Bandiera
Antonella Bandiera, Trieste IT
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20130197102 | 3D MATRICES OF HUMAN ELASTIN-LIKE POLIPEPTIDES AND METHOD OF PREPARATION THEREOF - 3D matrices or hydrogels made of human elastin-like polypeptides and their preparation are described. Said matrices can be obtained by enzymatic cross-linking of such polypeptides and can be used in the biomedical and pharmaceutical fields as support the growth of cells, isolated or as multicellular association, both on the surface and inside the matrix. Said matrices can also deliver pharmacologically active molecules, which are incorporated and then released in a controlled manner. | 08-01-2013 |
Dario Bandiera, Milano IT
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20110281267 | FUNCTIONALIZED MICROFLUIDIC DEVICE FOR IMMUNOFLUORESCENCE - It is described a microfluidic device, for use in the field of analytical fluorescence based assays and, in particular, in FISH assays. | 11-17-2011 |
Giuseppe Bandiera, Ehrendingen CH
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20090297698 | METHOD FOR OXIDISING A THERMOCOUPLE SHEATH - A method for forming an oxygen resistant aluminum oxide layer on an outer surface of a thermocouple sheath composed of a nickel alloy containing between 1% to 7% aluminium comprises removing a pre-formed oxide layer from the outer surface so as to create a prepared sheath; performing a controlled oxidation by subjecting the prepared sheath to atmospheric conditions at a temperature between 1000° C. and 1250° C. so as to form the oxygen resistant layer on the thermocouple sheath and to thus form an oxidised sheath; and cooling the oxidised sheath so as to prepare the oxidized sheath for service. | 12-03-2009 |
20100020848 | PROTECTIVE TUBES FOR THERMOCOUPLES - Protective tubes for thermocouples exposed to oxidizing atmospheres at temperatures in the region of approximately 1100° C. are produced from a single-crystal nickel-based superalloy, preferably from an alloy having the following chemical composition (in % by weight): 7.7-8.3 Cr, 5.0-5.25 Co, 2.0-2.1 Mo, 7.8-8.3 W, 5.8-6.1 Ta, 4.9-5.1 Al, 1.3-1.4 Ti, 0.11-0.15 Si, 0.11-0.15 Hf, 200-750 ppm C, 50-400 ppm B, remainder nickel and unavoidable impurities. Protective tubes of this type exhibit good strength and good oxidation resistance under severe stress conditions. | 01-28-2010 |
20100021338 | HIGH-TEMPERATURE ALLOY - An iron-based high-temperature alloy is disclosed which contains the following chemical composition: 20% by weight Cr; 5 to 6% by weight Al; 4% by weight Ta; 4% by weight Mo; 3 to 4% by weight Re; 0.2% by weight Zr; 0.05% by weight B; 0.1% by weight Y; 0.1% by weight Hf; 0 to 0.05% by weight C; and remainder Fe and unavoidable impurities. The alloy can be produced at low cost and can possess outstanding oxidation resistance and good mechanical properties at temperatures up to 1200° C. | 01-28-2010 |
20140050609 | OXIDATION RESISTANT NICKEL ALLOY - The present invention relates to an oxidation resistant Nickel alloy, characterized in the following chemical composition (in % by weight): 4-7 Cr, 4-5 Si, 0.1-0.2 Y, 0.1-0.2 Mg, 0.1-0.2 Hf, remainder Ni and unavoidable impurities. A preferred embodiment has the following chemical composition (in % by weight): 6 Cr, 4.4 Si, 0.1 Y, 0.15 Mg, 0.1 Hf, remainder Ni and unavoidable impurities. This alloy has an improved oxidation resistance, good creep properties at high temperatures and. | 02-20-2014 |
Sebastien Bandiera, Corenc FR
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20150340597 | MAGNETORESISTIVE ELEMENT HAVING ENHANCED EXCHANGE BIAS AND THERMAL STABILITY FOR SPINTRONIC DEVICES - Magnetic element including a first magnetic layer having a first magnetization; a second magnetic layer having a second magnetization; a tunnel barrier layer between the first and the second magnetic layers; and an antiferromagnetic layer exchanged coupling the second magnetic layer such that the second magnetization is pinned below a critical temperature of the antiferromagnetic layer, and can be freely varied when the antiferromagnetic layer is heated above that critical temperature. The magnetic element also includes an oxygen gettering layer between the second magnetic layer and the antiferromagnetic layer, or within the second magnetic layer. The magnetic element has reduced insertion of oxygen atoms in the antiferromagnetic layer and possibly reduced diffusion of manganese in the second magnetic layer resulting in an enhanced exchange bias and/or enhanced resistance to temperature cycles and improved life-time. | 11-26-2015 |
Sebastien Bandiera, Grenoble FR
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20150129946 | SELF REFERENCE THERMALLY ASSISTED MRAM WITH LOW MOMENT FERROMAGNET STORAGE LAYER - A mechanism is provided for a thermally assisted magnetoresistive random access memory device (TAS-MRAM) with reduced power for reading and writing. A tunnel barrier is disposed adjacent to a ferromagnetic sense layer and a ferromagnetic storage layer, such that the tunnel barrier is sandwiched between the ferromagnetic sense layer and the ferromagnetic storage layer. An antiferromagnetic pinning layer is disposed adjacent to the ferromagnetic storage layer. The pinning layer pins a magnetic moment of the storage layer until heating is applied. The storage layer includes a non-magnetic material to reduce a storage layer magnetization as compared to not having the non-magnetic material. The sense layer includes the non-magnetic material to reduce a sense layer magnetization as compared to not having the non-magnetic material. A reduction in the storage layer magnetization and sense layer magnetization reduces the magnetostatic interaction between the storage layer and sense layer, resulting in less read/write power. | 05-14-2015 |
Sébastien Bandiera, La Tronche FR
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20120313192 | MAGNETIC STICK AND MEMORY CELL COMPRISING SUCH A STACK - A magnetic stack with out of plane magnetisation, the magnetic stack including: a first magnetic layer constituted of one or more materials selected from the following group: cobalt, iron and nickel and magnetic alloys based on the materials; a second layer constituted of a metallic material able to confer to an assembly formed by the first and the second layers a perpendicular anisotropy of interfacial origin when the second layer has a shared interface with the first layer; and a third layer deposited on the first layer, the second layer being deposited on the third layer, the third layer being constituted of a metallic material having a miscibility less than 10% with the material of the first layer. | 12-13-2012 |
Sébastien Bandiera, La Tronche FR
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20120313192 | MAGNETIC STICK AND MEMORY CELL COMPRISING SUCH A STACK - A magnetic stack with out of plane magnetisation, the magnetic stack including: a first magnetic layer constituted of one or more materials selected from the following group: cobalt, iron and nickel and magnetic alloys based on the materials; a second layer constituted of a metallic material able to confer to an assembly formed by the first and the second layers a perpendicular anisotropy of interfacial origin when the second layer has a shared interface with the first layer; and a third layer deposited on the first layer, the second layer being deposited on the third layer, the third layer being constituted of a metallic material having a miscibility less than 10% with the material of the first layer. | 12-13-2012 |
Silvio Bandiera, Paris FR
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20090005253 | Double Hybrid System Based on Gene Silencing by Transcriptional Interference - The invention relates to a novel double hybrid system and to the uses thereof. This system provides, in particular, a tool that enables the detection of the interruption of a protein-protein interaction. The developed system uses transcription interference as a mechanism for detecting a breaking up of interacting protein pairs. The developed double hybrid system can be applied to the screening of molecules enabling the detection of molecules breaking up a protein-protein interaction as well as enabling the identification of alleles lacking in the interaction of proteins involved in the protein-protein interactions. | 01-01-2009 |
Simonetta Bandiera, Paris FR
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20140134728 | METHODS FOR ADJUSTING EXPRESSION OF MITOCHONDRIAL GENOME BY MICRORNA - The present invention relates to a method for adjusting the expression of the mitochondrial genome in a human cell comprising a step consisting of modulating the expression of a least one mi RNA selected from the group consisting of hsa-mi R-1973, hsa-mi R-1275, hsa-mi R-494, hsa-mi R-513a-5p, hsa-mi R-1246, hsa-mi R-328, hsa-mi R-1908, hsa-mi R-1972, hsa-mi R-1974, hsa-mi R-1977, hsa-mi R-638, hsa-mi R-1978 and hsa-mi R-1201. | 05-15-2014 |
Tiziano Bandiera, Pavia IT
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20100197665 | INDAZOLE DERIVATIVES AS KINASE INHIBITORS FOR THE TREATMENT OF CANCER - Substituted indazole derivatives of formula (I) and pharmaceutically acceptable salts thereof, as defined in the specification, process for their preparation and pharmaceutical compositions comprising them are disclosed; the compounds of the invention may be useful in therapy in the treatment of diseases associated with a dysregulated protein kinase activity, like cancer formula (I). | 08-05-2010 |
Tiziano Bandiera, Gambolo'(pv) IT
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20090023745 | Substituted Pyrazolo[4,3-c]Pyridine Derivatives Active as Kinase Inhibitors - Substituted pyrazolo[4,3-c]pyridine derivatives of formula (I) and pharmaceutically acceptable salts thereof, as defined in the specification, process for their preparation and pharmaceutical compositions comprising them are disclosed; the compounds of the invention may be useful in therapy in the treatment of diseases associated with a dysregulated protein kinase activity, like cancer. | 01-22-2009 |
Tiziano Bandiera, Gambolo' (pv) IT
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20110230470 | SUBSTITUTED PYRAZOLO[4,3-C]PYRIDINE DERIVATIVES ACTIVE AS KINASE INHIBITORS - Substituted pyrazolo[4,3-c]pyridine derivatives of formula (I) and pharmaceutically acceptable salts thereof, as defined in the specification, process for their preparation and pharmaceutical compositions comprising them are disclosed; the compounds of the invention may be useful in therapy in the treatment of diseases associated with a dysregulated protein kinase activity, like cancer. | 09-22-2011 |
20130281490 | Disubstituted Beta-lactones as Inhibitors of N-Acylethanolamine Acid Amidase (NAAA) - The present invention provides compounds and pharmaceutical compositions for inhibiting N-acylethanolamine acid amidase (NAAA). Inhibition of NAAA is contemplated as a method to sustain the levels of palmitoylethanolamide (PEA) and oleylethanolamide (OEA), two substrates of NAAA, in conditions characterized by reduced concentrations of PEA and OEA. The invention also provides methods for treating inflammatory diseases and pain, and other disorders in which decreased levels of PEA and OEA are associated with the disorder. | 10-24-2013 |
20140155421 | SUBSTITUTED PYRIMIDINYL-PYRROLES ACTIVE AS KINASE INHIBITORS - The present invention relates to substituted pyrimidinyl-pyrrole compounds of formula (I) which modulate the activity of protein kinases and are therefore useful in treating diseases caused by dysregulated protein kinase activity, in particular Janus kinases. The present invention also provides methods for preparing these compounds, pharmaceutical compositions comprising these compounds, and methods of treating diseases utilizing such compounds or the pharmaceutical compositions containing them. | 06-05-2014 |
20140163034 | INHIBITORS OF ANANDAMIDE TRANSPORT AND THEIR THERAPEUTIC USES - Nucleic acid and polypeptide sequences corresponding to FLAT, a partly cytosolic variant of the intracellular anandamide-degrading enzyme, fatty acid amide hydrolase-1 (FAAH-1), are provided. FLAT lacks amidase activity but binds the endocannibinoid anandamide and facilitates its transport into cells. A chemical scaffold for the inhibition of anandamide transport is identified. Compositions of the invention prevent anandamide internalization in vitro, interrupt anandamide deactivation in vivo, and cause profound CB | 06-12-2014 |
20140288170 | META-SUBSTITUTED BIPHENYL PERIPHERALLY RESTRICTED FAAH INHIBITORS - The present invention provides methods of making and using peripherally restricted inhibitors of fatty acid amide hydrolase (FAAH). The present invention provides compounds and compositions that suppress FAAH activity and increases anandamide levels outside the central nervous system (CNS). The present invention also sets forth methods for inhibiting FAAH as well as methods for treating conditions such as, but not limited to, pain, inflammation, immune disorders, dermatitis, mucositis, the over reactivity of peripheral sensory neurons, neurodermatitis, and an overactive bladder. Accordingly, the invention also provides compounds, methods, and pharmaceutical compositions for treating conditions in which the selective inhibition of peripheral FAAH (as opposed to CNS FAAH) would be of benefit. | 09-25-2014 |
Tiziano Bandiera, Gambolo IT
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20090136513 | BICYCLO-PYRAZOLES ACTIVE AS KINASE INHIBITORS - A compound having formula (I): wherein: R, A, R | 05-28-2009 |
20090149457 | 1H-Thieno[2,3-c]Pyrazole Compounds Useful as Kinase Inhibitors - There are provided thieno[2,3-c]pyrazole derivatives of formula (I), wherein A is an aryl or heteroaryl ring, on which the substituent-NHZR | 06-11-2009 |
20090163503 | SUBSTITUTED PYRROLO-PYRAZOLE DERIVATIVES ACTIVE AS KINASE INHIBITORS - Substituted pyrrolo-pyrazole derivatives of formula (I) and pharmaceutically acceptable salts thereof, as defined in the specification, process for their preparation and pharmaceutical compositions comprising them are disclosed; the compounds of the invention may be useful in therapy in the treatment of diseases associated with dysregulated protein kinase activity, like cancer. | 06-25-2009 |
20110288088 | SUBSTITUTED PYRROLO-PYRAZOLE DERIVATIVES ACTIVE AS KINASE INHIBITORS - Substituted pyrrolo-pyrazole derivatives of formula (I) and pharmaceutically acceptable salts thereof, as defined in the specification, process for their preparation and pharmaceutical compositions comprising them are disclosed; the compounds of the invention may be useful in therapy in the treatment of diseases associated with dysregulated protein kinase activity, like cancer. | 11-24-2011 |
20150111892 | ACID CERAMIDASE INHIBITORS AND THEIR USE AS MEDICAMENTS - The present invention concerns, in a first aspect, compounds of Formula I as defined herein, pharmaceutically acceptable salts thereof and pharmaceutical compositions containing such compounds. The present invention also relates to compounds of Formula I for use as acid ceramidase inhibitors, and in the treatment of cancer and other disorders in which modulation of the levels of ceramide is clinically relevant. | 04-23-2015 |
Tiziano Bandiera, Gambolo (pavia) IT
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20090239924 | 1H-FURO[3,2-C]PYRAZOLE COMPOUNDS USEFUL AS KINASE INHIBITORS - Furo[3,2-c]pyrazole derivatives of formula (I) as defined in the description, and pharmaceutically acceptable salts thereof, wherein A is an aryl or heteroaryl ring, —NHZR | 09-24-2009 |