metaphase or interphase chromosomes, with a first set of labeled oligonucleotide probes under in situ hybridization conditions to produce a contacted sample comprising labeled chromosomes, where i. each of the labeled oligonucleotide probes is complementary to a non-repetitive, unique sequence in a region that flanks the centromere of a single chromosome of the plurality of chromosomes; and ii. hybridization of the labeled oligonucleotide probes to the chromosomes produces a distinct labeling pattern for each hybridized chromosome, thereby allowing each of the labeled chromosomes to be distinguished from one another; b) imaging the hybridized chromosomes to provide an image showing the labeling pattern for each labeled chromosome; and c) enumerating a labeled chromosome based on the labeling pattern of said labeled chromosome. A composition and kits for performing the method are also provided. | 09-02-2010 |
| 20100330556 | GENOME ANALYSIS USING A NICKING ENDONUCLEASE - A method of genome analysis is provided. In certain embodiments, the method of comprises: a) contacting a genomic sample comprising a double-stranded DNA with a site-specific nicking endonuclease to provide a nicked double-stranded DNA comprising a plurality of nick sites, in which the nicking endonuclease nicks a site adjacent to a variable nucleotide; b) contacting the nicked double-stranded DNA with a polymerase in the presence of a nucleotide composition comprising a first labeled nucleotide comprising a first label, thereby producing a labeled double-stranded DNA that is not labeled at every nick site; c) stretching out the labeled double-stranded DNA to provide a stretched, labeled double-stranded DNA; and d) imaging the stretched, labeled double-stranded DNA to identify a labeling pattern on the stretched labeled double-stranded DNA. | 12-30-2010 |
| 20100330557 | GENOMIC COORDINATE SYSTEM - A method of sample analysis is provided. In certain embodiments, the method comprises: a) site-specifically labeling a test genome with at least two different labels to produce a labeled genome labeled at a plurality of discrete sites across the genome; b) stretching a nucleic acid of the labeled genome to produce a linear pattern of the different labels along a region of a stretched nucleic acid; c) reading the labels along the region to provide a test pattern comprising a sequence of colors emitted by the labels; d) comparing the test pattern to a plurality of reference patterns obtained from a reference genome, in which the reference patterns are mapped to corresponding genomic locations in the reference genome; and e) identifying one or more reference patterns that match the test pattern, thereby mapping a location for the region in the test genome. | 12-30-2010 |
| Patent application number | Description | Published |
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| 20110022688 | OBTAINING AND DISPLAYING NETWORK TOPOLOGY INFORMATION - Computer-readable media, methods and network information computer systems are provided for obtaining network topology information about a relationship between a configuration item and a network of configuration items based upon a property of the selected configuration item, and displaying the network topology information as a topological map. | 01-27-2011 |
| 20110202511 | GRAPH SEARCHING - Systems, methods, and other embodiments associated with graph searching are described. One example method includes selecting a first engine for searching a graph for instances of a pre-specified sub-graph. The example method may also include controlling execution of a search for the pre-specified sub-graph using the first engine. The example method may also include storing performance data describing a performance indicator of the search. | 08-18-2011 |
| 20110231418 | GRAPH TRANSFORMATION - Systems, methods, and other embodiments associated with graph transformation are described. One example method includes transforming a base graph into a folded graph as a function of a folding query. | 09-22-2011 |
| 20110270861 | GRAPH QUERY ADAPTATION - Systems, methods, and other embodiments associated with graph query adaptation are described. One example method includes generating an adapted topological query from a base topological query. The adapted topological query may be generated upon detecting a pre-specified sub-graph in the base topological query. The example method may also include executing the adapted topological query on a stored graph to generate a query result. | 11-03-2011 |
| 20110295841 | VIRTUAL TOPOLOGICAL QUERIES - Systems, methods, and other embodiments associated with virtual topological queries are described. One example method includes executing a first topological query on a stored graph to generate a first result graph. The example method may also include manipulating the first result graph to generate a virtual query result graph as a function of a second topological query. The example method may also include providing the virtual query result graph. | 12-01-2011 |
| 20120023409 | OBTAINING AND DISPLAYING NETWORK TOPOLOGY INFORMATION - Computer-readable media, methods and network information computer systems are provided for obtaining network topology information about a relationship between a configuration item and a network of configuration items based upon a property of the selected configuration item, and displaying the network topology information as a topological map. | 01-26-2012 |
