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Bae, US
Chulsung Bae, Henderson, NV US
| Patent application number | Description | Published |
|---|---|---|
| 20100041834 | Incorporation of functional groups into polymers using C-H activation - Designed functionality is incorporated onto a preformed aromatic polymer. The preformed aromatic polymer is provided in a reactive medium. Within that reactive medium is provided a borylation reagent and a catalyst for C—H borylation. A; and a C—H position on an aromatic ring on the preformed aromatic polymer is catalytically borylated with the borylating agent to form a borylated aromatic moiety on the preformed aromatic polymer as an incorporated boryl functionality. That boryl functionality may then be reacted with designed alternative functionalities. | 02-18-2010 |
Chulsung Bae, Las Vegas, NV US
| Patent application number | Description | Published |
|---|---|---|
| 20080262163 | Modification of polymers having aromatic groups through formation of boronic ester groups - The C—H bond of pendant aromatic groups such as commercial polystyrenes with three types of tacticities (syndiotactic, isotactic, atactic) undergo catalyzed functionalization with boron reagents. A boronic ester group formed on the polymer in the polystyrene was further converted to hydroxy and arene via oxidation and coupling reactions, respectively. These functionalizations proceeded without significantly affecting the molecular weight of starting polymer and the functional concentrations could be easily controlled by changing the ratio of boron reagent to monomer unit. | 10-23-2008 |
Dong Joo Bae, Plano, TX US
| Patent application number | Description | Published |
|---|---|---|
| 20080242018 | METHOD OF REDUCING CHANNELING OF ION IMPLANTS USING A SACRIFICIAL SCATTERING LAYER - Methods and devices for preventing channeling of dopants during ion implantation are provided. The method includes providing a semiconductor substrate and depositing a sacrificial scattering layer over at least a portion a surface of the substrate, wherein the sacrificial scattering layer includes an amorphous material. The method further includes ion implanting a dopant through the sacrificial scattering layer to within a depth profile in the substrate. Subsequently, the sacrificial scattering layer can be removed such that erosion of the substrate surface is less than one percent of a thickness of the sacrificial scattering layer. | 10-02-2008 |
Euiwon Bae, West Lafayette, IN US
| Patent application number | Description | Published |
|---|---|---|
| 20080310692 | System and method of organism identification - A system and method for identifying organisms by analysis of scattergrams of colonies is disclosed. cattergrams are obtained by culturing samples and illuminating the resultant colonies by a laser. The forward scattered light is imaged and subject to a feature extraction process. The feature vector may include Zernike or Chebyshev moments and may also include Harelick texture features. Feature vectors may be used to train a classification process using either supervised or unsupervised machine learning techniques. The classification process may be used to associate a colony phenotype with the genotype of the sample. | 12-18-2008 |
Euiyoung Bae, Oakland, WI US
| Patent application number | Description | Published |
|---|---|---|
| 20100042375 | System and Method for Designing Proteins - Various embodiments of the present invention include systems and methods for redesigning proteins. Various embodiments of the present invention present bioinformatic methods to redesign proteins to be more stable through optimization of local structural entropy. The redesigned proteins display significant increases in their thermal stabilities while retaining catalytic activity, and demonstrate a broadly applicable method. | 02-18-2010 |
Hong Bae, Farmington Hills, MI US
| Patent application number | Description | Published |
|---|---|---|
| 20100332080 | METHOD AND APPARATUS FOR PARKING ASSISTANCE - A method of providing assistance to a driver for parking a vehicle includes detection of a space and a location of the vehicle for vehicle parking. The method determines a feasibility for parking the vehicle into the space based on the space; calculates a parking path based on the space and the location; generates a constant target position of a steering wheel based on the parking path; generates a first human machine interface (HMI) signal that instructs the driver to turn the steering wheel based on the target position, wherein the first HMI signal is generated when the vehicle is not moving; monitors a steering wheel angle of the vehicle including comparing the steering wheel angle with the constant target position, and detecting that the steering wheel angle reaches a proximity of the target position. The method also includes generating a second HMI signal that instructs the driver to hold the steering wheel, wherein the second HMI signal is generated when the steering wheel angle has reached the proximity of the target position; generating a vehicle motion command after the steering wheel angle is held steadily according to the second HMI signal; and generating a third HMI signal based on the vehicle motion command. | 12-30-2010 |
Hong S. Bae, Farmington Hills, MI US
| Patent application number | Description | Published |
|---|---|---|
| 20110202227 | HEALTH PROGNOSIS FOR COMPLEX SYSTEM USING FAULT MODELING - A system and method for providing component and sub-system state of health prognosis in a complex system using fault models and component aging models. The method includes determining a current state of health value for a sub-system using fault signature test results and determining current state of health values for a plurality of components in the sub-system using the fault signature test results. The method also determines current state of health values for components in the system that cannot use fault signature test results using a first probability model and the current state of health values for the plurality of components. The method determines predicted future state of health values for the components in the sub-system using component aging models and determines a predicted future state of health value for the sub-system using a second probability model and the future state of health values of the components. | 08-18-2011 |
| 20110202494 | METHOD AND APPARATUS FOR VEHICLE COMPONENT HEALTH PROGNOSIS BY INTEGRATING AGING MODEL, USAGE INFORMATION AND HEALTH SIGNATURES - A system and method for determining the health of a component includes retrieving measured health signatures from the component, retrieving component usage variables, estimating component health signatures using an aging model, determining an aging derivative using the aging model and calculating an aging error based on the estimated component health signatures, the aging derivative and the measured health signatures. | 08-18-2011 |
Hong S. Bae, Sterling Heights, MI US
| Patent application number | Description | Published |
|---|---|---|
| 20100288030 | METHOD AND APPARATUS FOR REAL-TIME ESTIMATION OF FOUR WHEEL IMBALANCES FOR CHASSIS PROGNOSIS - A system and method for determining whether a particular wheel on a vehicle is un-balanced during operation of the vehicle. The method includes providing wheel angle signals from the wheels of the vehicle and providing a vibration measurement signal from a response point on the vehicle, such as from an accelerometer on a steering column of the vehicle. The method also includes generating a regression vector using the wheel angle signals. The method also includes generating an estimated parameter vector using a recursive least squares algorithm, the regression vector and the vibration measurement signal. The method then calculates an imbalanced magnitude value of each wheel of the vehicle using the estimated parameter vector. The method uses a persistency of excitation test to determine whether the parameter vector has converged to a true value to determine whether the calculated imbalanced magnitude values are accurate. | 11-18-2010 |
| 20110054758 | Method for Maintaining a Brake Rotor - A disc braking system of a vehicle determines the actual temperature of a brake rotor. The disc braking system compares the actual temperature of the brake rotor to a critical temperature of the brake rotor. The critical temperature of the brake rotor is a temperature above which damage and/or warping to the brake rotor may occur. The disc braking system applies a corrective measure to prevent damage to the brake rotor when the actual temperature of the brake rotor is greater than the critical temperature of the brake rotor. The corrective measure may include, but is not limited to: displaying a warning, adjusting a fraction control system of the vehicle, scheduling maintenance for the vehicle. | 03-03-2011 |
| 20110128161 | VEHICULAR WARNING DEVICE FOR PEDESTRIANS - A pedestrian warning system includes a sensing device that is provided on the vehicle for detecting a pedestrian within a predetermined zone around the vehicle. A warning device on the vehicle generates a warning signal perceived by the pedestrian outside the vehicle indicating a presence of the vehicle. A speed sensor senses a speed of the vehicle. A controller is configured to receive a signal from the sensing device indicating the detection of the pedestrian within the predetermined zone. The controller determines whether the speed of the vehicle is within a predetermine speed range. The controller actuates the warning device for warning the pedestrian of the close proximity to the vehicle in response to determining the vehicle traveling at a respective speed is within the predetermined speed range and detecting the presence of the pedestrian within the predetermined zone. | 06-02-2011 |
| 20110178671 | DIAGNOSIS OF WHEEL ALIGNMENT USING GPS - A method to monitor alignment of wheels of a vehicle through analysis of a GPS signal includes monitoring the GPS signal, determining an actual trajectory of the vehicle based upon the GPS signal, monitoring a vehicle sensor indicating an expected change in vehicle heading, determining an expected trajectory of the vehicle based upon the vehicle sensor, and indicating misalignment of the wheels of the vehicle based upon a comparison of the trajectories. | 07-21-2011 |
Hun Jai Bae US
| Patent application number | Description | Published |
|---|---|---|
| 20110168425 | CLEAN FLAME RETARDANT COMPOSITIONS WITH CARBON NANO TUBE FOR ENHANCING MECHANICAL PROPERTIES FOR INSULATION OF WIRE AND CABLE - Commercial thermoplastic clean flame retardant materials in wire and cable insulation are mechanically unstable due to high filler loading. In the present invention, thermoplastic, black color, clean flame retardant composition using carbon nano tubes (CNT) is made. The resultant compositions possess very low smoke and toxicity. CNT with outer diameter of 40-60 nm and length of under 20 μm are used to increase mechanical properties and flame retardancy. Thermo plastically extruded composition consists of each component by parts by weight as follows: 100 of resin (polyolefin or 100 of polyolefin/ethylene propylene diene monomer (EPDM)), 90-150 of non halogen containing flame retardants, 1-20 of auxiliary secondary flame retardant agents, 2-4 of CNT (outer diameter of 40-60 nm) and length under 20 μm and 0.2-1.0 of antioxidants. A reliable method for producing thermoplastic black color clean flame retardant insulation material for wire and cable without deterioration of mechanical properties is discussed. | 07-14-2011 |
Hyungdae Bae, College Park, MD US
| Patent application number | Description | Published |
|---|---|---|
| 20110023617 | ULTRA-MINIATURE FIBER-OPTIC PRESSURE SENSOR SYSTEM AND METHOD OF FABRICATION - Ultra-miniature surface-mountable Fabry-Perot pressure sensor is constructed on an optical fiber which utilizes a 45° angled fiber tip covered with a reflective layer which steers the optical axis of the fiber by 90°. The Fabry-Perot cavity is formed on the sidewall of the fiber and a polymer-metal composite diaphragm is formed on the top of the Fabry-Perot cavity to operate as a pressure transducer. The sensor exhibits a sufficient linearity over the broad pressure range with a high sensitivity. The sensitivity of the sensor may be tuned by controlling the thickness of the diaphragm. The sensor may be used in a wide range of applications, including reliable in vivo low invasive pressure measurements of biological fluids, single sensor systems, as well as integral spatial-division-multiplexing sensor networks. Methods of batch production of uniform device-to-device Fabry-Perot pressure sensors of co-axial and cross-axial configurations are presented. | 02-03-2011 |
Jaehoon Bae, Bartlesville, OK US
| Patent application number | Description | Published |
|---|---|---|
| 20120023810 | METAL IMPURITY AND HIGH MOLECULAR WEIGHT COMPONENTS REMOVAL OF BIOMASS DERIVED BIOCRUDE - This invention relates to a process for production of transportation fuels from biomass. More particularly, this invention relates to a process for using solvent to remove metal impurities and high molecular weight components from biomass derived biocrude to prevent potential catalyst poisoning and catalyst bed plugging in biocrude-to-transportation fuel upgrading process. | 02-02-2012 |
Ji Bae, Duluth, GA US
| Patent application number | Description | Published |
|---|---|---|
| 20110246301 | METHODS TO ACCESS PRODUCT PLACEMENT DATA - A method is provided to that allows product placement data of specific items to be conveniently accessed. A user may submit a request for a specific item or items via a client device (e.g., a mobile device, laptop, desktop, etc.) to a server. The server responds with product placement data for providers (e.g., retailers, stores, service providers, libraries, etc.) of the item or items that are close geographically to the user's location. Other data may be included with the response including pricing information of the item, distance or directions to the provider, and promotions. | 10-06-2011 |
Joon-Ho Bae, Atlanta, GA US
| Patent application number | Description | Published |
|---|---|---|
| 20110235241 | Flexible supercapacitor, method of manufacturing the same, and device including the flexible supercapacitor - A flexible supercapacitor, a method of manufacturing the same, and a device including the same are provided, the flexible supercapacitor includes a first flexible electrode assembly, a second flexible electrode assembly corresponding to the first flexible electrode assembly, a separator for preventing contact between the first flexible electrode assembly and the second flexible electrode assembly, and an electrolyte between the first flexible electrode assembly and the second flexible electrode assembly. The flexible supercapacitor may include a tube including the first flexible electrode assembly, the second flexible electrode assembly, the separator, and the electrolyte. | 09-29-2011 |
Juyun Bae, Madison, WI US
| Patent application number | Description | Published |
|---|---|---|
| 20090325241 | SUGAR TRANSPORT SEQUENCES, YEAST STRAINS HAVING IMPROVED SUGAR UPTAKE, AND METHODS OF USE - Disclosed are nucleic acid constructs comprising coding sequences operably linked to a promoter not natively associated with the coding sequence. The coding sequences encode | 12-31-2009 |
Kiwan E. Bae, New York, NY US
| Patent application number | Description | Published |
|---|---|---|
| 20100189099 | METHOD AND SYSTEM FOR PROVIDING INTERDOMAIN TRAVERSAL IN SUPPORT OF PACKETIZED VOICE TRANSMISSIONS - An approach provides interdomain traversal to support packetized voice transmissions. A request for establishing a voice call is received from a source endpoint behind a first network address translator of a first domain, wherein the request specifies a directory number of a destination endpoint within a second domain. A network address is determined for communicating with the destination endpoint based on the directory number. Additionally, existence of a second network address translator within the second domain is determined. If the network address can be determined, a media path is established between the source endpoint and the destination endpoint based on the network address to support the voice call. | 07-29-2010 |
Kiwan Edward Bae, New York, NY US
| Patent application number | Description | Published |
|---|---|---|
| 20110149956 | METHOD AND SYSTEM FOR PROVIDING SECURE MEDIA GATEWAYS TO SUPPORT INTERDOMAIN TRAVERSAL - An approach provides interdomain traversal to support packetized voice transmissions. A signaling message is received for establishing a voice call from a first endpoint associated with a first domain to a second endpoint associated with a second domain. The first endpoint queries a STUN (Simple Traversal of UDP (User Datagram Protocol)) server to determine information relating to a firewall and network address translator that the first endpoint is behind, and to log into a TURN (Traversal Using Relay NAT (Network Address Translation)) server configured to establish a media path between the first endpoint and the second endpoint. A first proxy server serving the first endpoint communicates with an ENUM (Electronic Number) server to convert a directory number corresponding to the second endpoint to a network address. The first proxy server communicates with a second proxy server serving the second endpoint to establish the voice call. The STUN server, the TURN server and the ENUM server are maintained by service provider. The first endpoint is authenticated to permit exchange of a media stream over the media path. The media stream is relayed, if the first endpoint is successfully authenticated. | 06-23-2011 |
Kyongtae Ty Bae, Pittsburgh, PA US
| Patent application number | Description | Published |
|---|---|---|
| 20110213237 | ECHO-SPECIFIC K-SPACE REORDERING APPROACH TO COMPATIBLE DUAL-ECHO ARTERIOVENOGRAPHY - A dual-echo sequence technique provided herein empowers simultaneous acquisition of both TOF MRA and BOLD MRV in a single MR acquisition. By this approach, an echo-specific K-space ordering scheme permits the adjustment of the scan parameters that are compatible for each of the MRA and MRV. The image quality in the MRA and MRV acquired by this compatible dual-echo arteriovenography (CODEA) technique is comparable to that for conventional, single-echo MRA and MRV. When the technique is integrated with MOTSA, seamless vascular connectivity is achieved in both MRA and MRV over a large area of brain anatomy. The technique will facilitate routine clinical acquisition and application of dual-echo MRA and MRV, as both MRA and MRV can be acquired with minimal impact on the image quality and without adversely affecting the scan throughput. | 09-01-2011 |
Myung Bae, Poughkeepsie, NY US
| Patent application number | Description | Published |
|---|---|---|
| 20110289344 | AUTOMATED NODE FENCING INTEGRATED WITHIN A QUORUM SERVICE OF A CLUSTER INFRASTRUCTURE - A quorum service within a cluster infrastructure layer of a cluster environment comprising a plurality of nodes automatically triggers at least one automated fencing operation integrated within the quorum service, to reliably maintain a node usability state of each node of the plurality of nodes indicating an availability of each node to control and access at least one shared resource of the cluster. The quorum service reports the node usability state of each node as a cluster health status to at least one distributed application within an application layer of the cluster environment, to provide a reliable cluster health status of the plurality of nodes to the at least one distributed application for a failover of said at least one shared resource from control by a failed node from among the plurality of nodes to another node from among the plurality of nodes. | 11-24-2011 |
Myung M. Bae, Pleassant Valley, NY US
| Patent application number | Description | Published |
|---|---|---|
| 20080307095 | PERSISTENT GROUP MEMBERSHIP IN A DISTRIBUTING COMPUTING SYSTEM - A distributed system has a multiplicity of nodes. A group of the nodes subscribe to a group services process. The group is subject to dissolving. A list of persistent subscribers to the group is maintained. Subscriptions to members and states of the group that are persistent subscribers do not terminate in response to the group being dissolved. The persistent subscribers automatically receive a notice in response to the group being reestablished and do not need to re-subscribe to the group. | 12-11-2008 |
Myung M. Bae, Pleasant Valley, NY US
| Patent application number | Description | Published |
|---|---|---|
| 20080313333 | SCALABLE METHOD OF CONTINUOUS MONITORING THE REMOTELY ACCESSIBLE RESOURCES AGAINST NODE FAILURES FOR VERY LARGE CLUSTERS - The notion of controlling, using and monitoring remote resources in a distributed data processing system through the use of proxy resource managers and agents is extended to provide failover capability so that resource coverage is preserved and maintained even in the event of either temporary or longer duration node failure. Mechanisms are provided for consistent determination of resource status. Mechanisms are also provided which facilitate the joining of nodes to a group of nodes while still preserving remote resource operations. Additional mechanisms are also provided for the return of remote resource management to the control of a previously failed, but now recovered node, even if the failure had resulted in a node reset. | 12-18-2008 |
| 20090132501 | THREE-DIMENSIONAL DATA STRUCTURE FOR STORING DATA OF MULTIPLE DOMAINS AND THE MANAGEMENT THEREOF - A three-dimensional data structure for storing data is defined and maintained. The three-dimensional data structure includes at least one column of data having a depth greater than zero indicating that multiple data values are provided for multiple domains represented by the structure. The data structure also includes zero or more columns of data having a depth of zero indicating that the data value of a zero depth column is invariable for a plurality of domains represented by the structure. The structure is maintained by employing various operations including, create, write and read operations. | 05-21-2009 |
| 20090245518 | SECURE COMMUNICATIONS IN COMPUTER CLUSTER SYSTEMS - A system to improve communication security in cluster machine processing may include interconnected computers that can jointly process data. The system may also include a shared secret key used by each of the interconnected computers to encrypt, decrypt, and/or authenticate data being sent, or received, from one of the interconnected computers to another of the interconnected computers. The system may further include a new shared secret key used by each of the interconnected computers to encrypt, decrypt, and/or authenticate data being sent, or received, from one of the interconnected computers to another of the interconnected computers. In addition, the new shared secret key may coexist with the shared secret key without adversely affecting the joint processing of data performed by the plurality of interconnected computers. | 10-01-2009 |
| 20110258306 | Lock acquisition among node of divided cluster - The acquisition of a lock among nodes of a divided cluster is disclosed. A method is performable by each of at least one node of the cluster. A node waits for a delay corresponding to its identifier. The node asserts intent to acquire the lock by writing its identifier to X and Y variables where another node has failed to acquire the lock. The node waits for another node to acquire the lock where the other node has written to X, and proceeds where Y remains equal to its own identifier. The node waits for another node to acquire the lock where the other node has written to a Z variable, and writes its own identifier to Z and proceeds where the other node has failed. The node writes a value to Y indicating that it is acquiring the lock, and maintains acquisition by periodically writing to Z. | 10-20-2011 |
Myung Mun Bae, Pleasant Valley, NY US
| Patent application number | Description | Published |
|---|---|---|
| 20090282151 | SEMI-HIERARCHICAL SYSTEM AND METHOD FOR ADMINISTRATION OF CLUSTERS OF COMPUTER RESOURCES - A method for managing clustered computer resources, and particularly very large scale clusters of computer resources by a semi-hierarchical n level, n+1 tier approach. Controller resources and controlled resources exist at different hardware levels. The top level consists of controller nodes and a first tier is defined for at least part of the top level. At a last level, at which controlled nodes are found, a last tier is defined. Additional levels of controlled and controller resources may exist between the top and last levels. At least one logical intermediate tier is introduced between adjacent levels and comprises at least one proxy or set of proxy processes. | 11-12-2009 |
Sang Ho Bae, Austin, TX US
| Patent application number | Description | Published |
|---|---|---|
| 20090294867 | DUAL METAL GATES USING ONE METAL TO ALTER WORK FUNCTION OF ANOTHER METAL - Methods of forming dual metal gates and the gates so formed are disclosed. A method may include forming a first metal (e.g., NMOS metal) layer on a gate dielectric layer and a second metal (e.g., PMOS metal) layer on the first metal layer, whereby the second metal layer alters a work function of the first metal layer (to form PMOS metal). The method may remove a portion of the second metal layer to expose the first metal layer in a first region; form a silicon layer on the exposed first metal layer in the first region and on the second metal layer in a second region; and form the dual metal gates in the first and second regions. Since the gate dielectric layer is continuously covered with the first metal, it is not exposed to the damage from the metal etch process. | 12-03-2009 |
Sung Woo Bae, Austin, TX US
| Patent application number | Description | Published |
|---|---|---|
| 20110065161 | BIPOLAR SOLID STATE MARX GENERATOR - A high-voltage bipolar rectangular pulse generator using a high efficiency solid-state boosting front-end and an H-bridge output stage is described. The topology of the circuit generates rectangular pulses with fast rise time and allows easy step-up input voltage. In addition, the circuit is able to adjust positive or negative pulse width, dead-time between two pulses, and operating frequency. The intended application for such circuit is algae cell membrane rupture for oil extraction, although additional applications include biotechnology and plasma sciences medicine, and food industry. | 03-17-2011 |
Unmin Bae, Seattle, WA US
| Patent application number | Description | Published |
|---|---|---|
| 20080287792 | Ultrasonic Direct Strain Estimation Using Temporal and Spatial Correlation - Strain is directly estimated in ultrasound elasticity imaging without computing displacement or resorting to spectral analysis. Conventional ultrasound elasticity imaging relies on calculating displacement and strain is computed from a derivative of the displacement. However, for typical parameter values used in ultrasound elasticity imaging, the displacement can be as large as a hundred times or displacement differences. If a tiny error in the calculation of displacement occurs, this could drastically affect the calculation of strain. By directly estimating strain, image quality is enhanced and the reduction in computational effort facilitates commercialization to aid in diagnosing disease or cancerous conditions. | 11-20-2008 |
| 20100094131 | ULTRASONIC ESTIMATION OF STRAIN INDUCED BY IN VIVO COMPRESSION - An in vivo source of compression is used to cause a bodily structure of interest to expand and contract. Ultrasound signals are incident and their echoes are processed by a strain processor. Resulting strain images are freed from noise caused external sources of compression. A tissue stiffness index is calculated to obtain quantitative measure of stiffness. | 04-15-2010 |
| 20100292572 | METHOD AND SYSTEM OF STRAIN GAIN COMPENSATION IN ELASTICITY IMAGING - A method and system of strain gain compensation in elasticity imaging is provided. The system can include a probe ( | 11-18-2010 |
Woo Jin Bae, Ithaca, NY US
| Patent application number | Description | Published |
|---|---|---|
| 20110039105 | Non-aggregating nanoparticles and the use thereof - The present invention relates generally to non-aggregating nanoparticles, including ligand capped metal oxide nanoparticles. Methods for their synthesis and methods for their use, for example, for improved immersion lithography processes, are also disclosed. | 02-17-2011 |
Yong-Kug Bae US
| Patent application number | Description | Published |
|---|---|---|
| 20120122284 | METHOD OF MANUFACTURING A SEMICONDUCTOR DEVICE - A method of manufacturing a semiconductor device includes forming a plurality of gate structures including a metal on a substrate having an isolation layer, forming first insulating interlayer patterns covering sidewalls of the gate structures, forming first capping layer patterns and a second capping layer pattern on the gate structures and the first insulating interlayer patterns, the first capping layer patterns covering upper faces of the gate structures, and the second capping layer pattern overlapping the isolation layer, partially removing the first insulating interlayer patterns using the first and the second capping layer patterns as etching masks to form first openings that expose portions of the substrate, forming metal silicide patterns on the portions of the substrate exposed in the forming of the first openings, and forming conductive structures on the metal silicide patterns. | 05-17-2012 |
You Han Bae, Salt Lake City, UT US
| Patent application number | Description | Published |
|---|---|---|
| 20080213379 | Tumor environment-induced ligand-expressing nanocarrier system - Drug delivery compositions for specific delivery of a drug to a tumor are described. These compositions include a core for sequestering the drug and a shell to which a ligand is attached for delivery of a drug to target cells. Since normal cells may also be targeted by the ligand, the compositions embed the ligand in the shell until the localized conditions surrounding the tumor cause the ligand to be displayed on the surface of the shell. One composition exhibits shrinkage of the shell at tumor pH, whereas another composition exhibits extension of the ligand at tumor pH. Still another composition causes the ligand to be exhibited at an elevated temperature. | 09-04-2008 |
| 20090060955 | Drug delivery vehicle that mimics viral properties - A drug delivery vehicle for targeted delivery of a drug mimics viral properties of size, capsid-like protein capsule, cell-specific entry, toxin release, destruction of infected cells, and migration to neighboring cells. This vehicle, termed a virogel, contains a hydrophobic polymeric core, a hydrophilic inner shell, a hydrophilic outer shell, and a ligand. An illustrative drug-loaded virogel includes poly(L-histidine-co-phenylalanine) as the core, doxorubicin loaded in the core, polyethylene glycol as the inner shell, bovine serum albumin as the outer shell, and folic acid as the ligand. | 03-05-2009 |
| 20090274753 | PH-SENSITIVE POLYMERIC MICELLES FOR DRUG DELIVERY - Mixed micelles containing poly(L-histidine)-poly(ethylene glycol) block copolymer and poly(L-lactic acid)-poly(ethylene glycol) block copolymer are a pH-sensitive drug carrier that release the drug in an acidic microenvironment, but not in the blood. Since the microenvironment of solid tumors is acidic, these mixed micelles are useful for treating cancer, including those cancers exhibiting multidrug resistance. Targeting ligands, such as folate, can also be attached to the mixed micelles for enhancing drug delivery into cells. Methods of treating a warm-blooded animal with such a drug are disclosed. | 11-05-2009 |
| 20100009926 | PH-SENSITIVE POLYMERIC MICELLES FOR DRUG DELIVERY - Mixed micelles containing poly(L-histidine-co-phenylalanine)-poly(ethylene glycol) block copolymer and poly(L-lactic acid)-poly(ethylene glycol) block copolymer are a pH-sensitive drug carrier that release the drug in an acidic microenvironment, but not in the blood. Since the microenvironment of solid tumors is acidic, these mixed micelles are useful for treating cancer, including those cancers exhibiting multidrug resistance. Targeting ligands, such as folate, can also be attached to the mixed micelles for enhancing drug delivery into cells. Methods of treating a warm-blooded animal with such a drug are disclosed. | 01-14-2010 |
| 20100056843 | Brachytherapy Seed With Fast Dissolving Matrix for Optimal Delivery of Radionuclides To Cancer Tissue - A system, method and device for treating tumor cells utilizing a resorbable therapy seed made up of microspheres containing a beta-particle-emitting radiation source and a resorbable polymer matrix. These seeds are implanted within the tumor and then rapidly dissolved or broken so as to release the microspheres. These microspheres then spread within a preselected target area and provide radiation therapy in a predetermined amount and at a preselected rate according the specific needs and necessities of the users. The configuration of the microspheres, the types of radiation provided and the location and use of these microspheres provides desired localized treatment to target cells while preferentially avoiding undesired damage to surrounding tissue. The present invention provides a method for making the seeds, as well as a method for utilizing the seeds as a part of the treatment method. | 03-04-2010 |
| 20100056844 | BRACHYTHERAPY SEED WITH FAST DISSOLVING MATRIX FOR OPTIMAL DELIVERY OF RADIONUCLIDES TO CANCER TISSUE - A system, method and device for treating tumor cells utilizing a resorbable therapy seed made up of microspheres containing a beta- or alpha-particle-emitting radiation source and a resorbable polymer matrix. These seeds are implanted within the tumor and then rapidly dissolved so as to release the microspheres from the polymer matrix. These microspheres then spread within a preselected target area and provide radiation therapy in a predetermined amount and at a preselected rate according the specific needs and necessities of the users. The configuration of the microspheres, the types of radiation provided and the location and use of these microspheres provides desired localized treatment to target cells while preferentially avoiding or minimizing undesired damage to surrounding tissue. The present invention provides a method for making the seeds, as well as a method for utilizing the seeds as a part of the treatment method. | 03-04-2010 |
| 20110027347 | POLYMERSOMES AND METHODS OF MAKING AND USING THEREOF - Described herein is the synthesis and pharmacology of polymersomes containing one or more bioactive agents. The polymersome is generally derived from a polymer having the formula XY | 02-03-2011 |
Younsoo Bae, Madison, WI US
| Patent application number | Description | Published |
|---|---|---|
| 20080248097 | POLYMERIC MICELLES FOR COMBINATION DRUG DELIVERY - The invention provides block polymers, micelles, and micelle formulations for combination drug therapy. Polyamide block polymers, such as those of formulas I and II are useful, for example, for preparation of mixed drug micelles, including simply mixed micelles, physically mixed micelles, and chemically mixed micelles. The invention further provides methods of treating cancer, and inhibiting and killing cancer cells. Also provided are methods for the preparation of polymer drug conjugates and intermediates for their synthesis. | 10-09-2008 |
| 20090232762 | COMPOSITIONS FOR DELIVERY OF THERAPEUTIC AGENTS - The invention provides a polyamide compounds and compositions, in addition to methods for their preparation and methods for their use. The invention also provides micelle compositions that include encapsulated therapeutic agents, for example, nucleic acids or prodrugs, and methods for their preparation. The invention further provides methods of delivering therapeutic agents to cells and methods of activating therapeutic prodrugs. | 09-17-2009 |
Younsoo Bae, Lexington, KY US
| Patent application number | Description | Published |
|---|---|---|
| 20100119529 | ELASTIN-LIKE POLYMER DELIVERY VEHICLES - In invention concerns elastin-like polymer (ELP) drug delivery compositions and methods for the use thereof. In some aspects ELP delivery vehicles may be used to deliver therapeutic drugs such as Hsp90 antagonists. Furthermore, embodiments of the invention concern in vivo delivery with ELP compositions directed to target sites by the application of local hyperthermia therapy. Methods of the invention may have particular utility in the delivery of geldanamycin and related drugs. | 05-13-2010 |