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Baltazar
Baltazar Becerril, Morelos MX
| Patent application number | Description | Published |
|---|---|---|
| 20090105086 | Methods of selecting internalizing antibodies - This invention provides methods of selecting antibodies that are internalized into target cells. The methods generally involve contacting target cells with one or more members of an antibody phage display library. The members of the phage display library are also contacted with cells of a subtractive cell line. The target cells are then washed to remove the subtractive cell line cells and members of the phage display library that are non-specifically bound or weakly bound to the target cells. The target cells are cultured under conditions where members of the phage display library can be internalized if bound to an internalizing marker and internalized members of the phage display library are then identified. | 04-23-2009 |
Baltazar Deleon, Iii, Austin, TX US
| Patent application number | Description | Published |
|---|---|---|
| 20100223419 | COPY CIRCUMVENTION IN A VIRTUAL NETWORK ENVIRONMENT - A method, system, and computer program product for circumventing data copy operations in a virtual network environment. The method includes copying a data packet from a user space to a first kernel space of a first logical partition (LPAR). Using a hypervisor, a mapped address of a receiving virtual Ethernet driver in a second LPAR is requested. The first mapped address is associated with a buffer of the receiving virtual Ethernet driver. The data packet is copied directly from the first kernel space of the first LPAR to a destination in a second kernel space of the second LPAR. The destination is determined utilizing the mapped address. The direct copying to the destination bypasses (i) a data packet copy operation from the first kernel space to a transmitting virtual Ethernet driver of the first LPAR, and (ii) a data packet copy operation via the hypervisor. The receiving virtual Ethernet driver is notified that the data packet has been successfully copied to the destination in the second LPAR. | 09-02-2010 |
Baltazar De Leon, Iii, Autin, TX US
| Patent application number | Description | Published |
|---|---|---|
| 20100153974 | OBTAIN BUFFERS FOR AN INPUT/OUTPUT DRIVER - Disclosed is a computer implemented method, computer program product, and apparatus to obtain buffers in a multiprocessor system. A software component receives a call from an I/O device driver for a buffer, the call including at least one parameter, and walks a bucket data structure to a current bucket. The software component then determines whether the current bucket is free, and obtains a buffer list contained with the current bucket. Responsive to a determination that the current bucket is free, the software component determines whether sufficient buffers are obtained based on the parameter. Upon determining there are sufficient buffers obtained, the software component provides the current bucket and a second bucket as a single buffer list to the I/O device driver. | 06-17-2010 |
Baltazar Gomez-Mancilla, Basel CH
| Patent application number | Description | Published |
|---|---|---|
| 20100249136 | ORGANIC COMPOUNDS - The invention concerns the use an mGluR modulator, e.g. an mGluR5 modulator, for the treatment, prevention or delay of progression of Parkinson's Disease and associated disorders | 09-30-2010 |
Baltazar Gomez-Mancilla, Portage, MI US
| Patent application number | Description | Published |
|---|---|---|
| 20100035251 | BioMarkers for the Progression of Alzheimer's Disease - The genetic polymorphism LRRK2 (leucine-rich repeat kinase 2)-T1602S is significantly associated with conversion from mild cognitive impairment (MCI) to Alzheimer's disease (AD), with the patients with TT genotype being at greater risk to progress to Alzheimer's disease. The LRRK2-T2352 also showed a trend for conversion to Alzheimer's disease, with the patients with CC genotype tending to progress to Alzheimer's disease. Similar to the APOE-E4 allele, in the presence of a BuChE-K variant, LRRK2-T1602S and LRRK2-T2352 showed a greater association with the rate of conversion from mild cognitive impairment to Alzheimer's disease. In another study with placebo-treated Alzheimer's disease patients, LRRK2-T1602S and LRRK2-T2352 showed a same trend of association. The Alzheimer's disease patients with TT genotype of LRRK2-T1602S or CC genotype of LRRK2-T2352 tended to decline faster on cognitive performance over 6 months, especially in the presence of a BuChE-K variant. The association between the two common LRRK2 polymorphisms and Alzheimer's disease progression shows that LRRK2 may play a role in Alzheimer's disease pathogenesis, especially disease progression, and that polymorphisms of LRRK2 can be used as biomrkers of this progression. | 02-11-2010 |