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Babich, US

Alan F. Babich, Mission Viejo, CA US

Patent application number	Description	Published
20090271789	METHOD, APPARATUS AND ARTICLE OF MANUFACTURE FOR TIMEOUT WAITS ON LOCKS - Embodiments of the invention provide techniques for performing timeout waits of process threads. Generally, a thread requesting access to locked resource sends a timeout request to a timeout handler process, and then goes to sleep. The timeout request is received by a receiving thread of the timeout handler process. The receiving thread may insert the timeout request into a minimum heap of timeout requests, and may determine whether the inserted request is due earlier than any of the existing timeout requests. If so, the receiving thread may interrupt a timing thread of the timeout handler process. The timing thread may then wait until reaching the requested timeout, and then send a wakeup message to the sleeping thread.	10-29-2009

John W. Babich, North Scituate, MA US

Patent application number	Description	Published
20080312446	IMAGING AGENTS FOR DIAGNOSIS OF PARKINSON'S DISEASE - Generally, the present invention is directed to central nervous system dopamine transporter-imaging agents and methods of use thereof. In certain embodiments, the present invention relates to radiolabeled piperidine derivatives for use as imaging agents in the diagnosis of Parkinson's disease. Another aspect of the present invention relates to piperidine monoamine transporter ligands, comprising a functional group capable of chelating a radionuclide, e.g., technetium, and methods of use thereof.	12-18-2008
20090023787	TECHNETIUM-DIPYRIDINE COMPLEXES, AND METHODS OF USE THEREOF - One aspect of the invention relates to novel complexes of technetium (Tc) with various heteroaromatic ligands, e.g., pyridyl and imidazolyl ligands, and their use in radiopharmaceuticals for a variety of clinical diagnostic and therapeutic applications. Another aspect of the invention relates to novel pyridyl ligands that form a portion of the aforementioned complexes. Methods for the preparation of the technetium complexes are also described. Another aspect of the invention relates to novel pyridyl ligands based on derivatized lysine, alanine and bis-amino acids for conjugation to small peptides by solid phase synthetic methods. Additionally, the invention relates to methods for imaging regions of a mammal using the complexes of the invention.	01-22-2009
20090117032	Imaging Agents for Early Detection and Monitoring of Cardiovascular Plaque - The present invention relates in part to imaging agents comprised of a targeting moiety and a label, such as a radionuclide or paramagnetic contrast agent, and methods of use thereof.	05-07-2009
20100228012	PENDANT FATTY ACID IMAGING AGENTS - The disclosure provides pendant fatty acid compounds for use in diagnostic imaging, (particularly the cardiovascular system), as well as kits comprised of the same. The disclosure also provides for a method administering a imaging agent with a high specificity for the myocardium.	09-09-2010
20110206608	Pharmaceutical Composition Of A Radioiodinated Benzamide Derivative And Methods Of Making Same - Provided is a pharmaceutical composition comprising radioiodinated N-(2-(diethylamino)ethyl)-4-(4-fluorobenzamido)-5-iodo-2-methoxybenzamide of Formula I. The pharmaceutical composition provides a stable formulation for both storing and administering to patients having melanoma. Also provided is a novel method of iodinating the precursor compound.	08-25-2011
20110229410	TECHNETIUM-DIPYRIDINE COMPLEXES, AND METHODS OF USE THEREOF - One aspect of the invention relates to novel complexes of technetium (Tc) with various heteroaromatic ligands, e.g., pyridyl and imidazolyl ligands, and their use in radiopharmaceuticals for a variety of clinical diagnostic and therapeutic applications. Another aspect of the invention relates to novel pyridyl ligands that form a portion of the aforementioned complexes. Methods for the preparation of the technetium complexes are also described. Another aspect of the invention relates to novel pyridyl ligands based on derivatized lysine, alanine and bis-amino acids for conjugation to small peptides by solid phase synthetic methods. Additionally, the invention relates to methods for imaging regions of a mammal using the complexes of the invention.	09-22-2011

John W. Babich, Quincy, MA US

Patent application number	Description	Published
20090148382	Technetium- and rhenium-bis(heteroaryl) complexes, and methods of use thereof - One aspect of the invention relates to complexes of technetium (Tc) and rhenium (Re) with various heteroaromatic ligands, e.g., quinolinyl and isoquinolinyl ligands, and their use in fluorescence and radioimaging for a variety of clinical diagnostic applications, as well as radiopharmaceuticals for therapeutic applications. Another aspect of the invention relates to quinolinyl and isoquinolinyl ligands that form a portion of the aforementioned complexes. Methods for the preparation of the technetium and rhenium complexes are also described. Another aspect of the invention relates to quinolinyl and isoquinolinyl ligands based on derivatized lysine, alanine and bis-amino acids for conjugation to small peptides by solid phase synthetic methods. Additionally, the invention relates to methods for imaging regions of a mammal using the complexes of the invention.	06-11-2009
20100303725	Technetium- and Rhenium-Bis(heteroaryl) Complexes, and Methods of Use Thereof - One aspect of the invention relates to complexes of a radionuclide with various heteroaryl ligands, e.g., imidazolyl and pyridyl ligands, and their use in radiopharmaceuticals for a variety of clinical diagnostic and therapeutic applications. Another aspect of the invention relates to imidazolyl and pyridyl ligands that form a portion of the aforementioned complexes. Methods for the preparation of the radionuclide complexes are also described. Another aspect of the invention relates to imidazolyl and pyridyl ligands based on derivatized lysine, alanine and bis-amino acids for conjugation to small peptides by solid phase synthetic methods. Additionally, the invention relates to methods for imaging regions of a mammal using the complexes of the invention.	12-02-2010

J. W. Babich, Cambridge, MA US

Patent application number	Description	Published
20080213172	RADIOIMAGING MOIETIES COUPLED TO PEPTIDEASE-BINDING MOIETIES FOR IMAGING TISSUES AND ORGANS THAT EXPRESS PEPTIDASES - Conjugates, methods and kits are described for imaging tissues and organs that express one or more peptidases. In a preferred embodiment of the invention, a series of di-(2-pyridylmethyl)amine (D) ligands, which can bind M(CO)	09-04-2008

Michael Babich, Westlake Village, CA US

Patent application number	Description	Published
20090053290	TRANSDERMAL DRUG DELIVERY COMPOSITIONS AND TOPICAL COMPOSITIONS FOR APPLICATION ON THE SKIN - Transdermal delivery compositions and topical compositions for application to the skin are provided. The transdermal delivery composition includes at least two penetrants working synergistically but by disparate biochemical pathways. In one embodiment, the transdermal delivery system includes benzyl alcohol and lecithin organogel. The transdermal delivery compositions are used in a variety of topical compositions as a means of transdermally delivering and topically administering different drugs and agents, including compositions promoting collagen biosynthesis, retinoids and skin lighteners, chemical denervation agents such as BOTOX®, anti-fungal agents, anesthetics and non-steroidal anti-inflammatory drugs (NSAIDs). In addition, these topical compositions may be used in combination with non-ablative treatment modalities, such as microdermabrasion, laser-based skin remodeling and radio-frequency-based skin remodeling.	02-26-2009

William L. Babich, Orlando, FL US

Patent application number	Description	Published
20100077692	METAL ROOF TRUSS HAVING GENERALLY S-SHAPED WEB MEMBERS - The metal truss assembly disclosed herein is made from generally U-shaped metal chords and multiple generally S-shaped web members extending between the chords. A typical truss assembly has a pair of elongated, opposed, diverging metal upper chords and a lower chord, with the chords each forming generally U-shaped channels defining an interior chord space. A plurality of elongated metal web members extend between the upper and lower chords, with each of the web members extending into the interior space of an upper chord and the lower chord and attached to the chords. The web members, as taught herein, have a generally S-shaped cross-section. The shape of the web members is an advancement of prior art web members.	04-01-2010

William L. Babich US

Patent application number	Description	Published
20110277416	METAL ROOF TRUSS HAVING GENERALLY S-SHAPED WEB MEMBERS - The metal truss assembly disclosed herein is made from generally U-shaped metal chords and multiple generally S-shaped web members extending between the chords. A typical truss assembly has a pair of elongated, opposed, diverging metal upper chords and a lower chord, with the chords each forming generally U-shaped channels defining an interior chord space. A plurality of elongated metal web members extend between the upper and lower chords, with each of the web members extending into the interior space of an upper chord and the lower chord and attached to the chords. The web members, as taught herein, have a generally S-shaped cross-section. The shape of the web members is an advancement of prior art web members.	11-17-2011