| Patent application number | Description | Published |
|---|
| 20080287488 | Use of a Sulfonamide Compound For Improving the Pharmacokinetics of a Drug - A method for improving the pharmacokinetics of drugs, which are metabolized by cytochrome P450 monooxygenase is disclosed. More specifically it relates to a method for improving the pharmacokinetics of retroviral protease inhibitors and in particular for improving the pharmacokinetics of human immunodeficiency virus (HIV) protease inhibitors. A pharmaceutical composition and its use in the manufacture of a medicament for the inhibition or treatment of an HIV infection or AIDS in a human being are also part of the invention. | 11-20-2008 |
| 20090176813 | AQUEOUS SUSPENSIONS OF TMC278 - This invention concerns pharmaceutical compositions for administration via intramuscular or subcutaneous injection, comprising micro- or nanoparticles of the NNRTI compound TMC278, suspended in an aqueous pharmaceutically acceptable carrier, and the use of such pharmaceutical compositions in the treatment and prophylaxis of HIV infection. | 07-09-2009 |
| 20090197903 | PROCESS FOR PREPARING SPRAY DRIED FORMULATION OF TMC125 - This invention relates to a process for producing a spray-dried powder comprising microcrystalline cellulose in a solid dispersion of the anti-HIV compound etravirine (TMC125) in a water-soluble polymer. | 08-06-2009 |
| 20100120795 | POWDERS FOR RECONSTITUTION - This invention relates to powders for reconstitution comprising the NNRTI TMC278 dispersed in certain water-soluble polymers, which can be used in the treatment of HIV infection. | 05-13-2010 |
| 20110077261 | PREVENTION OF HIV-INFECTION - This invention relates to the use of a parenteral formulation comprising the NNRTI TMC278 for the long term prevention of HIV infection in a subject at risk of being infected by HIV, which comprises the intermittent administration of the said formulation at long time intervals. | 03-31-2011 |
| 20110256206 | IMPLANTABLE DEVICES FOR TREATING HIV - The present invention relates to an implantable device comprising a biocompatible, biodegradable polymer mixed with TMC278 and with one or more release-enhancing agents selected from the group consisting of poloxamers, polysorbates, and a combination of dimethyl sulfoxide (DMSO) and poly(vinyl pyrrolidone)(PVP). | 10-20-2011 |
| 20110275654 | LONG TERM TREATMENT OF HIV-INFECTION WITH TMC278 - This invention relates to the use of a parenteral formulation comprising an anti-virally effective amount of TMC278 or a pharmaceutically acceptable acid-addition salt thereof, and a carrier, for the manufacture of a medicament for the treatment of a subject being infected with HIV, wherein the formulation is to be administered intermittently at a time interval of at least one week. | 11-10-2011 |
| 20120028998 | CO-CRYSTAL OF ETRAVIRINE AND NICOTINAMIDE - Etravirine (TMC125) nicotinamide co-crystal, its preparation, and use in the treatment of HIV infection. | 02-02-2012 |
| Patent application number | Description | Published |
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| 20110224944 | TESTABLE VIBRATION MONITORING DEVICE AND METHOD - A vibration monitoring device having a reference axis and is provided with two accelerometers fixed to a common support. Each accelerometer includes: an inertia mass movable parallel to the reference axis between an intermediate rest position and two opposite limits, an internal test circuit for moving the inertia mass from a rest position towards a first of the two opposite limits in one testable direction in the absence of vibration of the common support, and sensing means for delivering an acceleration signal corresponding to the motion of the inertia mass parallel to the reference axis, the acceleration signal containing a first signal portion corresponding to the motion of the inertia mass between the intermediate rest position and the first of the two opposite limits, and a second signal portion corresponding to the motion of the inertia mass between the intermediate rest position and the other of the two opposite limits. Remarkably, the testable directions of the two accelerometers are opposite to one another. | 09-15-2011 |
| 20110234199 | DISTRIBUTED SAFETY MONITORING SYSTEM PROVIDED WITH A SAFETY LOOP AND METHOD OF TESTING SUCH A SYSTEM - A distributed safety monitoring system is provided with a first safety loop for connecting safety relays in series to a common power supply. The opening of any one of the safety relays can be detected by a current detector located in the safety loop. Each safety relay is part of a local safety monitoring device, which is provided with a local power supply and a test circuit, to allow local testing of the safety relay independently from the common power supply. Hence, the safety relays can be tested simultaneously. | 09-29-2011 |
| 20120046900 | INSTABILITY MONITORING DEVICE AND SYSTEM, IN PARTICULAR FOR A RAIL VEHICLE - An instability monitoring device for a rail vehicle, includes: at least a first accelerometer for delivering a first acceleration signal in response to vibration along a reference axis, at least a first solid-state safety relay, having two main terminals and being switchable between a closed state and an open state, and a programmable logic device connected to the first accelerometer and to the first solid-state relay, the programmable logic device is a field programmable gate array (FPGA) or a complex programmable logic device (CPLD), provided with non-volatile logic blocks running simultaneously in parallel and implementing an instability monitoring algorithm to change the state of the first solid-state relay based on an instability condition of the first acceleration signal. | 02-23-2012 |
