Patent application number | Description | Published |
20120258546 | Automated On-Instrument pH Adjustment - A method of preparing a sequencing device includes determining a sensitivity of a pH of a solution to a first reagent, determining an amount of the first reagent to add to the solution to approach a target pH, adding the amount of the first reagent to the solution, and diluting a nucleotide solution with the solution. | 10-11-2012 |
20120261274 | METHODS AND APPARATUS FOR MEASURING ANALYTES - A method is provided to sample a sensor array. The method can include measuring a waveform associated with a chemical event occurring on the sensor array. The waveform can include at least one region associated with expected measured values and at least one region associated with unpredictable measured values. The method can also include applying a first frame averaging to the at least one region associated with the expected measured values. Here, a first number of frames can be included in the first frame averaging. Further, the method can include applying a second frame averaging to the at least one region associated with the unpredictable measured values, where a second number of frames can be included in the second frame averaging. The second number of frames can be less than the first number of frames. | 10-18-2012 |
20120265474 | METHODS AND APPARATUS FOR MEASURING ANALYTES - A method, computer program product, and system are provided to calibrate a sensor array with a plurality of sensors. The method can include sweeping a voltage of a reference electrode from a first voltage to a second voltage, where the reference electrode is in fluid communication with the sensor array. The output voltage of each of the plurality of sensors can be monitored at one or more voltages within the first and second voltages. An overall average gain of the plurality of sensors can be calculated at each of the one or more voltages. Further, an acquisition window for the sensor may can be determined. The acquisition window can include a maximum distribution of sensors that provides a maximal overall average gain at a particular reference electrode voltage. | 10-18-2012 |
20130143221 | Method and Apparatus for Identifying Defects in a Chemical Sensor Array - In one implementation, a method for operating an apparatus is described. The method includes applying a bias voltage to place a transistor of a reference sensor in a known state. The reference sensor is in an array of sensors that further includes a chemical sensor coupled to a reaction region for receiving at least one reactant. The method further includes acquiring an output signal from the reference sensor in response to the applied bias voltage. The method further includes determining a defect associated with the array if the output signal does not correspond to the known state. | 06-06-2013 |
20130231870 | METHODS AND COMPUTER PROGRAM PRODUCTS FOR COMPRESSION OF SEQUENCING DATA - A compression method includes measuring a waveform associated with a chemical event occurring on a sensor array, wherein the waveform comprises at least one region associated with expected measured values and at least one region associated with unpredictable measured values; applying a first compression process to the waveform, the first compression process including an averaging of one or more frames in one or more portions of the waveform; and applying a second compression process to the waveform, the second compression process including a truncating of data corresponding to a portion of the waveform that is not related to a nucleotide incorporation component of the waveform. | 09-05-2013 |
20140324376 | METHODS AND APPARATUS FOR MEASURING ANALYTES - A method, computer program product, and system are provided to calibrate a sensor array with a plurality of sensors. The method can include sweeping a voltage of a reference electrode from a first voltage to a second voltage, where the reference electrode is in fluid communication with the sensor array. The output voltage of each of the plurality of sensors can be monitored at one or more voltages within the first and second voltages. An overall average gain of the plurality of sensors can be calculated at each of the one or more voltages. Further, an acquisition window for the sensor may can be determined. The acquisition window can include a maximum distribution of sensors that provides a maximal overall average gain at a particular reference electrode voltage. | 10-30-2014 |
Patent application number | Description | Published |
20100225666 | DIGITAL OPTICAL COMPARATOR - A digital optical comparator has a holder for a part under study. A light source illuminates the part and casts an image of the part onto a camera, which is provided with a lens. The image captured by the camera is displayed on a screen, and a drawing of the part is overlaid on the image of the part. Thus, defects in manufacturing can be easily and readily identified. In addition, a determination of whether the part is manufactured within tolerances can also be visually determined. | 09-09-2010 |
20120249820 | Automatic Determination of Compliance of a Part with a Reference Drawing - A system for visually comparing a part to a drawing of said part in computer memory or on a screen is provided. The system includes a camera for capturing either a single image or an image stream of the part, a computing module for receiving the image or image stream, for obtaining, scaling, positioning and displaying the drawing of the part on a display unit and for overlaying the drawing on the image or image stream. The system determines if the part is manufactured within predefined tolerances at least one control section. In use, a user defines at least one control section and the system performs a CAD-space to image-space transformation of each control section. A deviation between the CAD drawing and the part at each control section is calculated, and this deviation is indicated to the user. The deviation is compared to a predetermined tolerance in order to determine if the part at each control section is within the predetermined tolerance; and a pass/fail indication is determined based on the comparison. For more complex shapes, a user can select an entire geometrical shape, and the system automatically determines a plurality of control sections within the geometric shape, in order to provide the user with a shape pass/fail indication. | 10-04-2012 |
Patent application number | Description | Published |
20090240027 | INTERMEDIATES FOR MACROCYCLIC COMPOUNDS - The present invention is directed to novel macrocyclic compounds of formula (I) and their pharmaceutically acceptable salts, hydrates or solvates: | 09-24-2009 |
20110105389 | Macrocyclic Ghrelin Receptor Antagonists and Inverse Agonists and Methods of Using the Same - The present invention provides novel conformationally-defined macrocyclic compounds that have been demonstrated to be selective modulators of the ghrelin receptor (GRLN, growth hormone secretagogue receptor, GHS-R1a and subtypes, isoforms and/or variants thereof). Methods of synthesizing the novel compounds are also described herein. These compounds are useful as antagonists or inverse agonists of the ghrelin receptor and as medicaments for treatment and prevention of a range of medical conditions including, but not limited to, metabolic and/or endocrine disorders, obesity and obesity-associated disorders, appetite or eating disorders, addictive disorders, cardiovascular disorders, gastrointestinal disorders, genetic disorders, hyperproliferative disorders, central nervous system disorders and inflammatory disorders. | 05-05-2011 |
20110237785 | SPATIALLY-DEFINED MACROCYCLIC COMPOUNDS USEFUL FOR DRUG DISCOVERY - Novel spatially-defined macrocyclic compounds containing specific conformational control elements are disclosed. Libraries of these macrocycles are then used to select one or more macrocycle species that exhibit a specific interaction with a particular biological target. In particular, compounds according to the invention are disclosed as agonists or antagonists of a mammalian motilin receptor and a mammalian ghrelin receptor. | 09-29-2011 |
20110245459 | Processes for Intermediates for Macrocyclic Compounds - The present invention is directed to novel macrocyclic compounds of formula (I) and their pharmaceutically acceptable salts, hydrates or solvates: | 10-06-2011 |