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Baaske
Philipp Baaske, Munich DE
| Patent application number | Description | Published |
|---|---|---|
| 20110084218 | METHOD AND DEVICE FOR PARTICLE ANALYSIS USING THERMOPHORESIS - The present invention pertains to a device and method to measure thermo-optical, preferably thermophoretic, characteristics of particles in a solution. The method comprises the steps of: (a) providing a sample probe comprising marked particles in a solution; (b) providing a temperature control system for creating a temperature gradient within said sample probe by contact heating, electrical heating and/or cooling; (c) detecting the marked particles at a first time; (d) creating a temperature gradient within the sample probe by means of the temperature control system; (e) detecting the marked particles in the sample probe at a, preferably predetermined, second time and/or at a predetermined location within the temperature gradient, and (f) characterizing the particles based on said two detections. | 04-14-2011 |
Philipp Baaske, Munchen DE
| Patent application number | Description | Published |
|---|---|---|
| 20100044586 | FAST THERMO-OPTICAL PARTICLE CHARACTERISATION - The present invention relates to a method and an apparatus for a fast thermo-optical characterisation of particles. In particular, the present invention relates to a method and a device to measure the stability of (bio)molecules, the interaction of molecules, in particular biomolecules, with, e.g. further (bio)molecules, particularly modified (bio)molecules, particles, beads, and/or the determination of the length/size (e.g. hydrodynamic radius) of individual (bio)molecules, particles, beads and/or the determination of length/size (e.g. hydrodynamic radius). | 02-25-2010 |
| 20100330578 | THERMO-OPTICAL CHARACTERISATION OF NUCLEIC ACID MOLECULES - The present invention pertains to a method and a device for the determination of thermo-optical properties, particularly the size or size distribution, of fluorescently labeled biomolecules or biomolecule complexes, particularly nucleic acids, in a reaction solution. The method comprises the steps of: (i) providing a reaction solution with fluorescently labeled biomolecules or biomolecule complexes; (ii) irradiating a laser light beam into the solution to obtain a spatial temperature distribution in the solution around the irradiated laser light beam; (iii) exciting fluorescently said fluorescently labeled biomolecules and detecting the fluorescence at two or more defined regions representing different mean temperatures in said spatial temperature distribution, wherein said detection of fluorescence is performed at least once at a predetermined time after the start of the laser irradiation; and (iv) determining the thermo-optical properties, particularly the size or size distribution, of the fluorescently labeled biomolecules or biomolecule complexes from the detected fluorescence intensity or fluorescence intensity distribution. | 12-30-2010 |
Thomas Baaske, Geldern-Pont DE
| Patent application number | Description | Published |
|---|---|---|
| 20100037477 | CENTRIFUGAL DRIER - The present invention relates to a centrifugal dryer for the separation of pellet-like substances from process water, comprising a housing, a rotor arranged in the housing and a screen surrounding the rotor at the peripheral side, with the screen having at least one porous screen member which is placed in an arcuate manner around at least one screen carrier hoop and is releasably fastened thereto. In accordance with the invention, the screen is composed of a plurality of screen members which mutually overlap in the peripheral direction and are clamped tight to the screen carrier hoop by one or more tension belts which wrap around the mutually overlapping screen members at the peripheral side. Generally, differently made pliable, flexible and/or resiliently flexible tension members can be wrapped around screen members as a tension belt which are clamped and hereby hold the screen members together. | 02-18-2010 |