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Beard, CA
Chris Beard, Concord, CA US
| Patent application number | Description | Published |
|---|---|---|
| 20100047778 | Methylation Specific Primer Extension Assay for the Detection of Genomic Imprinting Disorders - Provided is a method for determining genomic imprinting disorders in a patient based upon methylation specific primer extension in a format amenable to high throughput and multiplex formats. After bisulfite modification of a genomic sample, DNA is amplified and hybridized to discrimination primers specific for a CpG dinucleotide site in the sample. Because no extension products from the discrimination primers are produced from DNA that has a deletion or functional inactivation at the CpG site, the sample may be diagnosed as having a genomic imprinting disorder by way of comparison with a normal sample. | 02-25-2010 |
| 20100136541 | IDENTIFICATION AND VERIFICATION OF METHYLATION MARKER SEQUENCES - The present invention relates to methods for identifying among the genes that are down-regulated in cells or tissues having disease including cancer, the CpG sites within the CpG islands of said genes, wherein the identified CpG sites show great potential for diagnostic utility. In another aspect, the present invention also provides methods of using the selected CpG sites for purposes of diagnosis, prognosis, staging, assessing or monitoring the therapy of or recovery from a disease such as cancer. | 06-03-2010 |
Nigel P. Beard, Redwood City, CA US
| Patent application number | Description | Published |
|---|---|---|
| 20090081768 | Devices and Methods for Thermally Isolating Chambers of an Assay Card - An assay card and devices and methods for isolating chambers on the assay card are described. The assay card comprises a substrate formed of one or more materials, e.g., plastic, having a softening temperature, the substrate defining channels communicating with respective reaction chambers. The assay card may be heated in a region of the channels to at least the softening temperature. The softened plastic may be deformed, e.g., with a tool which may or may not also provide the heat for softening the substrate. In this manner, the plastic of the substrate may be caused to at least partially obstruct the channels, thereby isolating the reaction chambers. The invention also relates to a method of manufacturing a tool device that includes pins for heating and deforming an assay card. | 03-26-2009 |
| 20090191098 | High Density Plate Filler - A filling apparatus for filling a microplate. The microplate having a plurality of wells each sized to receive an assay. The filling apparatus can comprise an assay input layer having a first surface and an opposing second surface. The assay input layer can comprise an assay input port extending from the first surface to the second surface and at least one pressure nodule extending from the second surface. An output layer can comprise a plurality of staging capillaries each having an inlet and an outlet. The output layer can further comprise a capillary plane disposed above the plurality of staging capillaries in fluid communication with the assay input port. The capillary plane can be sized to draw the assay from the assay input port to generally flood fill the plurality of staging capillaries. | 07-30-2009 |
| 20090197277 | High Density Plate Filler - A filling apparatus for filling a microplate. The microplate having a plurality of wells each sized to receive an assay. The filling apparatus can comprise an assay input layer having a first surface and an opposing second surface. The assay input layer can comprise an assay input port extending from the first surface to the second surface and at least one pressure nodule extending from the second surface. An output layer can comprise a plurality of staging capillaries each having an inlet and an outlet. A intermediate layer can be disposed between the assay input layer and the output layer. The intermediate layer can be flexible and comprise a plurality of microfluidic channels and a flow aperture being in fluid communication with the assay input port and the plurality of microfluidic channels. The assay input layer can be moveable relative to the intermediate layer such that the at least one pressure nodule engages the intermediate layer to apply a clamping force on at least a portion of one of the plurality of microfluidic channels to reduce flow of the assay therethrough. | 08-06-2009 |
| 20100236930 | Electrowetting Dispensing Devices and Related Methods - A method for dispensing liquid for use in biological analysis may comprise positioning liquid to be dispensed via electrowetting. The positioning may comprise aligning the liquid with a plurality of predetermined locations. The method may further comprise dispensing the aligned liquid from the plurality of predetermined locations through a plurality of openings respectively aligned with the predetermined locations. The dispensing may be via electrowetting. | 09-23-2010 |
| 20110020179 | Systems and Methods for Multiple Analyte Detection - Systems and methods for multiple analyte detection include a system for distribution of a biological sample that includes a substrate, wherein the substrate includes a plurality of sample chambers, a sample introduction channel for each sample chamber, and a venting channel for each sample chamber. The system may further include a preloaded reagent contained in each sample chamber and configured for nucleic acid analysis of a biological sample that enters the substrate and a sealing instrument configured to be placed in contact with the substrate to seal each sample chamber so as to substantially prevent sample contained in each sample chamber from flowing out of each sample chamber. The substrate can be constructed of detection-compatible and assay-compatible materials. | 01-27-2011 |
Patrick Beard, Pleasanton, CA US
| Patent application number | Description | Published |
|---|---|---|
| 20110066897 | METHODS AND APPARATUSES FOR DETERMINING PERMANENT MEMORY GROWTH - Methods and apparatuses that correlate a plurality of snapshots of system resources to identify allocation of permanent resource objects are described. Each snapshot may include an inventory of resource objects already allocated at the time of the snapshot. The plurality of snapshots may be taken at different instants over a period of time. Temporarily allocated resource objects may be filtered from the plurality of snapshots to identify permanent resource objects according to the correlation among the plurality of snapshots. | 03-17-2011 |
Patrick C. Beard, Pleasanton, CA US
| Patent application number | Description | Published |
|---|---|---|
| 20090292749 | Per thread garbage collection - Per thread garbage collection is disclosed. Objects associated only with a thread that created them are tracked. At a garbage collection time for a particular thread, it is determined which objects associated only with that thread remain reachable from a restricted root set associated with the thread. Any thread-only objects that are not determined to be reachable are garbage collected. | 11-26-2009 |
| 20110087713 | ASSOCIATIVE REFERENCES IN A GARBAGE COLLECTED PROGRAMMING ENVIRONMENT - Associative references in a garbage collected programming environment is disclosed. An indication that an object is not reachable from any root object. The object is kept alive if it is determined by a garbage collection process, based at least in part on data other than data comprising the object or managed by an application with which the object is associated, that the object is associated with at least one other object that has been determined to be reachable. | 04-14-2011 |
Patrick C. Beard, Danville, CA US
| Patent application number | Description | Published |
|---|---|---|
| 20090030959 | Associative references in a garbage collected programming environment - Associative references in a garbage collected programming environment is disclosed. An indication that an object is not reachable from any root object. The object is kept alive if it is determined by a garbage collection process, based at least in part on data other than data comprising the object or managed by an application with which the object is associated, that the object is associated with at least one other object that has been determined to be reachable. | 01-29-2009 |
Paul Beard, Milpitas, CA US
| Patent application number | Description | Published |
|---|---|---|
| 20080215901 | BATTERY POWERED DEVICE WITH DYNAMIC AND PERFORMANCE MANAGEMENT - A computing device operates over a range of voltages and frequencies and over a range of processor usage levels. The computing device includes at least a variable frequency generator, a variable voltage power supply and voltage supply level and clocking frequency management circuitry. The variable frequency generator is coupled to the processor and delivers a clock signal to the processor. The variable voltage power supply is coupled to the processor and delivers voltage to the processor. The voltage supply level and clocking frequency management circuitry adjust both the voltage provided by the variable voltage power supply and the frequency of the signal provided by the variable frequency generator. The computing device includes a temperature sensor that provides signals indicative of the temperature of the processor and the voltage supply level and clocking frequency management circuitry adjusts the voltage and/or the clocking frequency provided by the variable voltage power supply. The computing device may also include a fan controlled by the voltage supply level and clocking frequency management circuitry, the fan adjusting the temperature of the processor when activated. In cold weather applications, the computing device may further include a heater controlled by the voltage supply level and clocking frequency management circuitry that raises the temperature of the processor when activated. | 09-04-2008 |
Paul Beard, Miltipas, CA US
| Patent application number | Description | Published |
|---|---|---|
| 20080284613 | Method and system for controlling radio controlled devices - The present invention is a method and system for controlling a RC device via a secure radio link. In one embodiment of the invention, spread spectrum modulation may be employed which may provide a digital radio frequency (RF) link between a controller and a RC device. A controller may be coupled with a transmitter module and a radio controlled device may be coupled with a receiver module in accordance with the present invention to provide an add-on upgrade capability. The method and system for controlling a RC device may also include error detection and correction, interpolation of lost packets, failsafe technology and force-feedback telemetric technology to further enhance the user experience with radio controlled devices. | 11-20-2008 |
Shawn Beard, Livermore, CA US
| Patent application number | Description | Published |
|---|---|---|
| 20100161283 | STRUCTURAL HEALTH MONITORING NETWORK - A networked configuration of structural health monitoring elements. Monitoring elements such as sensors and actuators are configured as a network, with groups of monitoring elements each controlled by a local controller, or cluster controller. A data bus interconnects each cluster controller with a router, forming a networked group of “monitoring clusters” connected to a router. In some embodiments, the router identifies particular clusters, and sends commands to the appropriate cluster controllers, instructing them to carry out the appropriate monitoring operations. In turn, the cluster controllers identify certain ones of their monitoring elements, and direct them to monitor the structure as necessary. Data returned from the monitoring elements is sent to the cluster controllers, which then pass the information to the router. Other embodiments employ multiple sensor groups directly connected to a central controller, perhaps with distributed local control elements. Methods of operation are also disclosed. | 06-24-2010 |