Patent application number | Description | Published |
20100260396 | INTEGRATED SEGMENTATION AND CLASSIFICATION APPROACH APPLIED TO MEDICAL APPLICATIONS ANALYSIS - A novel multiscale approach that combines segmentation with classification to detect abnormal brain structures in medical imagery, and demonstrate its utility in detecting multiple sclerosis lesions in 3D MRI data. The method uses segmentation to obtain a hierarchical decomposition of a multi-channel, anisotropic MRI scan. It then produces a rich set of features describing the segments in terms of intensity, shape, location, and neighborhood relations. These features are then fed into a decision tree-based classifier, trained with data labeled by experts, enabling the detection of lesions in all scales. Unlike common approaches that use voxel-by-voxel analysis, our system can utilize regional properties that are often important for characterizing abnormal brain structures. Experiments show successful detections of lesions in both simulated and real MR images. | 10-14-2010 |
20130028516 | IMAGE REGISTRATION METHODS AND APPARATUS USING RANDOM PROJECTIONS - According to some aspects, a computer-implemented method of registering a first image and a second image is provided. The method comprises computer-implemented acts of logically dividing the first image into a first plurality of regions, logically dividing the second image into a second plurality of regions, projecting the first plurality of regions and the second plurality of regions into a lower dimensional space using random projections, determining, for each of the projected first plurality of regions, at least one of the projected second plurality of regions that is closest according to first criteria, and determining a transform that brings each of the projected first plurality of regions into a closest correspondence with the respective at least one of the projected second plurality of regions according to second criteria, the transform indicating the registration of the first image and the second image. According to some aspects, at least one computer readable medium encoding instructions that when executed perform such a method and/or a system for providing such a method is provided. | 01-31-2013 |
Patent application number | Description | Published |
20100035963 | Oligoribonucleotides and Methods of use Thereof for Treatment of Cardiovascular Disease - The invention relates to a double-stranded compound, preferably an oligoribonucleotide, which down-regulates the expression of one or more cardiovascular-related gene. The invention also relates to a pharmaceutical composition comprising the compound, or a vector capable of expressing the oligoribonucleotide compound, and a pharmaceutically acceptable carrier. The present invention also contemplates a method of treating a patient suffering from a cardiovascular disorder or other diseases comprising administering to the patient the pharmaceutical composition in a therapeutically effective dose so as to thereby treat the patient. | 02-11-2010 |
20100267814 | Targeting MicroRNAs for the Treatment of Liver Cancer - Provided herein are methods for the treatment of liver cancer. These methods encompass the administration of a compound comprising a modified oligonucleotide, wherein the modified oligonucleotide is targeted to a miRNA. Also provided herein are compositions for the treatment of liver cancer. Such compositions include compounds comprising a modified oligonucleotide, wherein the modified oligonucleotide is targeted to a miRNA. Certain miRNAs have been identified as overexpressed in liver cancer, such as, for example, hepatocellular carcinoma, and are thus selected for targeting by modified oligonucleotides. Further, certain miRNAs have been identified as overexpressed in hepatocellular carcinoma cells exposed to dioxin, and are thus selected for targeting by modified oligonucleotides. Antisense inhibition of certain of these miRNAs has been found to inhibit cell proliferation and induce apoptosis. | 10-21-2010 |
20110251150 | Targeting MicroRNAs For The Treatment Of Liver Cancer - Provided herein are methods for the treatment of liver cancer. These methods encompass the administration of a compound comprising a modified oligonucleotide, wherein the modified oligonucleotide is targeted to a miRNA. Also provided herein are compositions for the treatment of liver cancer. Such compositions include compounds comprising a modified oligonucleotide, wherein the modified oligonucleotide is targeted to a miRNA. Certain miRNAs have been identified as overexpressed in liver cancer, such as, for example, hepatocellular carcinoma, and are thus selected for targeting by modified oligonucleotides. Further, certain miRNAs have been identified as overexpressed in hepatocellular carcinoma cells exposed to dioxin, and are thus selected for targeting by modified oligonucleotides. Antisense inhibition of certain of these miRNAs has been found to inhibit cell proliferation and induce apoptosis. | 10-13-2011 |
20120232124 | COMPOSITIONS AND METHODS FOR PROGNOSIS AND TREATMENT OF PROSTATE CANCER - Described herein are compositions and methods for prognosis and treatment of prostate cancer patients. Specifically the invention relates to microRNA molecules associated with the prognosis of prostate cancer, as well as various nucleic acid molecules relating thereto or derived therefrom. | 09-13-2012 |
20120295962 | TARGETING MICRORNAS FOR THE TREATMENT OF LIVER CANCER - Provided herein are methods for the treatment of liver cancer. These methods encompass the administration of a compound comprising a modified oligonucleotide, wherein the modified oligonucleotide is targeted to a miRNA. Also provided herein are compositions for the treatment of liver cancer. Such compositions include compounds comprising a modified oligonucleotide, wherein the modified oligonucleotide is targeted to a miRNA. Certain miRNAs have been identified as overexpressed in liver cancer, such as, for example, hepatocellular carcinoma, and are thus selected for targeting by modified oligonucleotides. Further, certain miRNAs have been identified as overexpressed in hepatocellular carcinoma cells exposed to dioxin, and are thus selected for targeting by modified oligonucleotides. Antisense inhibition of certain of these miRNAs has been found to inhibit cell proliferation and induce apoptosis. | 11-22-2012 |
20140206854 | TARGETING MICRORNAS FOR THE TREATMENT OF LIVER CANCER - Provided herein are methods for the treatment of liver cancer. These methods encompass the administration of a compound comprising a modified oligonucleotide, wherein the modified oligonucleotide is targeted to a miRNA. Also provided herein are compositions for the treatment of liver cancer. Such compositions include compounds comprising a modified oligonucleotide, wherein the modified oligonucleotide is targeted to a miRNA. Certain miRNAs have been identified as overexpressed in liver cancer, such as, for example, hepatocellular carcinoma, and are thus selected for targeting by modified oligonucleotides. Further, certain miRNAs have been identified as overexpressed in hepatocellular carcinoma cells exposed to dioxin, and are thus selected for targeting by modified oligonucleotides. Antisense inhibition of certain of these miRNAs has been found to inhibit cell proliferation and induce apoptosis. | 07-24-2014 |
20140336241 | COMPOSITIONS AND METHODS FOR PROGNOSIS AND TREATMENT OF PROSTATE CANCER - Described herein are compositions and methods for prognosis and treatment of prostate cancer patients. Specifically the invention relates to microRNA molecules associated with the prognosis of prostate cancer, as well as various nucleic acid molecules relating thereto or derived therefrom. | 11-13-2014 |
20150216907 | METHODS FOR PREVENTION AND TREATMENT OF PREECLAMPSIA - Methods for treating or preventing preeclampsia or eclampsia by administering adherent stromal cells are described. The adherent stromal cells may be derived from bone marrow, placenta, or adipose tissue. Also described is the use of adherent stromal cells for the manufacture of a medicament, and an article of manufacture comprising a packaging material which comprises a label for use in treating or preventing preeclampsia or eclampsia. | 08-06-2015 |
Patent application number | Description | Published |
20140181928 | METHOD AND SYSTEM FOR PLANNING AND MANAGEMENT OF DIGITAL EVENTS - A method and system is provided that manages events involving an individual's digital assets and/or external services that the individual interfaces with using external service credentials. The method and system allow the individual to securely store digital assets and external service credentials used to login to external services. The method and system further allow the individual to create a plan of actions to be executed on specified dates, where the actions involve one or more of the individual's digital assets and/or involve one or more external services that the individual interfaces with using one or more external service credentials. The plan of actions takes the format of a timeline that includes one or more timeline events, where an action and a date are associated with a timeline event. | 06-26-2014 |
20150149338 | SYSTEM AND METHOD FOR INDEXING, MONITORING, AND INVENTORYING DIGITAL ASSETS - Method(s), system(s), apparatus(es), and computer program products are provided that can index, monitor, inventory, and/or monetize digital assets, such as documents, photographs, videos, blogs, online accounts, social media accounts, e-mail accounts, online banking accounts, etc. | 05-28-2015 |
Patent application number | Description | Published |
20130038680 | IN CAMERA IMPLEMENTATION OF SELECTING AND STITCHING FRAMES FOR PANORAMIC IMAGERY - A system, method, and computer program product for selecting qualifying frames from an image sequence for use in subsequent stitching into a composite panoramic image are disclosed. Incoming frames from any source may be cropped and downscaled prior to evaluation against qualifying criteria relating to image overlap and local motion. Qualifying images are saved and/or output. The resulting panoramic image generally uses fewer qualifying images and appears smoother and has fewer artifacts than those of the prior art. The qualifying criterion for image overlap is a predetermined overlap margin or percentage between a current image and a previous image from the sequence. The qualifying criterion for image motion includes a maximum amount of local motion, often due to passing objects. The embodiments may process incoming images in real time or from stored sequences. Problems may trigger user warnings. | 02-14-2013 |
20140111662 | METHOD FOR CREATING AUTOMATIC CINEMAGRAPHS ON AN IMAGING DEVICE - Embodiments are directed towards automatically creating a cinemagraph on at least an imaging device, where the cinemagraph can be created without additional user interaction beyond capturing an initial sequence of images, and indicating that a cinemagraph is to be created from the sequence. Automatic creation of the cinemagraph includes selecting an anchor frame within the sequence and aligning the other frames to the anchor frame. Detection and segmentation of moving objects within the sequence, with respect to the anchor frame are performed. A mask is generated and refined. Segmentation of masks are then unified, and combined with a background from the anchor frame to generate an animated sequence. | 04-24-2014 |
20150181115 | IN CAMERA IMPLEMENTATION OF SELECTING AND STITCHING FRAMES FOR PANORAMIC IMAGERY - A system, method, and computer program product for selecting qualifying frames from an image sequence for use in subsequent stitching into a composite panoramic image are disclosed. Incoming frames from any source may be cropped and downscaled prior to evaluation against qualifying criteria relating to image overlap and local motion. Qualifying images are saved and/or output. The resulting panoramic image generally uses fewer qualifying images and appears smoother and has fewer artifacts than those of the prior art. The qualifying criterion for image overlap is a predetermined overlap margin or percentage between a current image and a previous image from the sequence. The qualifying criterion for image motion includes a maximum amount of local motion, often due to passing objects. The embodiments may process incoming images in real time or from stored sequences. Problems may trigger user warnings. | 06-25-2015 |
Patent application number | Description | Published |
20130079231 | METHODS FOR OBTAINING A SEQUENCE - The invention generally relates to methods for obtaining a sequence, such as a consensus sequence or a haplotype sequence. In certain embodiments, methods of the invention involve determining an amount of amplifiable nucleic acid present in a sample, partitioning the nucleic acid based upon results of the determining step such that each partitioned portion includes, on average, a subset of unique sequences, sequencing the nucleic acid to obtain sequence reads, and assembling a consensus sequence from the reads. | 03-28-2013 |
20130157870 | METHODS FOR OBTAINING A SEQUENCE - The invention generally relates to methods for obtaining a sequence, such as a consensus sequence or a haplotype sequence. In certain embodiments, methods of the invention involve determining an amount of amplifiable nucleic acid present in a sample, partitioning the nucleic acid based upon results of the determining step such that each partitioned portion includes, on average, a subset of unique sequences, sequencing the nucleic acid to obtain sequence reads, and assembling a consensus sequence from the reads. | 06-20-2013 |