| Patent application number | Description | Published |
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| 20100099772 | METHODS, COMPOSITIONS, AND KITS FOR TREATING PAIN AND PRURITIS - The invention features a method for inhibiting one or more voltage-gated ion channels in a cell by contacting the cell with (i) a first compound that activates a channel-forming receptor that is present on nociceptors and/or pruriceptors; and (ii) a second compound that inhibits one or more voltage-gated ion channels when applied to the internal face of the channels but does not substantially inhibit said channels when applied to the external face of the channels, wherein the second compound is capable of entering nociceptors or pruriceptors through the channel-forming receptor when the receptor is activated. The invention also features a quarternary amine derivative or other permanently or transiently charged derivative of a compound that inhibits one or more voltage-gated ion channels when applied to the internal face of the channels but does not substantially inhibit said channels when applied to the external face of the channels. | 04-22-2010 |
| 20110086818 | METHODS, COMPOSITIONS, AND KITS FOR TREATING PAIN AND PRURITUS - The invention features methods, compositions, and kits for selective inhibition of pain-and itch sensing neurons (nociceptors and pruriceptors) by drug molecules of small molecule weight, while minimizing effects on non-pain-sensing neurons or other types of cells. | 04-14-2011 |
| 20120027693 | METHODS AND COMPOSITIONS FOR PREVENTING AND RELIEVING MUSCLE CRAMPS AND FOR RECOVERY FROM NEUROMUSCULAR IRRITABILITY AND FATIGUE FOLLOWING EXERCISE - The methods and compositions of the present invention are directed to the treatment or amelioration of muscle cramps using a composition that includes one or more TRPV1 channel activators, and/or one or more TRPA1 channel activators, and/or one or more ASIC channel activators. | 02-02-2012 |
| 20120172429 | PERMANENTLY CHARGED SODIUM AND CALCIUM CHANNEL BLOCKERS AS ANTI- INFLAMMATORY AGENTS - The invention provides compounds, compositions, methods, and kits for the treatment of neurogenic inflammation. | 07-05-2012 |
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| 20110040358 | Portable Semiconductor Diode Laser for Medical Treatment - Semiconductor lasers, in which the laser diode output is used directly for medical treatment, can be compact, lightweight and efficient. Lasers operating in the relatively “eye-safe” window of about 1350-1600 nm can be used to treat wounds and diseases of the skin and other organs, for example to cut, ablate or coagulate bodily tissues and fluids. Because the wavelength is eye-safe, the treatment can be through-space, and does not require the use of a fiber optic containment system. The device need not directly contact tissue. Such devices can be battery operated, are portable and self-contained, and thus are suitable for uses that are not confined to medical facilities, including use in emergency situations and in military operations. | 02-17-2011 |
| 20110122905 | SEMICONDUCTOR LASER ASSEMBLY AND PACKAGING SYSTEM - A system for self-aligning assembly and packaging of semiconductor lasers allows reduction of time, cost and testing expenses for high power density systems. A laser package mounting system, such as a modified TO-can (transistor outline can), has modifications that increase heat transfer from the active laser to a heat exchanger or other heat sink. A prefabricated heat exchanger assembly mounts both a laser package and one or more lenses. Direct mounting of a fan assembly to the package further minimizes assembly steps. Components may be physically and optically aligned during assembly by clocking and other indexing means, so that the entire system is self-aligned and focused by the assembly process without requiring post-assembly adjustment. This system can lower costs and thereby enable the use of high powered semiconductor lasers in low cost, high volume production, such as consumer items. | 05-26-2011 |
| Patent application number | Description | Published |
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| 20080319413 | PERCUTANEOUS ARRAY DELIVERY SYSTEM - A system for treating tissue includes a cannula having a proximal end, a distal end, and a lumen extending between the proximal and the distal ends, and an array of delivery tubes at least partially disposed within the lumen, each of the delivery tube having a lumen, wherein each of the delivery tubes is slidable relative to the cannula, and has a first configuration when inside the lumen, and a second configuration when outside the lumen. A system for treating tissue includes a treatment device having a distal end, and an indexing device for controlling a longitudinal position of the distal end of the treatment device relative to a target tissue region, the indexing device having a tubular portion for receiving the treatment device. | 12-25-2008 |
| 20100168500 | PERCUTANEOUS ARRAY DELIVERY SYSTEM - A system for treating tissue includes a cannula having a proximal end, a distal end, and a lumen extending between the proximal and the distal ends, and an array of delivery tubes at least partially disposed within the lumen, each of the delivery tube having a lumen, wherein each of the delivery tubes is slidable relative to the cannula, and has a first configuration when inside the lumen, and a second configuration when outside the lumen. A system for treating tissue includes a treatment device having a distal end, and an indexing device for controlling a longitudinal position of the distal end of the treatment device relative to a target tissue region, the indexing device having a tubular portion for receiving the treatment device. | 07-01-2010 |
| 20110077621 | LOCKING MECHANISM FOR A MEDICAL DEVICE - A locking mechanism for a medical device to selective lock a first elongate member from longitudinal movement relative to a second elongate member of the medical device. The locking mechanism includes a flexible tubular member disposed in a bore of a handle assembly of the medical device, and an actuator, such as a cam member having a cam or eccentric surface. Pivotable movement of the actuator from a first position to a second position compresses or deforms the flexible tubular member against the first elongate member to lock the first elongate member from longitudinal movement relative to the handle assembly. | 03-31-2011 |
| 20110077640 | LIQUID DELIVERY APPARATUS FOR TISSUE ABLATION - An apparatus for use in a tissue ablation procedure includes a base, a fluid delivery tube coupled to the base, a first lever rotatably coupled to the base, the first lever having a first end biased to press against a portion of the fluid delivery tube to thereby close a lumen within the fluid delivery tube, and a second end, and a securing mechanism for securing the base relative to an ablation device. An ablation system includes an ablation device having an electrode, a fluid delivery tube coupled to the ablation device, and a control for simultaneously activating the electrode and opening the fluid delivery tube. A method of performing tissue ablation includes operating a control to activate an electrode, thereby delivering ablation energy to target tissue, wherein the step of operating the control also causes fluid to be delivered to the target tissue. | 03-31-2011 |
