| Patent application number | Description | Published |
|---|
| 20090012300 | Process for the Preparation of an (Hetero) Arylamine - The present invention relates to a process for the preparation of an (hetero)arylamine, wherein an optionally substituted (hetero)aromatic bromide compound is contacted with a nucleophilic organic nitrogen-containing compound in the presence of a base, and a catalyst comprising a copper atom or ion and at least one ligand, said ligand comprising at least one coordinating oxygen atom, and if said oxygen atom is part of an OH group, then said OH group is attached to an aliphatic spa carbon atom or to a vinylic carbon atom. | 01-08-2009 |
| 20090043112 | Process for the Preparation of Enantiomerically Enriched Indoline-2-Carboxylic Acid - The present invention relates to a process for the preparation of an enantiomerically enriched optionally substituted indoline-2-carboxylic acid or a salt thereof, wherein an enantiomerically enriched chiral ortho-X-substituted phenylalanine compound, wherein X is a leaving group, is subjected to cyclisation, preferably at a temperature of below about 140° C., upon formation of the enantiomerically enriched indoline-2-carboxylic acid compound. | 02-12-2009 |
| 20100143981 | WHOLE-CELL CATALYTIC SYSTEM COMPRISING A HYDANTOINASE, A RACEMASE AND A CARBAMOYLASE - The present invention relates to a whole cell catalytic system for the preparation of an enantiomerically enriched α-amino acid from a corresponding hydantoin wherein hydantoinase, L-carbamoylase and hydantoin racemase are coexpressed in a recombinant micro-organism wherein the genes coding for these three enzymes are located on a single replicon. The present invention further relates to the use of such a whole cell catalytic system according in the preparation of an enantiomerically enriched L-α-amino acid from a corresponding hydantoin. | 06-10-2010 |
| 20100174092 | NOVEL 5 SUBSTITUTED HYDANTOINS - The present invention relates to 5-substituted hydantoins, a process for the preparation of 5-substituted hydantoins and the use of 5-substituted hydantoins in the preparation of enantiomerically enriched α-amino acids. Furthermore, the present invention relates to the preparation of pharmaceutically active products such as perindopril and ramipril using the novel 5-substituted hydantoins. | 07-08-2010 |
| 20100221796 | NOVEL CARBAMOYLGLYCINE DERIVATIVES - The present invention relates to carbamoylglycine derivatives, a process for the preparation of carbamoylglycine derivatives and the use of carbamoylglycine derivatives in the preparation of enantiomerically enriched α-amino acids. Furthermore, the present invention relates to the preparation of pharmaceutically active products such as perindopril and ramipril using the novel carbamoylglycine derivatives. | 09-02-2010 |
| 20100324304 | IMPROVED RAMIPRIL SYNTHESIS - The present invention relates to the preparation of ramipril (formula [1]) from unprotected (2S,3S,6S)-octahydrocyclopenta[b]pyrrole-2-carboxylic acid and to a method for preparing unprotected (2S,3S,6S)-octahydrocyclopenta[b]pyrrole-2-carboxylic acid. | 12-23-2010 |
| 20110008852 | CONVERGENT SYNTHESIS OF RENIN INHIBITORS AND INTERMEDIATES USEFUL THEREIN - Described is a method for the preparation of renin inhibitors such as aliskiren, and intermediates useful therein. The method introduces a nitrogen-containing intermediate such as a lactone of formula (8). with R | 01-13-2011 |
| 20110263871 | METHOD FOR THE SYNTHESIS OF A RAMIPRIL INTERMEDIATE - The present invention relates to a process for the preparation of octahydrocyclopenta[b]pyrrole-2-carboxylic acid and esters thereof of general formula (1) in the presence of a cobalt and/or nickel comprising catalyst and to the use of compounds of general formula (1) in the synthesis of ramipril. | 10-27-2011 |
