Patent application number | Description | Published |
20090208549 | Devices and Methods for Reverse Lipid Transport - The present disclosure relates to devices methods for the reverse transport of lipids such as cholesterols for the treatment diseases and conditions caused by vulnerable plaques. The devices can reduce or eliminate vulnerable plaques by transporting the plaques away from their location. | 08-20-2009 |
20090297577 | Local Delivery of Apolipoproteins and Their Derivatives - Disclosed are medical devices and methods for the local delivery and treatment of vascular conditions. The methods and treatments involve local delivery of at least one apolipoprotein. The vascular conditions described herein include plaque rupture, aneurysm, stenosis, restenosis, atherosclerosis, ischemic myocardial infarct and combinations thereof. | 12-03-2009 |
20090299466 | Local Delivery of Matrix Metalloproteinase Inhibitors - Disclosed are medical devices and methods for the local delivery and treatment of vascular conditions. The methods and treatments involve local delivery of at least one matrix metalloproteinase inhibitor. The vascular conditions described herein include plaque rupture, aneurysm, stenosis, restenosis, atherosclerosis and combinations thereof. | 12-03-2009 |
20100092534 | Combination Local Delivery Using a Stent - Described herein are implantable medical devices useful in treating vascular conditions such as restenosis. In one embodiment, stents are described in which a combination of bioactive agents is described for local delivery in the vasculature. The combination of bioactive agents comprises at least one compound capable of inhibiting smooth muscle cell proliferation and at least one compound capable of mitigating MCP- and/or TF induction. For example, a compound capable of inhibiting smooth muscle cell proliferation is a mTOR inhibitor and a compound capable of mitigating MCP-1 and/or TF induction is a corticosteroid. | 04-15-2010 |
20100124533 | Large Animal Model for Human-Like Advanced Atherosclerotic Plaque - An animal model for cardiovascular disease comprising one or more vascular plaque lesions formed at selected sites within a vascular segment of a nonhuman mammal. The vascular plaque lesion is formed by administering a hypercholesterolemic diet to the nonhuman mammal, inflicting an injury to the vascular wall at the selected site after a predetermined exposure to the hypercholesterolemic diet, and applying a hydrogel to the injured vascular wall. Another aspect of the invention provides a method for evaluating a test compound for an effect on atherosclerotic lesion formation comprising administering to a nonhuman mammal a hypercholesterolemic diet, and, after a defined period of time, isolating a segment of a blood vessel using a balloon catheter, inflicting an injury to the vascular wall within the isolated segment, and applying a hydrogel within the vascular segment. The method further comprises forming a vascular plaque lesion on the vascular wall at the site of the injury, delivering the test compound to the nonhuman mammal, and monitoring atherosclerotic lesion size and composition at the injured site after a defined period of exposure to the test compound. | 05-20-2010 |
20100137976 | Systems and Methods for Treating Heart Tissue Via Localized Delivery of Parp Inhibitors - The systems and methods of the present disclosure, in a broad aspect, provide for treatment of cardiac tissue via localized delivery of PARP inhibitors. These systems include a composition comprising at least one poly(ADP-ribose) polymerase (PARP) inhibitor; and at least one delivery device for introducing the composition into the cardiac tissue. | 06-03-2010 |
20100152832 | Apparatus and Methods for Treatment of Aneurysms With Fibrin Derived Peptide B-Beta - Disclosed herein are methods and stent grafts related to the treatment of aneurysms through the local administration of at least one fibrin derived peptide B-beta. The at least one fibrin derived peptide B-beta can be locally administered by one or more of placing them directly onto a stent graft, incorporating them into a coating found on a stent graft, including them in a delivery device that is associated with a stent graft and/or injecting them through delivery and/or injection catheters at or near the time of stent graft deployment. | 06-17-2010 |
20100280595 | Method and Device for Localized Administration of Calcium Chelating Agent - A system for treating atherosclerotic cardiovascular disease and cardiac valve dysfunction comprises delivering one or more calcium chelating agents locally to a treatment site. One aspect of the invention provides a method including delivering a nano-particulate calcium chelating agent into a vascular wall. Another aspect of the invention provides a method and device for forming a sealed chamber around a cardiac valve, releasing one or more calcium chelating agents into the sealed chamber and decalcifying a cardiac valve in need thereof. | 11-04-2010 |
20120269897 | POLY(TETRAFLUOROETHYLENE) POLYMER WITH NITRIC OXIDE DONATING SURFACE - Described herein are nitric oxide (NO)-donating poly(tetrafluoroethylene) (PTFE) polymers and polymer surfaces and methods of making and using the same. The NO-donating PTFE polymers can be used to fabricate at least a portion of an implantable medical device, coat at least a portion of an implantable medical device or form at least a portion of an implantable medical device. The NO-donating PTFE polymers provide controlled release of NO once implanted at or within the target site. | 10-25-2012 |
20140005591 | Devices and Methods for Photodynamically Modulating Neural Function in a Human | 01-02-2014 |