| Patent application number | Description | Published |
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| 20090263382 | STABLE AND SOLUBLE ANTIBODIES INHIBITING TNF ALPHA - The present invention relates to particularly stable and soluble scFv antibodies and Fab fragments specific for TNFα, which comprise specific light chain and heavy chain sequences that are optimized for stability, solubility, in vitro and in vivo binding of TNFα, and low immunogenicity. Said antibodies are designed for the diagnosis and/or treatment of TNFα-related disorders. The nucleic acids, vectors and host cells for expression of the recombinant antibodies of the invention, methods for isolating them and the use of said antibodies in medicine are also disclosed. | 10-22-2009 |
| 20120064077 | STABLE AND SOLUBLE ANTIBODIES INHIBITING TNF ALPHA - The present invention relates to particularly stable and soluble scFv antibodies and Fab fragments specific for TNFα, which comprise specific light chain and heavy chain sequences that are optimized for stability, solubility, in vitro and in vivo binding of TNFα, and low immunogenicity. Said antibodies are designed for the diagnosis and/or treatment of TNFα-related disorders. The nucleic acids, vectors and host cells for expression of the recombinant antibodies of the invention, methods for isolating them and the use of said antibodies in medicine are also disclosed. | 03-15-2012 |
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| 20080233110 | Intrabodies with defined framework that is stable in a reducing environment and applications thereof - A method for the isolation of CDRs in a defined framework that is stable and soluble in reducing environment is described as well as thus obtainable scFv. Starting from such scFv with defined framework a scFv library can be generated wherein the framework is conserved while at least one complementary determining region (CDR) is randomized. Such library, e.g. in yeast cells, is suitable for screening for antibody/CDR-interactions or for screening for antibodies. | 09-25-2008 |
| 20090029369 | GENETIC SELECTION SYSTEM TO IDENTIFY PROTEASES, PROTEASE SUBSTRATES AND PROTEASE INHIBITORS - The present invention concerns a tester protein for identifying and/or monitoring protease activity in a cellular assay suitable for high throughput screenings by growth selection, wherein the tester polypeptide is a non-regulatory protein carrying a protease cleavage sequence. Upon co-expression of the protease recognizing said cleavage sequence the tester protein is inactivated, which influences the growth and/or survival of the host cells under the chosen conditions. However, in the presence of protease inhibitor the growth phenotype is reversed. The system can be used to identify proteases, protease inhibitors, and protease cleavage sites. | 01-29-2009 |
| 20110159008 | Antibodies Binding To The Extracellular Domain Of The Receptor Tyrosine Kinase ALK - The present invention concerns an antibody specific for human ALK (Anaplastic Lymphoma Kinase), in particular a scFv, a nucleic acid sequence encoding it, its production and its use as a pharmaceutical or for diagnostic purposes. Said antibody is suitable for the local treatment of tumors, in particular glioblastoma. | 06-30-2011 |
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| 20100029290 | Apparatus and method for implementing configurable resource management policies - A resource management apparatus adapted to implement resource management policies for the management of resources of a system, being susceptible of being assigned to entities requesting services to the system. The resource management apparatus includes: a configuration interface adapted to receive resource management configuration data from a user, the configuration data including a resource management decision logic adapted to specify a resource management policy; a resource management policy implementation unit responsive to service requests from the requesting entities and adapted to manage the assignment of the resources of the system to the requesting entities based on the resource management decision logic. The configuration interface is adapted to receive, and the resource management policy implementation unit is adapted to manage resource management decision logic structured as a set of one or more decision rules, each decision rule including: a description of at least one service request intended to be governed by the decision rule; a description of a state of the system in respect of which the decision rule is intended to apply; and action to be taken by the apparatus in case the decision rule applies. | 02-04-2010 |
| 20100039999 | METHOD AND APPARATUS FOR MANAGING THE ASSIGNMENT OF RADIO RESOURCES OF A RADIO COMMUNICATIONS NETWORK - A method of managing radio resources of a radio communications network, includes: upon receiving a new service request for a service to be provided, assessing whether there are radio resources of a first set, adapted to and available for satisfying the request, and: in the affirmative case, exploiting the available radio resources for satisfying the new service request; in the negative case: calculating an amount of the adapted radio resources to be set free for satisfying the service request; assessing whether there is at least one first already served service request that, at the time the new service request is received, is being served using the calculated amount of radio resources of the first set, and that can continue to be served by assigning thereto radio resources of a second set, different from the first set, not adapted to serving the new serving request; in the affirmative case: calculating an amount of the radio resources of the second set necessary for serving the at least one already served service request; assessing whether the calculated amount of radio resources of the second set is available; if the calculated amount of radio resources of the second set is available, re-assigning to the at least one first already served service request the radio resources of the second set, and assigning to the new service request the radio resources of the first set previously assigned to the already served service request; in the negative case, refusing the new service request. | 02-18-2010 |
| 20100097948 | CHARACTERIZATION OF CO-CHANNEL INTERFERENCE IN A WIRELESS COMMUNICATION SYSTEM - Disclosed herein is a method for characterizing interference in a radio communication system including a plurality of radio transceiver stations configured to communicate with user equipments, the method including: measuring, by a user equipment in radio communication with a serving transceiver station, quantities indicative of interference from interfering transceiver stations; sending the measured quantities to the serving transceiver station; associating at least one codebook with the serving transceiver station, the codebook including a number of codewords each representing a respective quantized interference situation in an area covered by the serving transceiver station; and identifying in the codebook a codeword representative of the quantities measured by the user equipment. | 04-22-2010 |
| 20100159841 | CHARACTERIZATION OF CO-CHANNEL INTERFERENCE IN A WIRELESS COMMUNICATION SYSTEM, IN PARTICULAR A CELLULAR RADIO COMMUNICATION SYSTEM - A method for characterizing interference in a radio communication system including a plurality of user equipment communicating with transceiver stations, includes: determining quantities indicative of interference (attenuation or power) experienced by a transceiver station interfered by interfering user equipment; and exchanging between transceiver stations information based on these quantities and concerning interference from the interfering user equipment. In particular, the user equipment is in communication with respective serving transceiver stations, and exchanging includes sending from the serving transceiver stations to the interfered transceiver stations information concerning interference from user equipment served by the serving transceiver stations and interfering with the interfered transceiver stations. The method further includes grouping, by the serving transceiver station, the interfering user equipment according to a given grouping criterion in order to form groups thereof. | 06-24-2010 |
