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Ayares
David Ayares, Blacksburg, VA US
| Patent application number | Description | Published |
|---|---|---|
| 20100077494 | Ungulates with Genetically Modified Immune Systems - The present invention provides ungulate animals, tissue and organs as well as cells and cell lines derived from such animals, tissue and organs, which lack expression of functional endogenous immunoglobulin loci. The present invention also provides ungulate animals, tissue and organs as well as cells and cell lines derived from such animals, tissue and organs, which express xenogenous, such as human, immunoglobulin loci. The present invention further provides ungulate, such as porcine genomic DNA sequence of porcine heavy and light chain immunogobulins. Such animals, tissues, organs and cells can be used in research and medical therapy. In addition, methods are provided to prepare such animals, organs, tissues, and cells. | 03-25-2010 |
| 20110038841 | Multi-Transgenic Pigs for Diabetes Treatment - The present invention provides certain animals, and in particular porcine animals, tissue and cells derived from these, which lack any expression of functional alpha 1,3 galactosyltransferase (αGT) and express one or more additional transgenes which make them suitable donors for pancreatic islet xenotransplantation. Methods of treatment and prevention of diabetes using cells derived from such animals are also provided. | 02-17-2011 |
David L. Ayares, Blacksburg, VA US
| Patent application number | Description | Published |
|---|---|---|
| 20080250517 | Methods - The production of genetically modified animals, in which the genetic modifications are engineered in somatic cells cultured in vitro by gene targeting, is described. Genetically modified cells may then used as nuclear donors to produce, inter alia, live animals. The methods described can also be used to validate loci in animal chromosomes which are suitable sites for transgene addition to cells. | 10-09-2008 |
David Lee Ayares, Blacksburg, VA US
| Patent application number | Description | Published |
|---|---|---|
| 20090186097 | Transgenic Ungulates Expressing CTLA4-IG and Uses Thereof - The present invention provides ungulates, including pigs, expressing CTLA4-Ig, as well as tissue, organs, cells and cell lines derived from such animals. Such animals, tissues, organs and cells can be used in research and medical therapy, including xenotransplanation. In addition, methods are provided to prepare organs, tissues and cells expressing the CTLA4-Ig for use in xenotransplantation, and nucleic acid constructs and vectors useful therein. | 07-23-2009 |