Bedzyk
Joseph Bedzyk, Mentor, OH US
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20090308564 | METHOD OF FORMING A PATTERN - A method of forming a pattern includes providing an actual core having dimensions which are different from dimensions of an ideal core. A best fit spatial relationship of the actual core to a spatial envelope for an ideal core is determined. Locating surfaces in a die are moved to positions, at least some of which are offset from ideal core locating positions, in which the actual core is positioned in a best fit spatial relationship with the spatial envelope for the ideal core. A plurality of motors may be utilized to move the core locating surfaces to desired locating positions. The actual core is positioned in engagement with the core locating surfaces and a flow of wax is conducted into the die. If desired, a best fit spatial relationship of the actual core to a die cavity may be determined, rather than a best fit with an ideal core. | 12-17-2009 |
Laura A. Bedzyk, Odessa, DE US
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20110020794 | METHOD FOR THE DETECTION OF DIAGNOSTIC RNA - Methods for the direct detection of diagnostic target RNA have been developed, which obviate the need for time consuming RNA purification and isolation procedures. | 01-27-2011 |
20120122153 | ACID-CLEVABLE LINKERS EXHIBITING ALTERED RATES OF ACID HYDROLYSIS - An acid-cleavable peptide linker comprising aspartic acid and proline residues is disclosed. The acid-cleavable peptide linker provides an altered sensitivity to acid-hydrolytic release of peptides of interest from fusion peptides of the formula PEP1-L-PEP2. The inventive linker, L, is described in various embodiments, each of which provides substantially more rapid acid-release of peptides of interest than does a single aspartic acid-proline pair. In an additional aspect, a method of increasing the stability of an acid cleavable linkage to acid hydrolysis is also provided. | 05-17-2012 |
20140080998 | ACID-CLEAVABLE LINKERS EXHIBITING ALTERED RATES OF ACID HYDROLYSIS - An acid-cleavable peptide linker comprising aspartic acid and proline residues is disclosed. The acid-cleavable peptide linker provides an altered sensitivity to acid-hydrolytic release of peptides of interest from fusion peptides of the formula PEP1-L-PEP2. The inventive linker, L, is described in various embodiments, each of which provides substantially more rapid acid-release of peptides of interest than does a single aspartic acid-proline pair. In an additional aspect, a method of increasing the stability of an acid cleavable linkage to acid hydrolysis is also provided. | 03-20-2014 |
20140221608 | ACID-CLEAVABLE LINKERS EXHIBITING ALTERED RATES OF ACID HYDROLYSIS - An acid-cleavable peptide linker comprising aspartic acid and proline residues is disclosed. The acid-cleavable peptide linker provides an altered sensitivity to acid-hydrolytic release of peptides of interest from fusion peptides of the formula PEP1-L-PEP2. The inventive linker, L, is described in various embodiments, each of which provides substantially more rapid acid-release of peptides of interest than does a single aspartic acid-proline pair. In an additional aspect, a method of increasing the stability of an acid cleavable linkage to acid hydrolysis is also provided. | 08-07-2014 |
Mark D. Bedzyk, Pittsford, NY US
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20090122959 | COMPACT AND DURABLE ENCASEMENT FOR A DIGITAL RADIOGRAPHY DETECTOR - A digital radiography detector includes a housing and a radiographic image detector assembly. The housing has a first and second spaced planar members and four side walls defining a cavity. The radiographic image detector assembly is mounted within the cavity for converting a radiographic image to an electronic radiographic image. The detector assembly includes a scintillator screen and a detector array, and the detector assembly is bonded to the first planar member of the housing. | 05-14-2009 |
20100158197 | COMPACT AND DURABLE ENCASEMENT FOR A DIGITAL RADIOGRAPHY DETECTOR - A digital radiography detector includes a housing and a radiographic image detector assembly. The housing has a first and second spaced planar members and four side walls defining a cavity. The radiographic image detector assembly is mounted within the cavity for converting a radiographic image to an electronic radiographic image. The detector assembly includes a scintillator screen and a detector array, and the detector assembly is bonded to the first planar member of the housing. | 06-24-2010 |
20110272588 | COMPACT AND DURABLE ENCASEMENT FOR A DIGITAL RADIOGRAPHY DETECTOR - A digital radiography detector includes a housing having first and second spaced planar members and four side walls defining a cavity. A radiographic image detector assembly is mounted within the cavity for converting a radiographic image to an electronic radiographic image. The detector assembly includes a detector array mounted on a stiffener. A shock absorbing elastomer assembly is located within the cavity for absorbing shock to the detector array/stiffener in directions perpendicular to and parallel to the detector array/stiffener. | 11-10-2011 |
William Bedzyk, Odessa, DE US
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20140308751 | Assays for Analyte Homologs - Methods include adjusting a contribution of one of two analyte homologs to an amount of signal obtained in an assay for determining a total amount of the two analyte homologs in a sample. A non-assay receptor is employed that has a greater binding affinity for whichever of the two analyte homologs whose contribution to the amount of signal is to be adjusted. An amount of the non-assay receptor is sufficient to achieve an adjustment of the contribution of the analyte homolog to the signal. The assay for determining the total amount of the two analyte homologs is conducted where the assay utilizes at least one assay antibody. | 10-16-2014 |
20150037797 | IMMUNOASSAY FOR DETECTION OF SPECIFIC NUCLEIC ACID SEQUENCES SUCH AS MIRNAS - The invention relates to a method of detecting nucleic acid molecules by immunoassay detection. Detection of a specific nucleic acid molecule of interest is achieved by using a nucleic acid probe in solution which hybridizes in solution to the nucleic acid molecule of interest. Immunoassay detection is achieved by using an antibody specific for the hybrid formed by hybridization of the nucleic acid probe to the nucleic acid molecule of interest. | 02-05-2015 |
William D. Bedzyk, Odessa, DE US
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20120045847 | ASSAY FOR ANALYTES USING MULTIPLE RECEPTORS - A method for determining an analyte in a sample suspected of containing the analyte comprises providing in combination a medium, the sample, and two or more different receptors. Each different receptor binds to at least two different epitopic sites. One of the epitopic sites is a common binding site and one of the epitopic sites is non-common binding site. The non-common epitopic sites are different for each different receptor. The receptors exhibit mono-molecular binding. The medium is incubated under conditions for binding of the receptors to the epitopic sites. The medium is examined for the presence and/or amount of complexes comprising the epitopic sites and the receptors. The presence and/or amount of the complexes indicate the presence and/or amount of the analyte in the sample. | 02-23-2012 |