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Barden
Chris Barden, Halifax CA
| Patent application number | Description | Published |
|---|---|---|
| 20100076028 | Design and Synthesis of Novel Antimicrobials - The synthesis and activity of novel LpxA inhibitors is described, these inhibitors present antibacterial activity. The compounds were designed based on a receptor model developed using the crystal structure of LpxA and are arranged to have a favorable binding interaction at the active site of the enzyme. In particular, the compounds present the following formula (I) where V, W, X, Y and Z can be independently C, S, N or O and P1, P2 and P3 are ligands to bind to the three points of the proposed pharmacophore model. They can be chosen from a variety of groups. | 03-25-2010 |
Christopher J. Barden, Halifax CA
| Patent application number | Description | Published |
|---|---|---|
| 20100137388 | Therapeutic Pro-Antibiotic Agents and Methods of Use Thereof - The present invention provides for therapies characterized in part by co-administration or combination of antibiotic agents with medicinal compositions comprising as the pro-antibiotic active ingredient either a compound represented by a formula [I] or a pharmaceutically acceptable composite thereof; [wherein X represents oxygen, sulfur, NH, or N-alkyl; R | 06-03-2010 |
Christopher J. Barden, Lakeside CA
| Patent application number | Description | Published |
|---|---|---|
| 20110218200 | METHODS OF TREATING AMYLOID DISEASE USING ANALOGS OF 1-(4-NITROPHENYL) PIPERAZINE - The present invention is directed to compounds that inhibit amyloid aggregation and methods of treatment there-with. | 09-08-2011 |
Julian Barden, Marsfield AU
| Patent application number | Description | Published |
|---|---|---|
| 20080227122 | P2Y PURINERGIC RECEPTOR EXPRESSION FOR IDENTIFYING PRENEOPLASTIC AND NEOPLASTIC STATES - The present invention relates to methods for identifying pre-neoplastic and neoplastic states in mammals and in particular to a method for identifying pre-neoplasia and neoplasia in cells and tissues based on differential expression of P2Y purineric receptors. | 09-18-2008 |
| 20110111431 | METHOD FOR IDENTIFYING PRE-NEOPLASTIC AND/OR NEOPLASTIC STATES IN MAMMALS - The present invention relates to methods of identifying pre-neoplastic and/or neoplastic states in mammals and in particular to a method for identifying pre-neoplastic and neoplastic cells in tissues and body fluids, based on differential expression of purinergic receptors in these cells. | 05-12-2011 |
Julian Alexander Barden, Marsfield AU
| Patent application number | Description | Published |
|---|---|---|
| 20090192293 | ANTIBODIES TO NON-FUNCTIONAL P2X7 RECEPTOR - The present invention provides antibodies that specifically bind to P2X | 07-30-2009 |
| 20110092674 | Non-Functional P2X7 Receptor - The present invention provides antibodies that specifically bind to P2X | 04-21-2011 |
Julian Alexander Barden, New South Wales AU
| Patent application number | Description | Published |
|---|---|---|
| 20100105068 | HYBRIDOMAS PRODUCING ANTIBODIES AGAINST NON FUNCTIONAL P2X7 RECEPTOR - The present invention relates to the production of anti non functional P2X7 receptor monoclonal antibodies from hybridoma cell lines. | 04-29-2010 |
| 20100248266 | PURINERGIC (P2X) RECEPTORS IN EXTRA-CELLULAR BODY FLUID - The invention relates to purinergic (P2X) receptors, to detection of protein in extra-cellular body fluids and to antibodies for the diagnosis of a disease or condition, especially cancer. | 09-30-2010 |
| 20110177080 | NOVEL P2X7 EPITOPES - The invention relates to purinergic (P2X) receptors, more specifically to P2X7 receptors, the generation of antibodies and the use of antibodies and immunogens that are capable of selectively binding to a non ATP-binding P2X7 receptor but not to an ATP-binding P2X7 receptor, for the detection and treatment of disease conditions, especially cancer. | 07-21-2011 |
Julian Alexander Barden, North Ryde AU
| Patent application number | Description | Published |
|---|---|---|
| 20100036101 | ANTIBODIES AGAINST NON FUNCTIONAL P2X7 RECEPTOR - A recombinant or synthetic antibody or fragment thereof, said antibody or fragment thereof including three complementarity determining regions (CDR1 | 02-11-2010 |
| 20110110959 | ANTI-P2X7 PEPTIDES AND EPITOPES - The invention relates to the identification of a novel epitope on non-functional P2X | 05-12-2011 |
Michael C. Barden, Queensland AU
| Patent application number | Description | Published |
|---|---|---|
| 20090209049 | USE OF METAL COMPLEXES - A method of immobilising a target molecule on a substrate, which comprises exposing the target molecule to the substrate in the presence of a metal complex, wherein the target molecule is an unmodified target molecule, and wherein the metal complex is selected to provide a stable binding interaction between the target molecule and the substrate. | 08-20-2009 |
Nicholas Barden, Sainte-Foy CA
| Patent application number | Description | Published |
|---|---|---|
| 20080200411 | MEANS AND METHODS FOR DIAGNOSING AND TREATING AFFECTIVE DISORDERS - Nucleic acid molecules encoding an ATP-gated ion channel P2X7R which contains a mutation or a deletion are disclosed. Polypeptides encoded by the nucleic acid molecules and antibodies that specifically are directed to these polypeptides are disclosed. Aptamers that specifically bind the nucleic acid molecules, and primers for selectively amplifying the nucleic acid molecules are provided, kits, compositions, particularly pharmaceutical and diagnostic compositions comprising the nucleic acid molecules, vectors, polypeptides, aptamers, antibodies and/or primers, are provided. Methods for diagnosing affective disorders associated with a non-functional P2X7R protein, an altered ATP-gating of the P2X7R protein, an over or underexpression of the P2X7R protein or associated with the presence of any one of the nucleic acid molecules or polypeptides encoded thereby are disclosed. Additionally, the present invention relates to uses and methods for treating affective disorders employing a functional or non-functional ATP-gated ion-channel P2X7R, such as treatment with modulators of P2X7R activity. | 08-21-2008 |
Richard Mark Barden, Cambridge GB
| Patent application number | Description | Published |
|---|---|---|
| 20090141649 | Communication System and Method - In a communications system a transmitter is arranged to transmit asynchronous transfer mode (ATM) cells in which synchronous transfer mode (STM) channels are assembled. In order to minimise the bandwidth required at lease some of the ATM cells include one or more switch command(s) ( | 06-04-2009 |