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Baker, MA
Aaron B. Baker, Cambridge, MA US
| Patent application number | Description | Published |
|---|---|---|
| 20090220588 | Simultaneous Delivery of Receptors and/or Co-Receptors for Growth Factor Stability and Activity - The compositions and methods of the present invention relate to the co-delivery of a molecule and a polypeptide to cells to improve the therapeutic efficacy of the molecules. In one embodiment of the invention, the invention may improve delivery of growth factors by co-delivering these growth factors with their receptors and co-receptors, such as syndecans. Co-delivery of growth factors with syndecans, for example, may protect growth factors from proteolysis, enhance their activity, and target the growth factors to the cell surface to facilitate growth factor signaling. This novel approach to growth factor therapy could be extended to other systems and growth factors enabling the enhancement of multiple signaling pathways to achieve a desired therapeutic outcome. | 09-03-2009 |
Brett Baker, Framingham, MA US
| Patent application number | Description | Published |
|---|---|---|
| 20090044179 | MEDIA FOR PERFORMING PARALLEL PROCESSING OF DISTRIBUTED ARRAYS - One or more computer-readable media store executable instructions that, when executed by processing logic, perform parallel processing. The media store one or more instructions for initiating a single programming language, and identifying, via the single programming language, one or more data distribution schemes for executing a program. The media also store one or more instructions for transforming, via the single programming language, the program into a parallel program with an optimum data distribution scheme selected from the one or more identified data distribution schemes, and allocating the parallel program to two or more labs for parallel execution. The media further store one or more instructions for receiving one or more results associated with the parallel execution of the parallel program from the two or more labs, and providing the one or more results to the program. | 02-12-2009 |
| 20090044180 | DEVICE FOR PERFORMING PARALLEL PROCESSING OF DISTRIBUTED ARRAYS - A device for performing parallel processing includes a processor to initiate a single programming language, and identify, via the single programming language, one or more data distribution schemes for executing a program. The processor also transforms, via the single programming language, the program into a parallel program with an optimum data distribution scheme selected from the one or more identified data distribution schemes, and allocates the parallel program to two or more labs for parallel execution. The processor further receives one or more results associated with the parallel execution of the parallel program from the two or more labs, and provides the one or more results to the program. | 02-12-2009 |
| 20090044196 | METHOD OF USING PARALLEL PROCESSING CONSTRUCTS - A computing device-implemented method includes receiving a program, analyzing and transforming the program, determining an inner context and an outer context of the program based on the analysis of the program, and allocating one or more portions of the inner context of the program to two or more labs for parallel execution. The method also includes receiving one or more results associated with the parallel execution of the one or more portions from the two or more labs, and providing the one or more results to the outer context of the program. | 02-12-2009 |
| 20090044197 | DEVICE FOR USING PARALLEL PROCESSING CONSTRUCTS - A device, for performing parallel processing, includes a processor to receive one or more portions of an inner context of a program created for a technical computing environment, and allocate one or more portions of the inner context of the program to two or more labs for parallel execution. The processor is also configured to receive one or more results associated with the parallel execution of the one or more portions from the two or more labs, and provide the one or more results to an outer context of the program. | 02-12-2009 |
| 20090049435 | PARALLEL PROCESSING OF DISTRIBUTED ARRAYS - A computing device-implemented method includes initiating a single programming language, and identifying, via the single programming language, one or more data distribution schemes for executing a program. The method also includes transforming, via the single programming language, the program into a parallel program with an optimum data distribution scheme selected from the one or more identified data distribution schemes, and allocating the parallel program to two or more labs for parallel execution. The method further includes receiving one or more results associated with the parallel execution of the parallel program from the two or more labs, and providing the one or more results to the program. | 02-19-2009 |
| 20090089762 | FUNCTION CALL TRANSLATION - Methods and apparatus for using description information about a function to translate a call to the function into a call to a corresponding function in a second language. The methods include processing a definition of a function associated with a first language to create description information sufficient to enable translation of a call to the function into a call to a corresponding function in a second language without requiring processing of the definition of the function. In another aspect, the methods include providing a description file of items, each item including description information about a function associated with a first language, and using the file of description items to translate a first program file from the first language into a second language. In another aspect, the methods include providing a library file including functions defined by a first language; processing the library file to create a function library and a description file, the function library including one or more functions defined by a second language, each function in the function library being a translated version of a function in the library file; and using the description file to translate a program file from the first language into the second language, where each call in the program file to a function in the library file is translated into a call to a corresponding function in the second language. | 04-02-2009 |
| 20090132867 | MEDIA FOR USING PARALLEL PROCESSING CONSTRUCTS - One or more computer-readable media store executable instructions that, when executed by processing logic, perform parallel processing. The media store one or more instructions for receiving one or more portions of an inner context of a program created for a technical computing environment, allocating one or more portions of the inner context of the program to two or more labs for parallel execution, receiving one or more results associated with the parallel execution of the one or more portions from the two or more labs, and providing the one or more results to an outer context of the program. | 05-21-2009 |
| 20090144747 | COMPUTATION OF ELEMENTWISE EXPRESSION IN PARALLEL - An exemplary embodiment provides methods, systems and mediums for executing arithmetic expressions that represent elementwise operations. An exemplary embodiment provides a computing environment in which elementwise expressions may be executed in parallel by multiple execution units. In an exemplary embodiment, multiple execution units may reside on a network. | 06-04-2009 |
Christian Baker, Weymouth, MA US
| Patent application number | Description | Published |
|---|---|---|
| 20090124987 | Wound Chamber For Limb - A wound dressing includes a chamber ( | 05-14-2009 |
| 20100042127 | METHOD AND APPARATUS FOR PROCESSING DERMAL TISSUE - A portable and disposable device is provided for processing harvested dermal tissue. The device includes a housing presenting a handle having a gripping surface and a cutting head attached to the handle. A cutting assembly is supported by the cutting head and includes a plurality of spaced cutting blades that are rotatable with respect to the housing. A receptacle is disposed downstream of the cutting assembly and receives the sliced tissue from the cutting blades. The device is thus operable to slice harvested tissue into strips, and further into fine particles, that can be used for transplantation onto a wound site. | 02-18-2010 |
| 20110004168 | WOUND TREATMENT DEVICE EMPLOYING NEGATIVE PRESSURE - The present invention provides a device for wound treatment, comprising a chamber that includes an inner surface and defines a treatment space, the chamber being made of a flexible, impermeable material. The device further includes a plurality of structures configured to exert mechanical stress on a wound, the plurality of structures intruding from the inner surface of the chamber into the treatment space. The device further includes a tube having a first end connected to the chamber, the tube being in fluid communication with the treatment space so as to enable at least one selected from the group of applying negative pressure to the treatment space and applying a therapeutic modality. | 01-06-2011 |
Christian M. Baker, Weymouth, MA US
| Patent application number | Description | Published |
|---|---|---|
| 20110224729 | HALLUX VALGUS REPAIRS USING SUTURE-BUTTON CONSTRUCT - A technique and associated instrumentation for correcting large intermetatarsal angles that result from hallux valgus. The system includes a button and a suture loop attached to the button. A suture strand is threaded through holes in the button to attach the button to the suture. The suture ends are then brought together (by being swaged, spliced or cinched together, for example) to form the suture loop comprising a continuous, uninterrupted suture loop with a single strand of swaged-together ends. The swaged-together ends may be attached to a suture passing instrument such as a K-wire (Kirschner wire) that may be further used to drill a hole through the first and second metatarsals. The swaged-together ends of the suture are then passed through the drill holes in the first and second metatarsals; and the ends of the suture are pulled until the button abuts the second metatarsal. The swaged together portion of the suture loop is then cut, and the free suture ends are passed through holes in another (second) button. The suture ends are pulled to adjust the first metatarsal to a correct intermetatarsal angle, and the first metatarsal is secured in place by tying the ends of the suture together against the second button. | 09-15-2011 |
Christopher T. Baker, Waltham, MA US
| Patent application number | Description | Published |
|---|---|---|
| 20090042973 | Inhibitors of aspartyl protease - The present invention relates to a novel class of sulfonamides which are aspartyl protease inhibitors. In one embodiment, this invention relates to a novel class of HIV aspartyl protease inhibitors characterized by specific structural and physicochemical features. This invention also relates to pharmaceutical compositions comprising these compounds. The compounds and pharmaceutical compositions of this invention are particularly well suited for inhibiting HIV-1 and HIV-2 protease activity and consequently, may be advantageously used as anti-viral agents against the HIV-1 and HIV-2 viruses. This invention also relates to methods for inhibiting the activity of HIV aspartyl protease using the compounds of this invention and methods for screening compounds for anti-HIV activity. | 02-12-2009 |
Christopher T. Baker, Bedford, MA US
| Patent application number | Description | Published |
|---|---|---|
| 20080242716 | Ion Channel Modulators - The invention relates to compounds, compositions comprising the compounds, and methods of using the compounds and compound compositions. The compounds, compositions, and methods described herein can be used for the therapeutic modulation of ion channel function, and treatment of disease and disease symptoms, particularly those mediated by certain calcium channel subtype targets. | 10-02-2008 |
Christopher Todd Baker, Bedford, MA US
| Patent application number | Description | Published |
|---|---|---|
| 20080293722 | Ion Channel Modulators - The invention relates to compounds, compositions comprising the compounds, and methods of using the compounds and compound compositions. The compounds, compositions, and methods described herein can be used for the therapeutic modulation of ion channel function, and treatment of disease and disease symptoms, particularly those mediated by certain calcium channel subtype targets. | 11-27-2008 |
| 20100267697 | ION CHANNEL MODULATORS - The present teachings provide compounds of Formula (I) | 10-21-2010 |
Christopher Todd Baker, Waltham, MA US
| Patent application number | Description | Published |
|---|---|---|
| 20100124543 | SULPHONAMIDE DERIVATIVES AS PRODRUGS OF ASPARTYL PROTEASE INHIBITORS - The present invention relates to prodrugs of a class of sulfonamides which are aspartyl protease inhibitors. In one embodiment, this invention relates to a novel class of prodrugs of HIV aspartyl protease inhibitors characterized by favorable aqueous solubility, high oral bioavailability and facile in vivo generation of the active ingredient. This invention also relates to pharmaceutical compositions comprising these prodrugs. The prodrugs and pharmaceutical compositions of this invention are particularly well suited for decreasing the pill burden and increasing patient compliance. This invention also relates to methods of treating mammals with these prodrugs and pharmaceutical compositions. | 05-20-2010 |
Craig H. Baker, Shrewsbury, MA US
| Patent application number | Description | Published |
|---|---|---|
| 20110189877 | WATER-TIGHT ELECTRICAL CONNECTOR WITH LATERALLY COMPRESSED O-RING - An electrical connector housing system provides a water-tight o-ring seal between a receptacle housing and a plug housing without compressing the o-ring in the mating direction. The housing system includes at least two latch sliders that can be engaged to trap latch tabs within latch slots. The latch sliders are substantially unaffected by the o-ring compression, and are compatible with housing systems of almost any size and/or shape. Embodiments include a connector region surrounded by a curved wall having an o-ring groove in its outer surface, and the plug housing includes a shell which overlaps the curved wall and compresses the o-ring perpendicular to the mating direction. The housings can include integral electrical contacts and/or can accept one or more insertable contacts. The latch sliders. The latch mechanism can include a detent mechanism, and can require a tool for disengagement. | 08-04-2011 |
Darren P. Baker, Hingham, MA US
| Patent application number | Description | Published |
|---|---|---|
| 20090054632 | Hydrophobically-modified protein compositions and methods - Hydrophobically-modified proteins and methods of making them are described. A hydrophobic moiety is attached to a surface amino acid residue of the protein. The hydrophobic moiety can be a lipid or a peptide. Alternatively, the protein can be derivatized by a wide variety of chemical reactions that append a hydrophobic structure to the protein. The preferred protein is of mammalian origin and is selected from the group consisting of Sonic, Indian, and Desert hedgehog. The hydrophobic moiety is used as a convenient tether to which may be attached a vesicle such as a cell membrane, liposome, or micelle. | 02-26-2009 |
| 20100279316 | Antibodies to Phosphorylated IRAK4 - The present invention relates to antibodies that bind phosphorylated forms of IRAK4, methods of using such antibodies to detect IRAK4 biological activity, and methods for the detection, diagnosis, and prognostication of pathological conditions related to IRAK4 biological activity. ERAK4 is one member of a small family of highly conserved cytoplasmic signal transduction proteins characterized by the presence of an N-terminal “death domain” and a C-terminal serine-threonine kinase domain. IRAK4 functions in cytoplasmic signal transduction pathways by interacting with membrane spanning proteins which play, inter alia, critical roles in vertebrate immune system function. | 11-04-2010 |
David Gardner Baker, Shrewsbury, MA US
| Patent application number | Description | Published |
|---|---|---|
| 20100190615 | Energy absorbing suspension equipment for rowing and general exercise machines - An exercise device or exercise device attachment with an energy absorbing component configured to change shape so as to absorb energy in response to a compressive force by the user. Said energy absorption component returns substantially to its first shape in response to the removal of the compressive force. The energy-absorbing apparatus is configured to reduce a reaction force exerted on the user of said exercise equipment. | 07-29-2010 |
David James Baker, West Newbury, MA US
Donald Baker, North Attleboro, MA US
| Patent application number | Description | Published |
|---|---|---|
| 20080205685 | Spider - A spider for high-power, compact electro-acoustic transducers comprises a non-woven fiber blend encased in a thermoplastic elastomer. The spider is capable of supporting the longer stroke distances of the high-power, compact electro-acoustic transducers and exhibits improved fatigue and ageing resistance. | 08-28-2008 |
Garth Baker, Somerset, MA US
| Patent application number | Description | Published |
|---|---|---|
| 20090143828 | Methods and Devices For Minimally Invasive Spinal Connection Element Delivery - A device for delivery of a spinal rod to a bone anchor includes an inner tube and an outer tube disposed about at least a portion of the inner tube. The inner tube is adjustable relative to the outer tube along the longitudinal axis of the outer tube between a first position and a second position in which the distal end of the inner tube contacts the bone anchor. A spring is interposed between the inner tube and the outer tube to bias the inner tube distally. A locking member is coupled to the outer tube and is adjustable between a proximal position in which the locking member is spaced apart from the inner tube and a distal position in which the locking member inhibits proximal axial motion of the inner tube relative to the outer tube. | 06-04-2009 |
Garth G. Baker, Somerset, MA US
| Patent application number | Description | Published |
|---|---|---|
| 20080243190 | IN-LINE ROD REDUCTION DEVICE AND METHODS - The present invention provides methods and devices for placing a spinal fixation rod into a rod receiving opening in a spinal anchor and installing a fastener to secure the rod to the spinal anchor. In one embodiment, the system can include a cap having a bore extending therethrough, an elongate drive rod that is adapted to extend through the bore, and a fastener that is disposed on a distal portion of the drive rod. The cap can include a driving element that is adapted to cooperate with a complementary driving element disposed on the rod to form a driving mechanism. Actuation of the driver mechanism can be effective to advance the drive rod through the cap to thereby reduce a spinal rod into a rod receiving opening of the spinal anchor and install the fastener to secure the rod to the spinal anchor. | 10-02-2008 |
| 20090149892 | SYSTEM AND METHOD OF MANIPULATING SPINAL CONSTRUCTS - Systems of manipulating (e.g., compressing or distracting) a spinal construct are provided herein. In general, the system can include a surgical sleeve extending from a vertebra and a fulcrum movably coupled to some component of the system thereby allowing the fulcrum to be positioned at various location along the length of the sleeve. As indicated, the fulcrum can be movably coupled to virtually any component of the system. For example, the fulcrum can be movably coupled to the surgical sleeve, to a manipulation device sized and configured to receive the surgical sleeve, to a driver configured to apply a manipulation force, etc. Additionally, methods for manipulating a spinal construct are also provided herein. | 06-11-2009 |
| 20100004695 | SYSTEM AND METHOD FOR MANIPULATING A SPINAL CONSTRUCT - A system and device for manipulating a spinal construct is provided. For example, the manipulation device can include a drive member to be disposed within a first surgical sleeve extending from a first vertebra, and a coupling member positioned adjacent a second surgical sleeve. In one embodiment, at least one of the drive member and the coupling member can be releasably engaged to an actuation mechanism. In one aspect, the actuation mechanism can include a floating and/or auto-locking pivot point thereby allowing a user to quickly and easily position the manipulation device relative to the adjacent surgical sleeves. Additionally, a method of manipulating spinal constructs is also provided. | 01-07-2010 |
Geoffrey Alan Baker, Sandisfield, MA US
| Patent application number | Description | Published |
|---|---|---|
| 20110197535 | LAYING AND MECHANICALLY JOINING BUILDING PANELS OR CONSTRUCTION ELEMENTS - There is disclosed apparatus, method and system for mechanically joining abutting construction elements having a first split tongue located at one end of the connector and a second split tongue located at the other end of the connector. The first and second split tongues are adapted to be inserted into and locked onto grooves in abutting construction elements for holding the adjacent construction elements in abutting relationship. In an embodiment the grooves in said construction elements are formed into auxiliary groove containing members adapted to be integrated into an edge or face surface of the construction elements. | 08-18-2011 |
Haven Baker, Roslindale, MA US
| Patent application number | Description | Published |
|---|---|---|
| 20090035797 | Detection of Disease Associated Proteolysis - Described herein are methods and techniques to study the “degradome”. The degradome of a specific protease is the complete product of the natural substrate repertoire of that enzyme in a cell, tissue or organism. The complete set of proteases that are expressed at a particular moment or circumstance by a cell, tissue or organism produces the collective degradome. Included in the methods described herein are approaches that allow the direct identification and characterization of degradome peptides from approx. 400 to approx. 12,000 Da. The methods of the invention avoid the inherent problems of studying the peptidome by focusing on specific or unique proteolytic cleavages that occur as a result of endogenous protease activity induced by specific diseases. Once characterized, the presence of, or change in level of, specific peptides of the degradome can be used, e.g., to identify specific peptides having elevated levels compared to a reference normal/or to correlate identified peptides with specific proteins and/or to identify protein fragmentation patterns (e.g., peptide ladders) and the specific protease(s) that brought them about and then correlate this information with the presence or absense of a specific disease or condition. Thus, the methods of the invention can be used, for example, to identify new diagnostic markers and/or therapeutic targets, as specific clinical diagnostic methods for individual patients and as methods of monitoring the progress of a therapeutic regimen for the treatment of a patient. | 02-05-2009 |
Haven H. Baker, Belmont, MA US
| Patent application number | Description | Published |
|---|---|---|
| 20090187420 | Methods and Systems for Providing Individualized Wellness Profiles - Methods and systems for providing a user with personalized wellness and health information are described. More particularly, methods and systems are provided for creating an individual health profile display, presented on a network-based interface, based on the analysis of a user-submitted biological sample that has been compared to a knowledge database, and including information related to the comparison. | 07-23-2009 |
Keith Baker, Danvers, MA US
| Patent application number | Description | Published |
|---|---|---|
| 20110176994 | Buoyant Polymer Particles for Delivery of Therapeutic Agents to the Central Nervous System - The invention provides compositions and methods for treating a subject who has suffered from a central nervous system disorder. More particularly, the invention provides sustained polymeric drug delivery systems for direct delivery of therapeutic agents into the central nervous system. | 07-21-2011 |
Michael Baker, Dedham, MA US
| Patent application number | Description | Published |
|---|---|---|
| 20090158868 | Crank-Type Linear Actuator - A crank-type linear actuator may be used to provide linear actuation, for example, in a vehicle system. In general, the actuator may use a crank assembly to convert a unidirectional rotary drive motion into a reciprocating linear actuation motion. The actuator may also use magnetic elements and magnetic sensors for non-contact position control of the actuator. | 06-25-2009 |
Ralph S. Baker, Fitchburg, MA US
| Patent application number | Description | Published |
|---|---|---|
| 20110027018 | METHOD AND SYSTEM FOR TREATING CONTAMINATED MATERIALS - Provided is a method for treating contaminated soil. The method includes providing contaminated soil in a soil chamber that has at least one wall, and at least one floor, at least one heater coupled to or inside of at least one of the walls and at least one substantially elongated floor heater coupled to or in the floor. At least one of the walls at least partially includes a thermally conductive material configured to transfer heat from at least one of the heaters to an interior of the soil chamber. At least one of the walls at least partially encloses an interior of the soil chamber. At least one of the walls can move between a closed position during heating of the soil chamber, and an open position that allows a soil moving vehicle to access an interior of the soil chamber to provide or remove soil to and from the soil chamber unencumbered by piping located within the soil volume. The method also includes heating the contaminated soil within the soil chamber to substantially reduce the level of contaminants in the contaminated soil. | 02-03-2011 |
Ralph Sterman Baker, Fitchburg, MA US
| Patent application number | Description | Published |
|---|---|---|
| 20080217003 | Gas injection to inhibit migration during an in situ heat treatment process - Methods of treating a subsurface formation are described herein. Methods for treating a subsurface treatment area in a formation may include introducing a fluid into the formation from a plurality of wells offset from a treatment area of an in situ heat treatment process to inhibit outward migration of formation fluid from the in situ heat treatment process. | 09-11-2008 |
Richard L. Baker, Belmont, MA US
| Patent application number | Description | Published |
|---|---|---|
| 20110037776 | Method and Apparatus For The Identification and Selective Encoding of Changed Host Display Information - Changed Host Display Information (HDI) may be captured, selectively encoded, and optionally transmitted between participants over a session. Hints indicative of which portions of the HDI may have changed are collected and used to select areas of HDI for processing. Changed HDI is encoded using an encoding process selected from a number of encoding processes by determining which process is likely to efficiently encode that portion of the HDI. Where the HDI is divided into tiles for processing the encoding method selection may take place on a tile-by-tile basis, for example by counting the number of colors in the tile to be encoded. Changed HDI may be transmitted to viewers using paint commands containing pixel information and copy commands indicating that a portion of the HDI has been moved. | 02-17-2011 |
| 20110041085 | Method and Apparatus for the Transmission of Changed Host Display Information - Updates may be transmitted over a remote viewing session using a transmission protocol configured to allow sessions to be established, terminated, and used by participants. The transmission protocol provides a message structure that may be used to exchange administrative information associated with the session, as well as host display information to be transmitted from the host to the viewers over the session. A bounding rectangle construct may be used to convey positional information associated with the update or content of an update message. The messages may be passed directly between the host and viewers or via an intermediate service. The messages also may be used to allow viewers to highlight information on the display for a limited period of time so that the highlighting appears to the host and optionally to the other viewers on the session. | 02-17-2011 |
Stephen Baker, Long Meadow, MA US
| Patent application number | Description | Published |
|---|---|---|
| 20080252007 | NETWORK DRIVEN BOARD GAME INSTRUCTION GENERATOR AND METHODS FOR INTERACTION WITH PARTICIPANT - Interaction between a telephone system in a multiplayer board game providing real time input to game play in a multi player board game during the course of game play. Players make telephone calls to a special game play service provider at a remote phone number at the start of the game. The service provider then initiates a series of calls to the players' telephones during the course of game play. These calls provide game play input which could impact the outcome of the game. For example while playing a Monopoly board game, players may receive telephone calls during a forty five-minute period. The calls would provide instructions for various game effects, similar to Community Chest or Chance cards. Telephonic instructions also provide additional play experience during game play by occasionally dictating moves and instructions to game players, e.g., to improve the play experience and accelerate the game by driving property into the game and by driving money out of the game. | 10-16-2008 |