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Belmares
Michael Belmares, Campbell, CA US
| Patent application number | Description | Published |
|---|---|---|
| 20100092944 | DETECTION OF INFLUENZA VIRUS - The present application describes methods for detecting influenza A and/or influenza B and/or distinguishing between pathogenic and seasonal influenza A subtypes. Many of these preferred formats employ pan-specific antibodies (i.e., that react with all or at least multiple strains within an influenza type) to detect presence of influenza A and/or influenza B and PDZ domains in combination with panspecific antibodies to influenza A to distinguish pathogenic and seasonal influenza A subtypes. | 04-15-2010 |
| 20100112547 | METHODS AND COMPOSITIONS FOR DIAGNOSIS AND TREATMENT OF INFLUENZA - The invention provides method and compositions for determining the presence and amount of an influenza virus in a sample including high risk strains of Influenza A. Also provided are methods for determining whether a subject is infected with a influenza virus, as well as, the type and strain of the influenza virus. The methods involve contacting a sample from the subject with a PDZ polypeptides (PDZ) and/or PDZ ligands (PL) and determining whether binding interactions occur between PDZ and PL. Assays for identifying anti-viral agents are also provided, as well as, methods for using the compositions to alter PDZ binding to PL in influenza infected cells. | 05-06-2010 |
Michael Belmares, Sunnyvale, CA US
| Patent application number | Description | Published |
|---|---|---|
| 20090233380 | Methods and Compositions of Conjugating Gold to Biological Molecules - The present application describes methods for conjugating gold to biological molecules and conjugates resulting from the same. The method provides superior gold conjugated biomolecules with higher sensitivity than those made from conventional gold conjugation methods. | 09-17-2009 |
Michael P. Belmares, Sunnyvale, CA US
| Patent application number | Description | Published |
|---|---|---|
| 20100152294 | Assays For Detecting Inhibitors Of Binding Between COX-2 And PDZ Proteins - The invention provides an assay for determining whether a test agent is a COX modulator. In general terms, the assay includes: determining whether a test agent modulates binding of a PDZ-containing polypeptide to a COX PL-containing polypeptide. The PDZ-containing polypeptide may contain the PDZ domain of PDZ domain of MAGI1, TIP-1, MAST2, PSD95, or SHANK. The assays may be done in a cell-free environment or in a cellular environment, particularly using a neuronal cell. The invention finds use in a variety of therapeutic applications, including for identifying agents for use in treating cancer, pain, inflammation and neuronal conditions caused by acute insult, e.g., stroke. | 06-17-2010 |
Michael P. Belmares, Campbell, CA US
| Patent application number | Description | Published |
|---|---|---|
| 20100062985 | AGENTS AND METHODS FOR TREATING PAIN - The invention provides agents useful for treating pain. An exemplary agent comprises or consists of the a portion of a retroviral Tat protein. One such agent is the peptide Tat-NR2B9c. This peptide has previously been described as an agent for inhibiting damaging effects of stroke and similar conditions via inhibition of PSD95 interactions with NMDA receptors and/or NOS. The present application provides data showing that the Tat-NR2B9c peptides is effective in alleviation of pain. The alleviation of pain can be obtained at a dose of the peptide below the dose required to inhibit PSD-95 interactions with NMDAR or NOS. | 03-11-2010 |