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| 20090156693 | OPHTHALMIC COMPOSITIONS CONTAINING POLYSACCHARIDE/BORATE GELLING SYSTEM - Topical ophthalmic compositions that form a gel or partial gel upon application to the eye are described. The compositions are particularly useful as artificial tears and ocular lubricants, but may also be utilized for the topical delivery of pharmaceutically active compounds to the eye. The compositions contain a polysaccharide/borate gelling system. The polysaccharides that may be utilized contain cis-diol groups and have a structure that is predominately linear, with a slight degree of branching. | 06-18-2009 |
| 20100021561 | SELF-PRESERVED AQUEOUS PHARMACEUTICAL COMPOSITIONS - The use of borate/amino alcohol/zinc systems to enhance the antimicrobial activity of multi-dose pharmaceutical compositions is described. The compositions do not require a conventional anti-microbial preservative and therefore are referred to as being “self-preserved”. The compositions possess sufficient antimicrobial activity to satisfy the preservative efficacy requirements of the USP for aqueous ophthalmic compositions. | 01-28-2010 |
| 20100076045 | STABILIZED PHARMACEUTICAL SUB-MICRON SUSPENSIONS AND METHODS OF FORMING SAME - The present invention is directed to a pharmaceutical submicron suspension and a method of forming the submicron suspension. The submicron suspension is useful for delivery of relatively hydrophobic and/or low solubility therapeutic agent. The submicron suspension and method of forming the submicron suspension typically employ a polymeric material that aids in preventing aggregation of the therapeutic agent. | 03-25-2010 |
| 20100099771 | USE OF COOLING AGENTS TO RELIEVE MILD OCULAR IRRITATION AND ENHANCE COMFORT - Ophthalmic compositions containing very low concentrations (e.g., 1 to 50 ppm) of cooling agents are described. The cooling agents are less volatile and less prone to causing ocular discomfort than agents previously utilized to obtain an ocular cooling effect, such as menthol. The cooling agents are preferably contained in a vehicle that forms a gel or partial gel upon application to the eye. | 04-22-2010 |
| 20100266664 | Devices And Methods For Ophthalmic Drug Delivery - Disclosed are ophthalmic drug-delivery devices, comprising a body having a proximal end and a distal end, wherein the body includes a styrene elastomer matrix and a drug in contact with the matrix. Also disclosed are methods of treating or preventing an eye disease in a subject, that involve contacting an eye of the subject with an ophthalmic drug delivery device comprising a body having a proximal end and a distal end, wherein the body comprises a styrene elastomer matrix and a drug in contact with the matrix, wherein release of the drug from the device occurs over time following contacting of the device with the eye of the subject. | 10-21-2010 |
| 20100267664 | OPHTHALMIC COMPOSITIONS CONTAINING POLYSACCHARIDE-BORATE GELLING SYSTEM - Topical ophthalmic compositions that form a gel or partial gel upon application to the eye are described. The compositions are particularly useful as artificial tears and ocular lubricants, but may also be utilized for the topical delivery of pharmaceutically active compounds to the eye. The compositions contain a polysaccharide/borate gelling system. The polysaccharides that may be utilized contain cis-diol groups and have a structure that is predominately linear, with a slight degree of branching. | 10-21-2010 |
| 20110135743 | CARBOXYVINYL POLYMER-CONTAINING NANOPARTICLE SUSPENSIONS - The present invention generally relates to suspension compositions having a carboxyvinyl polymer such as a carbomer, a galactomannan such as guar, and a borate compound. A sparingly soluble particulate compound such as nepafenac is also included in the compositions. The sparingly soluble particulate compound has a small particle size to enhance bioavailability of the compound. | 06-09-2011 |
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| 20080315623 | Drag Reduction Device for a Motor Vehicle - A drag reduction device for a motor vehicle is provided that includes a substantially flat plate member preferably rotatably connected to a tailgate assembly. The tailgate assembly has at least one, but preferably two panels defining a cavity. The plate member can be selectively positioned at a first position and a second, third, or forth position. When in the first position, the plate member is inside the cavity. In the second position, the plate member is substantially vertical, and partially extending outside the cavity. In the third position, the plate member is extending forward, preferably in a horizontal orientation outside the cavity. When in the fourth position, the plate member is extending rearward, preferably in a horizontal orientation outside the cavity. The plate member is of sufficient length when in the second, third, and fourth positions to thereby reduce the coefficient of drag and lift on the vehicle. | 12-25-2008 |
| 20110206965 | COMBINATION OF HEAT PIPE AND LOUVERED FINS FOR AIR-COOLING OF LI-ION BATTERY CELL AND PACK - A heat pipe is described. The heat pipe includes a heat pipe body containing a working fluid; and a louvered cooling fin adjacent to one end of the heat pipe body, the louvered cooling fin extending outward from a surface of the heat pipe body. Air-cooled battery packs containing the heat pipe are also described. | 08-25-2011 |
| 20110244293 | SECONDARY BATTERY MODULE - A secondary battery module includes a plurality of secondary battery cells each having a measureable temperature and each spaced apart from an adjacent one of the secondary battery cells to define a cooling channel therebetween. The plurality of cells includes a first one of the cells having a measureable first temperature and a terminal one of the cells having a measureable terminal temperature and separated from the first one of the cells by at least one other of the cells. The module includes a fluid flowable within each of the cooling channels and in thermal energy exchange relationship with each of the cells, and a housing defining an inlet channel disposed in fluid flow communication with each of the cooling channels and configured for directing fluid flow uniformly to each of the cooling channels, and further defining a plurality of inlet ports in fluid flow communication with the inlet channel. | 10-06-2011 |
| 20110244294 | SECONDARY BATTERY THERMAL MANAGEMENT DEVICE AND SYSTEM - A thermal management device for dissipating thermal energy from a secondary battery cell includes a first plate defining a first channel and a second channel spaced apart from the first channel, wherein the first plate further defines an inlet port in communication with the first channel and an outlet port in communication with the second channel and spaced opposite the inlet port. The device includes a second plate configured for thermal energy exchange with the cell and disposed in contact with the first plate to define a cross-flow channel, wherein the cross-flow channel interconnects the first and second channels. A thermal management system includes a cell having a first temperature, a fluid having a second temperature that is less than the first temperature, and the device. The fluid is conveyable from the inlet port to the outlet port via the cross-flow channel to thereby dissipate thermal energy from the cell. | 10-06-2011 |
| 20110244295 | SECONDARY BATTERY MODULE - A secondary battery module includes a plurality of secondary battery cells each having a measureable temperature and each spaced apart from an adjacent one of the cells to define a cooling channel therebetween. The plurality of cells includes a first one of the cells having a measureable first temperature, and a terminal one of the cells having a measureable terminal temperature and separated from the first one of the cells by at least one other of the cells. The module includes a fluid flowable within each of the cooling channels and in thermal energy exchange relationship with each of the cells. The module includes a housing having a surface defining an inlet channel disposed in fluid flow communication with each of the cooling channels and configured for directing the fluid flow to each of the cooling channels. The surface has a shape defined by a spline. | 10-06-2011 |
| 20110274957 | SECONDARY BATTERY MODULE AND COMPOSITE ARTICLE THEREOF - A composite article for dissipating thermal energy from a secondary battery cell includes a first graphite layer, a second graphite layer spaced away from and arranged parallel to the first graphite layer, and a metal layer sandwiched between and disposed in contact with each of the first graphite layer and the second graphite layer. The composite article has a thermal conductivity of greater than or equal to about 1,200 W/mK and an electrical conductivity of greater than or equal to about 10,000 S/cm. A secondary battery module includes the composite article and a secondary battery cell having a length and an average measurable temperature along the length during operation of the secondary battery module. The composite article is disposed adjacent and in contact with the secondary battery cell to thereby dissipate thermal energy from the secondary battery cell during operation of the secondary battery module. | 11-10-2011 |
| 20110293984 | Enhanced high voltage terminal cooling with a high thermal conductivity coating - A battery cell pack having improved heat transfer is described. In one embodiment, the battery cell pack includes a plurality of battery cells, each battery cell having an anode foil and a cathode foil; a pair of taps, the first tap attached to the anode foil and the second tap attached to the cathode foil; wherein at least one battery cell has a high thermal conductivity coating on at least one side of the anode foil, or the cathode foil, or both; or at least one of the taps has a high thermal conductivity coating on at least one side; or both. Methods of improving the heat transfer of battery cell packs are also described. | 12-01-2011 |
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| 20080241105 | Method and reagents for the enhancement of virus transduction in the bladder epithelium - Agents and methods for enhancing recombinant virus transduction in the bladder epithelium are described. A first method involves contacting the luminal surface of the bladder with a composition comprising a transduction enhancing agent and an oncolytic virus. Alternatively, the luminal surface of the bladder can be contacted first with a pretreatment composition comprising a transduction enhancing agent and, subsequently, with a composition comprising an oncolytic virus. Bladder treatment compositions comprising a transduction enhancing agent and an oncolytic virus are also described. | 10-02-2008 |
| 20090068151 | Methods and reagents for the enhancement of virus transduction in the bladder epithelium - Agents and methods for enhancing recombinant virus transduction in the bladder epithelium are described. A first method involves contacting the luminal surface of the bladder with a composition comprising a transduction enhancing agent and an oncolytic virus. Alternatively, the luminal surface of the bladder can be contacted first with a pretreatment composition comprising a transduction enhancing agent and, subsequently, with a composition comprising an oncolytic virus. Bladder treatment compositions comprising a transduction enhancing agent and an oncolytic virus are also described. | 03-12-2009 |
| 20090318381 | Halogenated alkyl di-and trisaccharides, pharmaceutical formulations, diagnostic kits and methods of treatment - The present invention relates to a novel family of alkylated halogenated di- and trisaccharides which exhibit pharmaceutical efficacy in the areas of permeation enhancers, anti-microbial effects, anti-fugal effects, facilitation of diagnostic procedures. The invention further includes methods of treatment and diagnostic kits. | 12-24-2009 |
| 20100076089 | ANTIMICROBIAL GEL FORMULATIONS - Disclosed herein are formulations comprising an N-halogenated or N,N-dihalogenated amine compound dispersed in a water-swellable polymer, wherein the compound is 90% stable for at least 30 days at about 25° C. Also disclosed are methods of treating or preventing infections caused by a bacterial, a microbial, a sporal, a fungal or a viral activity using such formulations. | 03-25-2010 |
| 20100272783 | Methods of Treating Infections of the Nail - Disclosed herein are compositions and methods of treating or preventing an infection of the nail, claw, or hoof comprising administering to a subject a pharmaceutical composition comprising an N-halogenated or N,N-dihalogenated amine compound of the application. | 10-28-2010 |
| 20110190392 | Polysaccharide Based Antimicrobial Formulations - Described herein are antimicrobial formulations or compositions comprising an N-halogenated or N,N-dihalogenated amine compound and a saccharide-based gelling agent. Methods of using such formulations, including a method of preventing or treating an infection caused by a bacterial, a microbial, a sporal, a fungal or a viral activity, are also disclosed. | 08-04-2011 |
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| 20120122733 | COMPOSITION, DEVICE AND ASSOCIATED METHOD - The composition includes a first probe and a first initiator bonded to the first probe. The composition further includes a second probe and a second initiator bonded to the second probe. The first probe and the second probe are capable of binding to a single analyte. An associated kit, device, and method are provided. | 05-17-2012 |
| 20120122734 | COMPOSITION, DEVICE AND ASSOCIATED METHOD - A composition includes a first probe and a first initiator bonded to the first probe. The first probe is capable of binding to an analyte and the first initiator is capable of initiating a controlled polymerization reaction. An associated kit, device, and method are provided. | 05-17-2012 |
| 20120122735 | COMPOSITION, DEVICE AND ASSOCIATED METHOD - A composition includes a first probe, a first initiator component bonded to the first probe, a second probe, and a second initiator component bonded to the second probe. The first probe and the second probe are capable of binding to a single analyte, and the first initiator component and the second initiator component are capable of forming an initiator when present in proximity to each other and when the first probe and the second probe are bonded to the analyte. An associated kit, device, and method are provided. | 05-17-2012 |
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| 20080228366 | MODEL BASED VEHICLE OVERSPEED ALGORITHM - A system for limiting the speed of a vehicle includes a first module that generates a first torque signal based on a vehicle speed, a second module that generates a second torque signal based on a difference between a predetermined vehicle speed limit and the vehicle speed, and a third module that generates an output torque signal based on the first and second torque signals. The output torque signal is adapted to control the output torque of a motor. | 09-18-2008 |
| 20090118972 | INVERSE TORQUE MODEL SOLUTION AND BOUNDING - An engine control system includes a spark bound module that determines a bounded spark value based on a desired spark value, a torque bound module that determines a bounded torque value based on the bounded spark value and a desired torque value, and an inverse torque calculation module that determines a desired engine air value based on the bounded torque value and the square of the bounded spark value. The engine air value may be one of a desired air-per-cylinder value and a desired manifold air pressure value. The bounded spark value and the bounded torque value are determined based on one or more of a plurality of engine actuator positions. Related methods for determining the bounded spark value, the bounded torque value, and the engine air value are also provided. | 05-07-2009 |
| 20090118977 | CYLINDER FUELING COORDINATION FOR TORQUE ESTIMATION AND CONTROL - An engine control system comprises a torque control module and a fueling control module. The torque control module selectively generates a deactivation signal for a first cylinder of a plurality of cylinders of an engine based on a torque request. The fueling control module halts fuel delivery to the first cylinder based on the deactivation signal. The torque control module increases a spark advance of the engine at a first time after the fueling control module halts fuel injection for the first cylinder. The first time corresponds to an initial time combustion fails to occur in the first cylinder because fuel delivery has been halted. | 05-07-2009 |
| 20090118985 | SECURED COUNT OF CYLINDERS FUELED IN A COORDINATED TORQUE CONTROL SYSTEM - A control system for a vehicle includes a first counter that indicates a first count of a number of cylinders of an engine of the vehicle that are fueled. A second counter indicates a second count of the number of cylinders that are fueled. A control module determines a secure count based on the first count and the second count. The control module adjusts torque output of the engine based on the secure count. | 05-07-2009 |
| 20100075803 | SECURING THROTTLE AREA IN A COORDINATED TORQUE CONTROL SYSTEM - An engine system includes a throttle actuator module and a torque control module. The throttle actuator module controls a throttle actuator based on a desired throttle area. The torque control module determines an actuator torque. The torque control module determines a rate limited torque, a maximum torque, and a minimum torque based on the actuator torque and a predetermined rate of change. The torque control module determines the desired throttle area based on the actuator torque when the rate limited torque is greater than the maximum torque. The torque control module determines the desired throttle area based on the actuator torque when the rate limited torque is less than the minimum torque. | 03-25-2010 |
