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Bandiera

Dario Bandiera, Milano IT

Patent application numberDescriptionPublished
20110281267FUNCTIONALIZED MICROFLUIDIC DEVICE FOR IMMUNOFLUORESCENCE - It is described a microfluidic device, for use in the field of analytical fluorescence based assays and, in particular, in FISH assays.11-17-2011

Giuseppe Bandiera, Ehrendingen CH

Patent application numberDescriptionPublished
20090297698METHOD FOR OXIDISING A THERMOCOUPLE SHEATH - A method for forming an oxygen resistant aluminum oxide layer on an outer surface of a thermocouple sheath composed of a nickel alloy containing between 1% to 7% aluminium comprises removing a pre-formed oxide layer from the outer surface so as to create a prepared sheath; performing a controlled oxidation by subjecting the prepared sheath to atmospheric conditions at a temperature between 1000° C. and 1250° C. so as to form the oxygen resistant layer on the thermocouple sheath and to thus form an oxidised sheath; and cooling the oxidised sheath so as to prepare the oxidized sheath for service.12-03-2009
20100020848PROTECTIVE TUBES FOR THERMOCOUPLES - Protective tubes for thermocouples exposed to oxidizing atmospheres at temperatures in the region of approximately 1100° C. are produced from a single-crystal nickel-based superalloy, preferably from an alloy having the following chemical composition (in % by weight): 7.7-8.3 Cr, 5.0-5.25 Co, 2.0-2.1 Mo, 7.8-8.3 W, 5.8-6.1 Ta, 4.9-5.1 Al, 1.3-1.4 Ti, 0.11-0.15 Si, 0.11-0.15 Hf, 200-750 ppm C, 50-400 ppm B, remainder nickel and unavoidable impurities. Protective tubes of this type exhibit good strength and good oxidation resistance under severe stress conditions.01-28-2010
20100021338HIGH-TEMPERATURE ALLOY - An iron-based high-temperature alloy is disclosed which contains the following chemical composition: 20% by weight Cr; 5 to 6% by weight Al; 4% by weight Ta; 4% by weight Mo; 3 to 4% by weight Re; 0.2% by weight Zr; 0.05% by weight B; 0.1% by weight Y; 0.1% by weight Hf; 0 to 0.05% by weight C; and remainder Fe and unavoidable impurities. The alloy can be produced at low cost and can possess outstanding oxidation resistance and good mechanical properties at temperatures up to 1200° C.01-28-2010

Silvio Bandiera, Paris FR

Patent application numberDescriptionPublished
20090005253Double Hybrid System Based on Gene Silencing by Transcriptional Interference - The invention relates to a novel double hybrid system and to the uses thereof. This system provides, in particular, a tool that enables the detection of the interruption of a protein-protein interaction. The developed system uses transcription interference as a mechanism for detecting a breaking up of interacting protein pairs. The developed double hybrid system can be applied to the screening of molecules enabling the detection of molecules breaking up a protein-protein interaction as well as enabling the identification of alleles lacking in the interaction of proteins involved in the protein-protein interactions.01-01-2009

Tiziano Bandiera, Pavia IT

Patent application numberDescriptionPublished
20100197665INDAZOLE DERIVATIVES AS KINASE INHIBITORS FOR THE TREATMENT OF CANCER - Substituted indazole derivatives of formula (I) and pharmaceutically acceptable salts thereof, as defined in the specification, process for their preparation and pharmaceutical compositions comprising them are disclosed; the compounds of the invention may be useful in therapy in the treatment of diseases associated with a dysregulated protein kinase activity, like cancer formula (I).08-05-2010

Tiziano Bandiera, Gambolo' (pv) IT

Patent application numberDescriptionPublished
20110230470SUBSTITUTED PYRAZOLO[4,3-C]PYRIDINE DERIVATIVES ACTIVE AS KINASE INHIBITORS - Substituted pyrazolo[4,3-c]pyridine derivatives of formula (I) and pharmaceutically acceptable salts thereof, as defined in the specification, process for their preparation and pharmaceutical compositions comprising them are disclosed; the compounds of the invention may be useful in therapy in the treatment of diseases associated with a dysregulated protein kinase activity, like cancer.09-22-2011

Tiziano Bandiera, Gambolo'(pv) IT

Patent application numberDescriptionPublished
20090023745Substituted Pyrazolo[4,3-c]Pyridine Derivatives Active as Kinase Inhibitors - Substituted pyrazolo[4,3-c]pyridine derivatives of formula (I) and pharmaceutically acceptable salts thereof, as defined in the specification, process for their preparation and pharmaceutical compositions comprising them are disclosed; the compounds of the invention may be useful in therapy in the treatment of diseases associated with a dysregulated protein kinase activity, like cancer.01-22-2009

Tiziano Bandiera, Gambolo (pavia) IT

Patent application numberDescriptionPublished
200902399241H-FURO[3,2-C]PYRAZOLE COMPOUNDS USEFUL AS KINASE INHIBITORS - Furo[3,2-c]pyrazole derivatives of formula (I) as defined in the description, and pharmaceutically acceptable salts thereof, wherein A is an aryl or heteroaryl ring, —NHZR09-24-2009

Tiziano Bandiera, Gambolo IT

Patent application numberDescriptionPublished
20090136513BICYCLO-PYRAZOLES ACTIVE AS KINASE INHIBITORS - A compound having formula (I): wherein: R, A, R05-28-2009
200901494571H-Thieno[2,3-c]Pyrazole Compounds Useful as Kinase Inhibitors - There are provided thieno[2,3-c]pyrazole derivatives of formula (I), wherein A is an aryl or heteroaryl ring, on which the substituent-NHZR06-11-2009
20090163503SUBSTITUTED PYRROLO-PYRAZOLE DERIVATIVES ACTIVE AS KINASE INHIBITORS - Substituted pyrrolo-pyrazole derivatives of formula (I) and pharmaceutically acceptable salts thereof, as defined in the specification, process for their preparation and pharmaceutical compositions comprising them are disclosed; the compounds of the invention may be useful in therapy in the treatment of diseases associated with dysregulated protein kinase activity, like cancer.06-25-2009