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Balschmidt
Per Balschmidt, Horsholm DK
| Patent application number | Description | Published |
|---|---|---|
| 20100009898 | PROTEASE RESISTANT INSULIN ANALOGUES - The present invention relates to novel insulin analogues exhibiting resistance towards protease, wherein at least two amino acids are substituted and/or deleted relative to the parent insulin molecule. A method for the preparation of such insulin analogues, insulin preparations containing the insulin analogues of the invention and a method of treating diabetes mellitus using these insulin analogues is also provided. | 01-14-2010 |
| 20110021423 | Rapid Acting Insulin Analogues - The invention is related to fast acting insulin analogues which can form soluble mix-tures (pre-mixed or self-mixed) with long acting insulin analogues. The fast action is achieved through monomerizing substitutions/deletions in the C-terminus of the B-chain of human insulin and the mixability with long acting insulin analogues is achieved through a substitution of the Zn-binding His in position B10 of human insulin with a Gln amino acid residue. In one embodiment the invention is related to fast acting insulin analogues in which at least one of the natural amino acid residues in position B22-B30 in the human B-chain has been substituted with another amino acid residue having the effect of promoting formation of the monomeric form of insulin, the His amino acid residue in position 10 in the B-chain is substituted with a Gln and wherein further one or more of the amino acid residues in position B22-B30 optionally have been deleted. | 01-27-2011 |
| 20110092419 | PROTEASE-STABILIZED INSULIN ANALOGUES - The present invention relates to novel insulin analogues comprising mutations at position A14 in the A chain and at positions B27, B28, B29 and B30 in the B chain and exhibiting resistance towards protease; a method for the preparation of such insulin analogues; insulin preparations containing the insulin analogues of the invention; and, a method of treating diabetes mellitus using these insulin analogues. | 04-21-2011 |
Per Balschmidt, Espergaerde DK
| Patent application number | Description | Published |
|---|---|---|
| 20100055738 | Method for Making Acylated Polypeptides - The present invention related to a method of producing polypeptides in transformed host cells by expressing a precursor molecule of the desired polypeptide which are to be acylated in a subsequent in vitro step. The invention is also related to DNA-sequences, vectors and transformed host cells for use in the claimed method. Further, the present invention is related to certain precursors of the desired polypeptides and certain acylation methods. The invention provides a method for making polypeptides being preferentially acylated in certain lysine ε-amino groups. | 03-04-2010 |
| 20110046049 | Soluble, Stable Insulin-Containing Formulations with a Protamine Salt - The present invention relates to pharmaceutical formulations comprising insulin, an insulin analog, an insulin derivative, or a combination of any of the foregoing, and a salt of protamine, to methods of preparing such formulations, and to uses of such formulations in the treatment of diseases and conditions for which use of the insulin peptide(s) contained in such formulations is indicated. The present invention further relates to methods for increasing the stability and/or solubility of insulin in insulin-containing formulations at a pH less than 7.0 by adding a salt of protamine to the insulin-containing formulations. | 02-24-2011 |
Per Balschmidt, Hoersholm DK
| Patent application number | Description | Published |
|---|---|---|
| 20100120660 | HIGHLY CONCENTRATED INSULIN SOLUTIONS AND COMPOSITIONS - Highly concentrated insulin solutions and pharmaceutical compositions are described as are methods of their preparation and uses thereof. | 05-13-2010 |